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Invitrogen
CD142 Monoclonal Antibody (K06319_4H12)
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CD142 Antibody (MA5-55973) in IHC (P)
Immunohistochemistry analysis of CD142 in paraffin-embedded kidney tissue. Sample was incubated with CD142 monoclonal antibody (Product # MA5-55973) at a dilution of 7.5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature. ... View More
Product Details
MA5-55973
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
K06319_4H12
Immunogen
Recombinant human F3 (immunogen range is 91-160).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_3668205
Product Specific Information
Sequence of this protein is as follows: LTDEIVKDVK QTYLARVFSY PAGNVESTGS AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE
Target Information
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD142; Coagulation factor III; coagulation factor III (thromboplastin, tissue factor); TF; Thromboplastin; Tissue factor
Gene Aliases: CD142; F3; TF; TFA
UniProt ID: (Human) P13726
Entrez Gene ID: (Human) 2152
positive regulation of endothelial cell proliferation
activation of plasma proteins involved in acute inflammatory response
activation of blood coagulation via clotting cascade
activation of cysteine-type endopeptidase activity involved in apoptotic process
aging
blood coagulation
blood coagulation, extrinsic pathway
response to temperature stimulus
response to mechanical stimulus
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of smooth muscle cell migration
protein processing
cytokine-mediated signaling pathway
positive regulation of cell migration
response to estradiol
response to lipopolysaccharide
response to fluid shear stress
positive regulation of angiogenesis
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
response to low-density lipoprotein particle
cellular response to hydrogen peroxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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