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Proteintech
CD1d Monoclonal Antibody (1C12F1)
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Product Details
66257-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C12F1
Immunogen
CD1d Fusion Protein Ag11108 (18-302 aa encoded by BC027926)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SAEVPQRLF PLRCLQISSF ANSSWTRTDG LAWLGELQTH SWSNDSDTVR SLKPWSQGTF SDQQWETLQH IFRVYRSSFT RDVKEFAKML RLSYPLELQV SAGCEVHPGN ASNNFFHVAF QGKDILSFQG TSWEPTQEAP LWVNLAIQVL NQDKWTRETV QWLLNGTCPQ FVSGLLESGK SELKKQVKPK AWLSRGPSPG PGRLLLVCHV SGFYPKPVWV KWMRGEQEQQ GTQPGDILPN ADETWYLRAT LDVVAGEAAG LSCRVKHSSL EGQDIVLYWG GSYTSM (18-302 aa encoded by BC027926)
Target Information
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by the CD1d gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antigen-presenting glycoprotein CD1d; CD1d; CD1D antigen, d polypeptide; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; R3G1; T-cell surface glycoprotein CD1d; thymocyte antigen CD1D
Gene Aliases: CD1A; CD1D; R3; R3G1
UniProt ID: (Human) P15813
Entrez Gene ID: (Human) 912
viral process
detection of bacterium
heterotypic cell-cell adhesion
positive regulation of T cell proliferation
T cell selection
innate immune response
positive regulation of innate immune response
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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