Product References
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.
Frontiers in immunology
Masle-Farquhar E,Jeelall Y,White J,Bier J,Deenick EK,Brink R,Horikawa K,Goodnow CC
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Mon Mar 27 00:00:00 UTC 2023
Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance.
iScience
Que W,Ueta H,Hu X,Morita-Nakagawa M,Fujino M,Ueda D,Tokuda N,Huang W,Guo WZ,Zhong L,Li XK
17-1522-82 was used in Flow Cytometry to depict the temporal and spatial dynamics of immune cells in the spleen and liver in a murine model of spontaneous liver allograft acceptance.
Fri Sep 15 00:00:00 UTC 2023
HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression.
Theranostics
Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Tue Apr 18 00:00:00 UTC 2023
CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis.
Frontiers in immunology
Ma B,Kamle S,Akosman B,Khan H,Lee CM,Lee CG,Elias JA
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Tue Jan 10 00:00:00 UTC 2023
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Thu Dec 01 00:00:00 UTC 2022
Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy.
Biomedicines
Liu W,Chen H,Zhu Z,Liu Z,Ma C,Lee YJ,Bartlett DL,Guo ZS
17-1522-82 was used in Flow cytometry/Cell sorting to demonstrate that erastin can exert cytotoxicity on cancer cells via ferroptosis, but has little effect on immune activity by itself.
Wed Jun 15 00:00:00 UTC 2022
Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV.
Cell reports. Medicine
Takele Y,Mulaw T,Adem E,Shaw CJ,Franssen SU,Womersley R,Kaforou M,Taylor GP,Levin M,Müller I,Cotton JA,Kropf P
17-1522-82 was used in Flow Cytometry to identify three immunological markers associated with visceral leishmaniasis relapse in VL/HIV patients.
Tue Jan 18 00:00:00 UTC 2022
Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis.
The Prostate
Liu Y,Zhang Y,Zhang M,Meng J,Ma Q,Hao Z,Zheng M,Zhang L,Chen X,Liang C
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Tue Jan 11 00:00:00 UTC 2022
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Mon Jan 25 00:00:00 UTC 2021
Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance.
Frontiers in immunology
Maulloo CD,Cao S,Watkins EA,Raczy MM,Solanki AS,Nguyen M,Reda JW,Shim HN,Wilson DS,Swartz MA,Hubbell JA
17-1522-82 was used in Flow cytometry/Cell sorting to demonstrate that targeting glycoconjugates to lymph node APCs under homeostatic conditions leads to increased accumulation in the lymph nodes.
Wed Dec 22 00:00:00 UTC 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Fri Mar 19 00:00:00 UTC 2021
Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity.
International journal of molecular sciences
Lou Y,Wang J,Peng P,Wang S,Liu P,Xu LX
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Wed Sep 15 00:00:00 UTC 2021
MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.
The Journal of clinical investigation
Di Giorgio E,Wang L,Xiong Y,Akimova T,Christensen LM,Han R,Samanta A,Trevisanut M,Bhatti TR,Beier UH,Hancock WW
17-1522 was used in Flow cytometry/Cell sorting to study the role played by MEF2D in sustaining effector Foxp3+ Treg functions without abrogating their basal actions suggests its suitability for drug discovery efforts in cancer therapy.
Tue Dec 01 00:00:00 UTC 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
17-1522 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 UTC 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
17-1522 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 UTC 2020
Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+ CD25+ regulatory T cells.
Journal of cellular and molecular medicine
Ge Y,Huang M,Wu Y,Dong N,Yao YM
17-1522-82 was used in Flow Cytometry to investigate the role of IL-38 in mediating the activity of CD4+ CD25+ Tregs during sepsis.
Wed Jan 01 00:00:00 UTC 2020
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells.
JCI insight
Deng S,Sun Z,Qiao J,Liang Y,Liu L,Dong C,Shen A,Wang Y,Tang H,Fu YX,Peng H
17-1522-82 was used in Flow Cytometry to reveal that Erb-IL21 can target IL-21 to tumors and maximize the antitumor potential of checkpoint blockade by expending a subset of tumor antigen-specific CD8+ T cells to achieve effective tumor control.
