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Invitrogen
CD103 Monoclonal Antibody (2E7), Pacific Blue™
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Product Details
A15422
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Armenian hamster
/ IgG2
Class
Monoclonal
Type
Antibody
Clone
2E7
Immunogen
Mouse CD103. from C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL)
Conjugate
Excitation/Emission Max
404/455 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
<0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2534435
Target Information
CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD103; DC; DCs; Integrin alpha M290; Integrin alpha-E; Intregrin alpha E2; MGC141996
Gene Aliases: A530055J10; alpha-E1; alpha-M290; aM290; CD103; Itgae
UniProt ID: (Mouse) Q60677
Entrez Gene ID: (Mouse) 16407
Performance Guarantee
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