Product References
Cathepsin S inhibition in dendritic cells prevents Th17 cell differentiation in perivascular adipose tissues following vascular injury in diabetic rats.
Journal of biochemical and molecular toxicology
Peng H,Lv Y,Li C,Cheng Z,He S,Wang C,Liu J
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Fri Sep 01 00:00:00 UTC 2023
Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes.
JCI insight
Zhang M,Chong KK,Chen ZY,Guo H,Liu YF,Kang YY,Li YJ,Shi TT,Lai KK,He MQ,Ye K,Kahaly GJ,Shi BY,Wang Y
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Feb 08 00:00:00 UTC 2023
Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development.
Nature communications
Dhillon P,Mulholland KA,Hu H,Park J,Sheng X,Abedini A,Liu H,Vassalotti A,Wu J,Susztak K
14-0049-82 was used in Immunohistochemistry-immunofluorescence to indicate an important role of epigenetic derepression-induced ERV activation triggering renal fibroinflammation.
Thu Feb 02 00:00:00 UTC 2023
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor.
Cells
Rode AKO,Buus TB,Mraz V,Al-Jaberi FAH,Lopez DV,Ford SL,Hennen S,Eliasen IP,Klewe IV,Gharehdaghi L,Dragan A,Rosenkilde MM,Woetmann A,Skov L,Ødum N,Bonefeld CM,Kongsbak-Wismann M,Geisler C
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Immunohistochemistry
Fri Aug 19 00:00:00 UTC 2022
Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.
Cell discovery
Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue May 10 00:00:00 UTC 2022
Single-cell RNA sequencing reveals the molecular features of peripheral blood immune cells in children, adults and centenarians.
Frontiers in immunology
Zhong J,Ding R,Jiang H,Li L,Wan J,Feng X,Chen M,Peng L,Li X,Lin J,Yang H,Wang M,Li Q,Chen Q
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Jan 30 00:00:00 UTC 2023
Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.
Nature communications
McEvoy CM,Murphy JM,Zhang L,Clotet-Freixas S,Mathews JA,An J,Karimzadeh M,Pouyabahar D,Su S,Zaslaver O,Röst H,Arambewela R,Liu LY,Zhang S,Lawson KA,Finelli A,Wang B,MacParland SA,Bader GD,Konvalinka A,Crome SQ
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sat Dec 10 00:00:00 UTC 2022
Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells.
Biomolecules & therapeutics
Yoon H,Sung JH,Song MJ
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Mar 01 00:00:00 UTC 2021
Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation.
Cancers
Prat M,Salon M,Allain T,Dubreuil O,Noël G,Preisser L,Jean B,Cassard L,Lemée F,Tabah-Fish I,Pipy B,Jeannin P,Prost JF,Barret JM,Coste A
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue Apr 13 00:00:00 UTC 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Thu Oct 21 00:00:00 UTC 2021
Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Molecular therapy. Methods & clinical development
Kierkels GJJ,van Diest E,Hernández-López P,Scheper W,de Bruin ACM,Frijlink E,Aarts-Riemens T,van Dooremalen SFJ,Beringer DX,Oostvogels R,Kramer L,Straetemans T,Uckert W,Sebestyén Z,Kuball J
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Fri Sep 10 00:00:00 UTC 2021
Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Thomas R,Shaath H,Naik A,Toor SM,Elkord E,Decock J
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sun Mar 01 00:00:00 UTC 2020
Activation of Human Vδ2+ γδ T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cooper AJR,Lalor SJ,McLoughlin RM
14-0049-82 was used in Flow Cytometry to study the capacity of human Vδ2+ γδ T cells for rapid activation in response to S. aureus.
Sat Aug 15 00:00:00 UTC 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Sep 28 00:00:00 UTC 2020
Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.
The Journal of international medical research
He J,Xu Y,Yi M,Gu C,Zhu Y,Hu G
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Jul 01 00:00:00 UTC 2020
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.
Frontiers in immunology
Møller SH,Mellergaard M,Madsen M,Bermejo AV,Jepsen SD,Hansen MH,Høgh RI,Aldana BI,Desler C,Rasmussen LJ,Sustarsic EG,Gerhart-Hines Z,Daskalaki E,Wheelock CE,Hiron TK,Lin D,O'Callaghan CA,Wandall HH,Andresen L,Skov S
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Neutralization
Fri Apr 30 00:00:00 UTC 2021
Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer.
Cancers
Bauman JE,Ohr J,Gooding WE,Ferris RL,Duvvuri U,Kim S,Johnson JT,Soloff AC,Wallweber G,Winslow J,Gaither-Davis A,Grandis JR,Stabile LP
14-0049-82 was used in Flow Cytometry to establish the recommended Phase II dose (RP2D). Secondary objectives included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).
