Product References
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.
Nature genetics
Caswell DR,Gui P,Mayekar MK,Law EK,Pich O,Bailey C,Boumelha J,Kerr DL,Blakely CM,Manabe T,Martinez-Ruiz C,Bakker B,De Dios Palomino Villcas J,I Vokes N,Dietzen M,Angelova M,Gini B,Tamaki W,Allegakoen P,Wu W,Humpton TJ,Hill W,Tomaschko M,Lu WT,Haderk F,Al Bakir M,Nagano A,Gimeno-Valiente F,de Carné Trécesson S,Vendramin R,Barbè V,Mugabo M,Weeden CE,Rowan A,McCoach CE,Almeida B,Green M,Gomez C,Nanjo S,Barbosa D,Moore C,Przewrocka J,Black JRM,Grönroos E,Suarez-Bonnet A,Priestnall SL,Zverev C,Lighterness S,Cormack J,Olivas V,Cech L,Andrews T,Rule B,Jiao Y,Zhang X,Ashford P,Durfee C,Venkatesan S,Temiz NA,Tan L,Larson LK,Argyris PP,Brown WL,Yu EA,Rotow JK,Guha U,Roper N,Yu J,Vogel RI,Thomas NJ,Marra A,Selenica P,Yu H,Bakhoum SF,Chew SK,Reis-Filho JS,Jamal-Hanjani M,Vousden KH,McGranahan N,Van Allen EM,Kanu N,Harris RS,Downward J,Bivona TG,Swanton C
14-0808-82 was used in Immunohistochemistry to assess the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer.
Mon Jan 01 00:00:00 UTC 2024
Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice.
Scientific reports
Ito M,Iwama S,Sugiyama D,Yasuda Y,Okuji T,Kobayashi T,Zhou X,Yamagami A,Onoue T,Miyata T,Sugiyama M,Hagiwara D,Suga H,Banno R,Nishikawa H,Arima H
14-0808-82 was used in Immunohistochemistry to suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8+ T cells and decreased expression of CCL7 and CXCL9.
Wed Apr 12 00:00:00 UTC 2023
CD8 + T cell infiltration is associated with improved survival and negatively correlates with hypoxia in clear cell ovarian cancer.
Scientific reports
Guo N,Yang A,Farooq FB,Kalaria S,Moss E,DeVorkin L,Lesperance M,Bénard F,Wilson D,Tinker AV,Nathoo FS,Hamilton PT,Lum JJ
14-0808-82 was used in Immunohistochemistry to suggest that hypoxia may contribute to immune exclusion, primarily mediated by effects in stroma.
Fri Apr 21 00:00:00 UTC 2023
An enhancer variant associated with breast cancer susceptibility in Black women regulates TNFSF10 expression and antitumor immunity in triple-negative breast cancer.
Human molecular genetics
Han YJ,Zhang J,Hardeman A,Liu M,Karginova O,Romero R,Khramtsova GF,Zheng Y,Huo D,Olopade OI
14-0808-82 was used in Immunohistochemistry to suggest that TNFSF10 plays an important role in the regulation of antiviral immune responses in TNBC, and the expression is in part regulated by a genetic variant associated with breast cancer in Black women.
Sun Jan 01 00:00:00 UTC 2023
Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention.
NPJ precision oncology
Lee SB,Pan J,Xiong D,Palen K,Johnson B,Lubet RA,Shoemaker RH,Green JE,Fernando RI,Sei S,You M,Wang Y
14-0808-82 was used in Immunohistochemistry to indicate that our newly developed multi-peptide TOP2A vaccine is highly immunogenic, elicits TILs with vaccine specific TCRs, and is highly effective in preventing and intercepting TNBC development and progression in vivo.
Wed Oct 25 00:00:00 UTC 2023
Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma.
Frontiers in immunology
Digifico E,Erreni M,Mannarino L,Marchini S,Ummarino A,Anfray C,Bertola L,Recordati C,Pistillo D,Roncalli M,Bossi P,Zucali PA,D'Incalci M,Belgiovine C,Allavena P
14-0808-82 was used in Immunohistochemistry to demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumor progression in vivo.
Mon Jul 10 00:00:00 UTC 2023
Development of an Orthotopic HPV16-Dependent Base of Tongue Tumor Model in MHC-Humanized Mice.
Pathogens (Basel, Switzerland)
Schifflers C,Zottnick S,Förster JD,Kruse S,Yang R,Wiethoff H,Bozza M,Hoppe-Seyler K,Heikenwälder M,Harbottle RP,Michiels C,Riemer AB
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to present the development of a new HPV16 oncoprotein-dependent tumor model in MHC-humanized mice, modeling the major biologic features of HPV-driven tumors and presenting HLA-A2-restricted HPV16 epitopes.
Wed Jan 25 00:00:00 UTC 2023
β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma.
Cancer gene therapy
Bruno G,Nastasi N,Subbiani A,Boaretto A,Ciullini Mannurita S,Mattei G,Nardini P,Della Bella C,Magi A,Pini A,De Marco E,Tondo A,Favre C,Calvani M
14-0808-82 was used in Immunohistochemistry to investigate whether the β3-adrenergic receptor modulation influenced the host immune system response against tumor.
Thu Jun 01 00:00:00 UTC 2023
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion.
Nature communications
Liu HJ,Du H,Khabibullin D,Zarei M,Wei K,Freeman GJ,Kwiatkowski DJ,Henske EP
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to show that mTORC1-hyperactivity, present in many human tumors including tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM), drives B7-H3 expression leading to suppression of cytotoxic CD4+ T cells.
Fri Mar 03 00:00:00 UTC 2023
Targeting eIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer.
The Journal of clinical investigation
Zhao N,Kabotyanski EB,Saltzman AB,Malovannaya A,Yuan X,Reineke LC,Lieu N,Gao Y,Pedroza DA,Calderon SJ,Smith AJ,Hamor C,Safari K,Savage S,Zhang B,Zhou J,Solis LM,Hilsenbeck SG,Fan C,Perou CM,Rosen JM
14-0808-82 was used in Immunohistochemistry to show that therapeutically targeting the RNA helicase eIF4A by Zotatifin, the first-in-class eIF4A inhibitor, exerts pleiotropic effects on both tumor cells and the tumor immune microenvironment in a diverse cohort of syngeneic triple-negative breast cancer (TNBC) mouse models.
Fri Dec 15 00:00:00 UTC 2023
TGF-β Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth.
International journal of molecular sciences
Marvin DL,Dijkstra J,Zulfiqar RM,Vermeulen M,Ten Dijke P,Ritsma L
14-0808-82 was used in Immunohistochemistry to study the role of Transforming Growth Factor β in melanoma liver metastasis.
Fri May 12 00:00:00 UTC 2023
Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal™-TSA multiplex immunohistochemistry.
STAR protocols
Quigley LT,Pang L,Tavancheh E,Ernst M,Behren A,Huynh J,Da Gama Duarte J
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to identify immature and mature tertiary lymphoid structures (TLSs).
Fri Mar 17 00:00:00 UTC 2023
Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy.
Journal for immunotherapy of cancer
van Elsas MJ,Labrie C,Etzerodt A,Charoentong P,van Stigt Thans JJC,Van Hall T,van der Burg SH
14-0808-82 was used in Immunohistochemistry-paraffin to identify a small but discernible CD163hi macrophage population, with high expression of several tumor-promoting macrophage markers and a functional anti-inflammatory transcriptome profile, but not other macrophages, to be responsible.
Wed Mar 01 00:00:00 UTC 2023
Sharpening up tumor microenvironment to enhance the efficacy of immune checkpoint blockade on head and neck cancer using a CpG-oligodeoxynucleotide.
Cancer immunology, immunotherapy : CII
Tseng JC,Yang JX,Liu YL,Su YW,Lee AY,Chen YW,Liu KJ,Luo Y,Hong YR,Chuang TH
14-0808-82 was used in Immunohistochemistry to examine tutor microenvironment effects in head and neck cancers.
Sun May 01 00:00:00 UTC 2022
A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells.
Molecular cell
Shen JZ,Qiu Z,Wu Q,Zhang G,Harris R,Sun D,Rantala J,Barshop WD,Zhao L,Lv D,Won KA,Wohlschlegel J,Sangfelt O,Laman H,Rich JN,Spruck C
14-0808-82 was used in Immunohistochemistry to identify FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells.
