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Invitrogen
CD85k (Gp49b) Polyclonal Antibody
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CD85k (Gp49b) Antibody (PA5-96569) in IHC (P)
Immunohistochemistry analysis of CD85k (Gp49b) in paraffin-embedded human colon carcinoma. Samples were incubated with CD85k (Gp49b) Polyclonal antibody (Product # PA5-96569) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-96569
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_0012653552)
Conjugate
Form
Liquid
Concentration
1.25 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808371
Product Specific Information
Immunogen sequence: QAGPLPKPTL WAEPGSVISW GNSVTIWCQG TLEAREYRLD KEESPAPWDR QNPLEPKNKA RFSIPSMTED YAGRYRCYYR SPVGWSQPSD PLELVMTGAY SKPTLSALPS PLVTSGKSVT LLCQSRSPMD TFLLIKERAA HPLLHLRSEH GAQQHQAEFP MSPVTSVHGG TYRCFSSHGF SHYLLSHPSD PLELIVSGSL EGPRPSPTRS VSTAAGPEDQ PLMPTGSVPH SGLRRHWE; Positive Samples: HL-60, Mouse liver, Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B4; CD85 antigen-like family member K; CD85k; glycoprotein 49 B; glycoprotein 49b; ILT-3; Immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; Leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; Leukocyte immunoglobulin-like receptor subfamily B member 4A; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte surface receptor; LIR-5; Mast cell surface glycoprotein Gp49B; Monocyte inhibitory receptor HM18
Gene Aliases: CD85K; gp49; Gp49b; GP49B2; HM18; ILT-3; ILT3; LILRB4; Lilrb4a; LIR-5; LIR5
UniProt ID: (Human) Q8NHJ6, (Mouse) Q64281
Entrez Gene ID: (Human) 11006, (Rat) 292594, (Mouse) 14728
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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