Product References
Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation.
JCI insight
Yang S,Du P,Cui H,Zheng M,He W,Gao X,Hu Z,Jia S,Lu Q,Zhao M
16-0281-82 was used in Flow Cytometry to identify a potential RFX1 inhibitor, adenosine diphosphate (ADP), providing a potential strategy for treating autoimmune diseases.
Mon Oct 23 00:00:00 UTC 2023
Benzophenone-3 exposure alters composition of tumor infiltrating immune cells and increases lung seeding of 4T1 breast cancer cells.
Advances in cancer biology - metastasis
Morin SM,Gregory KJ,Medeiros B,Terefe T,Hoshyar R,Alhusseiny A,Chen S,Schwartz RC,Jerry DJ,Vandenberg LN,Schneider SS
16-0281-82 was used in Cell culture to suggest that while BP3 may not directly affect the proliferation of TNBC, growth and metastasis of TNBC-derived tumors can be altered by BP3 exposures via the alterations in the immune populations of the tumor microenvironment.
Sat Jul 01 00:00:00 UTC 2023
Alanine-based spacers promote an efficient antigen processing and presentation in neoantigen polypeptide vaccines.
Cancer immunology, immunotherapy : CII
Aguilar-Gurrieri C,Barajas A,Rovirosa C,Ortiz R,Urrea V,de la Iglesia N,Clotet B,Blanco J,Carrillo J
16-0281-82 was used in Flow cytometry/Cell sorting to evaluate the impact of linker regions on the MHC-I-dependent antigen presentation using an in vitro assay that assesses the MHC-I presentation of SIINFEKL, a H-2 Kb-restricted OVA peptide.
Sat Jul 01 00:00:00 UTC 2023
Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.
iScience
Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC
16-0281-82 was used in Flow Cytometry to suggest that the modulation of the adrenergic signaling can be a complementary approach to αGC-based immunotherapy to mitigate iNKT-induced liver injury without compromising its antitumoral activity.
Fri Oct 20 00:00:00 UTC 2023
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
Science signaling
Jiang B,Wang S,Song G,Jiang Q,Fan M,Fang C,Li X,Soh CL,Manes TD,Cheru N,Qin L,Ren P,Jortner B,Wang Q,Quaranta E,Yoo P,Geirsson A,Davis RP,Tellides G,Pober JS,Jane-Wit D
16-0281-82 was used in In vitro Assay to identify a T cell-autonomous role for ZFYVE21 in promoting chronic vascular inflammation associated with allograft vasculopathy.
Tue Mar 21 00:00:00 UTC 2023
CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging.
Nature aging
Jin J,Mu Y,Zhang H,Sturmlechner I,Wang C,Jadhav RR,Xia Q,Weyand CM,Goronzy JJ
16-0281-82 was used in Cell culture to show that activated T cells from older adults contribute to inflammation by releasing mitochondrial DNA (mtDNA) into their environment due to an increased expression of the cytokine-inducible SH2-containing protein (CISH).
Mon May 01 00:00:00 UTC 2023
Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C
16-0281-82 was used in T-Cell Activation to evaluate the combination of a DPP4 inhibitor (anagliptin) and PD-L1 blockade in an NSCLC mouse model.
Wed Nov 01 00:00:00 UTC 2023
A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy.
JCI insight
Banerjee A,Li D,Guo Y,Mei Z,Lau C,Chen K,Westwick J,Klauda JB,Schrum A,Lazear ER,Krupnick AS
16-0281-82 was used in Flow cytometry/Cell sorting to describe the signaling properties of a potentially unique cytokine by design, where T cell surface binding and signaling are separated between 2 different families of receptors.
Mon May 23 00:00:00 UTC 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
16-0281-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 UTC 2021
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity.
Cellular & molecular immunology
Dumauthioz N,Tschumi B,Wenes M,Marti B,Wang H,Franco F,Li W,Lopez-Mejia IC,Fajas L,Ho PC,Donda A,Romero P,Zhang L
16-0281-86 was used in T-Cell Activation to indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation, metabolic fitness, and antitumor immunity in vivo.
Thu Jul 01 00:00:00 UTC 2021
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Frontiers in cell and developmental biology
Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F
16-0281-86 was used in T-Cell Activation to show the phenomenon of brown adipose tissue 'whitening' in old mice, induced by IFN-γ secretion by senescent T cells.
Tue Mar 23 00:00:00 UTC 2021
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge.
Frontiers in immunology
Saito T,Sako Y,Sato-Kaneko F,Hosoya T,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Chan M,Chu PJ,Cottam HB,Hayashi T,Carson DA,Corr M
16-0281-82 was used in Functional assays to find that 2D216 augmented the beneficial protective immune responses of MPLA as a co-adjuvant and showed an excellent safety profile.
Fri Dec 10 00:00:00 UTC 2021
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
16-0281-82 was used in Cell Culture to investigate the molecular basis for Siglec-1 binding to regulatory T cells using in vitro-induced cells as a model system.
Thu Aug 22 00:00:00 UTC 2024
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
16-0281-82 was used in T-Cell Activation to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 UTC 2021
Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals.
Science immunology
Jin J,Kim C,Xia Q,Gould TM,Cao W,Zhang H,Li X,Weiskopf D,Grifoni A,Sette A,Weyand CM,Goronzy JJ
16-0281-82 was used in Cell Culture to show that lysosome-deficient T cells rely on late endosomes rather than lysosomes as an mTORC1 activation platform, where mTORC1 is activated by sensing cytosolic amino acids.
Fri Jun 18 00:00:00 UTC 2021
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion.
Journal of experimental & clinical cancer research : CR
Fang W,Zhou T,Shi H,Yao M,Zhang D,Qian H,Zeng Q,Wang Y,Jin F,Chai C,Chen T
16-0281-82 was used in Functional assay to provide new ideas and targets for clinical breast cancer immunotherapy.
Mon Jan 04 00:00:00 UTC 2021
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
16-0281-82 was used in Flow Cytometry to report a function of FATS in tumor development via regulation of tumor immunity.
Wed Jul 14 00:00:00 UTC 2021
Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.
Cancer immunology research
De Martino M,Daviaud C,Diamond JM,Kraynak J,Alard A,Formenti SC,Miller LD,Demaria S,Vanpouille-Box C
16-0281-82 was used in Flow Cytometry to shed light on an immune escape mechanism driven by activin A and suggest that dual targeting of activin A and TGFβ may be required to optimally unleash radiation-induced antitumor immunity against breast cancer.
Fri Jan 01 00:00:00 UTC 2021
TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells.
Cellular & molecular immunology
Xie X,Zhu L,Jie Z,Li Y,Gu M,Zhou X,Wang H,Chang JH,Ko CJ,Cheng X,Sun SC
16-0281-82 was used in Flow cytometry/Cell sorting to show that TNF receptor-associated factor 2 (TRAF2) maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against infections.
Wed Sep 01 00:00:00 UTC 2021
Generation of a chemical genetic model for JAK3.
Scientific reports
Remenyi J,Naik RJ,Wang J,Razsolkov M,Verano A,Cai Q,Tan L,Toth R,Raggett S,Baillie C,Traynor R,Hastie CJ,Gray NS,Arthur JSC
16-0281-82 was used in Functional assay to generate a JAK3 Cys905Ser knockin mouse demonstrating decreased ability of covalent JAK3 inhibitors to block JAK3 function.
Wed May 12 00:00:00 UTC 2021
Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia.
