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Proteintech
CD40L/CD154 Polyclonal Antibody
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Product Details
16668-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD40L/CD154 Fusion Protein Ag10147 (1-261 aa encoded by BC071754)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MIETYNQTS PRSAATGLPI SMKIFMYLLT VFLITQMIGS ALFAVYLHRR LDKIEDERNL HEDFVFMKTI QRCNTGERSL SLLNCEEIKS QFEGFVKDIM LNKEETKKEN SFEMQKGDQN PQIAAHVISE ASSKTTSVLQ WAEKGYYTMS NNLVTLENGK QLTVKRQGLY YIYAQVTFCS NREASSQAPF IASLCLKSPG RFERILLRAA NTHSSAKPCG QQSIHLGGVF ELQPGASVFV NVTDPSQVSH GTGFTSFGLL KL (1-261 aa encoded by BC071754)
Target Information
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD154; CD40 antigen ligand; CD40 ligand; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5
Gene Aliases: CD154; CD40-L; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; TNFSF5; TRAP
UniProt ID: (Human) P29965, (Mouse) P27548
Entrez Gene ID: (Human) 959, (Mouse) 21947
inflammatory response
leukocyte cell-cell adhesion
activation of JUN kinase activity
platelet activation
B cell differentiation
T cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
tumor necrosis factor-mediated signaling pathway
B cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
isotype switching
immunoglobulin secretion
regulation of immune response
regulation of immunoglobulin secretion
positive regulation of NF-kappaB transcription factor activity
positive regulation of endothelial cell apoptotic process
positive regulation of immune response to tumor cell
immune response
signal transduction
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of MHC class II biosynthetic process
dendritic cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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