Product References
Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells.
Biology
Chiawpanit C,Panwong S,Sawasdee N,Yenchitsomanus PT,Panya A
12-9908-42 was used in Flow cytometry/Cell sorting to demonstrate the effects of genistein on reactivation of apoptosis cascade and increase the susceptibility of Cholangiocarcinoma cells to natural killer (NK-92) cells.
Sat Jul 23 00:00:00 UTC 2022
Doxorubicin sensitizes breast cancer cells to natural killer cells in connection with increased Fas receptors.
International journal of molecular medicine
Sawasdee N,Wattanapanitch M,Thongsin N,Phanthaphol N,Chiawpanit C,Thuwajit C,Yenchitsomanus PT,Panya A
12-9908-42 was used in Flow cytometry/Cell sorting to support the use of combined doxorubicin and NK immunotherapy in BC treatment.
Tue Mar 01 00:00:00 UTC 2022
The metabolism of cells regulates their sensitivity to NK cells depending on p53 status.
Scientific reports
Belkahla S,Brualla JM,Fayd'herbe de Maudave A,Falvo P,Allende-Vega N,Constantinides M,Khan AUH,Coenon L,Alexia C,Mitola G,Massa P,Orecchioni S,Bertolini F,Mnif W,Hernandez J,Anel A,Villalba M
12-9908-42 was used in Flow Cytometry to show that treatment of patients with DCA, or a biosimilar drug, could be a clinical option to increase the effectiveness of CAR T cell or allogeneic NK cell therapies.
Fri Feb 25 00:00:00 UTC 2022
Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1).
Scientific reports
Allende-Vega N,Marco Brualla J,Falvo P,Alexia C,Constantinides M,Fayd'herbe de Maudave A,Coenon L,Gitenay D,Mitola G,Massa P,Orecchioni S,Bertolini F,Marzo I,Anel A,Villalba M
12-9908-42 was used in Flow Cytometry to explore the potential and underlying mechanisms of metaformin in the treatment of hematologic cancers.
Tue Jan 25 00:00:00 UTC 2022
Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas.
Scientific reports
An Y,Jeon J,Sun L,Derakhshan A,Chen J,Carlson S,Cheng H,Silvin C,Yang X,Van Waes C,Chen Z
12-9908 was used in Flow cytometry/Cell sorting to observed predominantly late apoptosis mode of cell death after combinatorial treatments, and pan-caspase (ZVAD) and caspase-8 (ZIETD) inhibitors attenuated treatment-induced cell death.
Thu Mar 18 00:00:00 UTC 2021
Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas.
Scientific reports
An Y,Jeon J,Sun L,Derakhshan A,Chen J,Carlson S,Cheng H,Silvin C,Yang X,Van Waes C,Chen Z
12-9908 was used in Flow cytometry/Cell sorting to observed predominantly late apoptosis mode of cell death after combinatorial treatments, and pan-caspase (ZVAD) and caspase-8 (ZIETD) inhibitors attenuated treatment-induced cell death.
Thu Mar 18 00:00:00 UTC 2021
DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.
Journal of controlled release : official journal of the Controlled Release Society
Johnston MC,Nicoll JA,Redmond KM,Smyth P,Greene MK,McDaid WJ,Chan DKW,Crawford N,Stott KJ,Fox JP,Straubinger NL,Roche S,Clynes M,Straubinger RM,Longley DB,Scott CJ
12-9908-42 was used in Flow Cytometry to indicate the possible role of αDR5-nano particles containing FLIP modulators as a treatment for pancreatic cancer.
Mon Aug 10 00:00:00 UTC 2020
YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.
Cell death & disease
Wang Y,Guo S,Li D,Tang Y,Li L,Su L,Liu X
12-9908 was used in Flow cytometry/Cell sorting to demonstrate that YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in NSCLC cells.
Fri Apr 17 00:00:00 UTC 2020
YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.
Cell death & disease
Wang Y,Guo S,Li D,Tang Y,Li L,Su L,Liu X
12-9908 was used in Flow cytometry/Cell sorting to demonstrate that YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in NSCLC cells.
Fri Apr 17 00:00:00 UTC 2020
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.
Cell death & disease
Khawaja H,Campbell A,Roberts JZ,Javadi A,O'Reilly P,McArt D,Allen WL,Majkut J,Rehm M,Bardelli A,Di Nicolantonio F,Scott CJ,Kennedy R,Vitale N,Harrison T,Sansom OJ,Longley DB,Evergren E,Van Schaeybroeck S
12-9908 was used in Flow cytometry/Cell sorting to provide evidence for a role for RALB in apoptotic priming and suggests that RALB inhibition may be a promising strategy to improve response to TRAIL treatment in poor prognostic RASMT CRIS-B CRC.
