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Product Details
60208-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3H6B8
Immunogen
CD23 Fusion Protein Ag0425 (48-248 aa encoded by BC064417)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DTTQSLKQL EERAARNVSQ VSKNLESHHG DQMAQKSQST QISQELEELR AEQQRLKSQD LELSWNLNGL QADLSSFKSQ ELNERNEASD LLERLREEVT KLRMELQVSS GFVCNTCPEK WINFQRKCYY FGKGTKQWVH ARYACDDMEG QLVSIHSPEE QDFLTKHASH TGSWIGLRNL DLKGEFIWVD GSHVDYSNWA PG (48-248 aa encoded by BC064417)
Target Information
CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BLAST-2; C-type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD23; CD23 antigen; Fc epsilon receptor II; FC epsilon RII; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc-epsilon-RII; FceRII; Immunoglobulin E-binding factor; immunoglobulin epsilon-chain; Low affinity immunoglobulin epsilon Fc receptor; low-affinity IgE receptor; Lymphocyte IgE receptor
Gene Aliases: BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCER2; Fcer2a; IGEBF; Ly-42
UniProt ID: (Human) P06734, (Mouse) P20693
Entrez Gene ID: (Human) 2208, (Mouse) 14128
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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