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Invitrogen
CD105 (Endoglin) Chimeric Recombinant Rabbit Monoclonal Antibody (MJ7/18)
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FIGURE: 1 / 1
CD105 (Endoglin) Chimeric Antibody (MA5-48011) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of CD105 (Endoglin) in mouse splenocytes using CD105 (Endoglin) Chimeric Monoclonal Antibody (Product # MA5-48011). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with CD105 (Endoglin) Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor488 secondary antibody (1 µg/mL), showing membrane staining in a small subset of... View More
Product Details
MA5-48011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MJ7/18
Immunogen
MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074454
Product Specific Information
Specificity: MJ7/18 binds specifically to mouse CD105.
Target Information
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD105; Cell surface MJ7/18 antigen; Endoglin; ORW; transmembrane glycoprotein
Gene Aliases: AI528660; AI662476; CD105; Edg; Endo; Eng; S-endoglin
UniProt ID: (Mouse) Q63961
Entrez Gene ID: (Mouse) 13805
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
transforming growth factor beta binding
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
heart looping
positive regulation of systemic arterial blood pressure
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
protein phosphorylation
cell adhesion
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
negative regulation of cell migration
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
positive regulation of collagen biosynthetic process
intracellular signal transduction
wound healing
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
negative regulation of nitric-oxide synthase activity
cell chemotaxis
negative regulation of pathway-restricted SMAD protein phosphorylation
extracellular matrix constituent secretion
detection of hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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