Thu Oct 29 00:00:00 UTC 2020
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.
Cell death & disease
Khawaja H,Campbell A,Roberts JZ,Javadi A,O'Reilly P,McArt D,Allen WL,Majkut J,Rehm M,Bardelli A,Di Nicolantonio F,Scott CJ,Kennedy R,Vitale N,Harrison T,Sansom OJ,Longley DB,Evergren E,Van Schaeybroeck S
12-9908 was used in Flow cytometry/Cell sorting to provide evidence for a role for RALB in apoptotic priming and suggests that RALB inhibition may be a promising strategy to improve response to TRAIL treatment in poor prognostic RASMT CRIS-B CRC.
Thu Oct 29 00:00:00 UTC 2020
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.
Cell death and differentiation
Fauster A,Rebsamen M,Willmann KL,César-Razquin A,Girardi E,Bigenzahn JW,Schischlik F,Scorzoni S,Bruckner M,Konecka J,Hörmann K,Heinz LX,Boztug K,Superti-Furga G
12-9908 was used in Flow cytometry/Cell sorting to investigate the genetic basis underlying necroptotic cell death.
Sat Jun 01 00:00:00 UTC 2019
Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells.
Oncotarget
Ivanov VN,Wu J,Wang TJC,Hei TK
12-9908 was used in Flow cytometry/Cell sorting to study the impact of increasing the cytotoxic effects of cannabidiol and γ-irradiation in glioblastoma cells.
Fri Jan 25 00:00:00 UTC 2019
Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK-mediated DR5 regulation in colorectal cancer.
International journal of oncology
Kim SL,Min IS,Park YR,Lee ST,Kim SW
12-9908-42 was used in Flow Cytometry to suggest that LCN2 is responsible for TRAIL sensitivity and LCN2 may thus prove to be a promising target protein in DR-targeted CRC therapy.
Sat Dec 01 00:00:00 UTC 2018
Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.
Oncotarget
Ivanov VN,Wu J,Hei TK
12-9908 was used in Flow cytometry/Cell sorting to demonstrate that radiation-induced death in glioblastoma could be enhanced by CBD-mediated signaling.
Tue Sep 26 00:00:00 UTC 2017
Dual Agonist Surrobody Simultaneously Activates Death Receptors DR4 and DR5 to Induce Cancer Cell Death.
Molecular cancer therapeutics
Milutinovic S,Kashyap AK,Yanagi T,Wimer C,Zhou S,O'Neil R,Kurtzman AL,Faynboym A,Xu L,Hannum CH,Diaz PW,Matsuzawa S,Horowitz M,Horowitz L,Bhatt RR,Reed JC
12-9908 was used in Functional assays to investigate the use of dual agonist antibodies against DR4 and DR5 to induce cancer cell death, showing promise in future therapy.
Fri Jan 01 00:00:00 UTC 2016
Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models.
Clinical cancer research : an official journal of the American Association for Cancer Research
Liu Y,Hawkins OE,Vilgelm AE,Pawlikowski JS,Ecsedy JA,Sosman JA,Kelley MC,Richmond A
12-9908 was used in Flow cytometry/Cell sorting to indicate that treatment of melanoma with aurora kinase inhibitors and death receptor ligands causes apoptosis and reduction of cell viability.
Tue Dec 01 00:00:00 UTC 2015
Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors.
Stem cells (Dayton, Ohio)
Redjal N,Zhu Y,Shah K
12-9908 was used in Flow cytometry/Cell sorting to screen clinically relevant chemotherapeutic agents for their ability to sensitise resistant glioblastoma multiforme cell lines to TRAIL induced apoptosis.
Thu Jan 01 00:00:00 UTC 2015
Potential Therapeutic Effect of Natural Killer Cells on Doxorubicin-Resistant Breast Cancer Cells In Vitro.
PloS one
Hwang MH,Li XJ,Kim JE,Jeong SY,Lee SW,Lee J,Ahn BC
12-9908 was used in Flow cytometry/Cell sorting to explore the therapeutic effect of natural killer cells on human doxorubicin-sensitive and resistant breast adenocarcinoma.
Mon May 16 00:00:00 UTC 2016
Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages.
PloS one
Reddy A,Growney JD,Wilson NS,Emery CM,Johnson JA,Ward R,Monaco KA,Korn J,Monahan JE,Stump MD,Mapa FA,Wilson CJ,Steiger J,Ledell J,Rickles RJ,Myer VE,Ettenberg SA,Schlegel R,Sellers WR,Huet HA,Lehár J
Fri May 20 00:00:00 UTC 2016
TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids.
