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Proteintech
CD206 Monoclonal Antibody (44607), PE
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CD206 Antibody (PE-65155100TEST) in Flow
THP-1 cells were differentiated into macrophages by incubation in the presence of phorbol 12-myristate 13-acetate (PMA). THP-1-derived macrophages were surface stained with PE Anti-Human CD206 (Product # PE-65155100TEST), Clone: 15-2) (dashed line), or polarized in M2 macrophages by incubation with IL-4 (20 ng/mL) and IL-13 (20 ng/mL) for 48h and then surface stained with PE Anti-Human CD206 (Product # PE-65155100TEST), Clone: 15-2) (red) or isotype control (blue, solid line). Cells were not fixed.
Product Details
PE-65155100TEST
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
44607
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
10 µL/Test
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; CD206; hMR; Human mannose receptor; Macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1-like 1; MMR
Gene Aliases: bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR; MMR; MRC1; MRC1L1
UniProt ID: (Human) P22897
Entrez Gene ID: (Human) 4360
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