Invitrogen

CD36 Polyclonal Antibody

CD36 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD36 Antibody (PA1-16813) in IHC (P)

Immunohistochemical analysis of CD36 in human adipocytes. Samples were incubated in CD36 polyclonal antibody (Product # PA1-16813).

CD36 Antibody in Immunocytochemistry (ICC/IF)

CD36 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

CD36 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines and tissues owing to their inherent genetic constitution. Relative expression of Platelet glycoprotein 4 was observed in 3T3-L1 upon differentiation to adipocytes when compared to undifferentiated 3T3-L1; also the expression was higher in adipose and brown adipose when compared to other tissues tested using Anti-CD36 Polyclonal Antibody (Product # PA1-16813) in Western Blot. {RE}

Product Details

PA1-16813

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent

Immunocytochemistry (ICC/IF)

1:50-1:200

View 2 publications 2 publications

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Non-human primate, Pig, Rabbit, Rat

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corressponding to a region of human CD36 between residues 100-200.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_568487

Product Specific Information

This antibody shares 95% sequence homology with rat.

Target Information

CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Schwarz N,Fernando S,Chen YC,Salagaras T,Rao SR,Liyanage S,Williamson AE,Toledo-Flores D,Dimasi C,Sargeant TJ,Manavis J,Eddy E,Kanellakis P,Thompson PL,Tan JTM,Snel MF,Bursill CA,Nicholls SJ,Peter K,Psaltis PJ

PA1-16813 was used in Immunohistochemistry to show that colchicine exerts anti-atherosclerotic and plaque-stabilizing effects at low dose by inhibiting foam cell formation and cholesterol crystal-induced inflammation.

Sat Apr 01 00:00:00 UTC 2023

Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sat Apr 01 00:00:00 UTC 2023

Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.

Endocrine

Godoy-Lugo JA,Thorwald MA,Hui DY,Nishiyama A,Nakano D,Soñanez-Organis JG,Ortiz RM

Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Western Blot

Sat Jan 01 00:00:00 UTC 2022

Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.

Antioxidants & redox signaling

Potor L,Hendrik Z,Patsalos A,Katona É,Méhes G,Póliska S,Csősz É,Kalló G,Komáromi I,Combi Z,Posta N,Sikura KÉ,Pethő D,Oros M,Vereb G,Tóth C,Gergely P,Nagy L,Balla G,Balla J

PA1-16813 was used in Western Blot to conclude that ferrylHb in atherosclerotic lesion provokes the progression of the disease via polarizing macrophages.

Wed Oct 20 00:00:00 UTC 2021

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway.

Cell death & disease

Wang G,Chen JJ,Deng WY,Ren K,Yin SH,Yu XH

PA1-16813 was used in Western Blot to suggest that CTRP12 protects against atherosclerosis by enhancing RCT efficiency and mitigating vascular inflammation via the miR-155-5p/LXRα pathway.

Wed Mar 10 00:00:00 UTC 2021

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway.

Cell death & disease

Wang G,Chen JJ,Deng WY,Ren K,Yin SH,Yu XH

PA1-16813 was used in Western Blot to suggest that CTRP12 protects against atherosclerosis by enhancing RCT efficiency and mitigating vascular inflammation via the miR-155-5p/LXRα pathway.

Wed Mar 10 00:00:00 UTC 2021

Sea-Buckthorn Seed Oil Induces Proliferation of both Normal and Dysplastic Keratinocytes in Basal Conditions and under UVA Irradiation.

Journal of personalized medicine

Dudau M,Vilceanu AC,Codrici E,Mihai S,Popescu ID,Albulescu L,Tarcomnicu I,Moise G,Ceafalan LC,Hinescu ME,Enciu AM,Tanase C

PA1-16813 was used in Immunocytochemistry-immunofluorescence to show that sea-buckthorn seed oil stimulated the proliferation of dysplastic cells, while it also impaired the ability of both normal and dysplastic cells to migrate over a denuded area.

Wed Apr 07 00:00:00 UTC 2021

Sea-Buckthorn Seed Oil Induces Proliferation of both Normal and Dysplastic Keratinocytes in Basal Conditions and under UVA Irradiation.

Journal of personalized medicine

Dudau M,Vilceanu AC,Codrici E,Mihai S,Popescu ID,Albulescu L,Tarcomnicu I,Moise G,Ceafalan LC,Hinescu ME,Enciu AM,Tanase C

Wed Apr 07 00:00:00 UTC 2021

Physiological Doses of Hydroxytyrosol Modulate Gene Expression in Skeletal Muscle of Exercised Rats.

Life (Basel, Switzerland)

Casuso RA,Al Fazazi S,Plaza-Díaz J,Ruiz-Ojeda FJ,Rueda-Robles A,Aragón-Vela J,Huertas JR

PA1-16813 was used in Western Blotting to test whether physiological doses of hydroxytyrosol (HT) may alter the mRNA transcription of key metabolic genes in exercised skeletal muscle.

Sun Dec 12 00:00:00 UTC 2021

Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice.

