Proteintech

CD80/B7-1 Polyclonal Antibody

FIGURE: 1 / 5

CD80/B7-1 Antibody (14292-1-AP) in WB

Human peripheral blood leukocyte cells were subjected to SDS PAGE followed by western blot with 14292-1-AP (CD80/B7-1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

CD80/B7-1 Antibody in Flow Cytometry (Flow)

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Product Details

14292-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 6 publications 6 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD80/B7-1 Fusion Protein Ag5615 (36-228 aa encoded by BC042665)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IHVTKEVKE VATLSCGHNV SVEELAQTRI YWQKEKKMVL TMMSGDMNIW PEYKNRTIFD ITNNLSIVIL ALRPSDEGTY ECVVLKYEKD AFKREHLAEV TLSVKADFPT PSISDFEIPT SNIRRIICST SGGFPEPHLS WLENGEELNA INTTVSQDPE TELYAVSSKL DFNMTTNHSF MCLIKYGHLR VNQT (36-228 aa encoded by BC042665)

Target Information

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients.

The British journal of ophthalmology

Kashyap S,Singh MK,Kumar N,Jha J,Lomi N,Meel R,Bakhshi S,Sen S,Singh L

Tue May 21 00:00:00 UTC 2024

Knockdown of HMGB1 inhibits the crosstalk between oral squamous cell carcinoma cells and tumor-associated macrophages.

International immunopharmacology

Wen J,Yin P,Su Y,Gao F,Wu Y,Zhang W,Chi P,Chen J,Zhang X

Thu Jun 01 00:00:00 UTC 2023

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Cellular signalling

Tian J,Zhang L,La X,Fan X,Li A,Wu C,An Y,Yan S,Dong X,Wu H,Li Z

Tue Aug 01 00:00:00 UTC 2023

A nanotherapeutic system for gastric cancer suppression by synergistic chemotherapy and immunotherapy based on iPSCs and DCs exosomes.

Cancer immunology, immunotherapy : CII

Li Y,Tian L,Zhao T,Zhang J

Thu Jun 01 00:00:00 UTC 2023

MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.

Molecular medicine reports

Gu C,Chen M,Li X,Geng D,Wang C

Thu Jun 01 00:00:00 UTC 2023

Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area.

Molecular neurobiology

Xu Y,Zhu ZH,Xu X,Sun HT,Zheng HM,Zhang JL,Wang HH,Fang JW,Liu YZ,Huang LL,Song ZW,Liu JB

Tue Aug 01 00:00:00 UTC 2023

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.

Journal of nanobiotechnology

Sha X,Dai Y,Chong L,Wei M,Xing M,Zhang C,Li J

Thu Dec 01 00:00:00 UTC 2022

The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness.

PLoS pathogens

Sugrue E,Wickenhagen A,Mollentze N,Aziz MA,Sreenu VB,Truxa S,Tong L,da Silva Filipe A,Robertson DL,Hughes J,Rihn SJ,Wilson SJ

Tue Nov 01 00:00:00 UTC 2022

Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation.

Drug delivery

Zheng J,Sun Y,Long T,Yuan D,Yue S,Zhang N,Yang Z

Thu Dec 01 00:00:00 UTC 2022

Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress-activated NF-κB pathway.

Journal of nanobiotechnology

Wang P,Hu G,Zhao W,Du J,You M,Xv M,Yang H,Zhang M,Yan F,Huang M,Wang X,Zhang L,Chen Y

Sat Mar 05 00:00:00 UTC 2022

Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy.

Asian journal of pharmaceutical sciences

Wang S,Liu X,Yang M,Ouyang L,Ding J,Wang S,Zhou W

Fri Jul 01 00:00:00 UTC 2022

Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy.

Asian journal of pharmaceutical sciences

Wang S,Liu X,Yang M,Ouyang L,Ding J,Wang S,Zhou W

Fri Jul 01 00:00:00 UTC 2022

Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.

Bioactive materials

Wang H,Liu H,Guo Y,Zai W,Li X,Xiong W,Zhao X,Yao Y,Hu Y,Zou Z,Wu J

Wed Jun 01 00:00:00 UTC 2022

Enhanced Immunotherapy Based on Combining the Pro-phagocytosis and Anti-phagocytosis Checkpoint Blockade for Tumor Eradication.

Journal of medicinal chemistry

Song W,Yang F,Yang H,Xu Y,Song SJ,Meng Y,Wei ST,Wan T,Zhou Y,Zhou B,Kuang J,Yu T,Qiu WX

Thu Nov 10 00:00:00 UTC 2022

Fe(III)-Chelated Polydopamine Nanoparticles for Synergistic Tumor Therapies of Enhanced Photothermal Ablation and Antitumor Immune Activation.

ACS applied materials & interfaces

Xu N,Hu A,Pu X,Li J,Wang X,Wang J,Huang Z,Liao X,Yin G

Wed Apr 13 00:00:00 UTC 2022

Immunotherapy landscape analyses of necroptosis characteristics for breast cancer patients.

Journal of translational medicine

Yu H,Lv W,Tan Y,He X,Wu Y,Wu M,Zhang Q

Thu Jul 21 00:00:00 UTC 2022

Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy.

International journal of nanomedicine

Zhang J,Li Z,Liu L,Li L,Zhang L,Wang Y,Zhao J

Tue May 10 00:00:00 UTC 2022

lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling.

Journal of immunology research

Ai Y,Liu S,Luo H,Wu S,Wei H,Tang Z,Li X,Zou C

Mon Jan 10 00:00:00 UTC 2022

Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia.

Biomaterials

Wang H,Guo Y,Wang C,Jiang X,Liu H,Yuan A,Yan J,Hu Y,Wu J

Mon Feb 01 00:00:00 UTC 2021

Differential immune responses of C57BL/6 mice to infection by Salmonella enterica serovar Typhimurium strain SL1344, CVCC541 and CMCC50115.

Virulence

Wei S,Huang J,Liu Z,Wang M,Zhang B,Lian Z,Guo Y,Han H

Sun Dec 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Activation B7-1 antigen; B-lymphocyte activation antigen B7; B7; B7 protein; BB1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; sCD 80; sCD80; soluble CD 80; soluble CD80; T-lymphocyte activation antigen CD80; TS/A-1

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Gene Aliases: B7; B7-1; B7.1; B71; BB1; Cd28l; CD28LG; CD28LG1; CD80; LAB7; Ly-53; Ly53; MIC17; TSA1

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UniProt ID: (Human) P33681, (Mouse) Q00609

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Entrez Gene ID: (Human) 941, (Mouse) 12519

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Function(s)

virus receptor activity protein binding coreceptor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD80/B7-1 Polyclonal Antibody

CD80/B7-1 Antibody (14292-1-AP) in WB

Product Details

14292-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Miscellaneous PubMed (MISC)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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