Thu Mar 17 00:00:00 UTC 2022
ZEB1 transcription factor promotes immune escape in melanoma.
Journal for immunotherapy of cancer
Plaschka M,Benboubker V,Grimont M,Berthet J,Tonon L,Lopez J,Le-Bouar M,Balme B,Tondeur G,de la Fouchardière A,Larue L,Puisieux A,Grinberg-Bleyer Y,Bendriss-Vermare N,Dubois B,Caux C,Dalle S,Caramel J
14-0808-82 was used in Immunohistochemistry to identify the ZEB1 transcription factor as a key determinant of melanoma immune escape, highlighting a previously unknown therapeutic target to increase efficacy of immunotherapy in melanoma.
Tue Mar 01 00:00:00 UTC 2022
Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages.
Cell reports
Hao J,Jin R,Zeng J,Hua Y,Yorek MS,Liu L,Mandal A,Li J,Zheng H,Sun Y,Yi Y,Yin D,Zheng Q,Li X,Ng CK,Rouchka EC,Egilmez NK,Jabbari A,Li B
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to support a role for E-FABP as a lipid sensor mediating n-3 FA-regulated macrophage function and skin health.
Tue Dec 13 00:00:00 UTC 2022
Immunogenic Death of Hepatocellular Carcinoma Cells in Mice Expressing Caspase-Resistant ROCK1 Is Not Replicated by ROCK Inhibitors.
Cancers
Naylor G,Julian L,Watson-Bryce S,Mullin M,Nibbs RJ,Olson MF
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to indicate that there is an important role for ROCK1 cleavage to limit immunogenic cell death, which was not replicated by systemic ROCK inhibitor administration.
Wed Nov 30 00:00:00 UTC 2022
Replication-Deficient Lymphocytic Choriomeningitis Virus-Vectored Vaccine Candidate for the Induction of T Cell Immunity against Mycobacterium tuberculosis.
International journal of molecular sciences
Belnoue E,Vogelzang A,Nieuwenhuizen NE,Krzyzaniak MA,Darbre S,Kreutzfeldt M,Wagner I,Merkler D,Lambert PH,Kaufmann SHE,Siegrist CA,Pinschewer DD
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to suggest that rLCMV may show utility for neonatal and/or adult vaccination efforts against pulmonary tuberculosis.
Mon Feb 28 00:00:00 UTC 2022
Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer.
Cancer research
Khayati K,Bhatt V,Lan T,Alogaili F,Wang W,Lopez E,Hu ZS,Gokhale S,Cassidy L,Narita M,Xie P,White E,Guo JY
14-0808-82 was used in Immunohistochemistry to exploit inducible expression of Atg5 shRNA to temporally control Atg5 levels and to generate reversible tumor-specific and systemic autophagy loss mouse models of KrasG12D/+;p53-/- (KP) non-small cell lung cancer (NSCLC).
Fri Dec 02 00:00:00 UTC 2022
Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Tumour Progression in the Regenerating Liver Following Partial Hepatectomy.
International journal of molecular sciences
Riddiough GE,Walsh KA,Fifis T,Kastrappis G,Tran BM,Vincan E,Muralidharan V,Christophi C,Gordon CL,Perini MV
14-0808-82 was used in Immunohistochemistry-immunofluorescence to investigate whether RASi exerts an antitumour effect within the regenerating liver following partial hepatectomy for CRLM and examines RASi-induced changes in the tumour immune microenvironment; (2) CRLM in mice was induced via intrasplenic injection of mouse colorectal tumour cells, followed by splenectomy on Day 0.
Mon May 09 00:00:00 UTC 2022
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.
Theranostics
Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to determine if attenuated host autophagy is sufficient to induce tumor rejection through reinforced adaptive immunity and whether dietary glutamine supplementation, mimicking attenuated host autophagy, is capable of promoting antitumor immunity.
Tue Aug 16 00:00:00 UTC 2022
Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation.
Cancer immunology research
Edwards KJ,Chang B,Babazada H,Lohith K,Park DH,Farwell MD,Sellmyer MA
14-0808-82 was used in Immunohistochemistry to suggest that the CD69 PET imaging approach detects CD69 expression with sufficient sensitivity to quantify immune cell activation in a syngeneic mouse immunotherapy model and could allow for the prediction of therapeutic immune responses to novel immunotherapies.
Thu Sep 01 00:00:00 UTC 2022
Precise delivery of doxorubicin and imiquimod through pH-responsive tumor microenvironment-active targeting micelles for chemo- and immunotherapy.
Materials today. Bio
Wen YH,Hsieh PI,Chiu HC,Chiang CW,Lo CL,Chiang YT
14-0808-82 was used in Immunohistochemistry-paraffin-immunofluorescence to show that these micelles exhibit precise pH responsiveness and ideal drug delivery capabilities for combined chemo- and immunotherapy; these results significantly contribute to the future development of nanomedicines in cancer therapy.
Thu Dec 15 00:00:00 UTC 2022
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 UTC 2022
A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity.
Science translational medicine
Roehlen N,Saviano A,El Saghire H,Crouchet E,Nehme Z,Del Zompo F,Jühling F,Oudot MA,Durand SC,Duong FHT,Cherradi S,Gonzalez Motos V,Almeida N,Ponsolles C,Heydmann L,Ostyn T,Lallement A,Pessaux P,Felli E,Cavalli A,Sgrignani J,Thumann C,Koutsopoulos O,Fuchs BC,Hoshida Y,Hofmann M,Vyberg M,Viuff BM,Galsgaard ED,Elson G,Toso A,Meyer M,Iacone R,Schweighoffer T,Teixeira G,Moll S,De Vito C,Roskams T,Davidson I,Heide D,Heikenwälder M,Zeisel MB,Lupberger J,Mailly L,Schuster C,Baumert TF
14-0808-82 was used in Immunohistochemistry (Paraffin) to provide preclinical proof of concept for CLDN1-specific monoclonal antibodies for the treatment of advanced liver fibrosis and cancer prevention.
Wed Dec 21 00:00:00 UTC 2022
Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention.
Frontiers in immunology
Ryan NM,Lamenza FF,Upadhaya P,Pracha H,Springer A,Swingler M,Siddiqui A,Oghumu S
14-0808-82 was used in Immunohistochemistry to demonstrate the immunomodulatory potential of black raspberry extracts and support the use of black raspberry-derived phytochemicals as a complementary approach to HNSCC chemoprevention and treatment.
Mon Aug 29 00:00:00 UTC 2022
Tumor-derived Jagged1 promotes cancer progression through immune evasion.
Cell reports
Meng J,Jiang YZ,Zhao S,Tao Y,Zhang T,Wang X,Zhang Y,Sun K,Yuan M,Chen J,Wei Y,Lan X,Chen M,David CJ,Chang Z,Guo X,Pan D,Chen M,Shao ZM,Kang Y,Zheng H
14-0808-82 was used in Immunohistochemistry to report that tumor-derived Jagged1 is a key regulator of the tumor immune microenvironment.
Tue Mar 08 00:00:00 UTC 2022
Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models.
Disease models & mechanisms
Jeong H,Woo Lee Y,Park IH,Noh H,Kim SH,Kim J,Jeon D,Jang HJ,Oh J,On D,Uhm C,Cho K,Oh H,Yoon S,Seo JS,Kim JJ,Seok SH,Lee YJ,Hong SM,An SH,Yeon Kim S,Kim YB,Hwang JY,Lee HJ,Kim HB,Jeong DG,Song D,Song M,Park MS,Choi KS,Park JW,Seo JY,Yun JW,Shin JS,Lee HY,Nam KT,Seong JK
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to provide comprehensive insights into the pathogenic spectrum of COVID-19 using preclinical models.
Tue Nov 01 00:00:00 UTC 2022
T cells specific for α-myosin drive immunotherapy-related myocarditis.
Nature
Axelrod ML,Meijers WC,Screever EM,Qin J,Carroll MG,Sun X,Tannous E,Zhang Y,Sugiura A,Taylor BC,Hanna A,Zhang S,Amancherla K,Tai W,Wright JJ,Wei SC,Opalenik SR,Toren AL,Rathmell JC,Ferrell PB,Phillips EJ,Mallal S,Johnson DB,Allison JP,Moslehi JJ,Balko JM
14-0808-82 was used in Immunohistochemistry to identify clonal effector CD8+ T cells as the dominant cell population.
