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          • Primary Antibodies ›
          • CD35 Antibodies

          Invitrogen

          CD35 Chimeric Recombinant Rabbit Monoclonal Antibody (8C12)

          View all (104) CD35 antibodies

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          Cite CD35 Chimeric Recombinant Rabbit Monoclonal Antibody (8C12)

          • Antibody Testing Data (1)
          CD35 Chimeric Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
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          CD35 Chimeric Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
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          CD35 Chimeric Antibody (MA5-47853) in IHC (PFA)

          Immunohistochemistry (PFA fixed) analysis of CD35 in formalin fixed rat stomach slices using CD35 Chimeric Monoclonal Antibody (Product # MA5-47853) at a concentration of 3 µg/mL. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD35 Chimeric Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

          Product Details

          MA5-47853

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          3 µg/mL
          -

          Immunohistochemistry (Frozen) (IHC (F))

          Assay-dependent
          -

          Flow Cytometry (Flow)

          Assay-dependent
          -

          Immunoprecipitation (IP)

          Assay-dependent
          -
          Product Specifications

          Species Reactivity

          Mouse

          Host/Isotype

          Rabbit / IgG, kappa

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          8C12

          Immunogen

          Purified murine CR1 protein.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS

          Contains

          0.02% ProClin 300

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3074298

          Product Specific Information

          Specificity: Recognises an epitope on CD35 (CR1, 190 kDa), but not on CD21 (CR2, 145-150 kDa), which are alternative splice variants of primary Cr2 gene transcripts.

          Target Information

          CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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