Nature communications
Chatterjee J,Sanapala S,Cobb O,Bewley A,Goldstein AK,Cordell E,Ge X,Garbow JR,Holtzman MJ,Gutmann DH
16-0281-82 was used in Functional assays to elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic pathway glioma (Nf1OPG) mice, human and mouse RNAseq data, and two different experimental asthma models.
Wed Dec 08 00:00:00 UTC 2021
PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity.
Frontiers in immunology
Amici SA,Osman W,Guerau-de-Arellano M
16-0281-82 was used in Flow Cytometry to demonstrate the role of protein arginine N-methyltransferase 5 in T cell activation during multiple sclerosis.
Mon Dec 13 00:00:00 UTC 2021
EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8+ T Cells.
Frontiers in immunology
Stairiker CJ,Pfister SX,Hendrickson E,Yang W,Xie T,Lee C,Zhang H,Dillon C,Thomas GD,Salek-Ardakani S
16-0281-82 was used in In vitro Assay to support the requirement of EZH2 function in 4-1BB-mediated CD8+ T cell expansion and effector programming and emphasize the consideration that must be given when combining such antitumoral therapies.
Mon Feb 14 00:00:00 UTC 2022
A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.
Nature communications
Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y
16-0281-82 was used in ELISA to develop an assembly of exosome inhibitor and ferroptosis inducer via amphiphilic hyaluronic acid that enhances the response to PD-L1 checkpoint blockade.
Thu Sep 30 00:00:00 UTC 2021
Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores.
International journal of molecular sciences
Tanaka Y,Nakao A,Miyake Y,Higashi Y,Tanigaki R,Kataoka T
16-0281-82 was used in Cell Culture to reveal that NF-κB is dispensable for IFN-γ expression induced by PMA and calcium ionophores in EL4 cells expressing Eomes and primary effector T cells.
Fri Dec 03 00:00:00 UTC 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
16-0281 was used in Functional assays to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 UTC 2020
Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.
Immunity
Wu J,Dobbs N,Yang K,Yan N
16-0281-82 was used in Functional assay to investigate if mammalian stimulator of interferon genes possesses widespread IFN-independent activities that are important for restricting HSV-1 infection, tumor immune evasion and likely also adaptive immunity.
Tue Jul 14 00:00:00 UTC 2020
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Proceedings of the National Academy of Sciences of the United States of America
Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR
16-0281-86 was used in In vitro Assay to report that activation of regulatory CD8 T cells (CD8 Treg) that recognize the Qa-1 class Ib major histocompatibility complex (MHC), a mouse homolog of human leukocyte antigen-E (HLA-E), inhibits antibody-mediated immune rejection of heart allografts.
Tue Mar 17 00:00:00 UTC 2020
Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation.
Cell proliferation
Ma Y,Yang Q,Fan M,Zhang L,Gu Y,Jia W,Li Z,Wang F,Li YX,Wang J,Li R,Shao X,Wang YL
16-0281 was used in Flow cytometry/Cell sorting to study the TGF-β1 expression and distribution of regulatory T cells (Tregs) along the placental-maternal circulation route.
Fri May 01 00:00:00 UTC 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
16-0281 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 UTC 2020
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Wang J,Zhang X,Liu P,Zhang X,Wang J,Zheng X,Wei L,Peng Q,Liu C,Yan Q,Shen S,Li X,Ma J
16-0281 was used in Flow cytometry/Cell sorting to report that S100A8 significantly induced PD-L1 expression in monocytes/macrophages but not in tumor cells.
Fri May 01 00:00:00 UTC 2020
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
16-0281-86 was used in T-Cell Activation to investigate the associations between Th2 differentiation and miR-1165b-3p in asthma as well as the possible mechanisms.
Tue Sep 01 00:00:00 UTC 2020
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Investigative ophthalmology & visual science
Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X
16-0281-82 was used in Flow Cytometry to investigate the role of thymic stromal lymphopoietin secreted by Aspergillus fumigatus–stimulated dendritic cells during the T helper 17 immune response.
Tue Dec 01 00:00:00 UTC 2020
Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro.
Experimental hematology
He X,Dou A,Feng S,Roman-Rivera A,Hawkins C,Lawley L,Zhang J,Wunderlich M,Mizukawa B,Halene S,Patel A,Fang J
16-0281-86 was used in T-Cell Activation to examine the combined effect of LEN and Cys in MDS/AML cells and T cells.
Mon Jun 01 00:00:00 UTC 2020
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2.
BioMed research international
Zhao K,Tian Y,Wang J,Chen C,Pan B,Yan Z,Zhu S,Xu K
16-0281-86 was used in In vitro Assay to conclude that administration of Fluvastatin to donor mice showed protective effects against recipient aGVHD when compared to untreated mice due to the retention of effector T cells in lymphoid organs accompanying with reduction of nonlymphatic infiltration and related inflammatory cytokines.
Fri Sep 10 00:00:00 UTC 2021
Exosome miR-27a-3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma.
Thoracic cancer
Fan X,Wang J,Qin T,Zhang Y,Liu W,Jiang K,Huang D
16-0281 was used in Flow cytometry/Cell sorting to determine that dipocyte-derived exo-miR-27a-3p could alter the tumor microenvironment by inhibiting ICOS+ T cell proliferation and IFN-gamma secretion in vitro.
Mon Jun 01 00:00:00 UTC 2020
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
16-0281 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 UTC 2020
Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti-Lag-3 via reducing FGL1 expression.
Cancer medicine
Wang J,Wei W,Tang Q,Lu L,Luo Z,Li W,Lu Y,Pu J
16-0281 was used in Functional assays to investigate whether Oxysophocarpine can distinctly suppress hepatocellular carcinoma (HCC) cells and sensitize the immunotherapy of CD8+ T cells against HCC.
Thu Oct 01 00:00:00 UTC 2020
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
Journal for immunotherapy of cancer
Marshall LA,Marubayashi S,Jorapur A,Jacobson S,Zibinsky M,Robles O,Hu DX,Jackson JJ,Pookot D,Sanchez J,Brovarney M,Wadsworth A,Chian D,Wustrow D,Kassner PD,Cutler G,Wong B,Brockstedt DG,Talay O
16-0281 was used in Flow cytometry/Cell sorting to demonstrate that CCR4-dependent Treg recruitment into the tumor is an important tumor-extrinsic mechanism for immune resistance.
Sun Nov 01 00:00:00 UTC 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
16-0281 was used in Functional assays to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 UTC 2020
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.
Nature communications
Guo X,Pan Y,Xiong M,Sanapala S,Anastasaki C,Cobb O,Dahiya S,Gutmann DH
16-0281-86 was used in T-Cell Activation to define the axis in which neurons, T cells, and microglia interact to govern Neurofibromatosis-1 (NF1) low-grade glioma (LGG) growth.
Fri May 01 00:00:00 UTC 2020
Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation.
Science advances
Dou G,Tian R,Liu X,Yuan P,Ye Q,Liu J,Liu S,Zhou J,Deng Z,Chen X,Liu S,Jin Y
16-0281 was used in Flow cytometry/Cell sorting to provides strategies to arbitrarily engineer modular EVs that integrate the advantages of natural EVs and synthetic materials for various applications.
Wed Jul 01 00:00:00 UTC 2020
T-cells produce acidic niches in lymph nodes to suppress their own effector functions.
Nature communications
Wu H,Estrella V,Beatty M,Abrahams D,El-Kenawi A,Russell S,Ibrahim-Hashim A,Longo DL,Reshetnyak YK,Moshnikova A,Andreev OA,Luddy K,Damaghi M,Kodumudi K,Pillai SR,Enriquez-Navas P,Pilon-Thomas S,Swietach P,Gillies RJ
16-0281-82 was used in Flow Cytometry to identify lymph node paracortical zones as acidic niches in the immune system regulated by T-cells.
