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Invitrogen
CD184 (CXCR4) Monoclonal Antibody (9D9)
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FIGURE: 1 / 1
CD184 (CXCR4) Antibody (MA5-28302) in Flow
Flow cytometry of CD184 (CXCR4) in mouse anti Chicken CD184 / CXCR4, clone 9D9 Bursa cells were separated by density centrifugation and. Sample was incubated with CD184 (CXCR4) monoclonal antibody (Product # MA5-28302), followed by Goat anti Mouse IgG - FITC.
Product Details
MA5-28302
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
9D9
Immunogen
Chicken CXCR4 (chCXCR4) transfected HEK294 cells
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745265
Product Specific Information
This antibody recognizes the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin. CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Bursa cells may be used as a positive control for CXCR4 in flow cytometry.
Target Information
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development. CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 4; CC motif chemokine; CCmotif chemokine; CD antigen CD184; chemokine receptor CXCR4; CXC; CXC motif chemokine; HUMSTR
Entrez Gene ID: (Chicken) 395324
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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