Product References
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
MCD0830 was used in flow cytometry to assess this concept by combining vascular endothelial growth factor (VEGF) pathway inhibitors that remodel the tumor vasculature with the tricyclic antidepressant imipramine, which enhances autophagy in GBM cancer cells and unexpectedly reprograms immunosuppressive tumor-associated macrophages via inhibition of histamine receptor signaling to become immunostimulatory.
Mon Oct 10 00:00:00 UTC 2022
A Novel Selective Axl/Mer/CSF1R Kinase Inhibitor as a Cancer Immunotherapeutic Agent Targeting Both Immune and Tumor Cells in the Tumor Microenvironment.
Cancers
Jeon Y,Kang H,Yang Y,Park D,Choi B,Kim J,Kim J,Nam K
MCD0830 was used in Flow Cytometry to present Q702, a selective, potent small molecule inhibitor targeting Axl, Mer, and CSF1R, for oral administration.
Sun Oct 02 00:00:00 UTC 2022
Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts.
JCI insight
Sun Y,Anyalebechi JC,Sun H,Yumoto T,Xue M,Liu D,Liang Z,Coopersmith CM,Ford ML
Published figure using CD8 alpha monoclonal antibody (Product # MCD0830) in Flow Cytometry
Mon Mar 08 00:00:00 UTC 2021
Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila.
Genes to cells : devoted to molecular & cellular mechanisms
Kamemura K,Chen CA,Okumura M,Miura M,Chihara T
MCD0830 was used in flow cytometry to suggest that synaptic protein localization and ER quality control may be affected by disease mutations.
Thu Apr 01 00:00:00 UTC 2021
Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia.
International journal of molecular sciences
Parigger T,Gassner FJ,Scherhäufl C,Bakar AA,Höpner JP,Hödlmoser A,Steiner M,Catakovic K,Geisberger R,Greil R,Zaborsky N
MCD0830 was used in Flow cytometry/Cell sorting to indicate that in the CLL mouse model, a substantial fraction of non-CLL specific T cells becomes exhausted during disease progression in a bystander effect.
Tue Jun 22 00:00:00 UTC 2021
CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Sun Y,Xie J,Anyalebechi JC,Chen CW,Sun H,Xue M,Liang Z,Morrow KN,Coopersmith CM,Ford ML
MCD0830 was used in Flow cytometry/Cell sorting to demonstrate that immunologic experience is an important parameter that affects sepsis pathophysiology and can fundamentally change the outcome of modulating the CD28 pathway during sepsis.
Tue Dec 15 00:00:00 UTC 2020
Differential expansion of T central memory precursor and effector subsets is regulated by division speed.
Nature communications
Kretschmer L,Flossdorf M,Mir J,Cho YL,Plambeck M,Treise I,Toska A,Heinzel S,Schiemann M,Busch DH,Buchholz VR
Published figure using CD8 alpha monoclonal antibody (Product # MCD0830) in Flow Cytometry
Wed Jan 08 00:00:00 UTC 2020
Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.
Shock (Augusta, Ga.)
Klingensmith NJ,Fay KT,Lyons JD,Chen CW,Otani S,Liang Z,Chihade DB,Burd EM,Ford ML,Coopersmith CM
MCD0830 was used in Flow cytometry/Cell sorting to determine whether this represents a common host response to the combination of alcohol and sepsis by creating a new model in which mice with chronic alcohol ingestion were subjected to a different model of sepsis.
Mon Apr 01 00:00:00 UTC 2019
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Science translational medicine
Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL
MCD0830 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.
Wed Mar 21 00:00:00 UTC 2018
Increased mortality in CD43-deficient mice during sepsis.
PloS one
Fay KT,Chihade DB,Chen CW,Klingensmith NJ,Lyons JD,Ramonell K,Liang Z,Coopersmith CM,Ford ML
Published figure using CD8 alpha monoclonal antibody (Product # MCD0830) in Flow Cytometry
Tue Feb 19 00:00:00 UTC 2019
The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells.
Apoptosis : an international journal on programmed cell death
Prenek L,Boldizsár F,Kugyelka R,Ugor E,Berta G,Németh P,Berki T
MCD0830 was used in Immunocytochemistry-immunoflourescence to examine which apoptotic pathways are involved in glucocorticoid-induced thymocyte apoptosis.
Wed Feb 01 00:00:00 UTC 2017
CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis.
PloS one
Ramonell KM,Zhang W,Hadley A,Chen CW,Fay KT,Lyons JD,Klingensmith NJ,McConnell KW,Coopersmith CM,Ford ML
MCD0830 was used in Flow cytometry/Cell sorting to characterise CXCR4 as an important pathway that modulates immune dysfunction and mortality following sepsis in mice.
