Invitrogen

CD61 (Integrin beta 3) Recombinant Rabbit Monoclonal Antibody (7D5N1)

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View all (100) CD61 (Integrin beta 3) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35245

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Flow Cytometry (Flow)

1:50-1:200
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ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7D5N1

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 689-788 of human Integrin beta 3 (ITGB3/CD61) (P05106)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.75 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849148

Product Specific Information

Immunogen sequence: CVVRFQYYED SSGKSILYVV EEPECPKGPD ILVVLLSVMG AILLIGLAAL LIWKLLITIH DRKEFAKFEE ERARAKWDTA NNPLYKEATS TFTNITYRGT

Target Information

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: antigen CD61; CD61; GPIIIa; integrin beta 3; integrin beta 3 (Cd61); Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet gpIIIa; Platelet membrane glycoprotein IIIa

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Gene Aliases: BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; INGRB3; ITGB3

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UniProt ID: (Human) P05106, (Rat) Q8R2H2, (Mouse) O54890

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Entrez Gene ID: (Human) 3690, (Rat) 29302, (Mouse) 16416

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Function(s)
virus receptor activity fibronectin binding protease binding protein disulfide isomerase activity platelet-derived growth factor receptor binding protein binding coreceptor activity fibroblast growth factor binding enzyme binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding extracellular matrix binding integrin binding peptide binding fibrinogen binding receptor activity
Process(es)
positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation platelet degranulation cell-substrate junction assembly cell adhesion cell-matrix adhesion integrin-mediated signaling pathway blood coagulation positive regulation of endothelial cell migration negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage smooth muscle cell migration cell growth cell migration platelet activation extracellular matrix organization positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion activation of protein kinase activity negative regulation of lipid transport heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading tube development apolipoprotein A-I-mediated signaling pathway wound healing regulation of bone resorption negative regulation of low-density lipoprotein particle receptor biosynthetic process viral entry into host cell vascular endothelial growth factor receptor signaling pathway mesodermal cell differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipoprotein metabolic process leukocyte migration negative chemotaxis angiogenesis involved in wound healing platelet aggregation positive regulation of leukocyte migration protein folding cellular calcium ion homeostasis embryo implantation regulation of G-protein coupled receptor protein signaling pathway response to radiation positive regulation of fibroblast migration response to activity positive regulation of smooth muscle cell migration regulation of cell migration positive regulation of cell migration positive regulation of cell adhesion mediated by integrin positive regulation of osteoblast proliferation cellular response to drug response to platelet-derived growth factor positive regulation of MAPK cascade positive regulation of angiogenesis positive regulation of bone resorption positive regulation of smooth muscle cell proliferation regulation of release of sequestered calcium ion into cytosol negative regulation of cell death positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus positive regulation of glomerular mesangial cell proliferation positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway cellular response to insulin-like growth factor stimulus positive regulation of osteoclast differentiation cell projection morphogenesis
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