Mon Aug 17 00:00:00 UTC 2020
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death.
Nature communications
Hayashi K,Nikolos F,Lee YC,Jain A,Tsouko E,Gao H,Kasabyan A,Leung HE,Osipov A,Jung SY,Kurtova AV,Chan KS
16-0281 was used in Flow cytometry/Cell sorting to postulate that an intricate balance between immunostimulatory and inhibitory DAMPs could determine the outcome of drug-induced ICD and pose COX-2/prostaglandin E2 blockade as a strategy to harness ICD.
Mon Dec 07 00:00:00 UTC 2020
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.
Cell reports
Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA
16-0281-82 was used in Functional assay to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.
Tue Feb 04 00:00:00 UTC 2020
FOXO1 deficiency impairs proteostasis in aged T cells.
Science advances
Jin J,Li X,Hu B,Kim C,Cao W,Zhang H,Weyand CM,Goronzy JJ
16-0281 was used in Cell Culture to show that FOXO1 promotes lysosome function through the induction of the key transcription factor for lysosomal proteins, TFEB.
Wed Apr 01 00:00:00 UTC 2020
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
16-0281 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 UTC 2019
Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells.
International journal of molecular medicine
Xiao J,Zhang J,Li X,Dai X,Wang J,He Y,Wei L,Shi J,Gong N
16-0281 was used in Flow cytometry/Cell sorting to demonstrate that transduction with lenti-shRNA-Blimp1 (lentiviral-mediated B-lymphocyte-induced maturation protein-1 shRNA) modulated the maturation of DCs via MHC-II molecule suppression and inhibited alloreactive T cell activation.
Fri Feb 01 00:00:00 UTC 2019
KCa3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats.
Journal of the American Heart Association
She G,Ren YJ,Wang Y,Hou MC,Wang HF,Gou W,Lai BC,Lei T,Du XJ,Deng XL
16-0281 was used in Flow cytometry/Cell sorting to evaluate the impact of the specific KCa3.1 channel blocker TRAM-34 on cardiac fibrosis.
Tue Jan 08 00:00:00 UTC 2019
C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions.
Frontiers in immunology
Jimenez RV,Kuznetsova V,Connelly AN,Hel Z,Szalai AJ
16-0281-82 was used in Flow cytometry/Cell sorting to demonstrate that CRP dose-dependently increases the generation of MDSC from wild type mouse bone marrow progenitors and enhances MDSC production of intracellular reactive oxygen species (iROS).
Tue Nov 10 00:00:00 UTC 2020
Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.
Frontiers in immunology
Di Giovangiulio M,Rizzo A,Franzè E,Caprioli F,Facciotti F,Onali S,Favale A,Stolfi C,Fehling HJ,Monteleone G,Fantini MC
16-0281-82 was used in In vitro Assay to investigate the role of T helper type 1-like Tregs in the dextran sulfate model of colitis.
Wed Oct 21 00:00:00 UTC 2020
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
16-0281-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 UTC 2019
IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity.
Arteriosclerosis, thrombosis, and vascular biology
Li J,Xia N,Wen S,Li D,Lu Y,Gu M,Tang T,Jiao J,Lv B,Nie S,Liao M,Liao Y,Yang X,Hu Y,Shi GP,Cheng X
16-0281-82 was used in Cell Culture to establish a role of IL-33 in protecting mice from AAA formation by enhancing ST2-dependent aortic and systemic regulatory T-cell expansion and their immunosuppressive activities.
Fri Mar 01 00:00:00 UTC 2019
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
16-0281-82 was used in In vitro experiments to study the role of microRNA-210 in the immune imbalance of T lymphocyte subsets in psoriasis and suggest a potential therapeutic avenue.
Fri Jun 01 00:00:00 UTC 2018
Cross-Talk between Myeloid-Derived Suppressor Cells and Mast Cells Mediates Tumor-Specific Immunosuppression in Prostate Cancer.
Cancer immunology research
Jachetti E,Cancila V,Rigoni A,Bongiovanni L,Cappetti B,Belmonte B,Enriquez C,Casalini P,Ostano P,Frossi B,Sangaletti S,Chiodoni C,Chiorino G,Pucillo CE,Tripodo C,Colombo MP
16-0281 was used in in vitro experiments to suggest that CD40L–CD40 signaling may sustain immune suppression in those cancer patients characterized by accumulation of both mast cells and MDSCs.
Tue May 01 00:00:00 UTC 2018
Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.
Mucosal immunology
Varanasi SK,Rajasagi NK,Jaggi U,Rouse BT
16-0281 was used in Flow cytometry/Cell sorting to investigate IL-18's mechanisms to control of inflammatory lesions in the cornea caused by the herpes infection.
Thu Nov 01 00:00:00 UTC 2018
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.
Glia
Villadiego J,Labrador-Garrido A,Franco JM,Leal-Lasarte M,De Genst EJ,Dobson CM,Pozo D,Toledo-Aral JJ,Roodveldt C
Mon Jan 01 00:00:00 UTC 2018
Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis.
Archivum immunologiae et therapiae experimentalis
Sardar S,Kanne K,Andersson Å
16-0281-82 was used in Functional assay to explore the impact of genetic variations in MED13L on immune cells.
Mon Oct 01 00:00:00 UTC 2018
Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer.
Cancer immunology research
Zhou J,Li X,Wu X,Zhang T,Zhu Q,Wang X,Wang H,Wang K,Lin Y,Wang X
16-0281-82 was used in Functional assays to identify and analyze miRNAs enriched in exosomes derived from tumor-associated macrophages (TAMs) and assess their impact on CD4+ T cells, elucidating their role in modulating the Treg/Th17 ratio and fostering an immune-suppressive microenvironment conducive to epithelial ovarian cancer (EOC) progression and metastasis.
Sat Dec 01 00:00:00 UTC 2018
NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation.
Nature communications
Brosseau JP,Liao CP,Wang Y,Ramani V,Vandergriff T,Lee M,Patel A,Ariizumi K,Le LQ
16-0281 was used in Functional assays to study the role of the neurofibromatosis type 1 tumour suppressor gene in de novo tumorigenesis and malignant transformation.
Tue Nov 27 00:00:00 UTC 2018
Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.
Nature communications
Song H,Giorgi EE,Ganusov VV,Cai F,Athreya G,Yoon H,Carja O,Hora B,Hraber P,Romero-Severson E,Jiang C,Li X,Wang S,Li H,Salazar-Gonzalez JF,Salazar MG,Goonetilleke N,Keele BF,Montefiori DC,Cohen MS,Shaw GM,Hahn BH,McMichael AJ,Haynes BF,Korber B,Bhattacharya T,Gao F
16-0281 was used in Functional assays to provide insight into molecular mechanisms by which viral recombination contributes to HIV-1 persistence and immunopathogenesis.
Tue May 15 00:00:00 UTC 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
16-0281 was used in Functional assays to show that apolipoprotein E deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells, resulting in enhanced MHC-II-dependent antigen presentation and CD4+ T-cell activation.
Mon Aug 06 00:00:00 UTC 2018
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.
Nature communications
Compeer EB,Kraus F,Ecker M,Redpath G,Amiezer M,Rother N,Nicovich PR,Kapoor-Kaushik N,Deng Q,Samson GPB,Yang Z,Lou J,Carnell M,Vartoukian H,Gaus K,Rossy J
16-0281 was used in Functional assays to examine the endocytic journey of the T cell receptor.
