Product References
Engineering Escherichia coli for diagnosis and management of hyperuricemia.
Frontiers in bioengineering and biotechnology
Gencer G,Mancuso C,Chua KJ,Ling H,Costello CM,Chang MW,March JC
12-8888-42 was used in Flow cytometry/Cell sorting to show that reprogramming E. coli holds promise as a valid alternative synthetic biology therapy to monitor and maintain healthy serum uric acid levels.
Sat Jun 10 00:00:00 UTC 2023
CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.
Neoplasia (New York, N.Y.)
Feng D,Yan K,Liang H,Liang J,Wang W,Yu H,Zhou Y,Zhao W,Dong Z,Ling B
12-8888 was used in Flow cytometry/Cell sorting to determine that canonical Wnt signaling was aberrantly activated in HaCaT cells transfected with lentivirus expressing Piwil2 and in cervical lesion specimens of low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, and invasive carcinoma.
Fri Jan 01 00:00:00 UTC 2021
CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.
Neoplasia (New York, N.Y.)
Feng D,Yan K,Liang H,Liang J,Wang W,Yu H,Zhou Y,Zhao W,Dong Z,Ling B
12-8888 was used in Flow cytometry/Cell sorting to determine that canonical Wnt signaling was aberrantly activated in HaCaT cells transfected with lentivirus expressing Piwil2 and in cervical lesion specimens of low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, and invasive carcinoma.
Fri Jan 01 00:00:00 UTC 2021
Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers.
Drug metabolism and disposition: the biological fate of chemicals
Fung KL,Kapoor K,Pixley JN,Talbert DJ,Kwit AD,Ambudkar SV,Gottesman MM
12-8888-42 was used in Flow cytometry/Cell sorting to evaluate the efficacy of the BacMam baculovirus system to transduce cells grown in monolayers.
Mon Feb 01 00:00:00 UTC 2016
Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.
Drug metabolism and disposition: the biological fate of chemicals
Weidner LD,Fung KL,Kannan P,Moen JK,Kumar JS,Mulder J,Innis RB,Gottesman MM,Hall MD
12-8888 was used in Flow cytometry/Cell sorting to conclude that TQR is a potent inhibitor of human and mouse P-gp and shows no signs of being a substrate.
Mon Feb 01 00:00:00 UTC 2016
Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.
Drug metabolism and disposition: the biological fate of chemicals
Weidner LD,Fung KL,Kannan P,Moen JK,Kumar JS,Mulder J,Innis RB,Gottesman MM,Hall MD
12-8888 was used in Flow cytometry/Cell sorting to conclude that TQR is a potent inhibitor of human and mouse P-gp and shows no signs of being a substrate.
Mon Feb 01 00:00:00 UTC 2016
Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis.
Oncotarget
Feng D,Yan K,Zhou Y,Liang H,Liang J,Zhao W,Dong Z,Ling B
Published figure using CD338 (ABCG2) monoclonal antibody (Product # 12-8888-42) in Flow Cytometry
Tue Oct 04 00:00:00 UTC 2016
Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease.
Pulmonary circulation
Gaskill C,Marriott S,Pratap S,Menon S,Hedges LK,Fessel JP,Kropski JA,Ames D,Wheeler L,Loyd JE,Hemnes AR,Roop DR,Klemm DJ,Austin ED,Majka SM
12-8888-42 was used in Flow Cytometry to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the potential to translate these findings to vascular beds in other nonlung tissues, in this instance perivascular skin mesenchymal cells (MCs).
Thu Dec 01 00:00:00 UTC 2016
Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors.
Veterinary and comparative oncology
Cannon CM,Pozniak J,Scott MC,Ito D,Gorden BH,Graef AJ,Modiano JF
12-8888 was used in Flow cytometry/Cell sorting to investigate the effect of Aurora kinase inhibitors AZD1152 and VX680 on canine osteosarcoma cells.
Sun Mar 01 00:00:00 UTC 2015
A double blinded, placebo-controlled pilot study to examine reduction of CD34 +/CD117 +/CD133 + lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large B-cell lymphoma.
F1000Research
Ito D,Childress M,Mason N,Winter A,O'Brien T,Henson M,Borgatti A,Lewellen M,Krick E,Stewart J,Lahrman S,Rajwa B,Scott MC,Seelig D,Koopmeiners J,Ruetz S,Modiano J
12-8888 was used in Flow cytometry/Cell sorting to examine whether ABCB1 would reduce lymphoma progenitor cells, and extend the length of remission in dogs with therapy naive large B-cell lymphoma.
Tue Sep 14 00:00:00 UTC 2021
ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.
American journal of physiology. Cell physiology
Marriott S,Baskir RS,Gaskill C,Menon S,Carrier EJ,Williams J,Talati M,Helm K,Alford CE,Kropski JA,Loyd J,Wheeler L,Johnson J,Austin E,Nozik-Grayck E,Meyrick B,West JD,Klemm DJ,Majka SM
12-8888 was used in Flow cytometry/Cell sorting to highlight ABCG2(pos) lung MSC as a novel cell population that contributes to detrimental myofibroblast-mediated remodeling during pulmonary fibrosis.
Wed Oct 15 00:00:00 UTC 2014
Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression.
Vascular cell
Gorden BH,Saha J,Khammanivong A,Schwartz GK,Dickerson EB
12-8888 was used in Flow cytometry/Cell sorting to identify drug sequestration within cellular lysosomes as a drug resistance mechanism in vascular sarcomas marked by high CSF-1R expression.
Wed Oct 08 00:00:00 UTC 2014
Targeting the ABCG2-overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists.
British journal of pharmacology
To KK,Tomlinson B
12-8888 was used in Flow cytometry/Cell sorting to evaluate the potential circumvention of ABCG2-mediated multidrug resistance by commonly prescribed PPARγ agonists.