Hepatology communications

Xu Y,Zhu Y,Bawa FC,Hu S,Pan X,Yin L,Zhang Y

PA1-16813 was used in Western Blot to conclude that hepatocyte-specific overexpression of human carboxylesterase 1 attenuates diet-induced steatohepatitis and hyperlipidemia.

Wed Apr 01 00:00:00 UTC 2020

Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice.

Hepatology communications

Xu Y,Zhu Y,Bawa FC,Hu S,Pan X,Yin L,Zhang Y

PA1-16813 was used in Western Blot to conclude that hepatocyte-specific overexpression of human carboxylesterase 1 attenuates diet-induced steatohepatitis and hyperlipidemia.

Wed Apr 01 00:00:00 UTC 2020

Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.

Cell death & disease

Wu D,Jian C,Peng Q,Hou T,Wu K,Shang B,Zhao M,Wang Y,Zheng W,Ma Q,Li CY,Cheng H,Wang X,Zhao L

PA1-16813 was used in Western Blot to demonstrate that cardiac-specific knockout of Phb2 leads to accumulation of lipid droplets and causes heart failure.

Thu Mar 12 00:00:00 UTC 2020

Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis.

Arteriosclerosis, thrombosis, and vascular biology

Li Y,Xu Y,Jadhav K,Zhu Y,Yin L,Zhang Y

PA1-16813 was used in Western Blotting to showed that FOXA3 directly bound to the promoter of the Apoa1 gene to regulate its transcription.

Thu Aug 01 00:00:00 UTC 2019

Fatty acid transporter expression and regulation is impaired in placental macrovascular endothelial cells in obese women.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Yang X,Glazebrook P,Ranasinghe GC,Haghiac M,Calabuig-Navarro V,Minium J,O'Tierney-Ginn P

Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Immunohistochemistry

Fri Mar 01 00:00:00 UTC 2019

Dysregulated Lipid Transport Proteins Correlate With Pathogenesis and Outcome in Severe Alcoholic Hepatitis.

Hepatology communications

Maras JS,Das S,Bhat A,Kumar Vyas A,Yadav G,Chaudhary S,Sukriti S,Gupta AC,Bihari C,Mahiwall R,Sarin SK

Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Immunohistochemistry (Paraffin)

Sun Dec 01 00:00:00 UTC 2019

High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake.

International journal of molecular sciences

Yen CH,Chang HS,Yang TH,Wang SF,Wu HC,Chen YC,Lin KJ,Wang S

Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Western Blot

Sun Jul 22 00:00:00 UTC 2018

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.

Science (New York, N.Y.)

Wang Y,Kuang Z,Yu X,Ruhn KA,Kubo M,Hooper LV

Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Western Blot

Fri Sep 01 00:00:00 UTC 2017

Influence of high fat diet and resveratrol supplementation on placental fatty acid uptake in the Japanese macaque.

Placenta

O'Tierney-Ginn P,Roberts V,Gillingham M,Walker J,Glazebrook PA,Thornburg KL,Grove K,Frias AE

PA1-16813 was used in immunohistochemistry - paraffin section and western blot to study the effect of high fat diet and resveratrol supplementation on placental fatty acid uptake

Sat Aug 01 00:00:00 UTC 2015

Heterogeneity and immunophenotypic plasticity of malignant cells in human liposarcomas.

Stem cell research

Zhang Y,Young ED,Bill K,Belousov R,Peng T,Lazar AJ,Pollock RE,Simmons PJ,Lev D,Kolonin MG

PA1-16813 was used in immunohistochemistry to study the range of malignant cell types present in human liposarcomas

Sun Sep 01 00:00:00 UTC 2013

Heterogeneity and immunophenotypic plasticity of malignant cells in human liposarcomas.

Stem cell research

Zhang Y,Young ED,Bill K,Belousov R,Peng T,Lazar AJ,Pollock RE,Simmons PJ,Lev D,Kolonin MG

PA1-16813 was used in immunohistochemistry to study the range of malignant cell types present in human liposarcomas

Sun Sep 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: adipocyte membrane protein; CD36; CD36 antigen; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); cluster determinant 36; collagen type I receptor thrombospondin receptor; FAT; Fatty acid translocase; fatty acid translocase/CD36; fatty acid transport protein; Glycoprotein IIIb; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; scavenger receptor class B, member 3; SR-B3; Thrombospondin receptor

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Gene Aliases: BDPLT10; BOS_4156; CD36; CHDS7; FAT; GP3B; GP4; GPIIIB; GPIV; PAS-4; PAS4; PASIV; SCARB3

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UniProt ID: (Human) P16671, (Bovine) P26201, (Mouse) Q08857

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Entrez Gene ID: (Human) 948, (Bovine) 281052, (Pig) 733702, (Rabbit) 100008825, (Rat) 29184, (Mouse) 12491

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Function(s)

low-density lipoprotein receptor activity protein binding high-density lipoprotein particle binding lipid binding low-density lipoprotein particle binding transforming growth factor beta binding thrombospondin receptor activity lipoteichoic acid receptor activity lipoprotein particle binding oleic acid binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD36 Polyclonal Antibody

CD36 Antibody (PA1-16813) in IHC (P)

Product Details

PA1-16813

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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