Mon Apr 23 00:00:00 UTC 2018
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Immunity
Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM
16-0281 was used in Functional assays to demonstrate that glucokinase-dependent glycolysis regulates regulatory T cell migration.
Tue Nov 21 00:00:00 UTC 2017
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.
Cell metabolism
Mauro C,Smith J,Cucchi D,Coe D,Fu H,Bonacina F,Baragetti A,Cermenati G,Caruso D,Mitro N,Catapano AL,Ammirati E,Longhi MP,Okkenhaug K,Norata GD,Marelli-Berg FM
16-0281 was used in Flow cytometry/Cell sorting to examine the effects of saturated fatty acid-induced metabolic stress on trafficking patterns of CD4+ T-cells.
Tue Mar 07 00:00:00 UTC 2017
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Cell metabolism
Liberti MV,Dai Z,Wardell SE,Baccile JA,Liu X,Gao X,Baldi R,Mehrmohamadi M,Johnson MO,Madhukar NS,Shestov AA,Chio IIC,Elemento O,Rathmell JC,Schroeder FC,McDonnell DP,Locasale JW
16-0281 was used in Functional assays to develop a predictive model for selective targeting of the Warburg effect.
Tue Oct 03 00:00:00 UTC 2017
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Cell metabolism
Ma EH,Bantug G,Griss T,Condotta S,Johnson RM,Samborska B,Mainolfi N,Suri V,Guak H,Balmer ML,Verway MJ,Raissi TC,Tsui H,Boukhaled G,Henriques da Costa S,Frezza C,Krawczyk CM,Friedman A,Manfredi M,Richer MJ,Hess C,Jones RG
16-0281 was used in Flow cytometry/Cell sorting to show adaptive immunity is directly modulated by serine through the control of T cell proliferative capacity.
Tue Feb 07 00:00:00 UTC 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
16-0281 was used in Functional assays to disclose a novel mechanism underlying the negative regulation of antitumour CD8(+) T cells during HCC progression.
Wed Nov 20 00:00:00 UTC 2019
Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
Journal of immunology (Baltimore, Md. : 1950)
Hosokawa T,Kimura T,Nada S,Okuno T,Ito D,Kang S,Nojima S,Yamashita K,Nakatani T,Hayama Y,Kato Y,Kinehara Y,Nishide M,Mikami N,Koyama S,Takamatsu H,Okuzaki D,Ohkura N,Sakaguchi S,Okada M,Kumanogoh A
16-0281 was used in Functional assays to demonstrate that Lamtor1-deficient CD4(+) T cells exhibit marked reductions in proliferation, IL-2 production, Mechanistic target of rapamycin complex 1 activity, and expression of purine- and lipid-synthesis genes.
Fri Sep 15 00:00:00 UTC 2017
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase.
Chinese medicine
Houng JY,Tai TS,Hsu SC,Hsu HF,Hwang TS,Lin CJ,Fang LW
16-0281 was used in Functional assays to study how anti-inflammatory effects exerted by GTE are mediated via suppression of JNK phosphorylation in T cell activation.
Wed Sep 30 00:00:00 UTC 2020
Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor.
Mediators of inflammation
Zhao GJ,Zheng JY,Bian JL,Chen LW,Dong N,Yu Y,Hong GL,Chandoo A,Yao YM,Lu ZQ
16-0281 was used in Flow cytometry/Cell sorting to investigate the role of the TAM ligand, growth arrest-specific 6, as an immune modulator.
Mon Jul 10 00:00:00 UTC 2017
A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments.
Mediators of inflammation
Jia B,Zhao C,Li G,Kong Y,Ma Y,Wang Q,Wang B,Zeng H
16-0281 was used in Flow cytometry/Cell sorting to develop a novel strategy for distinguishing granulocytic myeloid-derived suppressor cells from monocytic MDSCs in septic mice by expression of CD48.
Mon Aug 14 00:00:00 UTC 2017
SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance.
Molecular pharmacology
Li J,Jing J,Bai Y,Li Z,Xing R,Tan B,Ma X,Qiu WW,Du C,Du B,Yang F,Tang J,Siwko S,Liu M,Chen H,Luo J
16-0281 was used in Functional assays to identify a betulinic acid derivative, SH479, able to modulate the Th17/Treg balance to ameliorate experimental autoimmune encephalomyelitis.
Mon May 01 00:00:00 UTC 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
16-0281-82 was used in Flow Cytometry to demonstrate that BM‚derived DC culture systems were heterogeneous, comprising of non‚adherent cells, adherent cells, mixed cells and firmly adherent cells.
Wed Nov 01 00:00:00 UTC 2017
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
16-0281-82 was used in T-Cell Activation to show that therapeutic vaccination against DLK1 results in slowed tumor growth, and compensatory expression of DLK2 by tumor-associated pericytes.
Tue Jan 12 00:00:00 UTC 2021
Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.
Scientific reports
Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z
16-0281 was used in Flow cytometry/Cell sorting to investigate whether Dermatophagoides farinae-31 modulates airway epithelial cell functions, and increases the frequency of lung-resident group 2 innate lymphoid cells.
Thu Aug 17 00:00:00 UTC 2017
BJ-3105, a 6-Alkoxypyridin-3-ol Analog, Impairs T Cell Differentiation and Prevents Experimental Autoimmune Encephalomyelitis Disease Progression.
PloS one
Timilshina M,Kang Y,Dahal I,You Z,Nam TG,Kim KJ,Jeong BS,Chang JH
16-0281 was used in in vitro experiments to study the inhibition of STAT phosphorylation by BJ-3105 and the resulting reduction in Th cell differentiation.
Tue Aug 22 00:00:00 UTC 2017
A Mouse Model of West Nile Virus Infection.
Current protocols in mouse biology
Graham JB,Swarts JL,Lund JM
16-0281 was used in Functional assays to develop a mouse model to study the breadth of symptoms and disease severity seen in human West Nile virus infection.
Wed Dec 20 00:00:00 UTC 2017
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
Nature
Xu T,Stewart KM,Wang X,Liu K,Xie M,Ryu JK,Li K,Ma T,Wang H,Ni L,Zhu S,Cao N,Zhu D,Zhang Y,Akassoglou K,Dong C,Driggers EM,Ding S
16-0281-82 was used in Immunohistochemistry, Flow Cytometry, Functional Assay to investigate T helper 17 cell differentiation and fate.
Thu Aug 10 00:00:00 UTC 2017
Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.
Scientific reports
Wang H,Mo L,Xiao X,An S,Liu X,Ba J,Wu W,Ran P,Yang P,Liu Z
16-0281 was used in an ELISA assay to demonstrate that Pplase is not a dustmite allergen but can enhance allergic responses.
Mon Feb 27 00:00:00 UTC 2017
Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts.
Oncotarget
Zhang S,Al-Maghout T,Bissinger R,Zeng N,Pelzl L,Salker MS,Cheng A,Singh Y,Lang F
16-0281 was used in Functional assays to suggest that epigallocatechin-3-gallate inhibits the Ca2+ entry into murine and human T cells.
Fri Oct 27 00:00:00 UTC 2017
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Nature
Karki R,Man SM,Malireddi RKS,Kesavardhana S,Zhu Q,Burton AR,Sharma BR,Qi X,Pelletier S,Vogel P,Rosenstiel P,Kanneganti TD
16-0281 was used in Flow cytometry/Cell sorting to explore a key role for NLRC3 in mediating protection against colorectal cancer.