Tue Nov 01 00:00:00 UTC 2022
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Cell
Shen JZ,Qiu Z,Wu Q,Finlay D,Garcia G,Sun D,Rantala J,Barshop W,Hope JL,Gimple RC,Sangfelt O,Bradley LM,Wohlschlegel J,Rich JN,Spruck C
14-0808-82 was used in Immunohistochemistry to demonstrate that FBXO44/SUV39H1 are crucial repressors of RE transcription, and their inhibition selectively induces DNA replication stress and viral mimicry in cancer cells.
Thu Jan 21 00:00:00 UTC 2021
Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart.
Circulation
Forte E,Perkins B,Sintou A,Kalkat HS,Papanikolaou A,Jenkins C,Alsubaie M,Chowdhury RA,Duffy TM,Skelly DA,Branca J,Bellahcene M,Schneider MD,Harding SE,Furtado MB,Ng FS,Hasham MG,Rosenthal N,Sattler S
14-0808 was used in Immunohistochemistry to investigate a role for cross-priming DC in post-MI myocardial impairment through presentation of self-antigen from necrotic cardiomyocytes to cytotoxic CD8+ T cells.
Tue Feb 23 00:00:00 UTC 2021
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Cancer discovery
Wei SC,Meijers WC,Axelrod ML,Anang NAS,Screever EM,Wescott EC,Johnson DB,Whitley E,Lehmann L,Courand PY,Mancuso JJ,Himmel LE,Lebrun-Vignes B,Wleklinski MJ,Knollmann BC,Srinivasan J,Li Y,Atolagbe OT,Rao X,Zhao Y,Wang J,Ehrlich LIR,Sharma P,Salem JE,Balko JM,Moslehi JJ,Allison JP
14-0808 was used in Immunohistochemistry to report a robust preclinical mouse model ofiImmune checkpoint inhibitors-associated myocarditis in which mono-allelic loss of Ctla4 in the context of complete genetic absence of Pdcd1 leads to premature death in approximately half of mice.
Mon Mar 01 00:00:00 UTC 2021
Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer.
Cell metabolism
Biancur DE,Kapner KS,Yamamoto K,Banh RS,Neggers JE,Sohn ASW,Wu W,Manguso RT,Brown A,Root DE,Aguirre AJ,Kimmelman AC
14-0808-82 was used in Immunohistochemistry to systematically investigate metabolic vulnerabilities in pancreatic ductal adenocarcinoma.
Tue Jan 05 00:00:00 UTC 2021
Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells.
Cellular & molecular immunology
Yu M,Pan H,Che N,Li L,Wang C,Wang Y,Ma G,Qian M,Liu J,Zheng M,Xie H,Ling L,Zhao Y,Guan X,Ding Q,Zhou W,Wang S
14-0808-82 was used in Immunohistochemistry to demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis, and MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer.
Wed Sep 01 00:00:00 UTC 2021
A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.
The Journal of clinical investigation
Veatch JR,Singhi N,Srivastava S,Szeto JL,Jesernig B,Stull SM,Fitzgibbon M,Sarvothama M,Yechan-Gunja S,James SE,Riddell SR
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to harness gene-modified T cells as a vaccine platform and developed cancer vaccines composed of autologous T cells modified with tumor antigens and additional adjuvant signals (Tvax).
Mon Aug 16 00:00:00 UTC 2021
Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy.
Small (Weinheim an der Bergstrasse, Germany)
Liu X,Jiang J,Chang CH,Liao YP,Lodico JJ,Tang I,Zheng E,Qiu W,Lin M,Wang X,Ji Y,Mei KC,Nel AE,Meng H
14-0808 was used in Immunohistochemistry to demonstrate that the DACHPt silicasome generates a significant improvement in survival outcome, which can be extended by delayed administration of the anti-PD-1 antibody.
Thu Apr 01 00:00:00 UTC 2021
The RAC1 Target NCKAP1 Plays a Crucial Role in the Progression of Braf;Pten-Driven Melanoma in Mice.
The Journal of investigative dermatology
Swaminathan K,Campbell A,Papalazarou V,Jaber-Hijazi F,Nixon C,McGhee E,Strathdee D,Sansom OJ,Machesky LM
14-0808 was used in Immunohistochemistry to examine the role of the NCKAP1 subunit of the pentameric cytoskeletal SCAR/WAVE complex in a mouse model of melanoma driven by BRAFV600E;PTEN loss.
Mon Mar 01 00:00:00 UTC 2021
Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo.
The American journal of pathology
Li M,McGhee EM,Shinno L,Lee K,Lin YL
14-0808-82 was used in Immunohistochemistry to show that butyrate treatment changed the property of HPV16 E6/E7-immortalized keratinocytes.
Fri Oct 01 00:00:00 UTC 2021
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Journal of immunology (Baltimore, Md. : 1950)
Jiang C,Zhao ML,Ramos L,Dobaczewska K,Herbert R,Hobbie K,Mikulski Z,Verkoczy L,Diaz M
14-0808-82 was used in Immunohistochemistry-immunofluorescence to implicate autoreactive IgM Abs in protection against T cell lymphoma.
Sat May 15 00:00:00 UTC 2021
Type of chemotherapy has substantial effects on the immune system in ovarian cancer.
Translational oncology
Vankerckhoven A,Baert T,Riva M,De Bruyn C,Thirion G,Vandenbrande K,Ceusters J,Vergote I,Coosemans A
14-0808-82 was used in Immunohistochemistry to compare six common chemotherapeutics used in ovarian cancer patients (carboplatin, paclitaxel, pegylated liposomal doxorubicin, gemcitabine, carboplatin-paclitaxel and carboplatin-gemcitabine) and studied their effects on the immune system in an ovarian cancer mouse model.
Tue Jun 01 00:00:00 UTC 2021
Ruxolitinib, a JAK1/JAK2 selective inhibitor, ameliorates acute and chronic steroid-refractory GvHD mouse models.
Immunotherapy
Huarte E,Peel M,Juvekar A,Dubé P,Sarah S,Stephens L,Stewart B,Long B,Czerniak P,Oliver J,Smith P
14-0808-82 was used in Immunohistochemistry to investigate ruxolitinib dosing in preclinical models of acute and chronic steroid-refractory graft-versus-host disease, and in a novel humanized model involving immunodeficient NOG mice transgenic for human IL-15.
Sun Aug 01 00:00:00 UTC 2021
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells.
Cell reports
Matas-Rico E,Frijlink E,van der Haar Àvila I,Menegakis A,van Zon M,Morris AJ,Koster J,Salgado-Polo F,de Kivit S,Lança T,Mazzocca A,Johnson Z,Haanen J,Schumacher TN,Perrakis A,Verbrugge I,van den Berg JH,Borst J,Moolenaar WH
14-0808-82 was used in Flow cytometry/Cell sorting to highlight an unexpected role for the pro-metastatic ATX-LPAR axis in suppressing CD8+ T cell infiltration to impede anti-tumor immunity, suggesting new therapeutic opportunities.
Tue Nov 16 00:00:00 UTC 2021
Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response.
Journal of translational medicine
Korpela SP,Hinz TK,Oweida A,Kim J,Calhoun J,Ferris R,Nemenoff RA,Karam SD,Clambey ET,Heasley LE
14-0808-80 was used in Immunohistochemistry (Paraffin) to reveal heterogeneous, tumor cell-intrinsic, EGFR/ERBB inhibitor-induced IFN pathway activation in HNSCC and suggest that individual tumor responses to oncogene-targeted agents are a sum of direct growth inhibitory effects and variably-induced participation of host immune cells.
Sat Jan 23 00:00:00 UTC 2021
STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis.
Biomedicines
Pang L,Huynh J,Alorro MG,Li X,Ernst M,Chand AL
14-0808 was used in Immunohistochemistry to investigate the role of STAT3 in retaining epithelial barrier integrity using dextran sulfate sodium (DSS)-induced colitis in two genetically modified mouse models, to either reduce STAT1/3 activation in response to IL-6 family cytokines with a truncated gp130STAT allele (GP130STAT/+), or by inducing short hairpin-mediated knockdown of Stat3 (shStat3).
