Proteintech

CD46 Polyclonal Antibody

CD46 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD46 Antibody (12494-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12494-1-AP (CD46 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CD46 Antibody in Immunoprecipitation (IP)

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Product Details

12494-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD46 Fusion Protein Ag3131 (38-340 aa encoded by BC030594)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PPTFEAMEL IGKPKPYYEI GERVDYKCKK GYFYIPPLAT HTICDRNHTW LPVSDDACYR ETCPYIRDPL NGQAVPANGT YEFGYQMHFI CNEGYYLIGE EILYCELKGS VAIWSGKPPI CEKVLCTPPP KIKNGKHTFS EVEVFEYLDA VTYSCDPAPG PDPFSLIGES TIYCGDNSVW SRAAPECKVV KCRFPVVENG KQISGFGKKF YYKATVMFEC DKGFYLDGSD TIVCDSNSTW DPPVPKCLKV STSSTTKSPA SSASGPRPTY KPPVSNYPGY PKPEEGILDS LDVWVIAVIV IAIV (38-340 aa encoded by BC030594)

Target Information

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.

Clinical and experimental immunology

Zhang Y,Jin S

Sun Sep 01 00:00:00 UTC 2019

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.

Molecular immunology

Mohlin FC,Nilsson SC,Levart TK,Golubovic E,Rusai K,Müller-Sacherer T,Arbeiter K,Pállinger É,Szarvas N,Csuka D,Szilágyi Á,Villoutreix BO,Prohászka Z,Blom AM

Mon Jun 01 00:00:00 UTC 2015

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.

Molecular immunology

Mohlin FC,Nilsson SC,Levart TK,Golubovic E,Rusai K,Müller-Sacherer T,Arbeiter K,Pállinger É,Szarvas N,Csuka D,Szilágyi Á,Villoutreix BO,Prohászka Z,Blom AM

Mon Jun 01 00:00:00 UTC 2015

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.

Molecular immunology

Mohlin FC,Nilsson SC,Levart TK,Golubovic E,Rusai K,Müller-Sacherer T,Arbeiter K,Pállinger É,Szarvas N,Csuka D,Szilágyi Á,Villoutreix BO,Prohászka Z,Blom AM

Mon Jun 01 00:00:00 UTC 2015

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.

Molecular immunology

Mohlin FC,Nilsson SC,Levart TK,Golubovic E,Rusai K,Müller-Sacherer T,Arbeiter K,Pállinger É,Szarvas N,Csuka D,Szilágyi Á,Villoutreix BO,Prohászka Z,Blom AM

Mon Jun 01 00:00:00 UTC 2015

Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma.

Oncology reports

Lu Z,Zhang C,Cui J,Song Q,Wang L,Kang J,Li P,Hu X,Song H,Yang J,Sun Y

Sat Feb 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; TLX; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen

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Gene Aliases: AHUS2; CD46; MCP; MIC10; TLX; TRA2.10

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UniProt ID: (Human) P15529, (Mouse) O88174

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Entrez Gene ID: (Human) 4179, (Mouse) 17221

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Function(s)

virus receptor activity complement binding endopeptidase activity enzyme inhibitor activity receptor activity protein binding cadherin binding

Process(es)

T cell mediated immunity proteolysis single fertilization regulation of Notch signaling pathway positive regulation of gene expression negative regulation of gene expression interleukin-10 production positive regulation of interleukin-10 production sequestering of extracellular ligand from receptor positive regulation of T cell proliferation negative regulation of catalytic activity positive regulation of memory T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of complement activation positive regulation of transforming growth factor beta production adaptive immune response complement activation, classical pathway regulation of complement activation innate immune response viral entry into host cell

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD46 Polyclonal Antibody

CD46 Antibody (12494-1-AP) in IHC (P)

Product Details

12494-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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