Thu Dec 22 00:00:00 UTC 2016
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
16-0281-82 was used in Flow Cytometry to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 UTC 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
16-0281 was used in Flow cytometry/Cell sorting to show in mice, that maternal hepatitis B virus (HBV) impairs CD8(+) T cell responses to HBV in her offspring, resulting in HBV persistence.
Tue May 17 00:00:00 UTC 2016
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Nature immunology
Martin BN,Wang C,Zhang CJ,Kang Z,Gulen MF,Zepp JA,Zhao J,Bian G,Do JS,Min B,Pavicic PG,El-Sanadi C,Fox PL,Akitsu A,Iwakura Y,Sarkar A,Wewers MD,Kaiser WJ,Mocarski ES,Rothenberg ME,Hise AG,Dubyak GR,Ransohoff RM,Li X
16-0281 was used in Functional assays to reveal a critical role for IL-1β produced by a T(H)17 cell-intrinsic ASC-NLRP3-caspase-8 inflammasome during inflammation of the central nervous system.
Sun May 01 00:00:00 UTC 2016
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
The Journal of experimental medicine
Hu H,Wang H,Xiao Y,Jin J,Chang JH,Zou Q,Xie X,Cheng X,Sun SC
16-0281 was used in Flow cytometry/Cell sorting to reveal the importance of deubiquitination in regulating Zap70 function.
Mon Mar 07 00:00:00 UTC 2016
ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings.
Science signaling
Weiss JM,Chen W,Nyuydzefe MS,Trzeciak A,Flynn R,Tonra JR,Marusic S,Blazar BR,Waksal SD,Zanin-Zhorov A
16-0281 was used in Chromatin immunoprecipitation to investigate the role of Rho-associated kinase 2 in the generation of T follicular helper cells.
Tue Jul 19 00:00:00 UTC 2016
Mitochondrial Superoxide Signaling Contributes to Norepinephrine-Mediated T-Lymphocyte Cytokine Profiles.
PloS one
Case AJ,Roessner CT,Tian J,Zimmerman MC
16-0281 was used in a cell stimulation assay to indicate that mitochondrial metabolism and O2-mediated redox signalling play a regulatory role in the T-lymphocyte response to norepinephrine.
Tue May 09 00:00:00 UTC 2017
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
The Journal of biological chemistry
Akhter N,Takeda Y,Nara H,Araki A,Ishii N,Asao N,Asao H
16-0281 was used in Functional assays to indicate that suppression of Ape1/Ref-1 redox function leads to increased cell surface retention of IL-12 and enhances Th1 responses.
Fri Nov 04 00:00:00 UTC 2016
Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses.
Scientific reports
Li Y,Wang H,Zhou X,Xie X,Chen X,Jie Z,Zou Q,Hu H,Zhu L,Cheng X,Brightbill HD,Wu LC,Wang L,Sun SC
16-0281 was used in Flow cytometry/Cell sorting to demonstrate a role for NF-κB inducing kinase in regulating the homeostasis and function of peripheral T cells.
Thu Feb 25 00:00:00 UTC 2016
Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
PloS one
Momose F,Seo N,Akahori Y,Sawada S,Harada N,Ogura T,Akiyoshi K,Shiku H
16-0281 was used in Flow cytometry/Cell sorting to statistically analyse miRNA microarray data, revealing that guanine-rich sequences are a dominant feature of exosome-dominant miRNAs.
Wed Apr 05 00:00:00 UTC 2017
Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.
Open biology
Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL
16-0281 was used in in vitro experiments to show that potential effector functions and basal proliferation of CD8 T cells are set by self-reactivity thresholds.
Tue Nov 01 00:00:00 UTC 2016
Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.
Open biology
Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL
16-0281 was used in in vitro experiments to show that potential effector functions and basal proliferation of CD8 T cells are set by self-reactivity thresholds.
Tue Nov 01 00:00:00 UTC 2016
Pulsed low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis.
JCI insight
Cline-Smith A,Gibbs J,Shashkova E,Buchwald ZS,Novack DV,Aurora R
16-0281 was used in Flow cytometry/Cell sorting to study how pulsing low doses of RANKL induces TcREG, which provides a potential treatment for postmenopausal osteoporosis.
Thu Aug 18 00:00:00 UTC 2016
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.
Nature communications
Tosiek MJ,Fiette L,El Daker S,Eberl G,Freitas AA
16-0281 was used in an ELISA assay to demonstrate that impaired delivery of IL-15 to CD4+ T cells in the colon down-modulates Foxp3 expression and enhances RORγt expression.
Fri Mar 11 00:00:00 UTC 2016
Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation.
Autophagy
Botbol Y,Patel B,Macian F
16-0281 was used in Functional assays to identify the signalling pathways that initiate and regulate macroautophagy in T cells.
Tue Sep 13 00:00:00 UTC 2016
Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs.
Proceedings of the National Academy of Sciences of the United States of America
Fiebiger BM,Maamary J,Pincetic A,Ravetch JV
16-0281 was used in Flow cytometry/Cell sorting to demonstrate that Fc variants that mimic the structural alterations induced by sialylation are candidates for the treatment of autoimmune disorders.
Tue May 05 00:00:00 UTC 2015
Role of caveolin-3 in lymphocyte activation.
Life sciences
Tran C,Stary CM,Schilling JM,Bentley B,Patel HH,Roth DM
16-0281 was used in Functional assays to demonstrate that Cav-3 may be a novel participant in B-cell expression, T-cell cytokine production and activation of inflammation.
Thu Jan 15 00:00:00 UTC 2015
A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Buchwald ZS,Yang C,Nellore S,Shashkova EV,Davis JL,Cline A,Ko J,Novack DV,DiPaolo R,Aurora R
16-0281 was used in Flow cytometry/Cell sorting to study the bone anabolic effect of receptor activator of NF-κB ligand in a murine model of osteoporosis.
Sat Aug 01 00:00:00 UTC 2015
Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J
16-0281 was used in in vitro experiments to study cell-specific deletion of C5aR1 using a GFP-reporter knock-in mouse model.
Sun Feb 15 00:00:00 UTC 2015
Newly recruited CD11b+, GR-1+, Ly6C(high) myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus.
Journal of immunology (Baltimore, Md. : 1950)
Clements DR,Sterea AM,Kim Y,Helson E,Dean CA,Nunokawa A,Coyle KM,Sharif T,Marcato P,Gujar SA,Lee PW
16-0281 was used in Flow cytometry/Cell sorting to demonstrate that reovirus augments tumour-associated immunosuppression immediately following its therapeutic administration.
Fri May 01 00:00:00 UTC 2015
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
16-0281 was used in Flow cytometry/Cell sorting to show the immunogenicity and protective efficacy of the DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Fri Mar 11 00:00:00 UTC 2016
Development of a graded index microlens based fiber optical trap and its characterization using principal component analysis.
Biomedical optics express
Nylk J,Kristensen MV,Mazilu M,Thayil AK,Mitchell CA,Campbell EC,Powis SJ,Gunn-Moore FJ,Dholakia K
16-0281 was used in Functional assays to demonstrate a miniaturised optical trapping probe for use in optically-mediated immunological synapse formation.
Wed Apr 01 00:00:00 UTC 2015
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.
Genome biology
Nestor CE,Ottaviano R,Reinhardt D,Cruickshanks HA,Mjoseng HK,McPherson RC,Lentini A,Thomson JP,Dunican DS,Pennings S,Anderton SM,Benson M,Meehan RR
16-0281 was used in Magnetic cell separation to report a dramatic and novel consequence of adaptation of mammalian cells to culture in which global loss of 5hmC occurs, suggesting rapid concomitant loss of methylcytosine dioxygenase activity.
