Proteintech

CD115 (c-fms) Monoclonal Antibody (AFS98)

View all (80) CSF1R (CD115) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

65095-1-IG

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

AFS98

Immunogen

Immunogen information and sequence are proprietary

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3

Contains

0.1% sodium azide

Storage conditions

4°C

Shipping conditions

Wet ice

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-fms; CD115; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; kinase CSFR; Macrophage colony-stimulating factor 1 receptor; OTTHUMP00000224093; Proto-oncogene c-Fms; proto-oncogene fms

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Gene Aliases: AI323359; CD115; CSF-1R; Csf1r; Csfmr; Fim-2; Fms; M-CSF-R; M-CSFR

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UniProt ID: (Mouse) P09581

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Entrez Gene ID: (Mouse) 12978

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity macrophage colony-stimulating factor receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein phosphatase binding cytokine binding protein homodimerization activity
Process(es)
positive regulation of protein phosphorylation immune system process protein phosphorylation inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway cell proliferation positive regulation of cell proliferation regulation of cell shape phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway hemopoiesis osteoclast differentiation positive regulation of cell migration ruffle organization cellular response to macrophage colony-stimulating factor stimulus macrophage colony-stimulating factor signaling pathway positive regulation of tyrosine phosphorylation of Stat3 protein innate immune response regulation of bone resorption cell-cell junction maintenance positive regulation of osteoclast differentiation phosphatidylinositol metabolic process protein autophosphorylation phosphatidylinositol-mediated signaling positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade cellular response to cytokine stimulus positive regulation of protein serine/threonine kinase activity positive regulation of chemokine secretion positive regulation of cell motility regulation of actin cytoskeleton reorganization
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