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Abnova
CD209 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 3
CD209 Antibody (H00030835-D01P) in WB
Western Blot analysis of CD209 expression in transfected 293T cell line (H00030835-T02) by CD209 MaxPab polyclonal antibody.
Lane 1: CD209 transfected lysate(45.80 KDa).
Lane 2: Non-transfected lysate.
Lane 1: CD209 transfected lysate(45.80 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00030835-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD209 (NP_066978.1, 1 a.a. approximately 404 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF TLLAGLLVQV SKVPSSISQE QSRQDAIYQN LTQLKAAVGE LSEKSKLQEI YQELTQLKAA VGELPEKSKL QEIYQELTRL KAAVGELPEK SKLQEIYQEL TWLKAAVGEL PEKSKMQEIY QELTRLKAAV GELPEKSKQQ EIYQELTRLK AAVGELPEKS KQQEIYQELT RLKAAVGELP EKSKQQEIYQ ELTQLKAAVE RLCHPCPWEW TFFQGNCYFM SNSQRNWHDS ITACKEVGAQ LVVIKSAEEQ NFLQLQSSRS NRFTWMGLSD LNQEGTWQWV DGSPLLPSFK QYWNRGEPNN VGEEDCAEFS GNGWNDDKCN LAKFWICKKS AASCSRDEEQ FLSPAPATPN PPPA
Target Information
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209; CD209 antigen; CD209 antigen-like protein A; DC-SIGN; Dendritic cell-specific ICAM-3-grabbing non-integrin; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965; MGC130443
Gene Aliases: CD209; Cd209a; CDSIGN; CIRE; CLEC4L; DC-SIGN; DC-SIGN1; Dcsign; SIGN-R1; SIGNR5
UniProt ID: (Human) Q9NNX6, (Mouse) Q91ZX1
Entrez Gene ID: (Human) 30835, (Mouse) 170786
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
endocytosis
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
cell-cell recognition
modulation by virus of host morphology or physiology
virion attachment to host cell
viral genome replication
antigen processing and presentation
intracellular signal transduction
regulation of T cell proliferation
innate immune response
viral entry into host cell
peptide antigen transport
intracellular transport of virus
regulation of gene expression
regulation of blood coagulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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