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Product Details
PA1-26457
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide surrounding amino acid 246 of human CD40 Ligand.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 30% glycerol, 0.5% BSA, 5mM EDTA
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_779619
Product Specific Information
PA1-26457 detects CD40L from human samples.
Target Information
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand CD154; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; tumor necrosis factor (ligand) superfamily, member 5; Tumor necrosis factor ligand superfamily member 5
Gene Aliases: CD154; CD40-L; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; TNFSF5; TRAP
UniProt ID: (Human) P29965, (Mouse) P27548, (Rat) Q9Z2V2
Entrez Gene ID: (Human) 959, (Mouse) 21947, (Rat) 84349
inflammatory response
leukocyte cell-cell adhesion
activation of JUN kinase activity
platelet activation
B cell differentiation
T cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
tumor necrosis factor-mediated signaling pathway
B cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
isotype switching
immunoglobulin secretion
regulation of immune response
regulation of immunoglobulin secretion
positive regulation of NF-kappaB transcription factor activity
positive regulation of endothelial cell apoptotic process
positive regulation of immune response to tumor cell
immune response
signal transduction
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of MHC class II biosynthetic process
dendritic cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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