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Invitrogen
CD49e Monoclonal Antibody (5H10-27 (MFR5))
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CD49e Antibody (MA5-46195) in Flow
Flow Cytometry analysis of CD49e using CD49e Monoclonal Antibody (5H10-27 (MFR5)) (Product # MA5-46195). Separation of murine bone marrow cells stained using anti-mouse CD49e (5H10-27(MFR5)) purified antibody (concentration in sample 0.56 μg/mL, DAR APC) from murine bone marrow cells unstained by primary antibody (DAR APC, black-dashed) in flow cytometry analysis (surface staining).
Product Details
MA5-46195
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
5H10-27 (MFR5)
Immunogen
C57BL/6 x A/J)F1 murine mast cell line
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2937587
Product Specific Information
This antibody recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells.
Target Information
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member E; CD49e; fibronectin receptor alpha polypeptide; Fibronectin receptor subunit alpha; Integrin alpha-5; Integrin alpha-F; VLA-5
Gene Aliases: Cd49e; Fnra; Itga5; VLA5
UniProt ID: (Mouse) P11688
Entrez Gene ID: (Mouse) 16402
cell-substrate junction assembly
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
integrin-mediated signaling pathway
memory
positive regulation of cell-substrate adhesion
positive regulation of cell migration
cell-substrate adhesion
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
endodermal cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of anoikis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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