Thu Apr 09 00:00:00 UTC 2020
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Thu Oct 29 00:00:00 UTC 2020
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
17-1522 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 UTC 2019
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
17-1522 was used in Flow cytometry/Cell sorting to explore a variety of IL-2 constructs expressed by a tumour-selective oncolytic vaccinia virus, designed to maintain IL-2 in the tumour microenvironment to reduce systemic toxicity.
Thu Nov 08 00:00:00 UTC 2018
RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer.
Oncoimmunology
Ahern E,Harjunpää H,O'Donnell JS,Allen S,Dougall WC,Teng MWL,Smyth MJ
17-1522 was used in Flow cytometry/Cell sorting to set the scene for clinical evaluation of denosumab use in patients receiving contemporary immune checkpoint blockade.
Tue Jan 12 00:00:00 UTC 2021
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
17-1522 was used in Flow cytometry/Cell sorting to demonstrate that T-bet+ Treg cells have an essential immunosuppressive function.
Thu Jun 15 00:00:00 UTC 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
17-1522-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 UTC 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
17-1522 was used in Flow cytometry/Cell sorting to demonstrate that combining an oncolytic virus with tumor-targeting immune checkpoint modulators elicits potent in situ autologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeutic effect.
Sat Jul 15 00:00:00 UTC 2017
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
17152282 was used in flow cytometry to characterize conventional and regulatory T cells during pregnancy
Tue Jan 10 00:00:00 UTC 2017
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.
Immunology and cell biology
Alberdi M,Iglesias M,Tejedor S,Merino R,López-Rodríguez C,Aramburu J
17-1522 was used in Flow cytometry/Cell sorting to show that NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context.
Sun Jan 01 00:00:00 UTC 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Mon Feb 13 00:00:00 UTC 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
17-1522 was used in Flow cytometry/Cell sorting to show that Cblb-/- T cells are less susceptible to PD-L1-mediated suppression of T cell proliferation and IFNγ secretion.
Tue Jun 27 00:00:00 UTC 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
17-1522 was used in Flow cytometry/Cell sorting to show that Cblb-/- T cells are less susceptible to PD-L1-mediated suppression of T cell proliferation and IFNγ secretion.
Tue Jun 27 00:00:00 UTC 2017
CD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway.
Stem cell research & therapy
Wei Y,Hu Z,Gu W,Liu G,Shi B,Liu E,Liu T
17-1522 was used in Flow cytometry/Cell sorting to suggest that CD44+CD117+ T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.
Thu Mar 09 00:00:00 UTC 2017
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Mon Aug 08 00:00:00 UTC 2016
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells.
Scientific reports
Wang DW,Dong N,Wu Y,Zhu XM,Wang CT,Yao YM
17-1522-82 was used in Flow Cytometry to conclude that rhIL-37 enhances the suppressive activity of CD4+CD25+ Tregs and might be a potential immunomodulator for the treatment of septic complications.
Mon Dec 12 00:00:00 UTC 2016
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
17-1522 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 UTC 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 17-1522-82) in Flow Cytometry
Thu Apr 28 00:00:00 UTC 2016
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Journal of leukocyte biology
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
17-1522 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.
Sat Nov 01 00:00:00 UTC 2014
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
Journal of immunology (Baltimore, Md. : 1950)
Mc Guire C,Wieghofer P,Elton L,Muylaert D,Prinz M,Beyaert R,van Loo G
17-1522 was used in Flow cytometry/Cell sorting to study the role of MALT1 in the development of experimental autoimmune encephalomyelitis.
Fri Mar 15 00:00:00 UTC 2013
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Altin JA,Goodnow CC,Cook MC
17-1522 was used in Flow cytometry/Cell sorting to investigate the mechanism and molecules involved in the formation of IL10+CTLA-4+Th2 inhibitory cells during chronic inflammation.
Fri Jun 01 00:00:00 UTC 2012
Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
BMC gastroenterology
Majowicz A,van der Marel S,te Velde AA,Meijer SL,Petry H,van Deventer SJ,Ferreira V
17-1522 was used in Flow cytometry/Cell sorting to identify a new method to generate in vitro iTreg cells (TregPMA cells) with demonstrated functionality in vivo.
Mon Dec 03 00:00:00 UTC 2012
