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CD71 Monoclonal Antibody (3C11F11)

CD71 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

CD71 Antibody (66180-1-IG) in ICC/IF

Immunofluorescent analysis of HeLa cells using 66180-1-IG (CD71 antibody) at dilution of 1:50 and Rhodamine-Goat anti-Mouse IGG.

CD71 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD71 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

CD71 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

66180-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:400

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3C11F11

Immunogen

CD71 Fusion Protein Ag21612 (511-751 aa encoded by BC001188)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.8 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QNVKHPVTG QFLYQDSNWA SKVEKLTLDN AAFPFLAYSG IPAVSFCFCE DTDYPYLGTT MDTYKELIER IPELNKVARA AAEVAGQFVI KLTHDVELNL DYERYNSQLL SFVRDLNQYR ADIKEMGLSL QWLYSARGDF FRATSRLTTD FGNAEKTDRF VMKKLNDRVM RVEYHFLSPY VSPKESPFRH VFWGSGSHTL PALLENLKLR KQNNGAFNET LFRNQLALAT WTIQGAANAL SG (511-751 aa encoded by BC001188)

Target Information

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Functionalized biological metal-organic framework with nanosized coronal structure and hierarchical wrapping pattern for enhanced targeting therapy.

Chemical engineering journal (Lausanne, Switzerland : 1996)

Wang H,Li S,Wang L,Liao Z,Zhang H,Wei T,Dai Z

Sun Jan 15 00:00:00 UTC 2023

Targeting the Na⁺/K⁺ ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity.

Free radical biology & medicine

Leng B,Deng L,Tan J,Lee WT,Cao CR,Wang ZP,Huang DJ,Nie X,Bian JS

Tue Aug 01 00:00:00 UTC 2023

Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human.

Disease markers

Liu W,Wu Y,Zhang N,Liu S,Zhou L

Wed Sep 07 00:00:00 UTC 2022

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Cell death & disease

Henning Y,Blind US,Larafa S,Matschke J,Fandrey J

Fri Jul 29 00:00:00 UTC 2022

Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy.

Bioengineering & translational medicine

Hu F,Deng C,Zhou Y,Liu Y,Zhang T,Zhang P,Zhao Z,Miao H,Zheng W,Zhang W,Wang M,Ma X

Sun May 01 00:00:00 UTC 2022

Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.

Free radical biology & medicine

Han P,Wang X,Zhou T,Cheng J,Wang C,Sun F,Zhao X

Sun Nov 20 00:00:00 UTC 2022

Role of ferroptosis-related genes in coronary atherosclerosis and identification of key genes: integration of bioinformatics analysis and experimental validation.

BMC cardiovascular disorders

Meng Q,Xu Y,Ling X,Liu H,Ding S,Wu H,Yan D,Fang X,Li T,Liu Q

Fri Jul 29 00:00:00 UTC 2022

SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking.

PLoS genetics

Tian Y,Kang Q,Shi X,Wang Y,Zhang N,Ye H,Xu Q,Xu T,Zhang R

Tue Jun 01 00:00:00 UTC 2021

GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.

Cell death discovery

Wang L,Ouyang S,Li B,Wu H,Wang F

Wed Nov 03 00:00:00 UTC 2021

Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation.

The Journal of biological chemistry

Kitano M,Kizuka Y,Sobajima T,Nakano M,Nakajima K,Misaki R,Itoyama S,Harada Y,Harada A,Miyoshi E,Taniguchi N

Tue Aug 24 00:00:00 UTC 2021

The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production.

The Journal of biological chemistry

Deng QW,Zhang J,Li T,He WM,Fang L,Lee HC,Zhao YJ

Fri Oct 18 00:00:00 UTC 2019

The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production.

The Journal of biological chemistry

Deng QW,Zhang J,Li T,He WM,Fang L,Lee HC,Zhao YJ

Fri Oct 18 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: CD antigen CD71; CD71; p90; T9; TR; Transferrin receptor protein 1

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Gene Aliases: CD71; IMD46; p90; T9; TFR; TFR1; TFRC; TR; TRFR

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UniProt ID: (Human) P02786

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Entrez Gene ID: (Human) 7037

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Function(s)

virus receptor activity glycoprotein binding double-stranded RNA binding transferrin receptor activity protein binding Hsp70 protein binding transferrin transmembrane transporter activity identical protein binding protein homodimerization activity poly(A) RNA binding chaperone binding

Process(es)

regulation of cell growth response to hypoxia cellular iron ion homeostasis acute-phase response aging response to nutrient response to iron ion response to manganese ion osteoclast differentiation positive regulation of B cell proliferation receptor internalization response to retinoic acid transferrin transport cellular response to drug positive regulation of T cell proliferation regulation of cell proliferation positive regulation of bone resorption positive regulation of isotype switching response to copper ion viral entry into host cell iron ion import

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD71 Monoclonal Antibody (3C11F11)

CD71 Antibody (66180-1-IG) in ICC/IF

Product Details

66180-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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