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Invitrogen
CD210 (IL-10R) Monoclonal Antibody (1B1.3a), Functional Grade, eBioscience™
Product Details
16-2101-85
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B1.3a
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2573082
Product Specific Information
Description: The 1B1.3A monoclonal antibody reacts with mouse CD210, which is also known as the IL-10 receptor. CD210 is a member of the interferon receptor-like family that is expressed on a variety of hematopoietic cells, including thymocytes, T cells, B cells, NK cells, monocytes, and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation.
The 1B1.3A antibody has been reported to have neutralizing activity.
Applications Reported: The 1B1.3A antibody has been reported for use in functional assays.
Storage and handling: Use in a sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: Greater than 90%, as determined by SDS-PAGE.
Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
Aggregation: Less than 10%, as determined by HPLC.
Target Information
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD210; CDw210a; CDW210B; CRF2-4; CRFB4; D21S58; D21S66; I10R; I10R1; il-10 receptor; il-10 receptor antagonist; IL-10 receptor subunit alpha; IL-10R alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10R2; IL-10RA; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha
Gene Aliases: AW553859; CDw210; CDw210a; Il10r; Il10ra; mIL-10R
UniProt ID: (Mouse) Q61727
Entrez Gene ID: (Mouse) 16154
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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