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CD45RO Antibody (MA5-28402) in Flow
Flow cytometry of CD45RO in red cell lysed bovine blood. Sample was incubated in the presence of 10% rat serum, CD45RO monoclonal antibody (Product # MA5-28402) and gated on lymphoid cells. Figures are arranged as follows: A) FITC conjugated Mouse anti Bovine CD4 Antibody and RPE conjugated Mouse IgG3 isotype control. B) FITC conjugated Mouse anti Bovine CD4 Antibody and RPE conjugated Mouse anti Bovine CD45RO Antibody.
Product Details
MA5-28402
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
IL-A116
Immunogen
Bovine peripheral blood mononuclear cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Protein A
Storage buffer
PBS with 5% sucrose, 1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745364
Product Specific Information
Mouse anti Bovine CD45RO, clone IL-A116 recognizes the bovine homologue of the human CD45RO cell surface antigen.
Reconstitute by adding 1 mL distilled water.
Target Information
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: membrane tyrosine phosphatase; receptor-type tyrosine-protein phosphatase C
Gene Aliases: BOS_16201; cd45
Entrez Gene ID: (Bovine) 407152
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