Thu Jun 11 00:00:00 UTC 2020
Standardized 11-color flow cytometry panel for the functional phenotyping of human T regulatory cells.
Journal of biological methods
Manuszak C,Brainard M,Thrash E,Hodi FS,Severgnini M
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Sep 28 00:00:00 UTC 2020
MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo.
Molecular medicine reports
Lv M,Li Z,Liu J,Lin F,Zhang Q,Li Z,Wang Y,Wang K,Xu Y
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue Oct 01 00:00:00 UTC 2019
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Cell
Bradley T,Peppa D,Pedroza-Pacheco I,Li D,Cain DW,Henao R,Venkat V,Hora B,Chen Y,Vandergrift NA,Overman RG,Edwards RW,Woods CW,Tomaras GD,Ferrari G,Ginsburg GS,Connors M,Cohen MS,Moody MA,Borrow P,Haynes BF
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Thu Oct 04 00:00:00 UTC 2018
The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.
Acta Cardiologica Sinica
Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sat Sep 01 00:00:00 UTC 2018
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.
Cell
Horwitz JA,Bar-On Y,Lu CL,Fera D,Lockhart AAK,Lorenzi JCC,Nogueira L,Golijanin J,Scheid JF,Seaman MS,Gazumyan A,Zolla-Pazner S,Nussenzweig MC
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Thu Aug 10 00:00:00 UTC 2017
Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.
Cell research
Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sat Apr 01 00:00:00 UTC 2017
Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis.
Frontiers in immunology
Hou TY,Chen MR,Chou YC,Kan PC,Tsai YT,Cha TL
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.
Journal of leukocyte biology
de Bourayne M,Gallais Y,El Ali Z,Rousseau P,Damiens MH,Cochet C,Filhol O,Chollet-Martin S,Pallardy M,Kerdine-Römer S
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer.
JCI insight
Gu-Trantien C,Migliori E,Buisseret L,de Wind A,Brohée S,Garaud S,Noël G,Dang Chi VL,Lodewyckx JN,Naveaux C,Duvillier H,Goriely S,Larsimont D,Willard-Gallo K
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Fri Jun 02 00:00:00 UTC 2017
Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity.
Scientific reports
Zanin-Zhorov A,Kumari S,Hippen KL,Merkel SC,MacMillan ML,Blazar BR,Dustin ML
14-0049 was used in Flow cytometry/Cell sorting to study the regulatory mechanisms behind induced human regulatory T cells (iTregs) in vitro.
Mon Jun 26 00:00:00 UTC 2017
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-0049 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 UTC 2016
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Proceedings of the National Academy of Sciences of the United States of America
Jönsson P,Southcombe JH,Santos AM,Huo J,Fernandes RA,McColl J,Lever M,Evans EJ,Hudson A,Chang VT,Hanke T,Godkin A,Dunne PD,Horrocks MH,Palayret M,Screaton GR,Petersen J,Rossjohn J,Fugger L,Dushek O,Xu XN,Davis SJ,Klenerman D
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue May 17 00:00:00 UTC 2016
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Proceedings of the National Academy of Sciences of the United States of America
Jönsson P,Southcombe JH,Santos AM,Huo J,Fernandes RA,McColl J,Lever M,Evans EJ,Hudson A,Chang VT,Hanke T,Godkin A,Dunne PD,Horrocks MH,Palayret M,Screaton GR,Petersen J,Rossjohn J,Fugger L,Dushek O,Xu XN,Davis SJ,Klenerman D
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue May 17 00:00:00 UTC 2016
Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion.
Arthritis research & therapy
Noack M,Ndongo-Thiam N,Miossec P
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Thu Jun 23 00:00:00 UTC 2016
CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.
Molecular medicine reports
Tang ZS,Hao YH,Zhang EJ,Xu CL,Zhou Y,Zheng X,Yang DL
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Aug 01 00:00:00 UTC 2016
Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.
Experimental and therapeutic medicine
Zhao J,Ma J,Zhang X,Li Q,Yang X
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2016
Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.
Stem cell reports
Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue Oct 11 00:00:00 UTC 2016
Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Scientific reports
Kumar A,Abbas W,Colin L,Khan KA,Bouchat S,Varin A,Larbi A,Gatot JS,Kabeya K,Vanhulle C,Delacourt N,Pasquereau S,Coquard L,Borch A,König R,Clumeck N,De Wit S,Rohr O,Rouzioux C,Fulop T,Van Lint C,Herbein G
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Thu Apr 14 00:00:00 UTC 2016
BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms.
