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Product Details
PA5-97113
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1143-1257 of human CD171/L1CAM (NP_0004161)
Conjugate
Form
Liquid
Concentration
2.06 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808915
Product Specific Information
Immunogen sequence: IKRSKGGKYS VKDKEDTQVD SEARPMKDET FGEYRSLESD NEEKAFGSSQ PSLNGDIKPL GSDDSLADYG GSVDVQFNED GSFIGQYSGK KEKEAAGGND SSGATSPINP AVALE; Positive Samples: SH-SY5Y, Mouse brain; Cellular Location: Cell membrane, Cell projection, Single-pass type I membrane protein, growth cone
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody R1; CD 171; CD171; CD171 molecule; N-CAM L1; N-CAM-L1; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NILE; sCD171; sL1 CAM; sL1CAM; soluble CD 171; soluble CD171; soluble L1 CAM; soluble L1CAM
Gene Aliases: CAML1; CD171; HSAS; HSAS1; Hyd; L1; L1CAM; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; NCAML1; S10; SPG1
UniProt ID: (Human) P32004, (Rat) Q05695
Entrez Gene ID: (Human) 3897, (Mouse) 16728, (Rat) 50687
chemotaxis
cell adhesion
nervous system development
axon guidance
positive regulation of axon extension
leukocyte migration
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
cell surface receptor signaling pathway
multicellular organism development
positive regulation of cell-cell adhesion
cell differentiation
neuron projection development
cell-cell adhesion mediated by integrin
homotypic cell-cell adhesion
positive regulation of calcium-mediated signaling
cellular response to ethanol
cellular response to transforming growth factor beta stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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