Thu Jan 04 00:00:00 UTC 2018
CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis.
PloS one
Ramonell KM,Zhang W,Hadley A,Chen CW,Fay KT,Lyons JD,Klingensmith NJ,McConnell KW,Coopersmith CM,Ford ML
MCD0830 was used in Flow cytometry/Cell sorting to characterise CXCR4 as an important pathway that modulates immune dysfunction and mortality following sepsis in mice.
Thu Jan 04 00:00:00 UTC 2018
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia.
Oncoimmunology
Catakovic K,Gassner FJ,Ratswohl C,Zaborsky N,Rebhandl S,Schubert M,Steiner M,Gutjahr JC,Pleyer L,Egle A,Hartmann TN,Greil R,Geisberger R
Published figure using CD8 alpha monoclonal antibody (Product # MCD0830) in Flow Cytometry
Sat Jan 29 00:00:00 UTC 2022
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Nature communications
Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA
MCD0830 was used in Flow cytometry/Cell sorting to study how androgen levels protects against autoimmunity, and exploring the sex bias to androgen protection from T-cell-mediated autoimmune diseases.
Wed Apr 13 00:00:00 UTC 2016
Mice with an absent stress response are protected against ischemic renal injury.
Kidney international
Sreedharan R,Chen S,Miller M,Haribhai D,Williams CB,Van Why SK
MCD0830 was used in flow cytometry to determine if HSPs ameliorate ischemic renal injury in vivo using HSF-1 KO mice
Mon Sep 01 00:00:00 UTC 2014
Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control.
Journal of immunology (Baltimore, Md. : 1950)
Hogan T,Shuvaev A,Commenges D,Yates A,Callard R,Thiebaut R,Seddon B
MCD0830 was used in flow cytometry to study heterogeneous clonal T cell responses.
Mon Apr 15 00:00:00 UTC 2013
Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression.
Journal of immunology (Baltimore, Md. : 1950)
Schmitt EG,Haribhai D,Jeschke JC,Co DO,Ziegelbauer J,Yan K,Iwakura Y,Mishra MK,Simpson P,Salzman NH,Williams CB
MCD0830 was used in flow cytometry to examine Treg cell control of chronic autoimmunity in a lymphoreplete host.
Sun Dec 01 00:00:00 UTC 2013
Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells.
Immunology letters
Fuertbauer E,Zaujec J,Uhrin P,Raab I,Weber M,Schachner H,Bauer M,Schütz GJ,Binder BR,Sixt M,Kerjaschki D,Stockinger H
MCD0830 was used in flow cytometry to characterize mice deficient in podoplanin and explore the effect of podoplanin modulation on T cell populations.
Mon Jul 14 00:00:00 UTC 2014
Identification of gingipain-specific I-A(b) -restricted CD4+ T cells following mucosal colonization with Porphyromonas gingivalis in C57BL/6 mice.
Molecular oral microbiology
Bittner-Eddy PD,Fischer LA,Costalonga M
MCD0830 was used in flow cytometry to elucidate the role of CD4+ T cells in Porphyromonas gingivalis infection
Sun Dec 01 00:00:00 UTC 2013
The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis.
Journal of neuroinflammation
Cravens PD,Kieseier BC,Hussain R,Herndon E,Arellano B,Ben LH,Timmons BC,Castro-Rojas C,Hartung HP,Hemmer B,Weber MS,Zamvil SS,Stüve O
MCD0830 was used in flow cytometry to test if a differential composition of immune cells within the central nervous system modulates the age-associated susceptibility to autoimmune disease.
Fri May 24 00:00:00 UTC 2013
Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.
Cancer research
Hurez V,Daniel BJ,Sun L,Liu AJ,Ludwig SM,Kious MJ,Thibodeaux SR,Pandeswara S,Murthy K,Livi CB,Wall S,Brumlik MJ,Shin T,Zhang B,Curiel TJ
MCD0830 was used in flow cytometry to elucidate age-specific tumor-associated immune dysfunction.
Sun Apr 15 00:00:00 UTC 2012
Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells.
Aging cell
Sun L,Hurez VJ,Thibodeaux SR,Kious MJ,Liu A,Lin P,Murthy K,Pandeswara S,Shin T,Curiel TJ
MCD0830 was used in flow cytometry to investigate the effects of age on immune regulation and auto-aggressive T cells.
Fri Jun 01 00:00:00 UTC 2012
Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.
Arteriosclerosis, thrombosis, and vascular biology
Sun J,Sukhova GK,Zhang J,Chen H,Sjöberg S,Libby P,Xia M,Xiong N,Gelb BD,Shi GP
MCD0830 was used in flow cytometry to study the contribution of cathepsin K to human abdominal aortic aneurysm lesions.