Fri Feb 12 00:00:00 UTC 2021
Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model.
Gastroenterology
Gebert J,Gelincik O,Oezcan-Wahlbrink M,Marshall JD,Hernandez-Sanchez A,Urban K,Long M,Cortes E,Tosti E,Katzenmaier EM,Song Y,Elsaadi A,Deng N,Vilar E,Fuchs V,Nelius N,Yuan YP,Ahadova A,Sei S,Shoemaker RH,Umar A,Wei L,Liu S,Bork P,Edelmann W,von Knebel Doeberitz M,Lipkin SM,Kloor M
14-0808-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin) to test the hypothesis that recurrent FSP vaccination alone or in combination with NSAID treatment can promote anti-FSP adaptive immunity sufficiently to reduce intestinal tumor burden and prolong overall survival.
Fri Oct 01 00:00:00 UTC 2021
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer.
Oncoimmunology
Yang J,Eresen A,Shangguan J,Ma Q,Yaghmai V,Zhang Z
14-0808 was used in Immunohistochemistry to test the hypothesis that IRE ablation can overcome TME immunosuppression to improve the efficacy of DC vaccination using KrasLSL-G12D-p53LSL-R172H-Pdx-1-Cre (KPC) orthotopic mouse model of PDAC.
Tue Feb 02 00:00:00 UTC 2021
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.
Nature
Zhang SM,Cai WL,Liu X,Thakral D,Luo J,Chan LH,McGeary MK,Song E,Blenman KRM,Micevic G,Jessel S,Zhang Y,Yin M,Booth CJ,Jilaveanu LB,Damsky W,Sznol M,Kluger HM,Iwasaki A,Bosenberg MW,Yan Q
14-0808-82 was used in Immunohistochemistry to enhance tumour immunogenicity and overcome immunotherapy resistance.
Fri Oct 01 00:00:00 UTC 2021
Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer.
Scientific reports
Fite BZ,Wang J,Kare AJ,Ilovitsh A,Chavez M,Ilovitsh T,Zhang N,Chen W,Robinson E,Zhang H,Kheirolomoom A,Silvestrini MT,Ingham ES,Mahakian LM,Tam SM,Davis RR,Tepper CG,Borowsky AD,Ferrara KW
14-0808 was used in Immunohistochemistry to assess the immunomodulatory effects of MR-guided HIFU and its combination with the innate immune agonist CpG and checkpoint inhibitor anti-PD-1.
Wed Jan 13 00:00:00 UTC 2021
Human immunodeficiency virus-1/simian immunodeficiency virus infection induces opening of pannexin-1 channels resulting in neuronal synaptic compromise: A novel therapeutic opportunity to prevent NeuroHIV.
Journal of neurochemistry
Gorska AM,Donoso M,Valdebenito S,Prideaux B,Queen S,Scemes E,Clements J,Eugenin E
14-0808-82 was used in Flow cytometry/Cell sorting to determine the contribution of Panx-1 to HIV and NeuroHIV.
Thu Jul 01 00:00:00 UTC 2021
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer.
NPJ breast cancer
Williams MM,Christenson JL,O'Neill KI,Hafeez SA,Ihle CL,Spoelstra NS,Slansky JE,Richer JK
14-0808-82 was used in Immunohistochemistry to demonstrate that immunogenic cytokines (e.g., GM-CSF) are suppressed in aggressive TNBC.
Thu May 27 00:00:00 UTC 2021
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Nature communications
Shang M,Yang H,Yang R,Chen T,Fu Y,Li Y,Fang X,Zhang K,Zhang J,Li H,Cao X,Gu J,Xiao J,Zhang Q,Liu X,Yu Q,Wang T
14-0808-82 was used in Immunohistochemistry to functionally screen metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2).
Mon Mar 29 00:00:00 UTC 2021
Female Immunity Protects from Cutaneous Squamous Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Budden T,Gaudy-Marqueste C,Craig S,Hu Y,Earnshaw CH,Gurung S,Ra A,Akhras V,Shenjere P,Green R,Jamieson L,Lear J,Motta L,Caulín C,Oudit D,Furney SJ,Virós A
14-0808-82 was used in Immunohistochemistry to show the immune response is sex biased in cSCC and highlights female immunity offers greater protection than male immunity.
Tue Jun 01 00:00:00 UTC 2021
Positron emission tomography imaging with 89Zr-labeled anti-CD8 cys-diabody reveals CD8+ cell infiltration during oncolytic virus therapy in a glioma murine model.
Scientific reports
Kasten BB,Houson HA,Coleman JM,Leavenworth JW,Markert JM,Wu AM,Salazar F,Tavaré R,Massicano AVF,Gillespie GY,Lapi SE,Warram JM,Sorace AG
14-0808-82 was used in Immunohistochemistry to show that accumulation in target areas, especially the spleen, was significantly reduced by blocking with the non-labeled diabody.
Wed Jul 28 00:00:00 UTC 2021
Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu X,Jiang J,Liao YP,Tang I,Zheng E,Qiu W,Lin M,Wang X,Ji Y,Mei KC,Liu Q,Chang CH,Wainberg ZA,Nel AE,Meng H
14-0808-82 was used in Immunohistochemistry to demonstrate that irinotecan is capable of triggering a chemo-immunotherapy response in an orthotopic KPC model.
Mon Mar 01 00:00:00 UTC 2021
Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer.
International journal of molecular sciences
Vito A,Rathmann S,Mercanti N,El-Sayes N,Mossman K,Valliant J
14-0808-82 was used in Immunohistochemistry to develop a combined therapy for triple negative breast cancer utilising radionuclide therapy and immune checkpoint blockade which improves overall survival.
Mon May 03 00:00:00 UTC 2021
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Nature
Conlon TM,John-Schuster G,Heide D,Pfister D,Lehmann M,Hu Y,Ertüz Z,Lopez MA,Ansari M,Strunz M,Mayr C,Angelidis I,Ciminieri C,Costa R,Kohlhepp MS,Guillot A,Günes G,Jeridi A,Funk MC,Beroshvili G,Prokosch S,Hetzer J,Verleden SE,Alsafadi H,Lindner M,Burgstaller G,Becker L,Irmler M,Dudek M,Janzen J,Goffin E,Gosens R,Knolle P,Pirotte B,Stoeger T,Beckers J,Wagner D,Singh I,Theis FJ,de Angelis MH,O'Connor T,Tacke F,Boutros M,Dejardin E,Eickelberg O,Schiller HB,Königshoff M,Heikenwalder M,Yildirim AÖ
14-0808-82 was used in Immunohistochemistry (Paraffin) to demonstrate differential expression, signalling, and target gene expression of the lymphotoxin β-receptor in response to cigarette smoke in humans and mice.
Tue Dec 01 00:00:00 UTC 2020
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
14-0808 was used in Immunohistochemistry-immunofluorescence to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 UTC 2020
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Cancer cell
Dheilly E,Battistello E,Katanayeva N,Sungalee S,Michaux J,Duns G,Wehrle S,Sordet-Dessimoz J,Mina M,Racle J,Farinha P,Coukos G,Gfeller D,Mottok A,Kridel R,Correia BE,Steidl C,Bassani-Sternberg M,Ciriello G,Zoete V,Oricchio E
14-0808-80 was used in Immunohistochemistry (Paraffin) to find that follicular lymphoma patients harbor a recurrent hotspot mutation targeting tyrosine 132 (Y132D) in cathepsin S (CTSS) that enhances protein activity.
Mon May 11 00:00:00 UTC 2020
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Cancer discovery
Mondello P,Tadros S,Teater M,Fontan L,Chang AY,Jain N,Yang H,Singh S,Ying HY,Chu CS,Ma MCJ,Toska E,Alig S,Durant M,de Stanchina E,Ghosh S,Mottok A,Nastoupil L,Neelapu SS,Weigert O,Inghirami G,Baselga J,Younes A,Yee C,Dogan A,Scheinberg DA,Roeder RG,Melnick AM,Green MR
14-0808 was used in Flow cytometry/Cell sorting to show that these two classes of mutations yield different degrees of disruption of the epigenome, with HAT mutations being more severe and associated with inferior clinical outcome.
