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NeoBiotechnologies
CD56/NCAM1/NKH1 Monoclonal Antibody (NCAM1, 795)
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Product Details
4684-MSM5-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
NCAM1, 795
Immunogen
Recombinant human NCAM1 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen recognized by monoclonal antibody 5.1H11; CD-56; CD56; E NCAM; N CAM1; N-CAM-1; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Aliases: CD56; MSK39; N-CAM; N-CAM-1; NCAM; NCAM-1; NCAM-C; NCAM1; NCAMC
UniProt ID: (Human) P13591, (Rat) P13596
Entrez Gene ID: (Human) 4684, (Rat) 24586
MAPK cascade
cell adhesion
axon guidance
positive regulation of GTPase activity
viral entry into host cell
regulation of synaptic plasticity
interferon-gamma-mediated signaling pathway
regulation of exocyst assembly
cell surface receptor signaling pathway
aging
learning or memory
response to inorganic substance
response to lead ion
peripheral nervous system axon regeneration
response to fluoxetine
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
thalamus development
organ regeneration
neuron projection development
multicellular organismal response to stress
homotypic cell-cell adhesion
response to cocaine
neuron development
positive regulation of calcium-mediated signaling
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
negative regulation of cell death
cellular response to molecule of bacterial origin
cellular response to inorganic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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