The Journal of experimental medicine
Hatzi K,Nance JP,Kroenke MA,Bothwell M,Haddad EK,Melnick A,Crotty S
14-0049 was used in Flow cytometry/Cell sorting to demonstrate the effects of BCL6 on Tfh biology and provide insight into how it mediates distinct cell context-dependent phenotypes.
Mon Apr 06 00:00:00 UTC 2015
Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency.
Arthritis & rheumatology (Hoboken, N.J.)
Van Eyck L,De Somer L,Pombal D,Bornschein S,Frans G,Humblet-Baron S,Moens L,de Zegher F,Bossuyt X,Wouters C,Liston A
14-0049 was used in Flow cytometry/Cell sorting to determine the underlying genetic defect responsible for severe early onset and refractory systemic lupus erythematosus.
Mon Jun 01 00:00:00 UTC 2015
The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages.
eLife
Park C,Arthos J,Cicala C,Kehrl JH
14-0049 was used in Immunohistochemistry to reveal a specialised lymph node antigen delivery system capable of delivering gp120 and other pathogen-derived glycoproteins to B cells.
Mon Aug 10 00:00:00 UTC 2015
Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.
Journal of virology
Nunes-Cabaço H,Matoso P,Foxall RB,Tendeiro R,Pires AR,Carvalho T,Pinheiro AI,Soares RS,Sousa AE
14-0049 was used in Flow cytometry/Cell sorting to assess the direct impact of HIV-2 infection on the human thymus.
Sun Feb 01 00:00:00 UTC 2015
CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells.
Journal of leukocyte biology
Fox JM,Kasprowicz R,Hartley O,Signoret N
14-0049 was used in Functional assays to compare the behavior of CCR5 on in vitro generated human T-cell blasts, monocytes and MDMs and CHO-CCR5 transfectants.
Wed Jul 01 00:00:00 UTC 2015
Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Ly J,Lagman M,Saing T,Singh MK,Tudela EV,Morris D,Anderson J,Daliva J,Ochoa C,Patel N,Pearce D,Venketaraman V
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sun Nov 01 00:00:00 UTC 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue Sep 15 00:00:00 UTC 2015
Investigating the causes for decreased levels of glutathione in individuals with type II diabetes.
PloS one
Lagman M,Ly J,Saing T,Kaur Singh M,Vera Tudela E,Morris D,Chi PT,Ochoa C,Sathananthan A,Venketaraman V
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Dec 30 00:00:00 UTC 2015
Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma.
Oncoimmunology
Partlová S,Bouček J,Kloudová K,Lukešová E,Zábrodský M,Grega M,Fučíková J,Truxová I,Tachezy R,Špíšek R,Fialová A
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Thu Jan 01 00:00:00 UTC 2015
The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation.
Retrovirology
Valera MS,de Armas-Rillo L,Barroso-González J,Ziglio S,Batisse J,Dubois N,Marrero-Hernández S,Borel S,García-Expósito L,Biard-Piechaczyk M,Paillart JC,Valenzuela-Fernández A
14-0049 was used in Neutralization experiments to identify that the cellular complex, HDAC6/A3G, may be a antiviral factor capable of controlling HIV-1 infectiveness via degradation of Vif.
Wed Jun 24 00:00:00 UTC 2015
CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome.
Oncotarget
Huang Y,Ma C,Zhang Q,Ye J,Wang F,Zhang Y,Hunborg P,Varvares MA,Hoft DF,Hsueh EC,Peng G
14-0049 was used in Immunohistochemistry to delineate the dynamics and roles of CD4+ and CD8+ T cells in the pathogenesis of breast cancer.
Fri Jul 10 00:00:00 UTC 2015
Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation.
Oncoimmunology
de Haar C,Plantinga M,Blokland NJ,van Til NP,Flinsenberg TW,Van Tendeloo VF,Smits EL,Boon L,Spel L,Boes M,Boelens JJ,Nierkens S
14-0049 was used in Flow cytometry/Cell sorting to investigate the generation of a cord-blood derived Wilms Tumor 1 dendritic cell vaccine for cord blood transplanted AML patients.
Sun Nov 01 00:00:00 UTC 2015
Immune response to JC virus T antigen in patients with and without colorectal neoplasia.
Gut microbes
Butcher LD,Garcia M,Arnold M,Ueno H,Goel A,Boland CR
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue Jul 01 00:00:00 UTC 2014
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Journal of virology
Zhen A,Krutzik SR,Levin BR,Kasparian S,Zack JA,Kitchen SG
14-0049 was used in Flow cytometry/Cell sorting to investigate the role of the CD4 molecule in human monocyte development and function, showing that CD4 ligation triggers macrophage differentiation and enhances HIV infection.
