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Product Details
A15799
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
MEM-CD148/05
Immunogen
Human recombinant CD148 (amino acids 1-444)
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2534577
Product Specific Information
This antibody recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosine phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
Target Information
CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD148; CD148 antigen; Density-enhanced phosphatase 1; DEP-1; HPTP eta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; Receptor-type tyrosine-protein phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of
Gene Aliases: CD148; DEP1; HPTPeta; PTPRJ; R-PTP-ETA; SCC1
UniProt ID: (Human) Q12913
Entrez Gene ID: (Human) 5795
negative regulation of cell proliferation
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of cell adhesion
negative regulation of cell growth
negative regulation of cell migration
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of MAP kinase activity
positive regulation of cell adhesion
platelet-derived growth factor receptor signaling pathway
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
positive chemotaxis
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
contact inhibition
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