Invitrogen

CCR7 Chimeric Recombinant Rabbit Monoclonal Antibody (4B12)

View all (59) CCR7 antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-48306

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

10 µg/mL
-

Flow Cytometry (Flow)

Assay-dependent
-

Immunoprecipitation (IP)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4B12

Immunogen

This antibody was raised by immunizing rats with mouse CCR7 antigen.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074748

Product Specific Information

Specificity: This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation.

Target Information

CCR7 is a member of the G protein coupled receptor family, which is a subfamily of chemokines. CCR7 was identified to be induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. CCR7 is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries. Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: C-C chemokine receptor type 7; C-C CKR-7; CD197; chemokine (C-C) receptor 7; EBI1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus-induced G-protein coupled receptor 1; MIP-3 beta receptor

View more View less

Gene Aliases: CC-CKR-7; CCR-7; Ccr7; CD197; Cdw197; Cmkbr7; EBI1; Ebi1h

View more View less

UniProt ID: (Mouse) P47774

View more View less

Entrez Gene ID: (Mouse) 12775

View more View less

Function(s)
signal transducer activity G-protein coupled receptor activity chemokine receptor activity protein binding C-C chemokine receptor activity chemokine (C-C motif) ligand 19 binding chemokine (C-C motif) ligand 21 binding C-C motif chemokine 19 receptor activity C-C motif chemokine 21 receptor activity
Process(es)
establishment of T cell polarity myeloid dendritic cell chemotaxis lymphocyte chemotaxis across high endothelial venule positive regulation of dendritic cell antigen processing and presentation regulation of tolerance induction to self antigen positive regulation of hypersensitivity positive regulation of humoral immune response chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway activation of JUN kinase activity positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis actin cytoskeleton organization response to lipopolysaccharide regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to prostaglandin E chemokine (C-C motif) ligand 19 signaling pathway chemokine (C-C motif) ligand 21 signaling pathway positive regulation of T cell proliferation positive regulation of GTPase activity negative thymic T cell selection positive regulation of T-helper 1 cell differentiation positive regulation of receptor-mediated endocytosis lymph node development regulation of interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion positive regulation of phagocytosis positive regulation of T cell receptor signaling pathway positive regulation of filopodium assembly chemokine-mediated signaling pathway cellular response to cytokine stimulus response to nitric oxide interleukin-12 secretion positive regulation of neutrophil chemotaxis lymphocyte migration into lymph node mature conventional dendritic cell differentiation negative regulation of leukocyte apoptotic process positive regulation of cell motility positive regulation of thymocyte migration positive regulation of dendritic cell chemotaxis positive regulation of immunological synapse formation positive regulation of T cell costimulation positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation regulation of dendritic cell dendrite assembly
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support