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Alomone Labs, LTD
CD39 (extracellular) Polyclonal Antibody, FITC
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FIGURE: 1 / 2
CD39 (extracellular) Antibody (ANT-065-F-50UL) in Flow
Cell surface detection of CD39 in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-CD39 (extracellular)-FITC Antibody (#ANT-065-F), (2.5 µg).
Product Details
ANT-065-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KTSYAGVKEKYLSE, corresponding to amino acid residues 398-411 of human CD39, Extracellular loop
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP diphosphohydrolase; ATP-DPH; ATPDase; CD39; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; Ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; FLJ40921; FLJ40959; Lymphoid cell activation antigen; NTPDase 1; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1
Gene Aliases: 2610206B08Rik; AA408691; ATPDase; CD39; ENTPD1; NTPDase-1; SPG64
UniProt ID: (Human) P49961, (Mouse) P55772
Entrez Gene ID: (Human) 953, (Mouse) 12495, (Rat) 64519
G-protein coupled receptor signaling pathway
metabolic process
purine ribonucleoside diphosphate catabolic process
response to proline
response to gamma radiation
response to auditory stimulus
platelet activation
response to caffeine
response to lipopolysaccharide
response to ATP
negative regulation of dopamine secretion
response to interferon-beta
cellular response to interferon-alpha
response to morphine
protein homooligomerization
cellular response to lipopolysaccharide
cellular response to aluminum ion
cellular response to tumor necrosis factor
response to L-arginine
negative regulation of ATP biosynthetic process
cell adhesion
blood coagulation
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