Product References
Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.
EMBO molecular medicine
Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Oct 11 00:00:00 UTC 2023
IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma.
The Journal of experimental medicine
Reijers ILM,Rao D,Versluis JM,Menzies AM,Dimitriadis P,Wouters MW,Spillane AJ,Klop WMC,Broeks A,Bosch LJW,Lopez-Yurda M,van Houdt WJ,Rawson RV,Grijpink-Ongering LG,Gonzalez M,Cornelissen S,Bouwman J,Sanders J,Plasmeijer E,Elshot YS,Scolyer RA,van de Wiel BA,Peeper DS,van Akkooi ACJ,Long GV,Blank CU
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2023
Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a/β-catenin pathway in the myocardium of mice after myocardial infarction.
Phytotherapy research : PTR
Tian CX,Li MY,Shuai XX,Jiang F,Dong YL,Gui Y,Zhang ZL,Qin RJ,Kang ZY,Lin L,Sarapultsev A,Wu B,Luo SS,Hu DS
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun Jan 01 00:00:00 UTC 2023
High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway.
Cancer communications (London, England)
Wen Z,Sun H,Zhang Z,Zheng Y,Zheng S,Bin J,Liao Y,Shi M,Zhou R,Liao W
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2023
Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy.
Acta pharmaceutica Sinica. B
Cheng J,Zhao H,Li B,Zhang H,Zhao Q,Fu S,Han Y,Lu W,Shi J,Yang X
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Feb 01 00:00:00 UTC 2023
ZDHHC9 promotes colon tumor growth by inhibiting effector T cells.
Oncology letters
Chong X,Zhu L,Yu D,Chen S,Wang G,Yu Q,Ma X,Xu J,Chen H,An H
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun Jan 01 00:00:00 UTC 2023
Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis.
STAR protocols
Wang R,Wang M,Pei S,Zhang Y,Guo S,Guo W,Wu Z,Wang H,Li Y,Zhu Y,Meng LH,Lang J,Jin G,Xiao Y,Hu L,Kong X
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Dec 15 00:00:00 UTC 2023
Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development.
Frontiers in endocrinology
Bruggeman Y,Martens PJ,Sassi G,Viaene M,Wasserfall CH,Mathieu C,Gysemans C
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Dec 01 00:00:00 UTC 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Feb 13 00:00:00 UTC 2023
T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles.
Nature communications
Turco V,Pfleiderer K,Hunger J,Horvat NK,Karimian-Jazi K,Schregel K,Fischer M,Brugnara G,Jähne K,Sturm V,Streibel Y,Nguyen D,Altamura S,Agardy DA,Soni SS,Alsasa A,Bunse T,Schlesner M,Muckenthaler MU,Weissleder R,Wick W,Heiland S,Vollmuth P,Bendszus M,Rodell CB,Breckwoldt MO,Platten M
12-0081-82 was used in flow cytometry to find that CDNP-R848 induces tumor regression in experimental glioma by targeting blood-borne macrophages without requiring adaptive immunity.
Sat Feb 11 00:00:00 UTC 2023
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.
Cardiovascular research
Liu T,Meng Z,Liu J,Li J,Zhang Y,Deng Z,Luo S,Wang M,Huang Q,Zhang S,Fendt P,Devouassoux J,Li D,McKenzie ANJ,Nahrendorf M,Libby P,Guo J,Shi GP
12-0081-82 was used in Flow Cytometry to reveal an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
Tue May 02 00:00:00 UTC 2023
Bioengineered bacterial outer membrane vesicles encapsulated Polybia-mastoparan I fusion peptide as a promising nanoplatform for bladder cancer immune-modulatory chemotherapy.
Frontiers in immunology
Ren C,Li Y,Cong Z,Li Z,Xie L,Wu S
12-0081-82 was used in Flow Cytometry to design an ingenious antitumor platform by loading the Polybia-mastoparan I (MPI) fusion peptide into OMVs.
Mon Apr 03 00:00:00 UTC 2023
Caveolin-mediated cytosolic delivery of spike nanoparticle enhances antitumor immunity of neoantigen vaccine for hepatocellular carcinoma.
Theranostics
Lin Z,Jiang C,Wang P,Chen Q,Wang B,Fu X,Liang Y,Zhang D,Zeng Y,Liu X
12-0081-82 was used in Flow Cytometry to find that V-scVLPs can efficiently co-deliver the hepatocellular carcinoma (HCC)-specific neoantigen and the TLR9 agonist to DCs via caveolin-mediated endocytosis.
Thu Aug 10 00:00:00 UTC 2023
NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.
iScience
Valadares DG,Clay OS,Chen Y,Scorza BM,Cassel SL,Sutterwala FS,Wilson ME
12-0081-82 was used in Flow Cytometry to hypothesize that Nlrp12-expressing DCs are required for efficient dissemination and immune clearance of L. infantum from the site of initial infection.
Fri Mar 17 00:00:00 UTC 2023
Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells.
Nature communications
Iwanami N,Richter AS,Sikora K,Boehm T
12-0081-82 was used in Flow cytometry/Cell sorting to identify a role for Tnpo3 in regulating the splicing of the pre-mRNA encoding the cognate TCRα chain of iNKT cells.
Tue Jun 20 00:00:00 UTC 2023
RIPK3 controls MAIT cell accumulation during development but not during infection.
Cell death & disease
Patton T,Zhao Z,Lim XY,Eddy E,Wang H,Nelson AG,Ennis B,Eckle SBG,Souter MNT,Pediongco TJ,Koay HF,Zhang JG,Djajawi TM,Louis C,Lalaoui N,Jacquelot N,Lew AM,Pellicci DG,McCluskey J,Zhan Y,Chen Z,Lawlor KE,Corbett AJ
12-0081-82 was used in Flow cytometry/Cell sorting to suggest that, distinct from conventional T cells, the accumulation of MAIT cells is restrained by RIPK3 signalling, likely prior to thymic egress, in a manner independent of canonical apoptotic and necroptotic cell death pathways.
Sat Feb 11 00:00:00 UTC 2023
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Nature immunology
Scherer S,Oberle SG,Kanev K,Gerullis AK,Wu M,de Almeida GP,Puleston DJ,Baixauli F,Aly L,Greco A,Nizharadze T,Becker NB,Hoesslin MV,Donhauser LV,Berner J,Chu T,McNamara HA,Esencan Z,Roelli P,Wurmser C,Kleiter I,Vehreschild MJGT,Mayer CA,Knolle P,Klingenspor M,Fumagalli V,Iannacone M,Prlic M,Korn T,Pearce EL,Höfer T,Schulz AM,Zehn D
12-0081-82 was used in Flow cytometry/Cell sorting to show memory T cell precursors are resistant to pyrimidine starvation.
Wed Mar 01 00:00:00 UTC 2023
Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model.
Acta pharmaceutica Sinica. B
Zhang L,Zhu Y,Wei X,Chen X,Li Y,Zhu Y,Xia J,Huang Y,Huang Y,Wang J,Pang Z
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Aug 01 00:00:00 UTC 2022
The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.
PLoS biology
Tóth K,Lénárt N,Berki P,Fekete R,Szabadits E,Pósfai B,Cserép C,Alatshan A,Benkő S,Kiss D,Hübner CA,Gulyás A,Kaila K,Környei Z,Dénes Á
12-0081-82 was used in Flow Cytometry to investigate the function of NKCC1 ion transporter in microglia and inflammation in brain.
Sat Jan 01 00:00:00 UTC 2022
The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.
PLoS biology
Tóth K,Lénárt N,Berki P,Fekete R,Szabadits E,Pósfai B,Cserép C,Alatshan A,Benkő S,Kiss D,Hübner CA,Gulyás A,Kaila K,Környei Z,Dénes Á
12-0081-82 was used in Flow Cytometry to investigate the function of NKCC1 ion transporter in microglia and inflammation in brain.
Sat Jan 01 00:00:00 UTC 2022
Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.
Frontiers in aging neuroscience
Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Aug 26 00:00:00 UTC 2022
Neoantigen vaccine-induced CD4 T cells confer protective immunity in a mouse model of multiple myeloma through activation of CD8 T cells against non-vaccine, tumor-associated antigens.
Journal for immunotherapy of cancer
Bekri S,Rodney-Sandy R,Gruenstein D,Mei A,Bogen B,Castle J,Levey D,Cho HJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Feb 01 00:00:00 UTC 2022
Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement.
Nature communications
Liu J,Wang Y,Mu C,Li M,Li K,Li S,Wu W,Du L,Zhang X,Li C,Peng W,Shen J,Liu Y,Yang D,Zhang K,Ning Q,Fu X,Zeng Y,Ni Y,Zhou Z,Liu Y,Hu Y,Zheng X,Wen T,Li Z,Liu Y
12-0081-82 was used in Flow cytometry/Cell sorting to formulate a DNA-barcoded micellular system (DMS) encapsulating the Pin1 inhibitor AG17724.
Mon Jul 25 00:00:00 UTC 2022
Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement.
Nature communications
Liu J,Wang Y,Mu C,Li M,Li K,Li S,Wu W,Du L,Zhang X,Li C,Peng W,Shen J,Liu Y,Yang D,Zhang K,Ning Q,Fu X,Zeng Y,Ni Y,Zhou Z,Liu Y,Hu Y,Zheng X,Wen T,Li Z,Liu Y
12-0081-82 was used in Flow cytometry/Cell sorting to formulate a DNA-barcoded micellular system (DMS) encapsulating the Pin1 inhibitor AG17724.