Sun Mar 01 00:00:00 UTC 2020
CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients.
Gastroenterology
Hirth M,Gandla J,Höper C,Gaida MM,Agarwal N,Simonetti M,Demir A,Xie Y,Weiss C,Michalski CW,Hackert T,Ebert MP,Kuner R
14-0808 was used in Immunohistochemistry to determine that CCL21 and CXCL10 proteins promote the migration of pancreatic cancer cells toward sensory neurons in mice and are associated with increased frequency of cancer-associated pain in pancreatic ductal adenocarcinoma patients.
Sat Aug 01 00:00:00 UTC 2020
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.
Cell metabolism
Su W,Chapman NM,Wei J,Zeng H,Dhungana Y,Shi H,Saravia J,Zhou P,Long L,Rankin S,Kc A,Vogel P,Chi H
14-0808-82 was used in Immunohistochemistry to identify bidirectional metabolic signaling, specifically between immunoreceptor signaling and metabolism-mediated posttranslational lipid modifications, for the differentiation and maintenance of eTreg cells.
Tue Dec 01 00:00:00 UTC 2020
hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis.
Hepatology (Baltimore, Md.)
Xiong J,Liu T,Mi L,Kuang H,Xiong X,Chen Z,Li S,Lin JD
14-0808-80 was used in Immunohistochemistry (Paraffin) to show that heterogeneous nuclear ribonucleoprotein U (hnRNPU), a nuclear matrix protein that governs chromatin architecture and gene transcription, is a critical factor that couples chromatin disruption to NASH pathogenesis.
Wed Apr 01 00:00:00 UTC 2020
FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.
Cancer research
Okamoto T,Yeo SK,Hao M,Copley MR,Haas MA,Chen S,Guan JL
14-0808 was used in Western Blotting to show that depletion of FIP200 enhances immune checkpoint efficacy in non-responsive breast cancer.
Tue Sep 01 00:00:00 UTC 2020
Dynamic, Helminth-Induced Immune Modulation Influences the Outcome of Acute and Chronic Hepatitis B Virus Infection.
The Journal of infectious diseases
Loffredo-Verde E,Bhattacharjee S,Malo A,Festag J,Kosinska AD,Ringelhan M,Rim Sarkar S,Steiger K,Heikenwaelder M,Protzer U,Prazeres da Costa CU
14-0808 was used in Immunohistochemistry to study the pathogen-crosstalk during the different immune phases of schistosome infection and how this influences the outcome of acute and chronic Hepatitis B Virus infection.
Tue Apr 07 00:00:00 UTC 2020
Organoid-Transplant Model Systems to Study the Effects of Obesity on the Pancreatic Carcinogenesis in vivo.
Frontiers in cell and developmental biology
Lupo F,Piro G,Torroni L,Delfino P,Trovato R,Rusev B,Fiore A,Filippini D,De Sanctis F,Manfredi M,Marengo E,Lawlor RT,Martini M,Tortora G,Ugel S,Corbo V,Melisi D,Carbone C
14-0808 was used in Immunohistochemistry to study the effects of obesity on pancreatic carcinogenesis.
Mon Sep 28 00:00:00 UTC 2020
Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950)
Johnson AM,Bullock BL,Neuwelt AJ,Poczobutt JM,Kaspar RE,Li HY,Kwak JW,Hopp K,Weiser-Evans MCM,Heasley LE,Schenk EL,Clambey ET,Nemenoff RA
14-0808 was used in Immunohistochemistry-immunofluorescence to examine the effect of cancer cell-specific MHC class II (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti-PD-1 therapy using two orthotopic immunocompetent murine models of non-small cell lung cancer: CMT167 (CMT) and Lewis lung carcinoma (LLC).
Wed Apr 15 00:00:00 UTC 2020
NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy.
Journal of immunology (Baltimore, Md. : 1950)
Ogawa T,Ishitsuka Y,Nakamura Y,Kubota N,Saito A,Fujisawa Y,Watanabe R,Okiyama N,Suga Y,Roop DR,Fujimoto M
14-0808-82 was used immunohistochemistry (paraffin) show that the immunogenicity of a given hapten depends directly on the extent to which it induces antioxidant host defenses within the epidermal tissue.
Sat Aug 15 00:00:00 UTC 2020
Morphologic and Immunohistochemical Characterization of Spontaneous Lymphoma/Leukemia in NSG Mice.
Veterinary pathology
Tillman H,Janke LJ,Funk A,Vogel P,Rehg JE
14-0808-80 was used in Immunohistochemistry (Paraffin) to highlight that NSG mice may develop T-cell lymphoma at low frequency, necessitating the recognition of this spontaneously arising disease when interpreting studies.
Wed Jan 01 00:00:00 UTC 2020
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Nature communications
Hoefflin R,Harlander S,Schäfer S,Metzger P,Kuo F,Schönenberger D,Adlesic M,Peighambari A,Seidel P,Chen CY,Consenza-Contreras M,Jud A,Lahrmann B,Grabe N,Heide D,Uhl FM,Chan TA,Duyster J,Zeiser R,Schell C,Heikenwalder M,Schilling O,Hakimi AA,Boerries M,Frew IJ
14-0808 was used in Immunohistochemistry to show using an autochthonous ccRCC model that Hif1a is essential for tumour formation whereas Hif2a deletion has only minor effects on tumour initiation and growth.
Mon Aug 17 00:00:00 UTC 2020
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma.
Immunity, inflammation and disease
Alikhanyan K,Chen Y,Kraut S,Sotillo R
14-0808 was used in Immunohistochemistry-immunofluorescence to evaluate the role of both alveolar macrophages and interstitial macrophages in the development of EGFR mutant driven lung adenocarcinoma.
Mon Jun 01 00:00:00 UTC 2020
Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs.
Genes
Scherer A,Stephens VR,McGivney GR,Gutierrez WR,Laverty EA,Knepper-Adrian V,Dodd RD
14-0808 was used in Immunohistochemistry to highlight important strain-specific phenotypes of genomically-matched malignant peripheral nerve sheath tumors (MPNSTs) that have implications for the design of future studies using similar in vivo gene editing approaches.
Sat May 23 00:00:00 UTC 2020
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system.
Oncoimmunology
Klarenbeek S,Doornebal CW,Kas SM,Bonzanni N,Bhin J,Braumuller TM,van der Heijden I,Opdam M,Schouten PC,Kersten K,de Bruijn R,Zingg D,Yemelyanenko J,Wessels LFA,de Visser KE,Jonkers J
14-0808-82 was used in Immunohistochemistry to investigate treatment response and resistance to AZD8055, an inhibitor of mammalian target of rapamycin (mTOR), in the K14-cre;Cdh1Flox/Flox;Trp53Flox/Flox (KEP) mouse model of metastatic ILC.
Wed Jul 28 00:00:00 UTC 2021
Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.
Cell reports
Mohebiany AN,Ramphal NS,Karram K,Di Liberto G,Novkovic T,Klein M,Marini F,Kreutzfeldt M,Härtner F,Lacher SM,Bopp T,Mittmann T,Merkler D,Waisman A
14-0808 was used in Flow cytometry/Cell sorting to investigate the role of tumor-necrosis-factor-alpha-induced protein 3 in the central nervous system (CNS).
Tue Feb 04 00:00:00 UTC 2020
IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.
Oncoimmunology
Richardson LG,Nieman LT,Stemmer-Rachamimov AO,Zheng XS,Stafford K,Nagashima H,Miller JJ,Kiyokawa J,Ting DT,Wakimoto H,Cahill DP,Choi BD,Curry WT
14-0808 was used in Immunohistochemistry to investigate the association of Tregs with IDH mutations in human glioma and a murine IDH-mutant mouse model.
Thu Aug 20 00:00:00 UTC 2020
Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma.
Journal for immunotherapy of cancer
Saha D,Rabkin SD,Martuza RL
14-0808 was used in Immunohistochemistry to examine the combination of temozolomide and an oncolytic herpes simplex virus encoding murine interleukin 12, G47Δ-mIL12, in a mouse immunocompetent glioblastoma model generated from non-immunogenic 005 glioblastoma stem-like cells.