Fri Nov 01 00:00:00 UTC 2013
Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy.
ACS chemical biology
Das SG,Hermanson DL,Bleeker N,Lowman X,Li Y,Kelekar A,Xing C
12-8888 was used in Flow cytometry/Cell sorting to present new evidence for treatment of MDR cancers and offer mechanistic insights toward its preferential targeting of drug-resistant cancer.
Fri Feb 15 00:00:00 UTC 2013
Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype.
Molecules and cells
Yang WJ,Song MJ,Park EY,Lee JJ,Park JH,Park K,Park JH,Kim HP
12-8888 was used in Flow cytometry/Cell sorting to demonstrate that Sp1 and Sp3 transcription factors may play an important role in maintaining the side population phenotype of lung cancer cells.
Tue Oct 01 00:00:00 UTC 2013
Human prostate side population cells demonstrate stem cell properties in recombination with urogenital sinus mesenchyme.
PloS one
Foster BA,Gangavarapu KJ,Mathew G,Azabdaftari G,Morrison CD,Miller A,Huss WJ
12-8888 was used in Immunohistochemistry to show that the ABCG2 expressing side population from freshly digested prostate tissue is enriched for prostate stem cells.
Fri Jul 19 00:00:00 UTC 2013
New use for an old drug: inhibiting ABCG2 with sorafenib.
Molecular cancer therapeutics
Wei Y,Ma Y,Zhao Q,Ren Z,Li Y,Hou T,Peng H
12-8888 was used in Flow cytometry/Cell sorting to rediscover sorafenib as a potent inhibitor of ABCG2 in vitro.
Wed Aug 01 00:00:00 UTC 2012
Surface antigenic profiling of stem cells from human omentum fat in comparison with subcutaneous fat and bone marrow.
Cytotechnology
Dhanasekaran M,Indumathi S,Kanmani A,Poojitha R,Revathy KM,Rajkumar JS,Sudarsanam D
12-8888 was used in Flow cytometry/Cell sorting to investigate surface antigenic profiling of stem cells from human omentum fat, compared with subcutaneous fat and bone marrow..
Wed Feb 01 00:00:00 UTC 2012
Adverse Cell Culture Conditions Mimicking the Tumor Microenvironment Upregulate ABCG2 to Mediate Multidrug Resistance and a More Malignant Phenotype.
ISRN oncology
Cheng GM,To KK
12-8888 was used in Flow cytometry/Cell sorting to investigate the upregulation of ABCG2 by hypoxia, glucose deprivation and acidosis within the tumor microenvironment.
Thu Aug 23 00:00:00 UTC 2012
Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.
Biochemistry
Ni Z,Bikadi Z,Shuster DL,Zhao C,Rosenberg MF,Mao Q
12-8888 was used in Flow cytometry/Cell sorting to suggest that Pro(392) and Pro(485) are important in determining the overall transport activity and substrate selectivity of BCRP, respectively.
Tue Sep 20 00:00:00 UTC 2011
Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance.
PloS one
Goler-Baron V,Assaraf YG
12-8888 was used in Flow cytometry/Cell sorting to propose a composite model for the structure and function of MDR pump-rich EVs in cancer cells and their ability to confer multiple anticancer drug resistance.
Mon Jan 24 00:00:00 UTC 2011
Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport.
American journal of physiology. Cell physiology
Ni Z,Bikadi Z,Cai X,Rosenberg MF,Mao Q
12-8888 was used in Flow cytometry/Cell sorting to demonstrate the functional importance of several polar residues in breast cancer resistance protein activity.
Mon Nov 01 00:00:00 UTC 2010
Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport.
The Journal of pharmacology and experimental therapeutics
Cai X,Bikadi Z,Ni Z,Lee EW,Wang H,Rosenberg MF,Mao Q
12-8888 was used in Flow cytometry/Cell sorting to investigate the role of five basic residues, within or near the transmembrane region of breast cancer resistance protein, in transport activity.
Tue Jun 01 00:00:00 UTC 2010
Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2.
Molecular pharmacology
Bram EE,Adar Y,Mesika N,Sabisz M,Skladanowski A,Assaraf YG
12-8888 was used in Immunofluorescence to demonstrate that the imidazoacridinone (IA) determinants mediating cytotoxicity also facilitate ABCG2-dependent drug efflux and IA resistance.
Fri May 01 00:00:00 UTC 2009
Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells.
Cancer chemotherapy and pharmacology
Robey RW,Obrzut T,Shukla S,Polgar O,Macalou S,Bahr JC,Di Pietro A,Ambudkar SV,Bates SE
12-8888 was used in Flow cytometry/Cell sorting to suggest that becatecarin is transported by ABCG2 and is able to induce ABCG2 expression in cancer cells.
Sat Aug 01 00:00:00 UTC 2009
Arginine 383 is a crucial residue in ABCG2 biogenesis.
Biochimica et biophysica acta
Polgar O,Ediriwickrema LS,Robey RW,Sharma A,Hegde RS,Li Y,Xia D,Ward Y,Dean M,Ozvegy-Laczka C,Sarkadi B,Bates SE
12-8888 was used in Flow cytometry/Cell sorting to conclude that arginine 383 is a crucial residue for ABCG2 biogenesis, where even the most conservative mutations have a large impact.
Wed Jul 01 00:00:00 UTC 2009
Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line.
Cancer research
Wang J,Guo LP,Chen LZ,Zeng YX,Lu SH
12-8888 was used in Flow cytometry/Cell sorting to investigate the prevalence of side population cells and explore stem cell characteristics in a human nasopharyngeal carcinoma cell line.
Sun Apr 15 00:00:00 UTC 2007
