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CD21 Antibody (MA5-28319) in Flow
Flow cytometry of CD21 in red cell lysed bovine blood. Sample was incubated in the presence of 10% bovine serum, CD21 monoclonal antibody (Product # MA5-28319) and gated on lymphocytes. Figures are arranged as follows: A) RPE conjugated Mouse anti Bovine CD8b and FITC conjugated Mouse IgG1 isotype control. B) RPE conjugated Mouse anti Bovine CD8b and FITC conjugated Mouse anti Bovine CD21.
Product Details
MA5-28319
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CC21
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745282
Product Specific Information
Mouse anti Bovine CD21 monoclonal antibody, clone CC21 recognizes the bovine CD21 cell surface antigen, a approximately 145 kDa single pass type I membrane glycoprotein containing multiple sushi domains.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Complement C3d receptor (C3DR); complement component receptor 2; complement receptor 1 long isoform; complement receptor type 2; Complement Receptor type 2 (CR2); EBV-R; EVBR
Gene Aliases: BOS_15584; cd21
Entrez Gene ID: (Bovine) 407126
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