Proteintech

CD163 Polyclonal Antibody

CD163 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 11

CD163 Antibody (16646-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human tonsillitis tissue slide using (Product # 16646-1-AP) CD163 antibody at dilution of 1:2,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CD163 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

16646-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 43 publications 43 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:4,800

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

View 56 publications 56 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 3 publications 3 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD163 Fusion Protein Ag10029 (46-401 aa encoded by BC051281)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GTDKELRLV DGENKCSGRV EVKVQEEWGT VCNNGWSMEA VSVICNQLGC PTAIKAPGWA NSSAGSGRIW MDHVSCRGNE SALWDCKHDG WGKHSNCTHQ QDAGVTCSDG SNLEMRLTRG GNMCSGRIEI KFQGRWGTVC DDNFNIDHAS VICRQLECGS AVSFSGSSNF GEGSGPIWFD DLICNGNESA LWNCKHQGWG KHNCDHAEDA GVICSKGADL SLRLVDGVTE CSGRLEVRFQ GEWGTICDDG WDSYDAAVAC KQLGCPTAVT AIGRVNASKG FGHIWLDSVS CQGHEPAVWQ CKHHEWGKHY CNHNEDAGVT CSDGSDLELR LRGGGSRCAG TVEVEIQRLL GKVCDRG (46-401 aa encoded by BC051281)

Target Information

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein, a member of the scavenger receptor cysteine-rich superfamily, and a receptor for the hemoglobin-haptoglobin complex. CD163 protects tissues from free hemoglobin-mediated oxidative damage, and may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. Specifically, CD163 is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan's cells. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant. CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, and exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Further, CD163 also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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