Mon Jul 25 00:00:00 UTC 2022
Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation.
Nature cell biology
Meacham CE,Jeffery EC,Burgess RJ,Sivakumar CD,Arora MA,Stanley AM,Colby EM,Crane GM,Zhao Z,Morrison SJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun May 01 00:00:00 UTC 2022
Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance.
Disease markers
Zhang Y,Chang Y,Han Z,Ma K,Zeng X,Li L
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Oct 18 00:00:00 UTC 2022
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.
Nature communications
Schneider KM,Mohs A,Gui W,Galvez EJC,Candels LS,Hoenicke L,Muthukumarasamy U,Holland CH,Elfers C,Kilic K,Schneider CV,Schierwagen R,Strnad P,Wirtz TH,Marschall HU,Latz E,Lelouvier B,Saez-Rodriguez J,de Vos W,Strowig T,Trebicka J,Trautwein C
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Jul 08 00:00:00 UTC 2022
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.
Theranostics
Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Aug 16 00:00:00 UTC 2022
Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade.
Science advances
Lee H,Guo Y,Ross JL,Schoen S,Degertekin FL,Arvanitis C
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Nov 16 00:00:00 UTC 2022
Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.
Nature cancer
Shen M,Smith HA,Wei Y,Jiang YZ,Zhao S,Wang N,Rowicki M,Tang Y,Hang X,Wu S,Wan L,Shao ZM,Kang Y
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sat Jan 01 00:00:00 UTC 2022
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Cancers
Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I
12-0081-82 was used in Flow cytometry/Cell sorting to show that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth.
Wed Aug 31 00:00:00 UTC 2022
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Cancers
Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I
12-0081-82 was used in Flow cytometry/Cell sorting to show that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth.
Wed Aug 31 00:00:00 UTC 2022
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Cellular and molecular gastroenterology and hepatology
Serra M,Di Matteo M,Serneels J,Pal R,Cafarello ST,Lanza M,Sanchez-Martin C,Evert M,Castegna A,Calvisi DF,Mazzone M,Columbano A
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Aug 29 00:00:00 UTC 2022
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
eLife
Li J,Huang D,Lei B,Huang J,Yang L,Nie M,Su S,Zhao Q,Wang Y
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Dec 09 00:00:00 UTC 2022
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
12-0081-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 UTC 2022
Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.
Molecular oncology
Ma W,Wan Y,Zhang J,Yao J,Wang Y,Lu J,Liu H,Huang X,Zhang X,Zhou H,He Y,Wu D,Wang J,Zhao Y
12-0081-82 was used in Flow cytometry/Cell sorting to suggest that targeting the GAS2/CXCR4 axis is a potential therapeutic strategy for T-ALL.
Sat Oct 01 00:00:00 UTC 2022
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Frontiers in immunology
Kuttke M,Hromadová D,Yildirim C,Brunner JS,Vogel A,Paar H,Peters S,Weber M,Hofmann M,Kerndl M,Kieler M,Datler H,Musiejovsky L,Salzmann M,Lang M,Soukup K,Halfmann A,Sharif O,Schabbauer G
12-0081-82 was used in Flow cytometry/Cell sorting to show that the PI3K signaling pathway in dendritic cells contributes to disease pathology by promoting IL-6 mediated Th1 responses.
Mon May 09 00:00:00 UTC 2022
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
12-0081-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 UTC 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
12-0081-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 UTC 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
12-0081 was used in Flow cytometry/Cell sorting to identify a new role for AIM2 in controlling the onset of EAE.
Mon May 03 00:00:00 UTC 2021
Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.
EMBO molecular medicine
Mondal T,Shivange GN,Tihagam RG,Lyerly E,Battista M,Talwar D,Mosavian R,Urbanek K,Rashid NS,Harrell JC,Bos PD,Stelow EB,Stack MS,Bhatnagar S,Tushir-Singh J
12-0081-82 was used in Flow Cytometry, Western Blot to identify a potential clinically viable combinatorial strategy to revive solid cancer immunotherapy using death receptor agonism.
Fri Mar 05 00:00:00 UTC 2021
Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.
EMBO molecular medicine
Mondal T,Shivange GN,Tihagam RG,Lyerly E,Battista M,Talwar D,Mosavian R,Urbanek K,Rashid NS,Harrell JC,Bos PD,Stelow EB,Stack MS,Bhatnagar S,Tushir-Singh J
12-0081-82 was used in Flow Cytometry, Western Blot to identify a potential clinically viable combinatorial strategy to revive solid cancer immunotherapy using death receptor agonism.
Fri Mar 05 00:00:00 UTC 2021
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.
Proceedings of the National Academy of Sciences of the United States of America
McCorkell KA,Jayachandran N,Cully MD,Freund-Brown J,Weinkopff T,Monslow J,Hu Y,Puré E,Freedman BD,Alvarez JI,Cancro MP,May MJ
12-0081-82 was used in Flow cytometry/Cell sorting to reveal that IKK-α in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and establish that LEC-intrinsic IKK-α is absolutely essential for LN formation.
Tue Nov 30 00:00:00 UTC 2021
Exploiting a Rose Bengal-bearing, oxygen-producing nanoparticle for SDT and associated immune-mediated therapeutic effects in the treatment of pancreatic cancer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Nicholas D,Nesbitt H,Farrell S,Logan K,McMullin E,Gillan T,Kelly P,O'Rourke D,Porter S,Thomas K,O'Hagan BMG,Nomikou N,Callan B,Callan JF,McHale AP
12-0081-82 was used in Flow cytometry/Cell sorting to describe a robust means of preparing a pH-sensitive polymethacrylate-coated CaO2 nanoparticle that is capable of transiently alleviating tumour hypoxia.
Tue Jun 01 00:00:00 UTC 2021
Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
Frontiers in immunology
Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Feb 14 00:00:00 UTC 2022
IL-10-/- Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways.
Frontiers in immunology
Li Q,Li X,Quan H,Wang Y,Qu G,Shen Z,He C
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Sep 27 00:00:00 UTC 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-0081-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 UTC 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-0081-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 UTC 2021
Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-Associated Colon Cancer via Inhibiting Immune Tolerance.
Cellular and molecular gastroenterology and hepatology
Zhang X,Liu X,Zhou W,Du Q,Yang M,Ding Y,Hu R
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Mar 25 00:00:00 UTC 2022
G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.
Cell death & disease
Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jun 08 00:00:00 UTC 2021
Transient activation of tumoral DNA damage tolerance pathway coupled with immune checkpoint blockade exerts durable tumor regression in mouse melanoma.
Pigment cell & melanoma research
Zhuo M,Gorgun FM,Tyler DS,Englander EW
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sat May 01 00:00:00 UTC 2021
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
12-0081-82 was used in Flow cytometry/Cell sorting to unveil a new role of MSCs-Exo containing miR-223 in the treatment of acute graft-versus-host disease (aGvHD).
Fri Feb 26 00:00:00 UTC 2021
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
12-0081-82 was used in Flow cytometry/Cell sorting to unveil a new role of MSCs-Exo containing miR-223 in the treatment of acute graft-versus-host disease (aGvHD).
Fri Feb 26 00:00:00 UTC 2021
Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression.
Journal for immunotherapy of cancer
Pierini S,Mishra A,Perales-Linares R,Uribe-Herranz M,Beghi S,Giglio A,Pustylnikov S,Costabile F,Rafail S,Amici A,Facciponte JG,Koumenis C,Facciabene A
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2021
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Nature communications
Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Jul 14 00:00:00 UTC 2021
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
Frontiers in immunology
Di Giorgio E,Wang L,Xiong Y,Christensen LM,Akimova T,Han R,Samanta A,Trevisanut M,Brancolini C,Beier UH,Hancock WW
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Dec 17 00:00:00 UTC 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
12-0081 was used in Flow cytometry/Cell sorting to report enhanced toxicity of combined MDM2i and BETi towards AML cell lines, primary human blasts and mouse models, resulting from BETi's ability to evict an unexpected repressive form of BRD4 from p53 target genes, and hence potentiate MDM2i-induced p53 activation.
Mon Jan 11 00:00:00 UTC 2021
MITF induces escape from innate immunity in melanoma.
Journal of experimental & clinical cancer research : CR
Sánchez-Del-Campo L,Martí-Díaz R,Montenegro MF,González-Guerrero R,Hernández-Caselles T,Martínez-Barba E,Piñero-Madrona A,Cabezas-Herrera J,Goding CR,Rodríguez-López JN
12-0081-82 was used in Flow Cytometry to examine the potential role of the lineage survival oncogene MITF to modulate the anti-melanoma immune response.
Wed Mar 31 00:00:00 UTC 2021
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.
Nature communications
Zhao Z,Wang H,Shi M,Zhu T,Pediongco T,Lim XY,Meehan BS,Nelson AG,Fairlie DP,Mak JYW,Eckle SBG,de Lima Moreira M,Tumpach C,Bramhall M,Williams CG,Lee HJ,Haque A,Evrard M,Rossjohn J,McCluskey J,Corbett AJ,Chen Z
12-0081-82 was used in Flow Cytometry to highlight the potential utility of targeting MAIT cells to combat a range of bacterial pathogens.
