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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • CD44 Antibodies

          Proteintech

          CD44 Polyclonal Antibody

          308 References
          View all (259) CD44 antibodies
          Datasheet
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          Datasheet
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          Cite CD44 Polyclonal Antibody

          • Antibody Testing Data (23)
          CD44 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          CD44 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 23

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          CD44 Antibody (15675-1-AP) in ICC/IF

          Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 15675-1-AP (CD44 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD44 Antibody in Immunocytochemistry (ICC/IF)
          CD44 Antibody in Immunocytochemistry (ICC/IF)
          CD44 Antibody in Immunocytochemistry (ICC/IF)
          CD44 Antibody in Immunocytochemistry (ICC/IF)
          CD44 Antibody in Immunocytochemistry (ICC/IF)
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD44 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          CD44 Antibody in Western Blot (WB)
          CD44 Antibody in Western Blot (WB)
          CD44 Antibody in Western Blot (WB)
          CD44 Antibody in Western Blot (WB)
          CD44 Antibody in Western Blot (WB)
          CD44 Antibody in Western Blot (WB)
          CD44 Antibody in Flow Cytometry (Flow)
          CD44 Antibody in Flow Cytometry (Flow)
          CD44 Antibody in Immunoprecipitation (IP)

          Product Details

          15675-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 167 publications 167 publications

          Immunohistochemistry (IHC)

          -
          View 61 publications 61 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100-1:500
          -

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          1:100-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:200
          View 62 publications 62 publications

          Flow Cytometry (Flow)

          0.2 µg/1x10^6 cells
          View 9 publications 9 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 2 publications 2 publications

          Miscellaneous PubMed (MISC)

          -
          View 3 publications 3 publications

          Not applicable (N/A)

          -
          View 4 publications 4 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Bovine, Deer, Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          CD44 Fusion Protein Ag8143 (28-380 aa encoded by BC004372)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.27 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: CRFAGVFHV EKNGRYSISR TEAADLCKAF NSTLPTMAQM EKALSIGFET CRYGFIEGHV VIPRIHPNSI CAANNTGVYI LTSNTSQYDT YCFNASAPPE EDCTSVTDLP NAFDGPITIT IVNRDGTRYV QKGEYRTNPE DIYPSNPTDD DVSSGSSSER SSTSGGYIFY TFSTVHPIPD EDSPWITDST DRIPATSTSS NTISAGWEPN EENEDERDRH LSFSGSGIDD DEDFISSTIS TTPRAFDHTK QNQDWTQWNP SHSNPEVLLQ TTTRMTDVDR NGTTAYEGNW NPEAHPPLIH HEHHEEEETP HSTSTIQATP SSTTEETATQ KEQWFGNRWH EGYRQTPRED SHST (28-380 aa encoded by BC004372)

          Target Information

          CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

          View more View less

          Gene Aliases: AU023126; AW121933; AW146109; CD44; CD44A; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; METAA; MIC4; Pgp-1; Pgp1; RHAMM

          View more View less

          UniProt ID: (Human) P16070, (Mouse) P15379, (Rat) P26051

          View more View less

          Entrez Gene ID: (Human) 960, (Mouse) 12505, (Rat) 25406

          View more View less

          Function(s)
          cytokine receptor activity protein binding collagen binding hyaluronic acid binding hyalurononglucosaminidase activity epidermal growth factor receptor binding protein kinase binding cytokine binding phosphoprotein binding transmembrane signaling receptor activity
          Process(es)
          cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cell growth branching involved in ureteric bud morphogenesis wound healing involved in inflammatory response positive regulation of adaptive immune response negative regulation of mature B cell apoptotic process cell adhesion positive regulation of gene expression Wnt signaling pathway cell migration neuron projection development positive regulation of neutrophil apoptotic process macrophage fusion branching involved in prostate gland morphogenesis blood vessel maturation inflammatory response response to organic cyclic compound response to vitamin A
          It has to be done as per old AB suggested Products section.
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