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Product Details
MA5-17384
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
W3/13HLK
Immunogen
Rat thymocyte membrane
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 4-5mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538774
Target Information
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leukocyte sialoglycoprotein; leukosialin; leukosianin; sialophorin gpL115; W3/13 antigen
Gene Aliases: Cd43; gpL115; Lsn; Lsn1
Entrez Gene ID: (Rat) 24796
response to protozoan
negative regulation of type IV hypersensitivity
positive regulation of protein phosphorylation
chronic inflammatory response
negative regulation of cell adhesion
cell surface receptor signaling pathway
T cell costimulation
positive regulation of T cell proliferation
monocyte activation
negative regulation of T cell proliferation
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
negative thymic T cell selection
regulation of defense response to virus
regulation of immune response
negative regulation of T cell activation
thymocyte aggregation
apoptotic signaling pathway
Performance Guarantee
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