Fri Jul 16 00:00:00 UTC 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon May 10 00:00:00 UTC 2021
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
iScience
Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A
12-0081-82 was used in Flow Cytometry to demonstrate that both isoforms contribute to T cell function to different degrees.
Fri Jun 25 00:00:00 UTC 2021
Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction.
eLife
Ramos MIP,Tian L,de Ruiter EJ,Song C,Paucarmayta A,Singh A,Elshof E,Vijver SV,Shaik J,Bosiacki J,Cusumano Z,Jensen C,Willumsen N,Karsdal MA,Liu L,Langermann S,Willems S,Flies D,Meyaard L
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Jun 14 00:00:00 UTC 2021
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-0081 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 UTC 2020
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
The Journal of experimental medicine
Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Jul 06 00:00:00 UTC 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Oct 07 00:00:00 UTC 2020
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
EMBO molecular medicine
Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L
12-0081 was used in Flow cytometry/Cell sorting to determine steps within PD-1 signalling pathway that can be targeted in anticancer drugs.
Mon Jun 08 00:00:00 UTC 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
12-0081 was used in Flow cytometry/Cell sorting to study the HDAC inhibitor CG-745 and its function to enable the synergistic effects of the immune checkpoint inhibitor combination therapy in various cancers by suppressing tumor microenvironment.
Mon Sep 28 00:00:00 UTC 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
12-0081 was used in Flow cytometry/Cell sorting to study the HDAC inhibitor CG-745 and its function to enable the synergistic effects of the immune checkpoint inhibitor combination therapy in various cancers by suppressing tumor microenvironment.
Mon Sep 28 00:00:00 UTC 2020
IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion.
Molecular medicine reports
Liu M,Li Z,Yao W,Zeng X,Wang L,Cheng J,Ma B,Zhang R,Min W,Wang H
12-0081-82 was used in Flow Cytometry to investigate whether an iindoleamine 2,3‚dioxygenase (IDO) inhibitor synergized with radiotherapy (RT) can further inhibit tumor growth.
Wed Jan 01 00:00:00 UTC 2020
Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion.
Oncology letters
Shang K,Wang Z,Hu Y,Huang Y,Yuan K,Yu Y
12-0081 was used in Flow cytometry/Cell sorting to study the association between Indoleamine 2,3-dioxygenase 1 (IDO1) and T-cell exhaustion during tumor progression.
Mon Jun 01 00:00:00 UTC 2020
Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion.
Oncology letters
Shang K,Wang Z,Hu Y,Huang Y,Yuan K,Yu Y
12-0081 was used in Flow cytometry/Cell sorting to study the association between Indoleamine 2,3-dioxygenase 1 (IDO1) and T-cell exhaustion during tumor progression.
Mon Jun 01 00:00:00 UTC 2020
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease.
Experimental and therapeutic medicine
Li W,Chen S,Luo Y,Xia Y,Ma Q,Yao Q,Wu J
12-0081-83 was used in Immunocytochemistry, Flow Cytometry to investigate the infiltration of T cells in lesions in the central nervous system, in patients with and without Parkinson's Disease.
Sat Aug 01 00:00:00 UTC 2020
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease.
Experimental and therapeutic medicine
Li W,Chen S,Luo Y,Xia Y,Ma Q,Yao Q,Wu J
12-0081-83 was used in Immunocytochemistry, Flow Cytometry to investigate the infiltration of T cells in lesions in the central nervous system, in patients with and without Parkinson's Disease.
Sat Aug 01 00:00:00 UTC 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
12-0081-82 was used in Flow Cytometry to suggest that mini dendritic cell (DC) may serve as a facile and potent vaccine to boost anticancer immunotherapy.
Wed Apr 01 00:00:00 UTC 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
12-0081-82 was used in Flow Cytometry to suggest that mini dendritic cell (DC) may serve as a facile and potent vaccine to boost anticancer immunotherapy.
Wed Apr 01 00:00:00 UTC 2020
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
Aging
Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W
12-0081 was used in Flow cytometry/Cell sorting to provide important and novel insight into a regulatory axis involving microRNA-200a/PTEN/ PD-L1 axis, which determines osteosarcoma growth and the efficacy of PD-L1-targeted immunotherapy.
Fri Jan 24 00:00:00 UTC 2020
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
Aging
Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W
12-0081 was used in Flow cytometry/Cell sorting to provide important and novel insight into a regulatory axis involving microRNA-200a/PTEN/ PD-L1 axis, which determines osteosarcoma growth and the efficacy of PD-L1-targeted immunotherapy.
Fri Jan 24 00:00:00 UTC 2020
TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis.
Cancers
Chan YL,Lai WC,Chen JS,Tseng JT,Chuang PC,Jou J,Lee CT,Sun HS
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Jul 08 00:00:00 UTC 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Sep 17 00:00:00 UTC 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-0081-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 UTC 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-0081-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 UTC 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Mar 31 00:00:00 UTC 2020
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Nature communications
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
12-0081 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 UTC 2020
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Nature communications
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
12-0081 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 UTC 2020
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
NPJ vaccines
Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S
12-0081 was used in Flow cytometry/Cell sorting to demonstrate safe inclusion of IL-1β as an adjuvant in vaccination strategies, leading to full protection of mice against a high influenza virus challenge dose by raising potent T cell responses.
Tue Sep 19 00:00:00 UTC 2023
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
NPJ vaccines
Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S
12-0081 was used in Flow cytometry/Cell sorting to demonstrate safe inclusion of IL-1β as an adjuvant in vaccination strategies, leading to full protection of mice against a high influenza virus challenge dose by raising potent T cell responses.
Tue Sep 19 00:00:00 UTC 2023
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Mar 26 00:00:00 UTC 2021
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Aug 20 00:00:00 UTC 2020
Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime.
Frontiers in immunology
Zhang Z,Lu S,Dunmall LSC,Wang Z,Cheng Z,Zhang Z,Yan W,Chu Y,Gao D,Wang N,Li Y,Wang J,Li Y,Ji Y,Shan D,Li K,Wang P,Dong Y,Dong J,Lemoine NR,Pei D,Zhang L,Wang Y
12-0081 was used in Flow cytometry/Cell sorting to establish how a Virus-Infected Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can be utilised for treatment or prevention of lung cancer development in at-risk individuals.
Fri Apr 30 00:00:00 UTC 2021
SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity.
Cell reports
Khouili SC,Cook ECL,Hernández-García E,Martínez-López M,Conde-Garrosa R,Iborra S
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that SHP-1 inhibition improves CD11c+ cell-based vaccination against the parasite.
Tue Dec 01 00:00:00 UTC 2020
NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer.
Nature communications
Qin G,Wang X,Ye S,Li Y,Chen M,Wang S,Qin T,Zhang C,Li Y,Long Q,Hu H,Shi D,Li J,Zhang K,Zhai Q,Tang Y,Kang T,Lan P,Xie F,Lu J,Deng W
12-0081-82 was used in Flow Cytometry to verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes.
Fri Apr 03 00:00:00 UTC 2020
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports
Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P
12-0081 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.
Tue Sep 22 00:00:00 UTC 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun Nov 01 00:00:00 UTC 2020
Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.
iScience
Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T
12-0081 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.
Fri Jul 24 00:00:00 UTC 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
12-0081 was used in Flow cytometry/Cell sorting to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 UTC 2020
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.
Science advances
Ma C,Yang D,Wang B,Wu C,Wu Y,Li S,Liu X,Lassen K,Dai L,Yang S
12-0081 was used in Flow cytometry/Cell sorting to provide the first demonstration of GSDMD's role in controlling colitis and a detailed delineation of the underlying mechanism.
Fri May 01 00:00:00 UTC 2020
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.
Science advances
Ma C,Yang D,Wang B,Wu C,Wu Y,Li S,Liu X,Lassen K,Dai L,Yang S
12-0081 was used in Flow cytometry/Cell sorting to provide the first demonstration of GSDMD's role in controlling colitis and a detailed delineation of the underlying mechanism.
Fri May 01 00:00:00 UTC 2020
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
PloS one
Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Nov 16 00:00:00 UTC 2020
Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.
Cell reports
Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T
12-0081 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.
Tue Jun 16 00:00:00 UTC 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
12-0081 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 UTC 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
12-0081-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 UTC 2019
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
12-0081-82 was used in Flow Cytometry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 UTC 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
12-0081-82 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.
Mon Nov 04 00:00:00 UTC 2019
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Genome research
Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C
12-0081-82 was used in Flow cytometry/Cell sorting to describe a novel, unexplored phenomenon of a potential causal contribution of PZMs in autoreactive T cells in T1D pathogenesis.
Sun Dec 01 00:00:00 UTC 2019
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Genome research
Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C
12-0081-82 was used in Flow cytometry/Cell sorting to describe a novel, unexplored phenomenon of a potential causal contribution of PZMs in autoreactive T cells in T1D pathogenesis.
Sun Dec 01 00:00:00 UTC 2019
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Molecular oncology
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
12-0081 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.
Mon Apr 01 00:00:00 UTC 2019
Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2.