Mon Sep 01 00:00:00 UTC 2014
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Journal of virology
Zhen A,Krutzik SR,Levin BR,Kasparian S,Zack JA,Kitchen SG
14-0049 was used in Flow cytometry/Cell sorting to investigate the role of the CD4 molecule in human monocyte development and function, showing that CD4 ligation triggers macrophage differentiation and enhances HIV infection.
Mon Sep 01 00:00:00 UTC 2014
TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.
Journal of immunology (Baltimore, Md. : 1950)
Beswick EJ,Johnson JR,Saada JI,Humen M,House J,Dann S,Qiu S,Brasier AR,Powell DW,Reyes VE,Pinchuk IV
14-0049 was used in Flow cytometry/Cell sorting to investigate whether signalling through TLRs contribute to the regulation PD-1 ligands on CD90(+) myofibroblasts/fibroblasts upon colonic mucosal tolerance.
Mon Sep 01 00:00:00 UTC 2014
Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950)
Kshirsagar S,Riedl M,Billing H,Tönshoff B,Thangavadivel S,Steuber C,Staude H,Wechselberger G,Edelbauer M
14-0049 was used in Flow cytometry/Cell sorting to determine that therapeutic modulation of Akt activity could suppress chronic inflammatory processes in children with lupus.
Sat Nov 15 00:00:00 UTC 2014
OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Graves AJ,Padilla MG,Hokey DA
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Tue Jul 01 00:00:00 UTC 2014
High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function.
PloS one
Foley MH,Forcier T,McAndrew E,Gonzalez M,Chen H,Juelg B,Walker BD,Irvine DJ
14-0049 was used in Functional assays to study the impact of infected target cell migration on antigen recognition by HIV-specific CD8(+) T cells in a 3D collagen model of peripheral tissue.
Tue Oct 14 00:00:00 UTC 2014
Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis.
BMC musculoskeletal disorders
Fukuda S,Kohsaka H,Takayasu A,Yokoyama W,Miyabe C,Miyabe Y,Harigai M,Miyasaka N,Nanki T
14-0049 was used in Immunofluorescence to suggest that a selective CB(2) agonist could be a new therapy for rheumatoid arthritis that inhibits production of inflammatory mediators from FLS, and osteoclastogenesis.
Tue Aug 12 00:00:00 UTC 2014
Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.
Cancer immunology research
Choi BD,Gedeon PC,Herndon JE,Archer GE,Reap EA,Sanchez-Perez L,Mitchell DA,Bigner DD,Sampson JH
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sun Sep 01 00:00:00 UTC 2013
Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Timblin GA,Schlissel MS
14-0049 was used in Flow cytometry/Cell sorting to identify a novel pathway responsible for the transcriptional repression of Rag in developing B cells using an in vitro model system.
Fri Nov 01 00:00:00 UTC 2013
Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Ma C,Zhang Q,Ye J,Wang F,Zhang Y,Wevers E,Schwartz T,Hunborg P,Varvares MA,Hoft DF,Hsueh EC,Peng G
14-0049 was used in Immunohistochemistry to suggest that intratumoural γδ T cells may serve as independent prognostic biomarkers, and potential therapeutic targets for human breast cancer.
Thu Nov 15 00:00:00 UTC 2012
Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis.
PloS one
Zhang L,Li YG,Li YH,Qi L,Liu XG,Yuan CZ,Hu NW,Ma DX,Li ZF,Yang Q,Li W,Li JM
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Fri Jul 27 00:00:00 UTC 2012
Rapid and sensitive detection of rare cancer cells by the coupling of immunomagnetic nanoparticle separation with ELISA analysis.
International journal of nanomedicine
Cheng HY,Lai LJ,Ko FH
14-0049 was used in Magnetic cell separation to develop a rapid and sensitive method for detecting cancer cells occurring at low concentration.
Thu Jan 24 00:00:00 UTC 2013
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.
Critical care (London, England)
Zhang Y,Li J,Lou J,Zhou Y,Bo L,Zhu J,Zhu K,Wan X,Cai Z,Deng X
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Wed Dec 07 00:00:00 UTC 2011
Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.
Diabetes
Hughson A,Bromberg I,Johnson B,Quataert S,Jospe N,Fowell DJ
14-0049 was used in Flow cytometry/Cell sorting to determine the relative proportions of effector and regulatory T cells in the CD4+CD25+Foxp3+ T-cell compartment in varying type 1 diabetes disease states.
Mon Aug 01 00:00:00 UTC 2011
Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.
