Proteintech

CD45 Polyclonal Antibody

CD45 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD45 Antibody (20103-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using 20103-1-AP ( CD45 Antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CD45 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

CD45 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20103-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 38 publications 38 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:800

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

View 20 publications 20 publications

Flow Cytometry (Flow)

0.5 µg/1x10^6 cells

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Dog, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD45 Fusion Protein Ag13712 (550-750 aa encoded by BC014239)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KIYDLHKKR SCNLDEQQEL VERDDEKQLM NVEPIHADIL LETYKRKIAD EGRLFLAEFQ SIPRVFSKFP IKEARKPFNQ NKNRYVDILP YDYNRVELSE INGDAGSNYI NASYIDGFKE PRKYIAAQGP RDETVDDFWR MIWEQKATVI VMVTRCEEGN RNKCAEYWPS MEEGTRAFGD VVVKINQHKR CPDYIIQKLN IV (550-750 aa encoded by BC014239)

Target Information

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD45; CD45 antigen; L-CA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220

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Gene Aliases: B220; CD45; CD45R; GP180; L-CA; LCA; loc; Ly-5; LY5; Lyt-4; PTPRC; RT7; T200

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UniProt ID: (Human) P08575, (Mouse) P06800, (Rat) P04157

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Entrez Gene ID: (Human) 5788, (Mouse) 19264, (Rat) 24699

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Function(s)

protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding protein kinase binding phosphoprotein phosphatase activity heparin binding hydrolase activity phosphatase activity heparan sulfate proteoglycan binding protein kinase regulator activity

Process(es)

Performance Guarantee

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CD45 Polyclonal Antibody

CD45 Antibody (20103-1-AP) in IHC (P)

Product Details

20103-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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