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          • Primary Antibodies ›
          • CD10 Antibodies

          Invitrogen

          CD10 Monoclonal Antibody (3G9D10)

          Advanced Verification
          View all (168) CD10 antibodies

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          Datasheet
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          Datasheet
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          Cite CD10 Monoclonal Antibody (3G9D10)

          • Antibody Testing Data (8)
          • Advanced Verification (3)
          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 11

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          CD10 Antibody (MA5-15440) in IHC (P)

          Immunohistochemical analysis of CD10 was performed using formalin-fixed paraffin-embedded mouse kidney and mouse heart tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for ... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD10 Antibody in Western Blot (WB)
          CD10 Antibody in Western Blot (WB)
          CD10 Antibody
          CD10 Antibody
          CD10 Antibody

          Product Details

          MA5-15440

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200-1:1,000
          -

          ELISA (ELISA)

          1:10,000
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          3G9D10

          Immunogen

          Purified recombinant fragment of CD10 expressed in E. Coli.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          Conc. Not Determined

          Storage buffer

          ascites

          Contains

          0.03% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10980657

          Product Specific Information

          MA5-15440 targets CD10 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

          The MA5-15440 immunogen is purified recombinant fragment of CD10 expressed in E. Coli.
          .

          Target Information

          CD10, also known as the Common Acute Lymphocytic Leukemia Antigen (CALLA) and neutral endopeptidase (NEP), is a Zn2+-dependent metallo-peptidase with neutral metalloendopeptidase activity. It is a 100 kDa type II transmembrane glycoprotein encoded by a gene that exists in a single copy of greater than 45 kb. The 5' untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts, although the coding region remains unaffected by alternative splicing. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils and plays a role in stromal cell-dependent B lymphopoiesis. It is expressed on immature B cells in adult bone marrow, mature B cells in germinal centers, and cells from patients with chronic myelocytic leukemia (CML). Additionally, CD10 is present on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas. Beyond the hematopoietic compartment, CD10 is highly expressed on the brush border of enterocytes and renal tubules and glomeruli, as well as on breast myoepithelial cells, bile canaliculi, and fibroblasts. CD10 cleaves peptides at the amino side of hydrophobic residues, inactivating several biologically active peptides, including endothelin, glucagon, gastrin, neurotensin, bradykinin, enkephalins, substance P, oxytocin, and others. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie Tooth Disease, highlighting its significance in both normal physiological processes and disease states.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; Enkephalinase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; NEP; Neprilysin; neprilysin-390; neprilysin-411; Neutral endopeptidase 24.11; SFE; Skin fibroblast elastase

          View more View less

          Gene Aliases: CALLA; CD10; CMT2T; EPN; MME; NEP; SFE

          View more View less

          UniProt ID: (Human) P08473

          View more View less

          Entrez Gene ID: (Human) 4311

          View more View less

          Function(s)
          endopeptidase activity metalloendopeptidase activity protein binding metallopeptidase activity exopeptidase activity zinc ion binding peptide binding
          Process(es)
          kidney development angiotensin maturation proteolysis peptide metabolic process sensory perception of pain creatinine metabolic process beta-amyloid metabolic process cellular response to cytokine stimulus cellular response to UV-A cellular response to UV-B replicative senescence
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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