PloS one
Chandrasekaran S,Marshall JR,Messing JA,Hsu JW,King MR
12-9908 was used in Flow cytometry/Cell sorting to show that culturing breast cancer cell lines as 3D tumor spheroids results in higher resistance to TRAIL-mediated apoptosis.
Thu Dec 24 00:00:00 UTC 2015
Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma cells with functional p53 deficiency and resistance to EGFR blockade.
PloS one
Boyko-Fabian M,Niehr F,Distel L,Budach V,Tinhofer I
12-9908 was used in Flow cytometry/Cell sorting to investigate the causal relationship between p53 deficiency and arsenic trioxide sensitivity.
Wed Dec 09 00:00:00 UTC 2015
Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors.
Oncogene
Bagci-Onder T,Agarwal A,Flusberg D,Wanningen S,Sorger P,Shah K
12-9908 was used in Flow cytometry/Cell sorting to investigate the molecular dynamics of TRAIL-based combination therapies for cancer treatment.
Thu Jun 06 00:00:00 UTC 2013
The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer.
The Journal of biological chemistry
Zhang N,Wang X,Huo Q,Li X,Wang H,Schneider P,Hu G,Yang Q
12-9908 was used in Flow cytometry/Cell sorting to point to a protective function of Metadherin (MTDH) against TRAIL-induced death.
Fri Mar 29 00:00:00 UTC 2013
Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA.
International journal of cancer
Piechocki MP,Wu GS,Jones RF,Jacob JB,Gibson H,Ethier SP,Abrams J,Yagita H,Venuprasad K,Wei WZ
12-9908 was used in Flow cytometry/Cell sorting to investigate whether TRAIL-R2 DNA vaccination can induce proapoptotic antibody to trigger apoptosis of tumour cells.
Sat Dec 01 00:00:00 UTC 2012
Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A.
Neoplasia (New York, N.Y.)
Woldemichael GM,Turbyville TJ,Vasselli JR,Linehan WM,McMahon JB
Published figure using CD262 (DR5) monoclonal antibody (Product # 12-9908-42) in Flow Cytometry
Wed Aug 01 00:00:00 UTC 2012
Molecular identification of an MHC-independent ligand recognized by a human {alpha}/{beta} T-cell receptor.
Blood
Hanada K,Wang QJ,Inozume T,Yang JC
12-9908 was used in Flow cytometry/Cell sorting to elucidate the nature of the ligand for a α/β TCR that lyses renal cell carcinoma cells regardless of MHC type.
Thu May 05 00:00:00 UTC 2011
A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Dompe N,Rivers CS,Li L,Cordes S,Schwickart M,Punnoose EA,Amler L,Seshagiri S,Tang J,Modrusan Z,Davis DP
Published figure using CD262 (DR5) monoclonal antibody (Product # 12-9908-42) in Flow Cytometry
Tue Oct 25 00:00:00 UTC 2011
Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo.
Neuro-oncology
Nagane M,Shimizu S,Mori E,Kataoka S,Shiokawa Y
12-9908 was used in Flow cytometry/Cell sorting to suggest that anti-TRAIL-receptor2 (DR5) is the predominant TRAIL receptor mediating apoptotic signals in human glioma cells.
Thu Jul 01 00:00:00 UTC 2010
Inability of plasmacytoid dendritic cells to directly lyse HIV-infected autologous CD4+ T cells despite induction of tumor necrosis factor-related apoptosis-inducing ligand.
Journal of virology
Chehimi J,Papasavvas E,Tomescu C,Gekonge B,Abdulhaqq S,Raymond A,Hancock A,Vinekar K,Carty C,Reynolds G,Pistilli M,Mounzer K,Kostman J,Montaner LJ
12-9908 was used in Flow cytometry/Cell sorting to investigate the function of plasmacytoid dendritic cells in chronic HIV-1 infection.
Mon Mar 01 00:00:00 UTC 2010
Measurement of conatumumab-induced apoptotic activity in tumors by fine needle aspirate sampling.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Zoog SJ,Ma CY,Kaplan-Lefko PJ,Hawkins JM,Moriguchi J,Zhou L,Pan Y,Hsu CP,Friberg G,Herbst R,Hill J,Juan G
12-9908 was used in Flow cytometry/Cell sorting to suggest that fine needle aspirate sampling is a practical method to cytometrically evaluate tumours for pharmacological impact in a clinical setting.