Wed Feb 04 00:00:00 UTC 2015
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis.
Nature communications
Pan W,Zhu S,Dai D,Liu Z,Li D,Li B,Gagliani N,Zheng Y,Tang Y,Weirauch MT,Chen X,Zhu W,Wang Y,Chen B,Qian Y,Chen Y,Fang J,Herbst R,Richman L,Jallal B,Harley JB,Flavell RA,Yao Y,Shen N
16-0281 was used in Functional assays to suggest miR-125a as a critical factor in controlling autoimmune diseases through stabilizing Treg-mediated immune homeostasis.
Tue May 12 00:00:00 UTC 2015
An atlas of mouse CD4(+) T cell transcriptomes.
Biology direct
Stubbington MJ,Mahata B,Svensson V,Deonarine A,Nissen JK,Betz AG,Teichmann SA
16-0281 was used in Flow cytometry/Cell sorting to show that hundreds of genes are regulated purely by alternative splicing to extend our knowledge of the role of post-transcriptional regulation in cell differentiation.
Fri Apr 03 00:00:00 UTC 2015
Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.
BMC cancer
Gillgrass AE,Chew MV,Krneta T,Ashkar AA
16-0281 was used in Flow cytometry/Cell sorting to investigate the potential role of IL-15 for metastatic reduction in breast cancer via effects on NK1.1+ cells.
Thu Apr 16 00:00:00 UTC 2015
Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation.
PloS one
Mimche PN,Brady LM,Keeton S,Fenne DS,King TP,Quicke KM,Hudson LE,Lamb TJ
16-0281 was used in Flow cytometry/Cell sorting to investigate the contribution of Ephrin B2 to dendritic cell responses.
Wed Jun 01 00:00:00 UTC 2016
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.
Stem cell reports
Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L
16-0281 was used in Flow cytometry/Cell sorting to elucidate the molecules and mechanisms pertinent to the low immunogenicity of undifferentiated embryonic stem cells.
Tue Nov 10 00:00:00 UTC 2015
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Nature
Olszak T,Neves JF,Dowds CM,Baker K,Glickman J,Davidson NO,Lin CS,Jobin C,Brand S,Sotlar K,Wada K,Katayama K,Nakajima A,Mizuguchi H,Kawasaki K,Nagata K,Müller W,Snapper SB,Schreiber S,Kaser A,Zeissig S,Blumberg RS
16-0281-82 was used in Functional assay to uncover a novel pathway of IEC-dependent regulation of mucosal homeostasis and highlight a critical role of IL-10 in the intestinal epithelium, with broad implications for diseases such as inflammatory bowel disease.
Thu May 22 00:00:00 UTC 2014
Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.
Journal of autoimmunity
Tang X,Zhang B,Jarrell JA,Price JV,Dai H,Utz PJ,Strober S
16-0281 was used in Functional assays to determine how different invariant natural killer T cell subsets contribute to lupus pathogenesis.
Thu May 01 00:00:00 UTC 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
16-0281 was used in Flow cytometry/Cell sorting to study regulation of the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis during autophagy.
Tue Jul 01 00:00:00 UTC 2014
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K
16-0281 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.
Sat Mar 15 00:00:00 UTC 2014
The number of responding CD4 T cells and the dose of antigen conjointly determine the TH1/TH2 phenotype by modulating B7/CD28 interactions.
Journal of immunology (Baltimore, Md. : 1950)
Rudulier CD,McKinstry KK,Al-Yassin GA,Kroeger DR,Bretscher PA
16-0281 was used in Functional assays to show that a greater number of Ag-dependent CD4 T cell interactions are required to generate Th2 than Th1 cells.
Sun Jun 01 00:00:00 UTC 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
16-0281 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 UTC 2014
Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells.
Carcinogenesis
Rizzo A,De Mare V,Rocchi C,Stolfi C,Colantoni A,Neurath MF,Macdonald TT,Pallone F,Monteleone G,Fantini MC
16-0281 was used in in vitro experiments to investigate the potential influence of Smad7 on colorectal cancer growth and which immune cell subsets might be involved.
Tue Jul 01 00:00:00 UTC 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
16-0281 was used in an ELISA assay to study the effect of NIZ on vaccine immune modulation.
Mon Jan 05 00:00:00 UTC 2015
In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.
Cytokine
Zhou Q,Hu Y,Howard OM,Oppenheim JJ,Chen X
16-0281 was used in Functional assays to demonstrate that the TNF-TNFR2 pathway plays a crucial role in the reciprocal stimulatory effect of Th17 cells and Tregs.
Wed Jan 01 00:00:00 UTC 2014
Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
BMC biology
Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R
16-0281 was used in an ELISA assay to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.
Fri May 09 00:00:00 UTC 2014
Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes.
PloS one
Qian L,Zhang M,Wu S,Zhong Y,Van Tol E,Cai W
16-0281 was used in Functional assays to demonstrate that AKGs can modulate immune responses by boosting the proliferation and maturation of murine lymphocytes in vitro.
Fri Jul 31 00:00:00 UTC 2015
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.
Frontiers in cellular neuroscience
Bodhankar S,Chen Y,Lapato A,Vandenbark AA,Murphy SJ,Offner H
16-0281 was used in Flow cytometry/Cell sorting to investigate PD-L1 and PD-L2 expressing cell types that affect T-cell activation post stroke, and how these could be targeted therapeutically.
Tue Aug 26 00:00:00 UTC 2014
Antitumor immunity induced after α irradiation.
Neoplasia (New York, N.Y.)
Gorin JB,Ménager J,Gouard S,Maurel C,Guilloux Y,Faivre-Chauvet A,Morgenstern A,Bruchertseifer F,Chérel M,Davodeau F,Gaschet J
16-0281 was used in in vitro experiments to determine that α irradiation is an immunogenic cell death inducer.
Tue Apr 01 00:00:00 UTC 2014
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Cancer cell
Engels B,Engelhard VH,Sidney J,Sette A,Binder DC,Liu RB,Kranz DM,Meredith SC,Rowley DA,Schreiber H
16-0281 was used in Functional assays to investigate relapse after adoptive therapy, showing that relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Mon Apr 15 00:00:00 UTC 2013
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Nature immunology
Garris CS,Wu L,Acharya S,Arac A,Blaho VA,Huang Y,Moon BS,Axtell RC,Ho PP,Steinberg GK,Lewis DB,Sobel RA,Han DK,Steinman L,Snyder MP,Hla T,Han MH
16-0281-82 was used in Inhibition experiments to identify the non-functioning S1P1 gene as a key factor contributing to the development of severe experimental autoimmune encephalomyelitis.
Fri Nov 01 00:00:00 UTC 2013
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells.
The Journal of experimental medicine
Kwan WH,van der Touw W,Paz-Artal E,Li MO,Heeger PS
16-0281 was used in Western Blotting to determine the mechanisms controlling natural regulatory T cell expansion.
Mon Feb 11 00:00:00 UTC 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
16-0281 was used in Functional assays to understand the function of autophagosome degradation in survival of activated T cells, by comparison of the effects of blocking autophagy at an early (atg5-/-) or late (rab7-/-) stage on T cell biology in mice.
Mon Jul 01 00:00:00 UTC 2013
Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy.