Journal of immunology (Baltimore, Md. : 1950)
Liu T,Yang Q,Cao YJ,Yuan WM,Lei AH,Zhou P,Zhou W,Liu YD,Shi MH,Yang Q,Tang JY,Wang HK,Zhang H,Yu Y,Zhou J
12-0081-82 was used in Flow Cytometry to indicate that COX-1 plays an important role in the development of TFH cells.
Thu Aug 15 00:00:00 UTC 2019
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Pain research & management
Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Dec 16 00:00:00 UTC 2019
Atherogenesis in the Carotid Artery with and without Interrupted Blood Flow of Two Hyperlipidemic Mouse Strains.
Journal of vascular research
Zhao J,Huangfu C,Chang Z,Grainger AT,Liu Z,Shi W
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Jan 27 00:00:00 UTC 2020
Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.
Journal of nanobiotechnology
Yuan SJ,Xu YH,Wang C,An HC,Xu HZ,Li K,Komatsu N,Zhao L,Chen X
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Oct 17 00:00:00 UTC 2019
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.
EBioMedicine
Tong Y,Zhou L,Yang L,Guo P,Cao Y,Qin FX,Liu J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jan 01 00:00:00 UTC 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Jul 22 00:00:00 UTC 2019
SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tao Z,McCall NS,Wiedemann N,Vuagniaux G,Yuan Z,Lu B
12-0081-82 was used in Flow Cytometry to show that Debio 1143 augments the tumor-specific adaptive immunity induced by ART, while reversing host immunosuppressive cell infiltrates in the tumor microenvironment in a TNFα, IFNγ, and CD8+ T-cell-dependent manner.
Fri Feb 01 00:00:00 UTC 2019
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Nature communications
Khattar E,Maung KZY,Chew CL,Ghosh A,Mok MMH,Lee P,Zhang J,Chor WHJ,Cildir G,Wang CQ,Mohd-Ismail NK,Chin DWL,Lee SC,Yang H,Shin YJ,Nam DH,Chen L,Kumar AP,Deng LW,Ikawa M,Gunaratne J,Osato M,Tergaonkar V
12-0081-82 was used in Flow Cytometry to provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy.
Fri Dec 13 00:00:00 UTC 2019
Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons.
Cell reports
Salvioni A,Belloy M,Lebourg A,Bassot E,Cantaloube-Ferrieu V,Vasseur V,Blanié S,Liblau RS,Suberbielle E,Robey EA,Blanchard N
12-0081-82 was used in Flow Cytometry to analyze the antigen presentation mechanisms underlying CD8 T cell-mediated control of the Toxoplasma gondii parasite in the CNS.
Tue Jun 11 00:00:00 UTC 2019
Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.
Current protocols in immunology
Chen Z,Wang H,D'Souza C,Koay HF,Meehan B,Zhao Z,Pediongco T,Shi M,Zhu T,Wang B,Kjer-Nielsen L,Eckle SBG,Rossjohn J,Fairlie DP,Godfrey DI,Strugnell RA,McCluskey J,Corbett AJ
12-0081-82 was used in Flow cytometry/Cell sorting to provide a step-by-step protocol for mucosal-associated invariant T (MAIT) cell sorting and adoptive transfer.
Sun Dec 01 00:00:00 UTC 2019
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
12-0081 was used in Immunohistochemistry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.
Tue Feb 20 00:00:00 UTC 2018
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Immunity
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
12-0081 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 UTC 2018
Insulin resistance causes inflammation in adipose tissue.
The Journal of clinical investigation
Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN
12-0081 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.
Mon Apr 02 00:00:00 UTC 2018
STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research
Moreira D,Adamus T,Zhao X,Su YL,Zhang Z,White SV,Swiderski P,Lu X,DePinho RA,Pal SK,Kortylewski M
12-0081 was used in Flow cytometry/Cell sorting to show a novel strategy combining STAT3 inhibition with Toll-like Receptor 9 (TLR9) stimulation to unleash immune response against prostate cancers regardless of the genetic background.
Sat Dec 01 00:00:00 UTC 2018
Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin.
Cancer immunology research
Bąbała N,Bovens A,de Vries E,Iglesias-Guimarais V,Ahrends T,Krummel MF,Borst J,Bins AD
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that tight junction protein-1 cannot be used as a marker of tight junctions in a variety of cells.
Sun Jul 01 00:00:00 UTC 2018
A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors.
PLoS pathogens
Leoni V,Vannini A,Gatta V,Rambaldi J,Sanapo M,Barboni C,Zaghini A,Nanni P,Lollini PL,Casiraghi C,Campadelli-Fiume G
12-0081 was used in Flow cytometry/Cell sorting to analyse the efficacy of a fully-virulent HER2-retargeted oncolytic HSV, demonstrating its ability to elicit a local immune response and systemic therapy vaccine effects.
Wed Aug 01 00:00:00 UTC 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.
Oncology reports
Lei H,Wang G,Zhang J,Han Q
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sat Dec 01 00:00:00 UTC 2018
Absence of Receptor Guanylyl Cyclase C Enhances Ileal Damage and Reduces Cytokine and Antimicrobial Peptide Production during Oral Salmonella enterica Serovar Typhimurium Infection.
Infection and immunity
Majumdar S,Mishra V,Nandi S,Abdullah M,Barman A,Raghavan A,Nandi D,Visweswariah SS
12-0081 was used in Flow cytometry/Cell sorting to suggest that the receptor guanylyl cyclase C confers a survival advantage during gut-mediated Salmonella enterica serovar Typhimurium pathogenesis.
Tue May 01 00:00:00 UTC 2018
Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.
Experimental and therapeutic medicine
Wang P,Lu Y,Chen S,Chen Y,Hu C,Zuo Y
12-0081-82 was used in Flow Cytometry to evaluate the immunoprotective effects of Bu Shen Huo Xue formula on premature ovarian failure and the underlying mechanisms.
Sun Apr 01 00:00:00 UTC 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Nov 08 00:00:00 UTC 2018
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.
Cell reports
Ravussin A,Youm YH,Sander J,Ryu S,Nguyen K,Varela L,Shulman GI,Sidorov S,Horvath TL,Schultze JL,Dixit VD
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jul 31 00:00:00 UTC 2018
REV-ERBα Regulates TH17 Cell Development and Autoimmunity.
Cell reports
Amir M,Chaudhari S,Wang R,Campbell S,Mosure SA,Chopp LB,Lu Q,Shang J,Pelletier OB,He Y,Doebelin C,Cameron MD,Kojetin DJ,Kamenecka TM,Solt LA
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Dec 26 00:00:00 UTC 2018
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.
mSphere
Quach D,Collins F,Parameswaran N,McCabe L,Britton RA
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.
Nature communications
Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Mar 02 00:00:00 UTC 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Thu Sep 06 00:00:00 UTC 2018
Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.
Frontiers in physiology
Lim D,Kim W,Lee C,Bae H,Kim J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Sep 30 00:00:00 UTC 2020
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
12-0081 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 UTC 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
12-0081 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 UTC 2018
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.
Journal of neuroinflammation
Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Sep 21 00:00:00 UTC 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Nov 20 00:00:00 UTC 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sat Sep 01 00:00:00 UTC 2018
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Nature communications
Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G
12-0081 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.
Wed Apr 18 00:00:00 UTC 2018
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Nature communications
Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G
12-0081 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.
Wed Apr 18 00:00:00 UTC 2018
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
Cell reports
Li S,Hong Z,Wang Z,Li F,Mei J,Huang L,Lou X,Zhao S,Song L,Chen W,Wang Q,Liu H,Cai Y,Yu H,Xu H,Zeng G,Wang Q,Zhu J,Liu X,Tan N,Wang C
12-0081 was used in Flow cytometry/Cell sorting to characterise a STING-specific small-molecular inhibitor that may be applied for potentially manipulating the STING-mediated clinical diseases.
Tue Dec 18 00:00:00 UTC 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
12-0081 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 UTC 2019
Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.
Oncotarget
Nakata J,Nakajima H,Hayashibara H,Imafuku K,Morimoto S,Fujiki F,Motooka D,Okuzaki D,Hasegawa K,Hosen N,Tsuboi A,Oka Y,Kumanogoh A,Oji Y,Sugiyama H
12-0081 was used in Flow cytometry to provide the concept that in the clinical setting, combination vaccine of WT1-specific cytotoxic T lymphocyte and helper peptides would be more advantageous than the CTL peptide vaccine alone.
Tue Nov 13 00:00:00 UTC 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
12-0081 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 UTC 2018
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Cell reports
Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S
Tue Sep 11 00:00:00 UTC 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
Mon Aug 06 00:00:00 UTC 2018
A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin.
PloS one
Carlow DA,Tra MC,Ziltener HJ
12-0081 was used in Flow cytometry/Cell sorting to examine P-selectin ligand expression on activated CD8+ T cells in murine adoptive transfer models.
Tue Mar 26 00:00:00 UTC 2019
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
12-0081 was used in Flow cytometry/Cell sorting to show that the deubiquitinase POH1 negatively regulates the immune response triggered by inflammasome activation.
Fri Oct 12 00:00:00 UTC 2018
MAIT cells contribute to protection against lethal influenza infection in vivo.
