Product References
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.
Frontiers in immunology
Masle-Farquhar E,Jeelall Y,White J,Bier J,Deenick EK,Brink R,Horikawa K,Goodnow CC
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Mon Mar 27 00:00:00 UTC 2023
HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression.
Theranostics
Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Tue Apr 18 00:00:00 UTC 2023
CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis.
Frontiers in immunology
Ma B,Kamle S,Akosman B,Khan H,Lee CM,Lee CG,Elias JA
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Tue Jan 10 00:00:00 UTC 2023
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Thu Dec 01 00:00:00 UTC 2022
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Tue Jan 11 00:00:00 UTC 2022
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Mon Jan 25 00:00:00 UTC 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Fri Mar 19 00:00:00 UTC 2021
Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity.
International journal of molecular sciences
Lou Y,Wang J,Peng P,Wang S,Liu P,Xu LX
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Wed Sep 15 00:00:00 UTC 2021
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Fri Jun 26 00:00:00 UTC 2020
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
14-1522 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 UTC 2019
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
The Journal of experimental medicine
Seki A,Rutz S
14-1522 was used in Flow cytometry/Cell sorting to develop an optimised approach for Cas9/RNP transfection of primary mouse and human T cells without TCR stimulation, that results in near complete loss of target gene expression at the population level.
Mon Mar 05 00:00:00 UTC 2018
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.
Journal of immunology research
Chen T,Hou X,Ni Y,Du W,Han H,Yu Y,Shi G
14-1522 was used in Flow cytometry/Cell sorting to study the impaired immunosupression function in asthmatic patients in regard to T cell phenotype.
Wed Nov 14 00:00:00 UTC 2018
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
14152282 was used in flow cytometry to characterize conventional and regulatory T cells during pregnancy
Tue Jan 10 00:00:00 UTC 2017
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Journal of immunology (Baltimore, Md. : 1950)
Marshall NB,Vong AM,Devarajan P,Brauner MD,Kuang Y,Nayar R,Schutten EA,Castonguay CH,Berg LJ,Nutt SL,Swain SL
14152282 was used in flow cytometry to determine that NKG2C/E identifies the CD4 T cell effector subset ThCTL that develop in the lung during influenza A virus infection in mice
Wed Feb 01 00:00:00 UTC 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Mon Feb 13 00:00:00 UTC 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Tue Jun 27 00:00:00 UTC 2017
Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells.
Scientific reports
Chien CH,Yu HC,Chen SY,Chiang BL
14152282 was used in flow cytometry to generate and characterize Treg-of-B cells
Wed Apr 12 00:00:00 UTC 2017
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-1522 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 UTC 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Mon Aug 08 00:00:00 UTC 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Mon Aug 08 00:00:00 UTC 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Mon Aug 08 00:00:00 UTC 2016
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.
Clinical & translational immunology
Li K,Baird M,Yang J,Jackson C,Ronchese F,Young S
14-1522 was used in Flow cytometry/Cell sorting to provide valuable data for further research into in vitro expansion of CD4(+) Th1-like cells, with potential applications to cancer treatment involving ACT.
Mon Aug 01 00:00:00 UTC 2016
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
14-1522 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 UTC 2015
Regulatory T cells require TCR signaling for their suppressive function.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt AM,Lu W,Sindhava VJ,Huang Y,Burkhardt JK,Yang E,Riese MJ,Maltzman JS,Jordan MS,Kambayashi T
14-1522 was used in Flow cytometry/Cell sorting to reveal that T cell receptor-mediated PLCγ activation is required for Tregs to inhibit Tconv proliferation.
Fri May 01 00:00:00 UTC 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 14-1522-82) in Flow Cytometry
Thu Apr 28 00:00:00 UTC 2016
KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production.
Proceedings of the National Academy of Sciences of the United States of America
Pabbisetty SK,Rabacal W,Maseda D,Cendron D,Collins PL,Hoek KL,Parekh VV,Aune TM,Sebzda E
14-1522 was used in Flow cytometry/Cell sorting to identify the first transcription factor to distinguish between i/pTreg and tTreg ontogeny and demonstrate that KLF2 is a therapeutic target for the production of regulatory T cells.
Tue Jul 01 00:00:00 UTC 2014
Dynamic equilibrium of heterogeneous and interconvertible multipotent hematopoietic cell subsets.
Scientific reports
Weston W,Zayas J,Perez R,George J,Jurecic R
14-1522 was used in Flow cytometry/Cell sorting to suggest that interconvertible multipotent hematopoietic cell subsets coexist in a homeostatically maintained dynamic equilibrium which is regulated by currently unknown cell-intrinsic mechanisms.
