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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • CD81 Antibodies

          Proteintech

          CD81 Monoclonal Antibody (1G2C6)

          96 References
          View all (66) CD81 antibodies

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          Datasheet
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          Cite CD81 Monoclonal Antibody (1G2C6)

          • Antibody Testing Data (7)
          CD81 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          CD81 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 7

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          CD81 Antibody (66866-1-IG) in IHC (P)

          Immunohistochemical analysis of paraffin-embedded human tonsilitis tissue slide using 66866-1-Ig (CD81 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD81 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD81 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD81 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD81 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD81 Antibody in Western Blot (WB)
          CD81 Antibody in Flow Cytometry (Flow)
          CD81 Antibody in Flow Cytometry (Flow)

          Product Details

          66866-1-IG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:3,000
          View 92 publications 92 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:1,000
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication

          Flow Cytometry (Flow)

          0.2 µg
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          1G2C6

          Immunogen

          CD81 Fusion Protein Ag27298

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • Biotin Plus
          • CoraLite Plus 488
          • Request custom conjugation

          Form

          Liquid

          Concentration

          1000 µg/mL

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice

          Product Specific Information

          Aliquoting is unnecessary for -20°C storage.

          Target Information

          CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: 26 kDa cell surface protein TAPA-1; CD81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); Target of the antiproliferative antibody 1; Tetraspanin-28; Tetraspanin28; Tspan-28

          View more View less

          Gene Aliases: CD81; CVID6; S5.7; TAPA1; TSPAN28

          View more View less

          UniProt ID: (Human) P60033

          View more View less

          Entrez Gene ID: (Human) 975

          View more View less

          Function(s)
          protein binding MHC class II protein complex binding transferrin receptor binding
          Process(es)
          activation of MAPK activity cell surface receptor signaling pathway protein localization cell proliferation positive regulation of cell proliferation response to wounding positive regulation of B cell proliferation receptor internalization regulation of protein stability regulation of growth positive regulation of 1-phosphatidylinositol 4-kinase activity positive regulation of transcription from RNA polymerase II promoter viral entry into host cell receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response protein localization to lysosome cellular response to low-density lipoprotein particle stimulus positive regulation of protein catabolic process in the vacuole regulation of cell motility
          It has to be done as per old AB suggested Products section.
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