Nature communications
van Wilgenburg B,Loh L,Chen Z,Pediongco TJ,Wang H,Shi M,Zhao Z,Koutsakos M,Nüssing S,Sant S,Wang Z,D'Souza C,Jia X,Almeida CF,Kostenko L,Eckle SBG,Meehan BS,Kallies A,Godfrey DI,Reading PC,Corbett AJ,McCluskey J,Klenerman P,Kedzierska K,Hinks TSC
12-0081 was used in Flow cytometry/Cell sorting to study the role of mucosal associated invariant T cells in protection against respiratory viral infections.
Fri Nov 09 00:00:00 UTC 2018
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Cell
Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC
12-0081 was used in Flow cytometry/Cell sorting to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.
Thu Mar 09 00:00:00 UTC 2017
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Cell
Kortlever RM,Sodir NM,Wilson CH,Burkhart DL,Pellegrinet L,Brown Swigart L,Littlewood TD,Evan GI
12-0081 was used in Flow cytometry/Cell sorting to show that Myc extensively programs an immune suppressive stroma that is obligatory for tumour progression.
Thu Nov 30 00:00:00 UTC 2017
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Oct 17 00:00:00 UTC 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
12-0081 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 UTC 2017
Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.
Circulation research
Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R
12-0081 was used in Flow cytometry/Cell sorting to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.
Fri Mar 31 00:00:00 UTC 2017
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.
The Journal of clinical investigation
Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM
12-0081 was used in Flow cytometry/Cell sorting to demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitising therapeutics.
Wed Mar 01 00:00:00 UTC 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Apr 12 00:00:00 UTC 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Mon Jun 05 00:00:00 UTC 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Mar 21 00:00:00 UTC 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Wed Nov 20 00:00:00 UTC 2019
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Feb 01 00:00:00 UTC 2017
Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.
Chinese medical journal
Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sat May 20 00:00:00 UTC 2017
Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1.
Immunology and cell biology
Gurung HR,Carr MM,Carr DJ
12-0081 was used in Flow cytometry/Cell sorting to suggest that newly created lymphatic vessels in the cornea driven by HSV-1 infection are critical in the delivery of soluble viral antigen to the draining lymph node.
Sun Jan 01 00:00:00 UTC 2017
Immunological phenotype of the murine Lrba knockout.
Immunology and cell biology
Gámez-Díaz L,Neumann J,Jäger F,Proietti M,Felber F,Soulas-Sprauel P,Perruzza L,Grassi F,Kögl T,Aichele P,Kilimann M,Grimbacher B,Jung S
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun Oct 01 00:00:00 UTC 2017
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA biology
Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu May 04 00:00:00 UTC 2017
Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition.
Genes & nutrition
Roselli M,Devirgiliis C,Zinno P,Guantario B,Finamore A,Rami R,Perozzi G
12-0081 was used in Flow cytometry/Cell sorting to study, using a mouse model, the effects of supplementary dietary microbes on obesity-associated inflammation and gut microbiota composition.
Thu Oct 01 00:00:00 UTC 2020
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Oct 01 00:00:00 UTC 2020
A polysaccharide component from Strongylocentrotus nudus eggs inhibited hepatocellular carcinoma in mice by activating T lymphocytes.
Oncology letters
Zhang M,Liu Y,Li J,Ke M,Yu J,Dou J,Wang H,Zhou C
12-0081 was used in Flow cytometry/Cell sorting to indicate that SEP-S is a polysaccharide component possessing high anti-hepatocellular carcinoma activity.
Wed Mar 01 00:00:00 UTC 2017
Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.
Experimental and therapeutic medicine
Wang J,Gao ZP,Qin S,Liu CB,Zou LL
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun Oct 01 00:00:00 UTC 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon May 15 00:00:00 UTC 2017
Transient Treg depletion enhances therapeutic anti-cancer vaccination.
Immunity, inflammation and disease
Fisher SA,Aston WJ,Chee J,Khong A,Cleaver AL,Solin JN,Ma S,Lesterhuis WJ,Dick I,Holt RA,Creaney J,Boon L,Robinson B,Lake RA
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nature communications
Rossey I,Gilman MS,Kabeche SC,Sedeyn K,Wrapp D,Kanekiyo M,Chen M,Mas V,Spitaels J,Melero JA,Graham BS,Schepens B,McLellan JS,Saelens X
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Feb 13 00:00:00 UTC 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Aug 01 00:00:00 UTC 2017
Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.
Oncoimmunology
Schröder M,Loos S,Naumann SK,Bachran C,Krötschel M,Umansky V,Helming L,Swee LK
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.
Oncotarget
Gao Z,Jin YQ,Wu W
12-0081 was used in Flow cytometry/Cell sorting to show that suppressor of cytokine signaling-3 (SOCS3) significantly inhibits CD8+T cell maturation, interferon-γ (IFN-γ) production and alopecia areata in mice.
Tue May 16 00:00:00 UTC 2017
SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.
Oncotarget
Gao Z,Jin YQ,Wu W
12-0081 was used in Flow cytometry/Cell sorting to show that suppressor of cytokine signaling-3 (SOCS3) significantly inhibits CD8+T cell maturation, interferon-γ (IFN-γ) production and alopecia areata in mice.
Tue May 16 00:00:00 UTC 2017
Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations.
Islets
Pawlick R,Gala-Lopez B,Pepper AR,Abualhassan N,Bruni A,Suzuki K,Rayat G,Elliott JF,Shapiro AMJ
12-0081-82 was used in Flow cytometry/Cell sorting to suggest that brief treatment of isolated islets with low energy grenz rays before allotransplantation can significantly reduce passenger leukocytes and promote graft survival, possibly by inducing donor dendritic cells to differentiate toward a tolerogenic phenotype.
Tue Jul 04 00:00:00 UTC 2017
Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations.
Islets
Pawlick R,Gala-Lopez B,Pepper AR,Abualhassan N,Bruni A,Suzuki K,Rayat G,Elliott JF,Shapiro AMJ
12-0081-82 was used in Flow cytometry/Cell sorting to suggest that brief treatment of isolated islets with low energy grenz rays before allotransplantation can significantly reduce passenger leukocytes and promote graft survival, possibly by inducing donor dendritic cells to differentiate toward a tolerogenic phenotype.
Tue Jul 04 00:00:00 UTC 2017
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.
Scientific reports
Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK
12008182 was used in flow cytometry to establish a method to isolate apoptotic bodies from cultured cells to 99% purity
Fri Jan 06 00:00:00 UTC 2017
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.
Scientific reports
Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK
12008182 was used in flow cytometry to establish a method to isolate apoptotic bodies from cultured cells to 99% purity
Fri Jan 06 00:00:00 UTC 2017
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.
Oncoimmunology
Lewis KE,Selby MJ,Masters G,Valle J,Dito G,Curtis WR,Garcia R,Mink KA,Waggie KS,Holdren MS,Grosso JF,Korman AJ,Jure-Kunkel M,Dillon SR
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jun 27 00:00:00 UTC 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Oct 11 00:00:00 UTC 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon May 21 00:00:00 UTC 2018
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Nov 16 00:00:00 UTC 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
12-0081 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 UTC 2022
γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.
Journal of neuroinflammation
Zhang X,Rocha-Ferreira E,Li T,Vontell R,Jabin D,Hua S,Zhou K,Nazmi A,Albertsson AM,Sobotka K,Ek J,Thornton C,Hagberg H,Mallard C,Leavenworth JW,Zhu C,Wang X
12-0081 was used in Flow cytometry/Cell sorting to study the contribution of different T cell subsets to white matter injury and consequent behavioural changes.
Wed Dec 20 00:00:00 UTC 2017
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
eLife
Wells AC,Daniels KA,Angelou CC,Fagerberg E,Burnside AS,Markstein M,Alfandari D,Welsh RM,Pobezinskaya EL,Pobezinsky LA
12-0081 was used in Flow cytometry/Cell sorting to identify a let-7-mediated mechanism that acts as a molecular brake controlling the magnitude of CD8 T-cell responses.
Mon Jul 24 00:00:00 UTC 2017
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
12-0081 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 UTC 2017
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Scientific reports
Soukup K,Halfmann A,Dillinger B,Poyer F,Martin K,Blauensteiner B,Kauer M,Kuttke M,Schabbauer G,Dohnal AM
12-0081 was used in Flow cytometry/Cell sorting to suggest that MAPK-activated protein kinase 2 deletion leads to an expansion of stimulatory CD103+ dendritic cells, mounting a potent CD8+ T cell anti-tumour response in mice.
Mon Sep 18 00:00:00 UTC 2017
MicroRNA expression profiles in human CD3+ T cells following stimulation with anti-human CD3 antibodies.
BMC research notes
Sousa IG,do Almo MM,Simi KC,Bezerra MA,Andrade RV,Maranhão AQ,Brigido MM
Tue Mar 14 00:00:00 UTC 2017
A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model.
Scientific reports
Kim BJ,Kim BR,Kook YH,Kim BJ
12-0081 was used in Flow cytometry/Cell sorting to evaluate the use of temperature sensitive Mycobacterium spp. for live vaccination against Mycobacterium tuberculosis and Mycobacterium abscessus.
Thu Nov 09 00:00:00 UTC 2017
Recombinant Mycobacterium smegmatis with a pMyong2 vector expressing Human Immunodeficiency Virus Type I Gag can induce enhanced virus-specific immune responses.