Fri May 01 00:00:00 UTC 2020
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Nature cancer
Poillet-Perez L,Sharp DW,Yang Y,Laddha SV,Ibrahim M,Bommareddy PK,Hu ZS,Vieth J,Haas M,Bosenberg MW,Rabinowitz JD,Cao J,Guan JL,Ganesan S,Chan CS,Mehnert JM,Lattime EC,White E
14-0808-82 was used in Immunohistochemistry to study autophagy promotion of tumor immune tolerance in regulating T-cell function and limiting interferon gene stimulation.
Tue Sep 01 00:00:00 UTC 2020
Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.
Nature communications
Wang G,Xu J,Zhao J,Yin W,Liu D,Chen W,Hou SX
14-0808 was used in Immunohistochemistry-immunofluorescence to reveal that Arf1-pathway knockdown not only kills cancer stem cells (CSCs) but also elicits a tumor-specific immune response that converts dying CSCs into a therapeutic vaccine, leading to durable benefits.
Fri Jan 10 00:00:00 UTC 2020
In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Journal for immunotherapy of cancer
Clark PA,Sriramaneni RN,Jin WJ,Jagodinsky JC,Bates AM,Jaquish AA,Anderson BR,Le T,Lubin JA,Chakravarty I,Arthur IS,Heinze CM,Guy EI,Kler J,Klar KA,Carlson PM,Kim KM,Kuo JS,Morris ZS
14-0808 was used in Immunohistochemistry to test whether in situ vaccination inhibits the development of brain metastases in a murine melanoma model.
Wed Jul 01 00:00:00 UTC 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
14-0808 was used in Immunohistochemistry-immunofluorescence to identify NAM as a potential strategy for the prevention and treatment of HR+ BC.
Thu Jul 30 00:00:00 UTC 2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications
von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS
14-0808 was used in Immunohistochemistry to show stimulation of glioma cell phagocytosis by blockage of anti-phagocytosis molecule CD47 is an ineffective process.
Fri Mar 20 00:00:00 UTC 2020
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
Journal for immunotherapy of cancer
Bergamaschi C,Pandit H,Nagy BA,Stellas D,Jensen SM,Bear J,Cam M,Valentin A,Fox BA,Felber BK,Pavlakis GN
14-0808 was used in Immunohistochemistry to show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of immunotherapy interventions.
Fri May 01 00:00:00 UTC 2020
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.
Nature
Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Griffin GK,Collins NB,Long AH,Doench JG,Kozono D,Levanon EY,Haining WN
14-0808 was used in Immunohistochemistry to show tumour cells can be sensitized to immunotherapy by introducing a loss of function mutation in RNA-editing enzyme ADAR1.
Tue Jan 01 00:00:00 UTC 2019
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.
Cancer cell
Dangaj D,Bruand M,Grimm AJ,Ronet C,Barras D,Duttagupta PA,Lanitis E,Duraiswamy J,Tanyi JL,Benencia F,Conejo-Garcia J,Ramay HR,Montone KT,Powell DJ,Gimotty PA,Facciabene A,Jackson DG,Weber JS,Rodig SJ,Hodi SF,Kandalaft LE,Irving M,Zhang L,Foukas P,Rusakiewicz S,Delorenzi M,Coukos G
14-0808-82 was used in Immunohistochemistry to investigate the role of chemokines in regulating T cell accumulation in solid tumors.
Mon Jun 10 00:00:00 UTC 2019
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Cancer cell
Jackstadt R,van Hooff SR,Leach JD,Cortes-Lavaud X,Lohuis JO,Ridgway RA,Wouters VM,Roper J,Kendall TJ,Roxburgh CS,Horgan PG,Nixon C,Nourse C,Gunzer M,Clark W,Hedley A,Yilmaz OH,Rashid M,Bailey P,Biankin AV,Campbell AD,Adams DJ,Barry ST,Steele CW,Medema JP,Sansom OJ
14-0808-82 was used in Immunohistochemistry to propose that NOTCH1 signaling is key to CRC progression and should be exploited clinically.
Mon Sep 16 00:00:00 UTC 2019
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.
Cell metabolism
Bieniasz-Krzywiec P,Martín-Pérez R,Ehling M,García-Caballero M,Pinioti S,Pretto S,Kroes R,Aldeni C,Di Matteo M,Prenen H,Tribulatti MV,Campetella O,Smeets A,Noel A,Floris G,Van Ginderachter JA,Mazzone M
14-0808-82 was used in Immunohistochemistry to investigate if podoplanin is involved in the attachment of tumor-associated macrophages subset to lymphatic endothelial cells (LECs).
Tue Nov 05 00:00:00 UTC 2019
CD8+ T cells induce cachexia during chronic viral infection.
Nature immunology
Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A
14-0808-82 was used in Immunohistochemistry to identify the role for CD8+ T cells in infection-associated cachexia.
Sat Jun 01 00:00:00 UTC 2019
Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Sen T,Della Corte CM,Milutinovic S,Cardnell RJ,Diao L,Ramkumar K,Gay CM,Stewart CA,Fan Y,Shen L,Hansen RJ,Strouse B,Hedrick MP,Hassig CA,Heymach JV,Wang J,Byers LA
14-0808 was used in Immunohistochemistry to show that combined treatment of SRA737, an oral CHK1 inhibitor, and anti-programmed death ligand 1 (PD-L1) leads to an antitumor response in multiple cancer models, including SCLC. As well as showing that, combining low, non-cytotoxic doses of gemcitabine with SRA737 + anti-PD-L1/anti-PD-1 significantly increased antitumorigenic CD8+ cytotoxic T cells, dendritic cells, and M1 macrophage populations in an SCLC model.
Sun Dec 01 00:00:00 UTC 2019
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.
Cancer immunology research
Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR
14-0808 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.
Mon Apr 01 00:00:00 UTC 2019
The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer.
British journal of cancer
Schreiber LM,Urbiola C,Das K,Spiesschaert B,Kimpel J,Heinemann F,Stierstorfer B,Müller P,Petersson M,Erlmann P,von Laer D,Wollmann G
14-0808 was used in Immunohistochemistry to present a case for a predominantly lytic treatment effect of chimeric vesicular stomatitis virus variant (VSV-GP) in a syngeneic mouse lung cancer model.
Tue Oct 01 00:00:00 UTC 2019
Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression.
Oncogene
Kim SJ,Garcia-Recio S,Creighton CJ,Perou CM,Rosen JM
14-0808-82 was used in Immunohistochemistry to analyzed the cellular and molecular differences between primary tumors and paired lung metastases using a syngeneic p53-null mammary tumor model of basal-like breast cancer.
Thu Aug 01 00:00:00 UTC 2019
Antiestrogens in combination with immune checkpoint inhibitors in breast cancer immunotherapy.
The Journal of steroid biochemistry and molecular biology
Márquez-Garbán DC,Deng G,Comin-Anduix B,Garcia AJ,Xing Y,Chen HW,Cheung-Lau G,Hamilton N,Jung ME,Pietras RJ
14-0808-82 was used in Immunohistochemistry to conclude that ERα antagonists that also promote ER downregulation may potentially benefit patients who are unresponsive to current endocrine therapies.
Tue Oct 01 00:00:00 UTC 2019
Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy.
Gene therapy
Mukhopadhyay A,Wright J,Shirley S,Canton DA,Burkart C,Connolly RJ,Campbell JS,Pierce RH
14-0808-82 was used in Immunohistochemistry to analyze the immunological changes induced with the new IT-pIL12/EP platform in both electroporated and distant, non-electroporated lesions.
Fri Feb 01 00:00:00 UTC 2019
A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.
Journal of mammary gland biology and neoplasia
Pénzváltó Z,Chen JQ,Tepper CG,Davis RR,Silvestrini MT,Umeh-Garcia M,Sweeney C,Borowsky AD
14-0808-82 was used in Immunohistochemistry to show that the NDLUCD cells have, so far, remained genetically and phenotypically stable over many generations, with consistent and reproducible results in immune intact preclinical cohorts.
Sat Jun 01 00:00:00 UTC 2019
Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy.
Journal for immunotherapy of cancer
Hanoteau A,Newton JM,Krupar R,Huang C,Liu HC,Gaspero A,Gartrell RD,Saenger YM,Hart TD,Santegoets SJ,Laoui D,Spanos C,Parikh F,Jayaraman P,Zhang B,Van der Burg SH,Van Ginderachter JA,Melief CJM,Sikora AG
14-0808 was used in Immunohistochemistry to identify that modulation of he tumor immune microenvironment with immunomodulatory drugs enhances susceptibility of treatment refractory tumors to chemradiotherapy.