Sun Jan 01 00:00:00 UTC 2012
ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development.
Journal of immunology (Baltimore, Md. : 1950)
Sag D,Wingender G,Nowyhed H,Wu R,Gebre AK,Parks JS,Kronenberg M,Hedrick CC
MCD0830 was used in flow cytometry to report that ABCG1 regulates iNKT cell development in a cell-intrinsic manner.
Sat Dec 01 00:00:00 UTC 2012
CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.
Journal of immunology (Baltimore, Md. : 1950)
Pagán AJ,Pepper M,Chu HH,Green JM,Jenkins MK
MCD0830 was used in flow cytometry to investigate which portions of CD28 are needed for T cells.
Sat Sep 15 00:00:00 UTC 2012
Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice.
Vaccine
Lumsden JM,Nurmukhambetova S,Klein JH,Sattabongkot J,Bennett JW,Bertholet S,Fox CB,Reed SG,Ockenhouse CF,Howard RF,Polhemus ME,Yadava A
MCD0830 was used in flow cytometry to optimize a P. vivax vaccine.
Wed May 09 00:00:00 UTC 2012
Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Journal of immunology (Baltimore, Md. : 1950)
Kastenmuller W,Gasteiger G,Subramanian N,Sparwasser T,Busch DH,Belkaid Y,Drexler I,Germain RN
MCD0830 was used in flow cytometry to report how Tregs suppress early immune responses after vaccination.
Thu Sep 15 00:00:00 UTC 2011
Granzyme B regulates antiviral CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Salti SM,Hammelev EM,Grewal JL,Reddy ST,Zemple SJ,Grossman WJ,Grayson MH,Verbsky JW
MCD0830 was used in flow cytometry to determine the role of granzyme B in immune regulation during viral infections.
Thu Dec 15 00:00:00 UTC 2011
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.
Nature immunology
Pepper M,Linehan JL,Pagán AJ,Zell T,Dileepan T,Cleary PP,Jenkins MK
MCD0830 was used in Flow cytometry/Cell sorting to suggest that TH1 cells induced by intravenous infection are more efficient at entering the memory pool than TH-17 cells induced by intranasal infection.
Fri Jan 01 00:00:00 UTC 2010
Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza.
Journal of immunology (Baltimore, Md. : 1950)
Zavitz CC,Bauer CM,Gaschler GJ,Fraser KM,Strieter RM,Hogaboam CM,Stampfli MR
MCD0830 was used in flow cytometry to develop and characterize a novel model of heterologous pulmonary infection using Bordetella parapertussis and influenza virus
Mon Feb 15 00:00:00 UTC 2010
Tracking epitope-specific T cells.
Nature protocols
Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK
MCD0830 was used in flow cytometry to track populations of T cells specific for a given peptide-major histocompatibility complex epitope
Tue Jun 30 00:00:00 UTC 2009
Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.
Vaccine
Seavey MM,Mosmann TR
MCD0830 was used in flow cytometry to report that estradiol prevents antigen loading of vaginal antigen presenting cells after intravaginal immunization.
Tue Apr 14 00:00:00 UTC 2009
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
Journal of immunology (Baltimore, Md. : 1950)
Koehn BH,Ford ML,Ferrer IR,Borom K,Gangappa S,Kirk AD,Larsen CP
MCD0830 was used in flow cytometry to investigate the role of the PD-1 pathway in the maintenance of graft survival.
Wed Oct 15 00:00:00 UTC 2008
Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
Journal of immunology (Baltimore, Md. : 1950)
Willoughby JE,Costello PS,Nicolas RH,Robinson NJ,Stamp G,Powrie F,Treisman R
MCD0830 was used in flow cytometry to compare the requirements for positive selection and T(reg) development.
Thu Nov 15 00:00:00 UTC 2007
Helper T cells regulate type-2 innate immunity in vivo.
Nature
Shinkai K,Mohrs M,Locksley RM
MCD0830 was used in flow cytometry to report that polarized type-2 immune responses are initiated independently of adaptive immunity.
Thu Jan 23 00:00:00 UTC 2003
High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
Journal of immunology (Baltimore, Md. : 1950)
Choi EM,Chen JL,Wooldridge L,Salio M,Lissina A,Lissin N,Hermans IF,Silk JD,Mirza F,Palmowski MJ,Dunbar PR,Jakobsen BK,Sewell AK,Cerundolo V
MCD0830 was used in flow cytometry to test if tetramers distinguish between high and low avidity T cell clones.
Sat Nov 15 00:00:00 UTC 2003