Scientific reports
Kim BJ,Gong JR,Kim GN,Kim BR,Lee SY,Kook YH,Kim BJ
12-0081 was used in Flow cytometry/Cell sorting to investigate the usefulness of rSmeg using pMyong2 in vaccinating against HIV-1.
Thu Mar 16 00:00:00 UTC 2017
Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.
PloS one
Hong J,Murugesan S,Betzig E,Hammer JA
12-0081 was used in Flow cytometry/Cell sorting to investigate the ligand-dependent contribution made by contractile actomyosin arcs populating the peripheral supramolecular activation cluster region of the immunological synapse to T cell receptor microcluster transport and proximal signaling in primary mouse T cells.
Mon Oct 16 00:00:00 UTC 2017
Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells.
Journal of neuroinflammation
Menendez CM,Carr DJJ
12-0081 was used in Flow cytometry/Cell sorting to characterise the capacity of Herpes simplex virus 1 to establish latency within olfactory bulb tissue and profile the local T lymphocyte response.
Fri Jun 23 00:00:00 UTC 2017
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.
Nature
Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Apr 21 00:00:00 UTC 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
12-0081 was used in Flow cytometry/Cell sorting to study how OTULIN may be critical in restraining life-threatening spontaneous inflammation and maintaining immune homeostasis.
Thu Aug 25 00:00:00 UTC 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue May 17 00:00:00 UTC 2016
Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling.
Cell metabolism
Fabbiano S,Suárez-Zamorano N,Rigo D,Veyrat-Durebex C,Stevanovic Dokic A,Colin DJ,Trajkovski M
12-0081 was used in Flow cytometry/Cell sorting to show that caloric restriction stimulates development of functional beige fat within the subcutaneous and visceral adipose tissue in mice.
Tue Sep 13 00:00:00 UTC 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2016
Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
The Journal of experimental medicine
Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.
Mon Nov 14 00:00:00 UTC 2016
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Frontiers in immunology
Akk A,Springer LE,Pham CT
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Sep 12 00:00:00 UTC 2016
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.
Frontiers in immunology
Schmitt ME,Sitte S,Voehringer D
12-0081 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.
Wed Nov 20 00:00:00 UTC 2019
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Sep 01 00:00:00 UTC 2016
New mouse model of acute adult T-cell leukemia generated by transplantation of AKT, BCLxL, and HBZ-transduced T cells.
Cancer science
Kasugai Y,Yoshida N,Ohshima K,Matsuo K,Seto M,Tsuzuki S
12-0081 was used in Flow cytometry/Cell sorting to develop methods to explore the role of candidate genes with the HBZ gene in adult T-cell leukemia/lymphoma development, producing a new mouse model.
Mon Aug 01 00:00:00 UTC 2016
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R
12-0081 was used in Flow cytometry/Cell sorting to show that small perturbations in TCR signal transduction pathways can have profound consequences on T cell differentiation and the development of autoimmune disease.
Fri Jul 15 00:00:00 UTC 2016
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
12-0081 was used in Flow cytometry/Cell sorting to study how Ccr5 is crucial in directing T cells toward the LGTV-infected brain, as well as in suppressing neutrophil-mediated inflammation within the CNS.
Wed Jun 01 00:00:00 UTC 2016
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
12-0081 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 UTC 2016
Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.
Experimental eye research
Liyanage SE,Gardner PJ,Ribeiro J,Cristante E,Sampson RD,Luhmann UF,Ali RR,Bainbridge JW
12-0081 was used in Flow cytometry/Cell sorting to demonstrate a standardised method for the identification and quantification of myeloid cells in diseased tissues.
Sat Oct 01 00:00:00 UTC 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
12-0081 was used in Flow cytometry/Cell sorting to understand the virological features of enterovirus 71 and the host responses resulting from enterovirus 71 infection.
Sun May 01 00:00:00 UTC 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Sun May 15 00:00:00 UTC 2016
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.
Nature communications
Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Oct 21 00:00:00 UTC 2016
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.
Nature communications
Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Jun 08 00:00:00 UTC 2016
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.
Scientific reports
Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Sep 13 00:00:00 UTC 2016
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Jul 11 00:00:00 UTC 2016
Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.
BMC complementary and alternative medicine
Zhang S,Liu X,Mei L,Wang H,Fang F
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that EGCG has anti-inflammatory, immune regulatory and antioxidant effects.
Wed Aug 31 00:00:00 UTC 2016
CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy.
EBioMedicine
Pourchet A,Fuhrmann SR,Pilones KA,Demaria S,Frey AB,Mulvey M,Mohr I
12-0081 was used in Flow cytometry/Cell sorting to establish TAP inhibitor-armed OVs that evade CD8(+) T-cells as an immunotherapy strategy to elicit potent anti-tumour responses.
Tue Mar 01 00:00:00 UTC 2016
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria journal
Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P
12-0081 was used in Flow cytometry/Cell sorting to evaluate the effect of artemisinins and cysteamine combination therapy on malarial phenotypes.
Fri May 06 00:00:00 UTC 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
12-0081 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 UTC 2016
Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis.
PloS one
Kamio T,Gu BW,Olson TS,Zhang Y,Mason PJ,Bessler M
12-0081 was used in Flow cytometry/Cell sorting to investigate how there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 axis which is important in normal hematopoiesis.
Fri Aug 12 00:00:00 UTC 2016
Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition.
Theranostics
Gao L,Zhang C,Gao D,Liu H,Yu X,Lai J,Wang F,Lin J,Liu Z
12-0081 was used in Flow cytometry/Cell sorting to investigate whether integrin αvβ6-targeted photodynamic therapy (PDT) of tumors using a DSAB-HK could trigger the host immune response, showing that DSAB-HK led to inhibited growth of 4T1 tumours and promoted maturation of dendritic cells.
Tue Dec 13 00:00:00 UTC 2016
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife
Yue R,Shen B,Morrison SJ
12-0081 was used in Flow cytometry/Cell sorting to study how Clec11a/Osteolectin maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Tue Dec 13 00:00:00 UTC 2016
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.
Nature communications
Szalay G,Martinecz B,Lénárt N,Környei Z,Orsolits B,Judák L,Császár E,Fekete R,West BL,Katona G,Rózsa B,Dénes Á
12-0081 was used in Flow cytometry/Cell sorting to investigate the influence of microglia on neuronal activity and survival in the injured brain in vivo.
Tue May 03 00:00:00 UTC 2016
Murine Splenic Natural Killer Cells Do Not Develop Immunological Memory after Re-Encounter with Mycobacterium bovis BCG.
PloS one
Kawahara M,Hasegawa N,Takaku H
12-0081 was used in Flow cytometry/Cell sorting to examine the manner of activation of, and the acquisition of specific memory by, natural killer cells following Bacillus Calmette-Guérin vaccination.
Sun Jul 31 00:00:00 UTC 2016
Lack of immunoediting in murine pancreatic cancer reversed with neoantigen.
JCI insight
Evans RA,Diamond MS,Rech AJ,Chao T,Richardson MW,Lin JH,Bajor DL,Byrne KT,Stanger BZ,Riley JL,Markosyan N,Winograd R,Vonderheide RH
12-0081 was used in Flow cytometry/Cell sorting to evaluate T cell immunity in an autochthonous mouse model of pancreatic cancer and identify a low mutational burden, absence of predicted neoepitopes derived from tumour mutations, and resistance to checkpoint immunotherapy.
Thu Sep 08 00:00:00 UTC 2016
Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection.
Cell death & disease
Cabral-Piccin MP,Guillermo LV,Vellozo NS,Filardy AA,Pereira-Marques ST,Rigoni TS,Pereira-Manfro WF,DosReis GA,Lopes MF
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that disposal of apoptotic CD8 T cells increases M2-macrophage differentiation and contributes to parasite persistence.
Thu May 19 00:00:00 UTC 2016
Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity.
Oncotarget
Ma J,Tian M,Fan X,Yu Q,Jing Y,Wang W,Li L,Zhou Z
12-0081 was used in Flow cytometry/Cell sorting to suggest that multistage-specific antigens could be targets for the next generation TB vaccine.
Tue Sep 27 00:00:00 UTC 2016
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Jan 01 00:00:00 UTC 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
12-0081 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 UTC 2015
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.
The Journal of clinical investigation
Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Mar 02 00:00:00 UTC 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
12-0081 was used in Flow cytometry/Cell sorting to conclude that chronic inflammatory microenvironments in old age lead to reductions in the fitness of B cell progenitor populations.
Tue Dec 01 00:00:00 UTC 2015
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
The Journal of experimental medicine
Sawada Y,Honda T,Hanakawa S,Nakamizo S,Murata T,Ueharaguchi-Tanada Y,Ono S,Amano W,Nakajima S,Egawa G,Tanizaki H,Otsuka A,Kitoh A,Dainichi T,Ogawa N,Kobayashi Y,Yokomizo T,Arita M,Nakamura M,Miyachi Y,Kabashima K
12-0081 was used in Flow cytometry/Cell sorting to study the inhibition of dendritic cell migration in the skin and the attenuation of contact hypersensitivity responses via Resolvin E1.