Tue Jan 15 00:00:00 UTC 2019
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.
Cancer discovery
Kaur A,Ecker BL,Douglass SM,Kugel CH,Webster MR,Almeida FV,Somasundaram R,Hayden J,Ban E,Ahmadzadeh H,Franco-Barraza J,Shah N,Mellis IA,Keeney F,Kossenkov A,Tang HY,Yin X,Liu Q,Xu X,Fane M,Brafford P,Herlyn M,Speicher DW,Wargo JA,Tetzlaff MT,Haydu LE,Raj A,Shenoy V,Cukierman E,Weeraratna AT
14-0808-82 was used in Immunohistochemistry to suggest that although age-related physical changes in the ECM can promote tumor cell motility, they may adversely affect the motility of some immune cells, resulting in an overall change in the immune microenvironment.
Tue Jan 01 00:00:00 UTC 2019
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Scientific reports
Wang Z,Sun K,Xiao Y,Feng B,Mikule K,Ma X,Feng N,Vellano CP,Federico L,Marszalek JR,Mills GB,Hanke J,Ramaswamy S,Wang J
14-0808 was used in Immunohistochemistry on paraffin embedded tissues to investigate the therapeutic potential of combining niraparib with anti-P-1 immune checkpoint inhibitors in preclinical tumour models.
Tue Feb 12 00:00:00 UTC 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
14-0808-82 was used in Immunohistochemistry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 UTC 2019
Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells.
Science advances
Feng M,Jin JQ,Xia L,Xiao T,Mei S,Wang X,Huang X,Chen J,Liu M,Chen C,Rafi S,Zhu AX,Feng YX,Zhu D
14-0808 was used in Immunohistochemistry to develop potent, selective inhibitors targeting the Wnt/B catenin pathway.
Wed May 01 00:00:00 UTC 2019
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers.
Nature communications
Zhang F,Parayath NN,Ene CI,Stephan SB,Koehne AL,Coon ME,Holland EC,Stephan MT
14-0808-82 was used in Immunohistochemistry to reprogramme tumor-associated macrophages into tumoricidal cells using mRNA nanoparticles. Local delivery of nanoparticles is a promising theraputic target.
Tue Sep 03 00:00:00 UTC 2019
A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy.
Advanced materials (Deerfield Beach, Fla.)
Mi Y,Smith CC,Yang F,Qi Y,Roche KC,Serody JS,Vincent BG,Wang AZ
14-0808 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to demonstrate a novel strategy to improve combination immunotherapy using nanotechnology.
Fri Jun 01 00:00:00 UTC 2018
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response.
The Journal of clinical investigation
Ubil E,Caskey L,Holtzhausen A,Hunter D,Story C,Earp HS
14-0808 was used in Immunohistochemistry to demonstrate that tumour-secreted protein S, a Mer/Tyro3 ligand, decreases macrophage M1 cytokine expression in vitro and in vivo.
Fri Jun 01 00:00:00 UTC 2018
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
ACS nano
Lu J,Liu X,Liao YP,Wang X,Ahmed A,Jiang W,Ji Y,Meng H,Nel AE
14-0808 was used in Immunohistochemistry to develop a chemo-immunotherapy approach to reduce the high mortality of metastatic breast cancer, utilising a liposomal carrier to trigger immunogenic cell death.
Tue Nov 27 00:00:00 UTC 2018
Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models.
Clinical cancer research : an official journal of the American Association for Cancer Research
Saha D,Wakimoto H,Peters CW,Antoszczyk SJ,Rabkin SD,Martuza RL
14-0808-82 was used in Immunohistochemistry to evaluate the cytotoxic effects of VEFGR tyrosine kinase inhibitor (TKI) axitinib in vitro and then tested antitumor efficacy of axitinib in combination with oncolytic herpes simplex virus (oHSV) expressing antiangiogenic cytokine murine IL12 (G47Δ-mIL12) in two orthotopic GSC-derived GBM models: patient-derived recurrent MGG123 GSCs, forming vascular xenografts in immunodeficient mice; and mouse 005 GSCs, forming syngeneic tumors in immunocomp
Sun Jul 15 00:00:00 UTC 2018
CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols.
Clinical cancer research : an official journal of the American Association for Cancer Research
Seo JW,Tavaré R,Mahakian LM,Silvestrini MT,Tam S,Ingham ES,Salazar FB,Borowsky AD,Wu AM,Ferrara KW
14-0808 was used in Immunohistochemistry to develop 64Cu-169cDb as an immunoPET imaging agent to target CD8+ T-cells.
Mon Oct 15 00:00:00 UTC 2018
Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay.
Cancer research
Gallotta M,Assi H,Degagné É,Kannan SK,Coffman RL,Guiducci C
14-0808 was used in Immunohistochemistry-immunofluorescence to demonstrate that local delivery of a toll-like receptor 9 agonist can change the immune content of an entire organ and enhance the efficacy of immune checkpoint inhibition.
Sat Sep 01 00:00:00 UTC 2018
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB
14-0808 was used in Immunohistochemistry to show that p38/MAPKAP Kinase 2 activity in the myeloid compartment promotes tumour progression by supporting tumour neoangiogenesis in vivo.
Tue May 01 00:00:00 UTC 2018
Immune checkpoint inhibition by anti-PDCD1 (anti-PD1) monoclonal antibody has significant therapeutic activity against central nervous system lymphoma in an immunocompetent preclinical model.
British journal of haematology
Qiu Y,Li Z,Pouzoulet F,Vishnu P,Copland JA,Knutson KL,Soussain C,Tun HW
14-0808 was used in Immunohistochemistry to perform a preclinical evaluation of anti-PDCD1 (anti-PD1) therapy in an immunocompetent orthotopic murine CNSL model.
Thu Nov 01 00:00:00 UTC 2018
Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.
International journal of cancer
Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ
14-0808 was used in Immunohistochemistry to study the role of alterations in macrophage recruitment and phenotype switching in the anti-cancer response produced in a mouse model of lung cancer chemoprevention with myo-inositol.
Sun Apr 01 00:00:00 UTC 2018
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
Nature communications
McGrail DJ,Federico L,Li Y,Dai H,Lu Y,Mills GB,Yi S,Lin SY,Sahni N
Tue Apr 03 00:00:00 UTC 2018
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.
PloS one
Yu JW,Bhattacharya S,Yanamandra N,Kilian D,Shi H,Yadavilli S,Katlinskaya Y,Kaczynski H,Conner M,Benson W,Hahn A,Seestaller-Wehr L,Bi M,Vitali NJ,Tsvetkov L,Halsey W,Hughes A,Traini C,Zhou H,Jing J,Lee T,Figueroa DJ,Brett S,Hopson CB,Smothers JF,Hoos A,Srinivasan R
14-0808 was used in Immunohistochemistry to characterise the tumour microenvironment of four commonly used syngeneic tumour models, and assess the range of immunogenicities they encompass.
Mon Apr 08 00:00:00 UTC 2019
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.
Hepatology communications
Morrison MC,Verschuren L,Salic K,Verheij J,Menke A,Wielinga PY,Iruarrizaga-Lejarreta M,Gole L,Yu WM,Turner S,Caspers MPM,Martínez-Arranz I,Pieterman E,Stoop R,van Koppen A,van den Hoek AM,Mato JM,Hanemaaijer R,Alonso C,Kleemann R
14-0808 was used in Immunohistochemistry to show that human molecular signatures can be used to evaluate the translational character of preclinical models for nonalcoholic steatohepatitis.
Sat Dec 01 00:00:00 UTC 2018
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
Oncoimmunology
Genoud V,Marinari E,Nikolaev SI,Castle JC,Bukur V,Dietrich PY,Okada H,Walker PR
14-0808 was used in Immunohistochemistry-immunofluorescence to suggest that SB28 is a particularly suitable model for optimization of GBM immunotherapy.
Sun Apr 07 00:00:00 UTC 2024
Induction of liver-specific intrahepatic myeloid cells aggregation expands CD8 T cell and inhibits growth of murine hepatoma.