Cancer gene therapy
Kanagawa N,Yanagawa T,Nakagawa T,Okada N,Nakagawa S
16-0281 was used in Functional assays to develop an immune-based antiangiogenic strategy against VEGFR2-expressing cells, improving antitumor effect of cytotoxic T lymphocytes.
Tue Jan 01 00:00:00 UTC 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
16-0281 was used in Functional assays to discover that the shared epitope contributes to arthritis severity by activating an osteoclast-mediated bone-destructive pathway.
Tue Jan 01 00:00:00 UTC 2013
Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ryan SO,Johnson JL,Cobb BA
16-0281 was used in Functional assays to reveal long-term persistence of an inflammation-associated neutrophil cell population constitutively producing IFN-γ.
Wed May 15 00:00:00 UTC 2013
n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.
The Journal of nutrition
Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS
16-0281 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.
Sun Sep 01 00:00:00 UTC 2013
Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.
Bone
Buchwald ZS,Kiesel JR,Yang C,DiPaolo R,Novack DV,Aurora R
16-0281 was used in Flow cytometry/Cell sorting to provide in vivo evidence that osteoclast-induced Treg cells have anti-resorptive activity and repress the immune system.
Sun Sep 01 00:00:00 UTC 2013
Rho kinase regulates induction of T-cell immune dysfunction in abdominal sepsis.
Infection and immunity
Hasan Z,Palani K,Zhang S,Lepsenyi M,Hwaiz R,Rahman M,Syk I,Jeppsson B,Thorlacius H
16-0281 was used in an ELISA assay to demonstrate that Rho kinase is a powerful regulator of T-cell immune dysfunction in abdominal sepsis.
Mon Jul 01 00:00:00 UTC 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
16-0281 was used in Western Blotting to determine that Nod2 is functional in murine CD4(+) T cells, but unnecessary for the regulation of colitis.
Thu Jul 31 00:00:00 UTC 2014
An efficient low cost method for gene transfer to T lymphocytes.
PloS one
Chicaybam L,Sodre AL,Curzio BA,Bonamino MH
16-0281 was used in Functional assays to describe a novel protocol for electroporation based modification of T lymphocytes.
Mon Sep 30 00:00:00 UTC 2013
A bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes.
PloS one
Zhao H,Karman J,Jiang JL,Zhang J,Gumlaw N,Lydon J,Zhou Q,Qiu H,Jiang C,Cheng SH,Zhu Y
16-0281 was used in Flow cytometry/Cell sorting to show that antigen-specific Tregs can also be induced in an antigen-specific setting in vitro.
Mon Dec 30 00:00:00 UTC 2013
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
The Journal of experimental medicine
Finlay DK,Rosenzweig E,Sinclair LV,Feijoo-Carnero C,Hukelmann JL,Rolf J,Panteleyev AA,Okkenhaug K,Cantrell DA
16-0281 was used in Flow cytometry/Cell sorting to explore the molecular pathways that mediate mTORC1 control of effector CD8+ T-cell differentiation.
Mon Dec 17 00:00:00 UTC 2012
SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.
European journal of immunology
Lee D,Kim J,Baker RG,Koretzky GA,Hammer DA
16-0281 was used in Functional assays to investigate the role of SLP-76 in chemokine-triggered T-cell adhesion, showing that SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.
Mon Oct 01 00:00:00 UTC 2012
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Ding Y,Fang X,Wang R,Sun Z
16-0281 was used in Flow cytometry/Cell sorting to conclude that protein kinase C-θ is able to control T cell-mediated immune responses by regulating naive T cell differentiation.
Fri Jun 01 00:00:00 UTC 2012
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one
Baru AM,Untucht C,Ganesh V,Hesse C,Mayer CT,Sparwasser T
16-0281 was used in Flow cytometry/Cell sorting to define culture conditions for efficient generation of eGFP(+)Foxp3(+) iTregs by use of DEREG mice.
Thu Feb 14 00:00:00 UTC 2013
MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway.
PloS one
Li M,Cao W,Liu H,Zhang W,Liu X,Cai Z,Guo J,Wang X,Hui Z,Zhang H,Wang J,Wang L
16-0281 was used in Western Blotting to study how MCPIP1 may play an important role in the down-regulation of IL-2 in activated T lymphocytes by an ARE-independent pathway.
Thu May 30 00:00:00 UTC 2013
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells.
Nature immunology
Feng X,Wang H,Takata H,Day TJ,Willen J,Hu H
16-0281 was used in Western Blotting to provide evidence that Foxp1 plays an indispensable role in maintaining naive T cell quiescence, in part by repressing IL-7Rα expression.
Wed Jun 01 00:00:00 UTC 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
16-0281 was used in Functional assays to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 UTC 2011
EpiChIP: gene-by-gene quantification of epigenetic modification levels.
Nucleic acids research
Hebenstreit D,Gu M,Haider S,Turner DJ,Liò P,Teichmann SA
16-0281 was used in Functional assays to develop a software package that analyses ChIP-seq data in order to quantify epigenetic modification levels for individual genes.
Tue Mar 01 00:00:00 UTC 2011
Suppressors of cytokine signaling inhibit effector T cell responses during Mycobacterium tuberculosis infection.
Immunology and cell biology
Srivastava V,Vashishta M,Gupta S,Singla R,Singla N,Behera D,Natarajan K
16-0281 was used in Functional assays to characterise the role of SOCS1 in regulating effector responses from CD4(+) and CD8(+) T cells during M. tuberculosis infection, showing that SOCS1 inhibits effector T cell response during infection.
Sat Oct 01 00:00:00 UTC 2011
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
Journal of immunology (Baltimore, Md. : 1950)
MacIver NJ,Blagih J,Saucillo DC,Tonelli L,Griss T,Rathmell JC,Jones RG
16-0281 was used in Immunopurification to demonstrate that Liver Kinase B1 is a critical regulator of T cell development, viability, activation, and metabolism.
Sat Oct 15 00:00:00 UTC 2011
SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Peterson LK,Shaw LA,Joetham A,Sakaguchi S,Gelfand EW,Dragone LL
16-0281 was used in Flow cytometry/Cell sorting to show that SLAP deficiency increases TCR signalling, which enhances the development and function of Tregs to prevent arthritis development in a KO mouse model.
Tue Feb 15 00:00:00 UTC 2011
Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Dolfi DV,Duttagupta PA,Boesteanu AC,Mueller YM,Oliai CH,Borowski AB,Katsikis PD
16-0281 was used in Functional assays to demonstrate the requirement for dendritic cells, Ag, and CD28 costimulation during the effector phase of the CD8(+) T cell response.
Fri Apr 15 00:00:00 UTC 2011
CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Landrigan A,Wong MT,Utz PJ
16-0281 was used in Functional assays to study the ability of oligodeoxynucleotides to activate and polarise T cells.
Thu Sep 15 00:00:00 UTC 2011
IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.
International immunology
Mori T,Miyamoto T,Yoshida H,Asakawa M,Kawasumi M,Kobayashi T,Morioka H,Chiba K,Toyama Y,Yoshimura A
16-0281 was used in Functional assays to elucidate the role of cytokines in chronic inflammation and joint destruction in rheumatoid arthritis.
Tue Nov 01 00:00:00 UTC 2011
Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells.
PloS one
Wang L,Lin J,Zhou Z,Huo R,Shen B,Sun Y,Li N
16-0281 was used in Functional assays to implicate up-regulated Th17 development as a mechanism of enhancing anti-tumour immunity.
Fri May 18 00:00:00 UTC 2012
RNA sequencing reveals two major classes of gene expression levels in metazoan cells.