Mon Oct 19 00:00:00 UTC 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Jun 01 00:00:00 UTC 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Dec 29 00:00:00 UTC 2015
CD31 signals confer immune privilege to the vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Cheung K,Ma L,Wang G,Coe D,Ferro R,Falasca M,Buckley CD,Mauro C,Marelli-Berg FM
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Oct 27 00:00:00 UTC 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Jul 10 00:00:00 UTC 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
12-0081 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 UTC 2015
A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Journal of leukocyte biology
Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W
12-0081 was used in Flow cytometry/Cell sorting to identify a novel Cd8 enhancer that directs expression in CD44(hi)CD62L(+) CD8(+) T cells, including innate-like and antigen-specific effector/memory CD8(+) T cells and in CD8αα(+) DCs.
Wed Apr 01 00:00:00 UTC 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Sep 12 00:00:00 UTC 2016
Fish-oil-derived n-3 PUFAs reduce inflammatory and chemotactic adipokine-mediated cross-talk between co-cultured murine splenic CD8+ T cells and adipocytes.
The Journal of nutrition
Monk JM,Liddle DM,De Boer AA,Brown MJ,Power KA,Ma DW,Robinson LE
12-0081 was used in Flow cytometry/Cell sorting to investigate the effect of n-3 polyunsaturated fatty acidson paracrine interactions between adipocytes and primary CD8+ T cells in a ratio observed in obese adipose tissue.
Wed Apr 01 00:00:00 UTC 2015
Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.
Human vaccines & immunotherapeutics
Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon May 16 00:00:00 UTC 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
12-0081 was used in Flow cytometry/Cell sorting to show the immunogenicity and protective efficacy of the DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Fri Mar 11 00:00:00 UTC 2016
Control of the Survival and Growth of Human Glioblastoma Grafted Into the Spinal Cord of Mice by Taking Advantage of Immunorejection.
Cell transplantation
Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M
12-0081 was used in Flow cytometry/Cell sorting to establish a glioblastoma multiforme xenograft model mouse.
Mon Apr 11 00:00:00 UTC 2016
Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.
BioMed research international
Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC
12-0081-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.
Mon Aug 01 00:00:00 UTC 2016
Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice.
Bioscience of microbiota, food and health
Kishino E,Takemura N,Masaki H,Ito T,Nakazawa M
12-0081 was used in Flow cytometry/Cell sorting to examine the effects of lactosucrose (4(G)-β-D-galactosylsucrose) on influenza A virus infections in mice.
Mon Nov 23 00:00:00 UTC 2015
Adjuvant effects of recombinant giant panda (Ailuropoda melanoleuca) IL-18 on the canine distemper disease vaccine in mice.
The Journal of veterinary medical science
Yan Y,Niu L,Deng J,Wang Q,Yu J,Zhang Y,Wang J,Chen J,Wei C,Tan X
12-0081 was used in Flow cytometry/Cell sorting to investigate the effect of giant panda IL-18 on canine distemper virus.
Sun Feb 01 00:00:00 UTC 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Dec 08 00:00:00 UTC 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Apr 28 00:00:00 UTC 2016
Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.
Cell transplantation
Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Mon Nov 16 00:00:00 UTC 2015
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.
Stem cell reports
Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Nov 10 00:00:00 UTC 2015
Protection against Mycobacterium tuberculosis infection offered by a new multistage subunit vaccine correlates with increased number of IFN-γ+ IL-2+ CD4+ and IFN-γ+ CD8+ T cells.
PloS one
Wang X,Zhang J,Liang J,Zhang Y,Teng X,Yuan X,Fan X
12-0081 was used in Flow cytometry/Cell sorting to investigate protein subunit vaccinations for control of tuberculosis, showing that a new multistage subunit vaccine increases numbers of T cells and protects against TB.
Wed Mar 09 00:00:00 UTC 2016
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
12-0081 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 UTC 2016
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.
Nature communications
Nussbaum C,Bannenberg S,Keul P,Gräler MH,Gonçalves-de-Albuquerque CF,Korhonen H,von Wnuck Lipinski K,Heusch G,de Castro Faria Neto HC,Rohwedder I,Göthert JR,Prasad VP,Haufe G,Lange-Sperandio B,Offermanns S,Sperandio M,Levkau B
12-0081 was used in Flow cytometry/Cell sorting to investigate how sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilising endothelial P-selectin.
Thu Apr 02 00:00:00 UTC 2015
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
12-0081 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.
Wed Aug 12 00:00:00 UTC 2015
Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
Nature communications
Lee CL,Castle KD,Moding EJ,Blum JM,Williams N,Luo L,Ma Y,Borst LB,Kim Y,Kirsch DG
12-0081 was used in Flow cytometry/Cell sorting to show that total-body irradiation promotes the expansion of a rare population of thymocytes that express oncogenic Kras(G12D).
Thu Sep 24 00:00:00 UTC 2015
Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.
PloS one
Yu H,Sui Y,Wang Y,Sato N,Frey B,Xia Z,Waldmann TA,Berzofsky J
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of IL-15 in regulating differentiation of T helper cell subsets, showing that it constrains mucosal T helper 17 cell generation.
Mon Jun 20 00:00:00 UTC 2016
Infection with Salmonella enterica Serovar Typhimurium Leads to Increased Proportions of F4/80+ Red Pulp Macrophages and Decreased Proportions of B and T Lymphocytes in the Spleen.
PloS one
Rosche KL,Aljasham AT,Kipfer JN,Piatkowski BT,Konjufca V
12-0081 was used in Flow cytometry/Cell sorting to investigate the cause of Salmonella-induced splenomegaly, showing that significantly increased proportions of F4/80+ red pulp macrophages likely play a major role.
Thu Apr 21 00:00:00 UTC 2016
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.
PloS one
Gaddipati S,Lu Q,Kasetti RB,Miller MC,Lu Q,Trent JO,Kaplan HJ,Li Q
12-0081 was used in Flow cytometry/Cell sorting to suggest a potential clinical application of TPCA-1 delivered by microparticles in treatment of CNV in the patients with age-related macular degeneration and other retinal neovascularization diseases.
Thu Apr 07 00:00:00 UTC 2016
Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection.
PloS one
Prasad S,Hu S,Sheng WS,Singh A,Lokensgard JR
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T-cells within the mouse brain during murine cytomegalovirus infection.
Mon Jun 27 00:00:00 UTC 2016
Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation.
PloS one
Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M
12-0081 was used in Flow cytometry/Cell sorting to determine the feasibility of ablation of the tumors formed after hiPSC-NS/PC transplantation through immunoregulation.
Tue Dec 01 00:00:00 UTC 2015
Effects of Feijining Decoction on vascular endothelial growth factor protein expression and changes of T cell subsets in Lewis lung carcinoma-bearing mice.
Biomedical reports
Zhou L,Pan Y,Xing Y,Gao H,Xie X,Yin D
12-0081 was used in Flow cytometry/Cell sorting to investigate the effects of Feijining Decoction (FJND) on VEGF protein expression and T-cell subsets in Lewis lung cancer bearing mice, showing that mice treated with FJND had significantly reduced VEGF and increased splenic CD4(+) and CD4(+)/CD8(+), suggesting that FJND can inhibit tumour growth.
Fri May 01 00:00:00 UTC 2015
BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.
International journal of clinical and experimental pathology
Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF
12-0081 was used in Immunofluorescence to determine that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression in DSS-induced colitis.
Tue Mar 01 00:00:00 UTC 2016
BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.
International journal of clinical and experimental pathology
Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF
12-0081 was used in Immunofluorescence to determine that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression in DSS-induced colitis.
Tue Mar 01 00:00:00 UTC 2016
Unexpected link between an antibiotic, pannexin channels and apoptosis.
Nature
Poon IK,Chiu YH,Armstrong AJ,Kinchen JM,Juncadella IJ,Bayliss DA,Ravichandran KS
12-0081 was used in Flow cytometry/Cell sorting to show that the quinolone antibiotic trovafloxacin is a novel PANX1 inhibitor.
Thu Mar 20 00:00:00 UTC 2014
LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.
The Journal of clinical investigation
Nakamura T,Hamuro J,Takaishi M,Simmons S,Maruyama K,Zaffalon A,Bentley AJ,Kawasaki S,Nagata-Takaoka M,Fullwood NJ,Itami S,Sano S,Ishii M,Barrandon Y,Kinoshita S
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of corneal stem cells in cornea homeostasis, showing that LRIG1 inhibits STAT3-dependent inflammation to maintain homeostasis.
Wed Jan 01 00:00:00 UTC 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
12-0081 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 UTC 2014
CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.
The Journal of allergy and clinical immunology
Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N
12-0081 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.
Mon Sep 01 00:00:00 UTC 2014
Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.
Cancer research
Cheng M,Qian L,Shen G,Bian G,Xu T,Xu W,Shen G,Hu S
12-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism by which commensal bacteria modulate the efficiency of tumoral immune surveillance in mucosal tissues.
Fri Aug 01 00:00:00 UTC 2014
CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.
Mucosal immunology
Rossini V,Zhurina D,Radulovic K,Manta C,Walther P,Riedel CU,Niess JH
12-0081 was used in Flow cytometry/Cell sorting to study immune cell communication during the development of transfer colitis.
Thu May 01 00:00:00 UTC 2014
Immune enhancement activities of silk lutein extract from Bombyx mori cocoons.
Biological research
Promphet P,Bunarsa S,Sutheerawattananonda M,Kunthalert D
12-0081 was used in Flow cytometry/Cell sorting to study how silk lutein extract from Bombyx mori cocoons enhanced both innate and adaptive immune functions.