Oncoimmunology
Lin YC,Hsu CY,Huang SK,Fan YH,Huang CH,Yang CK,Su WT,Chang PC,Dutta A,Liu YJ,Huang CT,Chen TC,Lin CY
14-0808 was used in Immunohistochemistry to study how the administration of a TLR9 agonist could be utilised as a liver-specific tumor immunotherapy.
Wed Oct 04 00:00:00 UTC 2023
Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II.
Oncoimmunology
Li HY,McSharry M,Walker D,Johnson A,Kwak J,Bullock B,Neuwelt A,Poczobutt JM,Sippel TR,Keith RL,Weiser-Evans MCM,Clambey E,Nemenoff RA
14-0808-82 was used in Immunohistochemistry to demonstrate that prostacyclin can inhibit lung cancer progression and suggest that prostacyclin analogs may serve as novel immunomodulatory agents in a subset of lung cancer patients.
Tue Jan 12 00:00:00 UTC 2021
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event.
Cell death & disease
Messenger ZJ,Hall JR,Jima DD,House JS,Tam HW,Tokarz DA,Smart RC
14-0808 was used in Immunohistochemistry to show that the deletion C/EBPΒ in pre-existing oncogenic Ha-Ras mouse skin tumors in vivo resulted in rapid tumor regression.
Mon Oct 15 00:00:00 UTC 2018
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Cell reports
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
14-0808 was used in Immunohistochemistry to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 UTC 2018
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Nature
Manguso RT,Pope HW,Zimmer MD,Brown FD,Yates KB,Miller BC,Collins NB,Bi K,LaFleur MW,Juneja VR,Weiss SA,Lo J,Fisher DE,Miao D,Van Allen E,Root DE,Sharpe AH,Doench JG,Haining WN
14-0808 was used in Immunohistochemistry to use in vivo genetic screening with CRISPR-Cas9 genome editing in transplantable tumours in immunotherapy treated mice to discover undescribed immunotherapy targets.
Thu Jul 27 00:00:00 UTC 2017
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.
Cell
Topper MJ,Vaz M,Chiappinelli KB,DeStefano Shields CE,Niknafs N,Yen RC,Wenzel A,Hicks J,Ballew M,Stone M,Tran PT,Zahnow CA,Hellmann MD,Anagnostou V,Strissel PL,Strick R,Velculescu VE,Baylin SB
14-0808 was used in Immunohistochemistry to investigate the pharmacologic and isoform specificity of HDACis to guide their addition to a DNMTi, thus devising a new treatment regimen for non-small-cell lung cancer.
Thu Nov 30 00:00:00 UTC 2017
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.
The Journal of experimental medicine
Rashidian M,Ingram JR,Dougan M,Dongre A,Whang KA,LeGall C,Cragnolini JJ,Bierie B,Gostissa M,Gorman J,Grotenbreg GM,Bhan A,Weinberg RA,Ploegh HL
14-0808 was used in Immunohistochemistry to discover the possible use of immuno-PET to monitor antitumor immune responses as a prognostic tool predicting patient response to checkpoint therapies.
Mon Aug 07 00:00:00 UTC 2017
Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies.
Cancer research
Rios-Doria J,Harper J,Rothstein R,Wetzel L,Chesebrough J,Marrero A,Chen C,Strout P,Mulgrew K,McGlinchey K,Fleming R,Bezabeh B,Meekin J,Stewart D,Kennedy M,Martin P,Buchanan A,Dimasi N,Michelotti E,Hollingsworth R
14-0808 was used in Immunohistochemistry to investigate whether antibody-drug conjugates conjugated with pyrrolobenzodiazepine dimer or tubulysin payloads induce immunogenic cell death, modulate the immune microenvironment, and could combine with immuno-oncology drugs to enhance antitumour activity.
Mon May 15 00:00:00 UTC 2017
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma.
Neuro-oncology
Antonios JP,Soto H,Everson RG,Moughon D,Orpilla JR,Shin NP,Sedighim S,Treger J,Odesa S,Tucker A,Yong WH,Li G,Cloughesy TF,Liau LM,Prins RM
14-0808 was used in Immunohistochemistry to elucidate the role that TIMs play in mediating adaptive immune resistance in the GBM microenvironment and provide evidence that they can be manipulated pharmacologically with agents that are clinically available.
Thu Jun 01 00:00:00 UTC 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
14080882 was used in immunohistochemistry to investigate the use of red blood cells expressing disease-associated autoantigenas a means of inducing antigen-specific tolerance
Tue Mar 21 00:00:00 UTC 2017
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.
Circulation. Heart failure
Bansal SS,Ismahil MA,Goel M,Patel B,Hamid T,Rokosh G,Prabhu SD
14-0808 was used in Immunohistochemistry to identify cardiac and splenic T cells in HF induce cardiac injury and how we can target specific leukocytes populations in immunomodulation.
Wed Mar 01 00:00:00 UTC 2017
Pathobiology of the 129:Stat1 -/- mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype.
Breast cancer research : BCR
Mori H,Chen JQ,Cardiff RD,Pénzváltó Z,Hubbard NE,Schuetter L,Hovey RC,Trott JF,Borowsky AD
14-0808 was used in Immunohistochemistry to investigate tumor progression in the 129:Stat1 (-/-) host compared with wild-type 129/SvEv, and describe the immune cell reaction to the tumors.
Sat Sep 02 00:00:00 UTC 2017
Mycobacterium tuberculosis infection modulates adipose tissue biology.
PLoS pathogens
Beigier-Bompadre M,Montagna GN,Kühl AA,Lozza L,Weiner J,Kupz A,Vogelzang A,Mollenkopf HJ,Löwe D,Bandermann S,Dorhoi A,Brinkmann V,Matuschewski K,Kaufmann SHE
14-0808 was used in Immunohistochemistry to conclude that adipose tissue is a potential niche for Mtb and that due to infection CD8+ T cells and NK cells are attracted to this tissue.
Sun Oct 01 00:00:00 UTC 2017
The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.
Oncotarget
Melis MHM,Nevedomskaya E,van Burgsteden J,Cioni B,van Zeeburg HJT,Song JY,Zevenhoven J,Hawinkels LJAC,de Visser KE,Bergman AM
14-0808-82 was used in Immunohistochemistry to provide new insights into the promoting role of the adaptive immune system in prostate cancer development.
Tue Nov 07 00:00:00 UTC 2017
Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation.
Molecular cancer
Tang X,Wang X,Zhao YY,Curtis JM,Brindley DN
14-0808 was used in Immunohistochemistry to determine the impact of doxycycline on circulating lysophosphatidate concentrations and tumor growth using a syngeneic orthotopic mouse model of breast cancer.
Wed Feb 08 00:00:00 UTC 2017
Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer.
Journal of translational medicine
Li L,Wang W,Pan H,Ma G,Shi X,Xie H,Liu X,Ding Q,Zhou W,Wang S
Tue Jan 31 00:00:00 UTC 2017
Relevance of CCL3/CCR5 axis in oral carcinogenesis.
Oncotarget
da Silva JM,Moreira Dos Santos TP,Sobral LM,Queiroz-Junior CM,Rachid MA,Proudfoot AEI,Garlet GP,Batista AC,Teixeira MM,Leopoldino AM,Russo RC,Silva TA
14-0808 was used in Immunohistochemistry to show how, in oral carcinogenesis, CCL3/CCR5 axis has pro-tumourigenic effects by inflammatory and angiogenic pathway induction and recruitment of eosinophils.
Tue Aug 01 00:00:00 UTC 2017
Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy.
Oncoimmunology
Yan X,Wang L,Zhang R,Pu X,Wu S,Yu L,Meraz IM,Zhang X,Wang JF,Gibbons DL,Mehran RJ,Swisher SG,Roth JA,Fang B
14-0808 was used in Immunohistochemistry to demonstrate that resistance to anti-PD-1 immunotherapy in syngeneic mouse lung cancer can be overcome by locoregional virotherapy.
Thu Feb 02 00:00:00 UTC 2023
Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth.
Journal of the American Heart Association
Lhoták Š,Gyulay G,Cutz JC,Al-Hashimi A,Trigatti BL,Richards CD,Igdoura SA,Steinberg GR,Bramson J,Ask K,Austin RC
Mon Aug 15 00:00:00 UTC 2016