Wed Sep 01 00:00:00 UTC 2010
TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
BMC musculoskeletal disorders
Bisgin A,Terzioglu E,Aydin C,Yoldas B,Yazisiz V,Balci N,Bagci H,Gorczynski RM,Akdis CA,Sanlioglu S
12-9908 was used in Flow cytometry/Cell sorting to study disease severity in patients with rheumatoid arthritis via TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells.
Fri Aug 27 00:00:00 UTC 2010
c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.
Molecular cancer
Fu L,Lin YD,Elrod HA,Yue P,Oh Y,Li B,Tao H,Chen GZ,Shin DM,Khuri FR,Sun SY
12-9908 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which perifosine enhances TRAIL-induced apoptosis.
Mon Dec 20 00:00:00 UTC 2010
Sensitization of human breast cancer cells to natural killer cell-mediated cytotoxicity by proteasome inhibition.
Clinical and experimental immunology
Ames E,Hallett WH,Murphy WJ
12-9908 was used in Flow cytometry/Cell sorting to investigate whether bortezomib can sensitise human breast cancer cells to killing by the human NK cell line, NK-92.
Sun Mar 01 00:00:00 UTC 2009
CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.
Cancer research
Lin YD,Chen S,Yue P,Zou W,Benbrook DM,Liu S,Le TC,Berlin KD,Khuri FR,Sun SY
12-9908 was used in Flow cytometry/Cell sorting to reveal a novel mechanism underlying flexible heteroarotinoid-induced apoptosis that involves induction of death receptor 5.
Tue Jul 01 00:00:00 UTC 2008
Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.
Cancer research
Zou W,Yue P,Khuri FR,Sun SY
12-9908 was used in Flow cytometry/Cell sorting to show that CDDO-Me (methyl-2-cyano-3,12-dioxoolean-1,9-dien-28-oate) triggers endoplasmic reticulum stress, leading to c-Jun NH(2)-terminal kinase-dependent, CCAAT/enhancer binding protein homologous protein-mediated dependent death receptor 5 up-regulation and apoptosis.
Mon Sep 15 00:00:00 UTC 2008
ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.
The Journal of biological chemistry
Song JH,Kandasamy K,Kraft AS
12-9908 was used in Flow cytometry/Cell sorting to demonstrate that a combination of ABT-737 and TRAIL induced significant cell death in multiple cancer types.
Fri Sep 05 00:00:00 UTC 2008
The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.
Cancer research
Liu X,Yue P,Chen S,Hu L,Lonial S,Khuri FR,Sun SY
12-9908 was used in Flow cytometry/Cell sorting to show the important role of DR5 up-regulation in human NSCLC cells in PS-341 and TRAIL induced apoptosis.
Tue May 15 00:00:00 UTC 2007
The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells.
The Journal of biological chemistry
Sun SY,Liu X,Zou W,Yue P,Marcus AI,Khuri FR
12-9908 was used in Immunofluorescence-cell culture cells to investigate the underlying mechanism by which farnesyltransferase inhibitors cause growth arrest or apoptosis in cancer cells, showing that it induces expression of death receptor 5.
Fri Jun 29 00:00:00 UTC 2007
Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells.
Cancer research
Earel JK,VanOosten RL,Griffith TS
Sun Jan 01 00:00:00 UTC 2006
c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.
Oncogene
Longley DB,Wilson TR,McEwan M,Allen WL,McDermott U,Galligan L,Johnston PG
12-9908 was used in Flow cytometry/Cell sorting to study the effect of c-FLIP on the apoptotic response to chemotherapies used in colorectal cancer.
Thu Feb 09 00:00:00 UTC 2006
Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors.
Cancer gene therapy
VanOosten RL,Earel JK,Griffith TS
12-9908 was used in Flow cytometry/Cell sorting to investigate the tumouricidal potential of a recombinant adenovirus encoding human TNFSF10.
Thu Jun 01 00:00:00 UTC 2006
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.
Cancer research
Hyer ML,Croxton R,Krajewska M,Krajewski S,Kress CL,Lu M,Suh N,Sporn MB,Cryns VL,Zapata JM,Reed JC
12-9908 was used in Flow cytometry/Cell sorting to investigate methods to sensitise cancer cells to TRAIL.
Wed Jun 01 00:00:00 UTC 2005
c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.
Cancer research
Zou W,Liu X,Yue P,Zhou Z,Sporn MB,Lotan R,Khuri FR,Sun SY
12-9908 was used in Flow cytometry/Cell sorting to show that activation of JNK pathway results in CDDO-Me-induced DR up-regulation, caspase-8 activation, and apoptosis.
Fri Oct 15 00:00:00 UTC 2004
