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Invitrogen
CD267 (TACI) Monoclonal Antibody (ebio8F10-3), PE, eBioscience™
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-Flow-20170216130641.jpg?time=20250104 "CD267 (TACI) Antibody in Flow Cytometry (Flow)")
FIGURE: 1 / 2
CD267 (TACI) Antibody (12-5942-81) in Flow
Staining of C57BL/6 splenocytes with Anti-Mouse CD19 FITC (Product # 11-0193-82) and 0.06 µg of Rat IgG2a kappa Isotype Control PE (Product # 12-4321-80) (left) or 0.06 µg of Anti-Mouse CD267 (TACI) PE (right). Cells in the lymphocyte gate were used for analysis.
-Flow-20170216130641.jpg?time=20250104)
-Flow-20170216130641.jpg?time=20250104?time=20250104 "CD267 (TACI) Antibody (12-5942-81) in Flow")
Product Details
12-5942-81
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a, kappa
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
ebio8F10-3
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_837121
Product Specific Information
Description: The monoclonal antibody eBio8F10.3 recognizes TACI (Transmembrane Activator and Calcium-modulator and CAML Interactor) also known as CD267. TACI is a type III membrane protein belonging to the TNF receptor superfamily. The ligand for TACI has been shown to be BAFF (BLyS) and APRIL. TACI is expressed on the surface of a subset of maturing splenic B cells of the transitional type termed T2. Genetic studies have shown a role for TACI in both stimulation and inhibition of B cell proliferation. This actual role for TACI in the mouse has still not been determined. Recently human TACI has been shown to have repressive activities which inhibit BAFF-R function.
Applications Reported: This ebio8F10-3 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This ebio8F10-3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD267; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; Transmembrane activator and CAML interactor; Tumor necrosis factor receptor superfamily member 13B
Gene Aliases: 1200009E08Rik; Taci; Tnfrsf13b
UniProt ID: (Mouse) Q9ET35
Entrez Gene ID: (Mouse) 57916
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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