Molecular systems biology
Hebenstreit D,Fang M,Gu M,Charoensawan V,van Oudenaarden A,Teichmann SA
16-0281 was used in Functional assays to investigate the global distribution of gene expression levels, suggesting that genes can be separated into two distinct groups: one group comprised of lowly expressed and putatively non-functional mRNAs, and the other of highly expressed mRNAs with active chromatin marks at their promoters.
Tue Jun 07 00:00:00 UTC 2011
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
Immunity
Mukasa R,Balasubramani A,Lee YK,Whitley SK,Weaver BT,Shibata Y,Crawford GE,Hatton RD,Weaver CT
16-0281 was used in Functional assays to reveal that the plasticity of the T helper 17 cell line is a result of the epigenetic instability of cytokine and transcription factor gene loci.
Fri May 28 00:00:00 UTC 2010
Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.
The Journal of allergy and clinical immunology
Jin SL,Goya S,Nakae S,Wang D,Bruss M,Hou C,Umetsu D,Conti M
16-0281 was used in Functional assays to demonstrate that PDE4B plays an essential role in Th2-cell activation and dendritic cell recruitment during airway inflammation in allergen-sensitised mice.
Wed Dec 01 00:00:00 UTC 2010
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
16-0281 was used in in vitro experiments to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 UTC 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
16-0281 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 UTC 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
16-0281 was used in Flow cytometry/Cell sorting to elucidate a role for CD30 in T cell differentiation.
Sun Aug 15 00:00:00 UTC 2010
B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.
Journal of immunology (Baltimore, Md. : 1950)
DiLillo DJ,Yanaba K,Tedder TF
16-0281 was used in Flow cytometry/Cell sorting to quantify B cell contributions to T cell-mediated anti-tumour immune responses.
Thu Apr 01 00:00:00 UTC 2010
Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.
The Journal of pharmacology and experimental therapeutics
Wang DW,Zhou RB,Yao YM,Zhu XM,Yin YM,Zhao GJ,Dong N,Sheng ZY
16-0281 was used in Flow cytometry/Cell sorting to reveal α7 nAChR to be a critical regulator for immunosuppressive function of CD4(+)CD25(+) Tregs.
Wed Dec 01 00:00:00 UTC 2010
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
PloS one
Chae HD,Siefring JE,Hildeman DA,Gu Y,Williams DA
16-0281 was used in Functional assays to suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3ζ in the immunological synapse.
Fri Nov 12 00:00:00 UTC 2010
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.
Cancer research
Gounaris E,Blatner NR,Dennis K,Magnusson F,Gurish MF,Strom TB,Beckhove P,Gounari F,Khazaie K
16-0281 was used in in vitro experiments to report that the ability of Treg cells to control inflammation is lost in the course of progressive disease in a mouse model of colon cancer.
Wed Jul 01 00:00:00 UTC 2009
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
16-0281 was used in Functional assays to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 UTC 2009
Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.
Journal of immunology (Baltimore, Md. : 1950)
Gatzka M,Newton RH,Walsh CM
16-0281 was used in an ELISA assay to suggest that alteration in thymocyte signaling thresholds impacts the sensitivity of peripheral T cell pools within the development of autoimmune diseases.
Wed Jul 01 00:00:00 UTC 2009
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chang M,Lee AJ,Fitzpatrick L,Zhang M,Sun SC
16-0281 was used in Functional assays to investigate the physiological functions of NF-kappaB inhibitors, showing that p105 regulates T cell homeostasis and prevents chronic inflammation.
Sun Mar 01 00:00:00 UTC 2009
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF.
Journal of immunology (Baltimore, Md. : 1950)
Kolly L,Karababa M,Joosten LA,Narayan S,Salvi R,Pétrilli V,Tschopp J,van den Berg WB,So AK,Busso N
16-0281 was used in Functional assays to investigate the contribution of ASC, NALP-3, IPAF, and caspase-1 to inflammatory arthritis, showing that the inflammatory role of ASC in arthritis is independent of caspase-1, NALP-3, and IPAF.
Tue Sep 15 00:00:00 UTC 2009
Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice.
Cellular immunology
Han GM,Zhao B,Jeyaseelan S,Feng JM
16-0281 was used in Functional assays to investigate the relationship between increased proportion of Foxp3(+) Treg cells and CD44(+) Tem cells with aging.
Tue Aug 25 00:00:00 UTC 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
16-0281 was used in Functional assays to develop cell-penetrating Ras inhibitors and to study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis; revealing a role of Ras in survival in T cells.
Mon Jan 05 00:00:00 UTC 2009
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.
Nature immunology
Xiao C,Srinivasan L,Calado DP,Patterson HC,Zhang B,Wang J,Henderson JM,Kutok JL,Rajewsky K
16-0281 was used in Flow cytometry/Cell sorting to investigate the mechanism behind the promotion of miR-17-92-induced lymphomagenesis.
Tue Apr 01 00:00:00 UTC 2008
Micropatterning of costimulatory ligands enhances CD4+ T cell function.
Proceedings of the National Academy of Sciences of the United States of America
Shen K,Thomas VK,Dustin ML,Kam LC
16-0281 was used in Functional assays to investigate the impact of spatial organisation of signalling complexes in the immunological synapse.
Tue Jun 03 00:00:00 UTC 2008
Dynamics of lung macrophage activation in response to helminth infection.
Journal of leukocyte biology
Siracusa MC,Reece JJ,Urban JF,Scott AL
16-0281 was used in Flow cytometry/Cell sorting to characterise the surface molecules, gene expression, and cell function of macrophages isolated from lung tissue after helminth infection.
Mon Dec 01 00:00:00 UTC 2008
Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway.
Immunology letters
Chen J,Panchanathan R,Choubey D
16-0281 was used in Functional assays to elucidate the signalling pathways that regulate Ifi202 expression in immune cells.
Sun Jun 15 00:00:00 UTC 2008
Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.
Journal of virology
Ohno S,Ono N,Seki F,Takeda M,Kura S,Tsuzuki T,Yanagi Y
16-0281 was used in Flow cytometry/Cell sorting to investigate the effects on measles infection after replacement of the V domain of mouse SLAM with human SLAM.
Thu Feb 01 00:00:00 UTC 2007
Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.
Journal of virology
Ohno S,Ono N,Seki F,Takeda M,Kura S,Tsuzuki T,Yanagi Y
16-0281 was used in Flow cytometry/Cell sorting to investigate the effects on measles infection after replacement of the V domain of mouse SLAM with human SLAM.
Thu Feb 01 00:00:00 UTC 2007
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.
Molecular and cellular biology
Zeng H,Di L,Fu G,Chen Y,Gao X,Xu L,Lin X,Wen R
16-0281 was used in Western Blotting to study how NF-kappaB activation is negatively regulated by phosphorylation of Bcl10.
Sun Jul 01 00:00:00 UTC 2007
Arming tumor-reactive T cells with costimulator B7-1 enhances therapeutic efficacy of the T cells.
Cancer research
Zheng G,Liu S,Wang P,Xu Y,Chen A
16-0281 was used in Flow cytometry/Cell sorting to establish that producing tumour-reactive T cells that ectopically express a costimulator can enhance the antitumour response.
Sat Jul 01 00:00:00 UTC 2006
The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Chae WJ,Henegariu O,Lee SK,Bothwell AL
16-0281 was used in Functional assays to show that deletion of glutamic acid in the leucine-zipper domain of Foxp3 causes loss of hyporesponsiveness upon antigenic stimulation.
Tue Jun 20 00:00:00 UTC 2006
