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Invitrogen
CD56 (NCAM) Polyclonal Antibody
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FIGURE: 1 / 4
CD56 (NCAM) Antibody (PA5-78072) in WB
Western blot was performed using Anti-CD56 (NCAM) Polyclonal Antibody(Product # PA5-78072) and a ~150kDa band corresponding to CD56 (NCAM) was observed across tissues tested. Membrane enriched extracts (30 µg lysate) of Mouse Cerebellum (Lane 1), Rat Cerebellum (Lane 2), Mouse Lung (Lane 3), Rat Jejunum (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # LC2002) by iBlot® 2 Dry Blotting System (Product # IB21001). The... View More
Product Details
PA5-78072
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human NCAM. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736193
Product Specific Information
Positive Control: Human brain, mouse brain, rat brain
Predicted Reactivity: Dog (94%), Cat (96%), Chicken (87%), Bovine (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen recognized by monoclonal antibody 5.1H11; CD-56; CD56; E NCAM; N CAM1; N-CAM-1; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Aliases: CD56; E-NCAM; MSK39; N-CAM; N-CAM-1; NCAM; NCAM-1; NCAM-C; NCAM1; NCAMC
UniProt ID: (Human) P13591, (Mouse) P13595, (Rat) P13596
Entrez Gene ID: (Human) 4684, (Mouse) 17967, (Rat) 24586
MAPK cascade
cell adhesion
axon guidance
positive regulation of GTPase activity
viral entry into host cell
regulation of synaptic plasticity
interferon-gamma-mediated signaling pathway
regulation of exocyst assembly
cell surface receptor signaling pathway
aging
learning or memory
response to lead ion
response to fluoxetine
thalamus development
neuron projection development
multicellular organismal response to stress
homotypic cell-cell adhesion
response to cocaine
neuron development
positive regulation of calcium-mediated signaling
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
negative regulation of cell death
response to inorganic substance
peripheral nervous system axon regeneration
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
organ regeneration
cellular response to molecule of bacterial origin
cellular response to inorganic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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