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          • Primary Antibodies ›
          • CD206 (MMR) Antibodies

          Proteintech

          CD206 Monoclonal Antibody (2A6A10)

          101 References
          View all (56) CD206 (MMR) antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
          Questions & Answers

          Cite CD206 Monoclonal Antibody (2A6A10)

          • Antibody Testing Data (6)
          CD206 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          CD206 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 6

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          CD206 Antibody (60143-1-IG) in IHC (P)

          Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using (Product # 60143-1-IG) (CD206 antibody) at dilution of 1:2,0000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD206 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD206 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD206 Antibody in Western Blot (WB)
          CD206 Antibody in Western Blot (WB)
          CD206 Antibody in Flow Cytometry (Flow)
          CD206 Antibody in Immunoprecipitation (IP)

          Product Details

          60143-1-IG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:4,000
          View 15 publications 15 publications

          Immunohistochemistry (IHC)

          -
          View 35 publications 35 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20,000
          -

          Immunocytochemistry (ICC/IF)

          Assay-dependent
          View 44 publications 44 publications

          Flow Cytometry (Flow)

          0.2 µg/1x10^6 cells
          View 4 publications 4 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication

          Not applicable (N/A)

          -
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human

          Published species

          Mouse, Rat

          Host/Isotype

          Mouse / IgG2a

          Class

          Monoclonal

          Type

          Antibody

          Clone

          2A6A10

          Immunogen

          Peptide

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • CoraLite 594
          • CoraLite Plus 488
          • Request custom conjugation

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1.

          Target Information

          CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; CD206; hMR; Human mannose receptor; Macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1-like 1; MMR

          View more View less

          Gene Aliases: bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR; MMR; MRC1; MRC1L1

          View more View less

          UniProt ID: (Human) P22897

          View more View less

          Entrez Gene ID: (Human) 4360

          View more View less

          Function(s)
          virus receptor activity receptor activity transmembrane signaling receptor activity protein binding mannose binding
          Process(es)
          receptor-mediated endocytosis signal transduction viral entry into host cell cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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