Fri Jun 06 00:00:00 UTC 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-1522 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 UTC 2015
Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.
Journal of immunology (Baltimore, Md. : 1950)
Huang H,Ma Y,Dawicki W,Zhang X,Gordon JR
14-1522 was used in Flow cytometry/Cell sorting to compare abilities of nTreg and iTreg cells to mediate tolerance in OVA-asthmatic C57BL/6 mice.
Thu Aug 01 00:00:00 UTC 2013
Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells.
Cellular immunology
Grishkan IV,Ntranos A,Calabresi PA,Gocke AR
14-1522 was used in Flow cytometry/Cell sorting to investigate whether double-negative T cells that accumulate in some autoimmune diseases can arise from hyper-stimulated pathogenic CD4+ T cells.
Thu Mar 20 00:00:00 UTC 2014
Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kuonen F,Laurent J,Secondini C,Lorusso G,Stehle JC,Rausch T,Faes-Van't Hull E,Bieler G,Alghisi GC,Schwendener R,Andrejevic-Blant S,Mirimanoff RO,Rüegg C
14-1522 was used in Flow cytometry/Cell sorting to demonstrate the critical role of KitL/c-Kit in promoting metastasis of 4T1 tumors growing in pre-irradiated mammary tissue.
Wed Aug 15 00:00:00 UTC 2012
Transcutaneous vaccination via laser microporation.
Journal of controlled release : official journal of the Controlled Release Society
Weiss R,Hessenberger M,Kitzmüller S,Bach D,Weinberger EE,Krautgartner WD,Hauser-Kronberger C,Malissen B,Boehler C,Kalia YN,Thalhamer J,Scheiblhofer S
14-1522 was used in Flow cytometry/Cell sorting to investigate the potential of transcutaneous immunisation via laser-generated micropores for induction of specific immune responses.
Mon Sep 10 00:00:00 UTC 2012
Alveolar macrophage dynamics in murine lung regeneration.
Journal of cellular physiology
Chamoto K,Gibney BC,Ackermann M,Lee GS,Lin M,Konerding MA,Tsuda A,Mentzer SJ
14-1522 was used in Flow cytometry/Cell sorting to investigate the contribution of alveolar macrophages to murine post-pneumonectomy lung growth.
Sat Sep 01 00:00:00 UTC 2012
Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.
PloS one
Langenhorst D,Gogishvili T,Ribechini E,Kneitz S,McPherson K,Lutz MB,Hünig T
14-1522 was used in Flow cytometry/Cell sorting to investigate the origin and fate of IL-10 producing Tregs.
Mon May 20 00:00:00 UTC 2013
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
The Journal of clinical investigation
Elkabets M,Gifford AM,Scheel C,Nilsson B,Reinhardt F,Bray MA,Carpenter AE,Jirström K,Magnusson K,Ebert BL,Pontén F,Weinberg RA,McAllister SS
14-1522 was used in Flow cytometry/Cell sorting to demonstrate that Sca1+cKit- hematopoietic BMCs of mouse hosts bearing instigating tumors promote growth of responding tumors.
Tue Feb 01 00:00:00 UTC 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-1522 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 UTC 2011
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications
Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M
14-1522 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Tue Sep 20 00:00:00 UTC 2011
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-1522 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 UTC 2009
Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms.
International immunology
Boehme SA,Chen EP,Franz-Bacon K,Sásik R,Sprague LJ,Ly TW,Hardiman G,Bacon KB
14-1522 was used in Flow cytometry/Cell sorting to suggest that CRTH2 has a pivotal role in mediating the inflammation and the underlying immune response following epicutaneous sensitization.
Thu Jan 01 00:00:00 UTC 2009
Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta.
Diabetes
Richer MJ,Straka N,Fang D,Shanina I,Horwitz MS
14-1522 was used in Functional assays to demonstrate the protective ability of regulatory T cells induced after coxsackievirus B4 infection in the presence of transforming growth factor-beta in preventing type 1 diabetes.
Thu May 01 00:00:00 UTC 2008
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.
The Journal of biological chemistry
Grigorian A,Lee SU,Tian W,Chen IJ,Gao G,Mendelsohn R,Dennis JW,Demetriou M
14-1522 was used in Flow cytometry/Cell sorting to investigate how the environment influences susceptibility to autoimmunity, showing that autoimmunity can be controlled through metabolite flux to N-glycan biosynthesis.
Fri Jul 06 00:00:00 UTC 2007
