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          • Primary Antibodies ›
          • CD81 Antibodies

          Proteintech

          CD81 Monoclonal Antibody (5A6), FITC Plus

          View all (66) CD81 antibodies

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          Cite CD81 Monoclonal Antibody (5A6), FITC Plus

          • Antibody Testing Data (1)
          CD81 Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.
          CD81 Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          CD81 Antibody (FITC-65195) in Flow

          1X10^6 human PBMCs were surface stained with 5 µL FITC Plus Anti-Human CD81 (FITC-65195, Clone: 5A6) (red) or Mouse IgG1 Isotype Control. Cells were not fixed. Lymphocytes were gated. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD81 Antibody in Flow Cytometry (Flow)

          Product Details

          FITC-65195

          Applications
          Tested Dilution
          Publications

          Flow Cytometry (Flow)

          Assay-dependent
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG1, kappa

          Class

          Monoclonal

          Type

          Antibody

          Clone

          5A6

          Immunogen

          Human OCI-LY8 cell line
          View immunogen

          Conjugate

          FITC Plus FITC Plus FITC Plus
          • Unconjugated
          • Atlantic Blue
          • Cardinal Red
          • CoraLite 594
          • CoraLite Plus 488
          • CoraLite Plus 647
          • CoraLite Plus 670
          • CoraLitePlus 405
          • CoraLitePlus 555
          • Request custom conjugation

          Excitation/Emission Max

          495/524 nm

          Form

          Liquid

          Purification

          Affinity chromatography

          Storage buffer

          PBS with 0.5% BSA

          Contains

          0.09% sodium azide

          Storage conditions

          4°C, store in dark

          Shipping conditions

          Wet ice

          Target Information

          CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: 26 kDa cell surface protein TAPA-1; CD81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); Target of the antiproliferative antibody 1; Tetraspanin-28; Tetraspanin28; Tspan-28

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          Gene Aliases: CD81; CVID6; S5.7; TAPA1; TSPAN28

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          UniProt ID: (Human) P60033

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          Entrez Gene ID: (Human) 975

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          Function(s)
          protein binding MHC class II protein complex binding transferrin receptor binding
          Process(es)
          activation of MAPK activity cell surface receptor signaling pathway protein localization cell proliferation positive regulation of cell proliferation response to wounding positive regulation of B cell proliferation receptor internalization regulation of protein stability regulation of growth positive regulation of 1-phosphatidylinositol 4-kinase activity positive regulation of transcription from RNA polymerase II promoter viral entry into host cell receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response protein localization to lysosome cellular response to low-density lipoprotein particle stimulus positive regulation of protein catabolic process in the vacuole regulation of cell motility
          It has to be done as per old AB suggested Products section.
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