Molecular pharmaceutics
Park J,Gao W,Whiston R,Strom TB,Metcalfe S,Fahmy TM
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Feb 07 00:00:00 UTC 2011
Generation of bivalent chromatin domains during cell fate decisions.
Epigenetics & chromatin
De Gobbi M,Garrick D,Lynch M,Vernimmen D,Hughes JR,Goardon N,Luc S,Lower KM,Sloane-Stanley JA,Pina C,Soneji S,Renella R,Enver T,Taylor S,Jacobsen SE,Vyas P,Gibbons RJ,Higgs DR
14-0049 was used in Flow cytometry/Cell sorting to investigate the patterns and levels of histone modifications at bivalent genes, showing the generation of bivalent chromatin domains during cell fate decisions.
Mon Jun 06 00:00:00 UTC 2011
A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice.
Cancer research
Demotte N,Wieërs G,Van Der Smissen P,Moser M,Schmidt C,Thielemans K,Squifflet JL,Weynand B,Carrasco J,Lurquin C,Courtoy PJ,van der Bruggen P
14-0049 was used in Flow cytometry/Cell sorting to suggest that a combination of galectin-3 ligands and therapeutic vaccination may induce more tumor regressions than vaccination alone.
Fri Oct 01 00:00:00 UTC 2010
Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis.
Journal of clinical periodontology
Zhang S,Crivello A,Offenbacher S,Moretti A,Paquette DW,Barros SP
14-0049 was used in Immunofluorescence to determine whether epigenetic modifications in the IFNG promoter are associated with an increase of IFNG transcription at different stages of periodontal diseases.
Mon Nov 01 00:00:00 UTC 2010
The length of and nonhydrophobic residues in the transmembrane domain of dengue virus envelope protein are critical for its retention and assembly in the endoplasmic reticulum.
Journal of virology
Hsieh SC,Tsai WY,Wang WK
14-0049 was used in Immunoprecipitation to investigate determinants in the E protein of dengue virus for its retention and assembly in the endoplasmic reticulum.
Sat May 01 00:00:00 UTC 2010
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Journal of leukocyte biology
Unsinger J,McDonough JS,Shultz LD,Ferguson TA,Hotchkiss RS
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Sat Aug 01 00:00:00 UTC 2009
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.
Retrovirology
Brudek T,Christensen T,Aagaard L,Petersen T,Hansen HJ,Møller-Larsen A
Published figure using CD4 monoclonal antibody (Product # 14-0049-82) in Flow Cytometry
Mon Nov 16 00:00:00 UTC 2009
Expression of endothelia and lymphocyte adhesion molecules in bronchus-associated lymphoid tissue (BALT) in adult human lung.
Respiratory research
Kawamata N,Xu B,Nishijima H,Aoyama K,Kusumoto M,Takeuchi T,Tei C,Michie SA,Matsuyama T
14-0049 was used in Immunohistochemistry to identify which adhesion molecules recruit specific subsets of lymphocytes into human bronchus-associated lymphoid tissue.
Thu Oct 22 00:00:00 UTC 2009
TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
Molecular immunology
Arimura Y,Vang T,Tautz L,Williams S,Mustelin T
14-0049 was used in Magnetic cell separation to investigate how PTP-PEST is down-regulated following T cell activation, and how that can lead to reduced IL-2 secretion following TCR and CD28 stimulation.
Sun Jun 01 00:00:00 UTC 2008
Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway.
Immunity
Bueno C,Lemke CD,Criado G,Baroja ML,Ferguson SS,Rahman AK,Tsoukas CD,McCormick JK,Madrenas J
14-0049 was used in Functional assays to show that this alternative pathway operates in the absence of Lck-dependent tyrosine-phosphorylation events and was initiated by the TCR-dependent activation of raft-enriched heterotrimeric Galpha11 proteins.
Sat Jul 01 00:00:00 UTC 2006
HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor.
Virology
Martín-García J,Cao W,Varela-Rohena A,Plassmeyer ML,González-Scarano F
14-0049 was used in Flow cytometry/Cell sorting to suggest an increased affinity for CD4 of brain-derived envelopes that may have originated from adaptation to replication in microglial cells.
Wed Mar 01 00:00:00 UTC 2006
Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolate.
Journal of virology
Martín-García J,Cocklin S,Chaiken IM,González-Scarano F
14-0049-82 was used in Inhibition Assays to investigate whether phenotypic changes between HIV-1(Bori-15) and HIV-1(Bori) were related to a different interaction of their soluble monomeric gp120 proteins with CD4 or 17b.
Wed Jun 01 00:00:00 UTC 2005
