Proteintech

CD41/Integrin alpha 2b Polyclonal Antibody

CD41/Integrin alpha 2b Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD41/Integrin alpha 2b Antibody (24552-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse spleen tissue slide using 24552-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CD41/Integrin alpha 2b Antibody in Western Blot (WB)

CD41/Integrin alpha 2b Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

24552-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD41/Integrin alpha 2b Fusion Protein Ag19459 (678-894 aa encoded by BC126442)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AELAVHLPQ GAHYMRALSN VEGFERLICN QKKENETRVV LCELGNPMKK NAQIGIAMLV SVGNLEEAGE SVSFQLQIRS KNSQNPNSKI VLLDVPVRAE AQVELRGNSF PASLVVAAEE GEREQNSLDS WGPKVEHTYE LHNNGPGTVN GLHLSIHLPG QSQPSDLLYI LDIQPQGGLQ CFPQPPVNPL KVDWGLPIPS PSPIHPAHHK RDRRQIFL (678-894 aa encoded by BC126442)

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Bioinformatics

Protein Aliases: alpha IIb; alphaIIb protein; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; integrin alpha 2b (Cd41b); Integrin alpha-IIb; integrin, alpha 2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/II Ia complex; platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK; protein phosphatase 1, regulatory subunit 93

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Gene Aliases: AI172977; alphaIIb; BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; ITGA2B; ITGAB; PPP1R93

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UniProt ID: (Human) P08514, (Mouse) Q9QUM0

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Entrez Gene ID: (Human) 3674, (Rat) 685269, (Mouse) 16399

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Function(s)

protein binding identical protein binding metal ion binding extracellular matrix binding fibrinogen binding

Process(es)

platelet degranulation positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway extracellular matrix organization platelet aggregation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD41/Integrin alpha 2b Polyclonal Antibody

CD41/Integrin alpha 2b Antibody (24552-1-AP) in IHC (P)

Product Details

24552-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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