Mon Apr 28 00:00:00 UTC 2014
Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.
PLoS pathogens
Nacer A,Movila A,Sohet F,Girgis NM,Gundra UM,Loke P,Daneman R,Frevert U
12-0081 was used in Flow cytometry/Cell sorting to show that significantly more CD8(+) T cells, neutrophils, and macrophages are recruited to postcapillary venules during ECM compared to hyperparasitemia.
Mon Dec 01 00:00:00 UTC 2014
Differential presentation of endogenous and exogenous hepatitis B surface antigens influences priming of CD8(+) T cells in an epitope-specific manner.
European journal of immunology
Riedl P,Reiser M,Stifter K,Krieger J,Schirmbeck R
12-0081 was used in Flow cytometry/Cell sorting to study whether presentation of endogenous and exogenous hepatitis B virus surface antigens on antigen-presenting cells targeted by vaccination and/or virus-harbouring hepatocytes influence the de novo priming of CD8 T cells.
Tue Jul 01 00:00:00 UTC 2014
Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Stoolman JS,Duncker PC,Huber AK,Segal BM
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of CXCL2 in atypical EAE, showing that site-specific chemokine expression regulates CNS inflammation and determines clinical phenotype.
Tue Jul 15 00:00:00 UTC 2014
CD40 ligand preferentially modulates immune response and enhances protection against influenza virus.
Journal of immunology (Baltimore, Md. : 1950)
Hashem AM,Gravel C,Chen Z,Yi Y,Tocchi M,Jaentschke B,Fan X,Li C,Rosu-Myles M,Pereboev A,He R,Wang J,Li X
12-0081 was used in Flow cytometry/Cell sorting to characterise an increased in vivo load of CD40-targeted Ag upon the secretion of the NP-CD40L fusion protein from adenovirus-infected cells.
Tue Jul 15 00:00:00 UTC 2014
Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
Inflammation
Pinhu L,Qin Y,Xiong B,You Y,Li J,Sooranna SR
12-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of Fas/FasL expression to the pathogenic immune response to pancreatitis.
Fri Aug 01 00:00:00 UTC 2014
Immunomodulatory effects of polysaccharide from marine fungus Phoma herbarum YS4108 on T cells and dendritic cells.
Mediators of inflammation
Chen S,Ding R,Zhou Y,Zhang X,Zhu R,Gao XD
12-0081 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory effects of polysaccharide from a marine fungus Phoma herbarum on T cells and dendritic cells.
Tue Sep 08 00:00:00 UTC 2015
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
12-0081-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 UTC 2014
P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.
PloS one
Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Sep 17 00:00:00 UTC 2015
A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome.
Acta neuropathologica communications
Yang M,Rainone A,Shi XQ,Fournier S,Zhang J
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Jan 08 00:00:00 UTC 2014
Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis.
The Journal of biological chemistry
Bhattacharya A,Parillon X,Zeng S,Han S,Eissa NT
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Sep 19 00:00:00 UTC 2014
Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
Biochimica et biophysica acta
Winslow V,Vaivoda R,Vasilyev A,Dombkowski D,Douaidy K,Stark C,Drake J,Guilliams E,Choudhary D,Preffer F,Stoilov I,Christmas P
12-0081 was used in Flow cytometry/Cell sorting to conclude that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes.
Sun Jun 01 00:00:00 UTC 2014
Chronic thoracic spinal cord injury impairs CD8+ T-cell function by up-regulating programmed cell death-1 expression.
Journal of neuroinflammation
Zha J,Smith A,Andreansky S,Bracchi-Ricard V,Bethea JR
12-0081 was used in Flow cytometry/Cell sorting to investigate CD8+ T-cell function by up-regulating programmed cell death-1 expression in chronic thoracic spinal cord injury.
Tue Apr 01 00:00:00 UTC 2014
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
PloS one
Adkins I,Kamanova J,Kocourkova A,Svedova M,Tomala J,Janova H,Masin J,Chladkova B,Bumba L,Kovar M,Ross PJ,Tuckova L,Spisek R,Mills KH,Sebo P
12-0081 was used in Flow cytometry/Cell sorting to analyse the modulatory effects of CyaA on adhesive, migratory and antigen presenting properties of Toll-like receptor-activated murine and human dendritic cells.
Mon Nov 16 00:00:00 UTC 2015
Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice.
Scientific reports
Montufar-Solis D,Vigneswaran N,Nakra N,Schaefer JS,Klein JR
12-0081 was used in Flow cytometry/Cell sorting to investigate the intestinal immunopathology caused by insufficient Roquin, showing that hematopoietic, not systematic, impairment of Roquin expression accounts for pathology.
Mon May 12 00:00:00 UTC 2014
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
PloS one
Deroost K,Lays N,Pham TT,Baci D,Van den Eynde K,Komuta M,Prato M,Roskams T,Schwarzer E,Opdenakker G,Van den Steen PE
12-0081 was used in Flow cytometry/Cell sorting to elucidate the contribution of hemozoin to hepatic injury in mouse malaria models.
Tue Jan 26 00:00:00 UTC 2016
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Cell reports
Toso A,Revandkar A,Di Mitri D,Guccini I,Proietti M,Sarti M,Pinton S,Zhang J,Kalathur M,Civenni G,Jarrossay D,Montani E,Marini C,Garcia-Escudero R,Scanziani E,Grassi F,Pandolfi PP,Catapano CV,Alimonti A
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that immune surveillance of senescent tumour cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.
Thu Oct 09 00:00:00 UTC 2014
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Blood
Doyle AD,Jacobsen EA,Ochkur SI,McGarry MP,Shim KG,Nguyen DT,Protheroe C,Colbert D,Kloeber J,Neely J,Shim KP,Dyer KD,Rosenberg HF,Lee JJ,Lee NA
12-0081 was used in Flow cytometry/Cell sorting to investigate the contributions of the granule proteins MBP-1 and EPX to eosinophil activity using double knockout mice.
Thu Aug 01 00:00:00 UTC 2013
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
The Journal of clinical investigation
Knight DA,Ngiow SF,Li M,Parmenter T,Mok S,Cass A,Haynes NM,Kinross K,Yagita H,Koya RC,Graeber TG,Ribas A,McArthur GA,Smyth MJ
12-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of host immunity to the anti-melanoma activity of BRAF inhibitors.
Fri Mar 01 00:00:00 UTC 2013
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine
Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK
12-0081 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.
Mon Nov 18 00:00:00 UTC 2013
Dose-dense chemotherapy improves mechanisms of antitumor immune response.
Cancer research
Chang CL,Hsu YT,Wu CC,Lai YZ,Wang C,Yang YC,Wu TC,Hung CF
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Jan 01 00:00:00 UTC 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America
Yang G,Parkhurst CN,Hayes S,Gan WB
12-0081 was used in Flow cytometry/Cell sorting to examine the effect of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex in a mouse model of EAE.
Tue Jun 18 00:00:00 UTC 2013
Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis.
Frontiers in immunology
Piras G,Rattazzi L,McDermott A,Deacon R,D'Acquisto F
12-0081 was used in Flow cytometry/Cell sorting to explore a possible correlation between T cell activation and changes in emotional behavior in a multiple sclerosis mouse model.
Fri Dec 06 00:00:00 UTC 2013
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Development (Cambridge, England)
Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL
12-0081 was used in Flow cytometry/Cell sorting to demonstrate an essential and non-redundant role for Cbx4 in thymic organogenesis.
Fri Feb 01 00:00:00 UTC 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Fri Nov 01 00:00:00 UTC 2013
IRF7-dependent IFN-β production in response to RANKL promotes medullary thymic epithelial cell development.
Journal of immunology (Baltimore, Md. : 1950)
Otero DC,Baker DP,David M
12-0081 was used in Flow cytometry/Cell sorting to study the role of IRF 3/7 and type I IFNs on thymic development.
Mon Apr 01 00:00:00 UTC 2013
Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damage.
Transplantation
Shimamura M,Seleme MC,Guo L,Saunders U,Schoeb TR,George JF,Britt WJ
12-0081 was used in Flow cytometry/Cell sorting to examine the lasting effect of Ganciclovir treatment on renal allografts after the discontinuation of prophylaxis.
Tue Jan 15 00:00:00 UTC 2013
Induction of rapid apoptosis for class I MHC molecule-restricted CD8(+) HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo.
International immunology
Nakagawa Y,Shimizu M,Norose Y,Takahashi M,Takahashi H
12-0081 was used in Flow cytometry/Cell sorting to provide evidence that exposure to free antigenic peptide leads to the rapid apoptosis of activated virus-specific CD8+ CTLs during infection in vivo.
Tue Jan 01 00:00:00 UTC 2013
n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.
The Journal of nutrition
Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS
12-0081 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.
Sun Sep 01 00:00:00 UTC 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Oct 01 00:00:00 UTC 2013
The crosstalk: Tumor-infiltrating lymphocytes rich in regulatory T cells suppressed cancer-associated fibroblasts.
Acta oncologica (Stockholm, Sweden)
Fu Z,Zuo Y,Li D,Xu W,Li D,Chen H,Zheng S
12-0081 was used in Flow cytometry/Cell sorting to investigate the suppression of CAFs and NFs by Tregs-rich TILs.
Fri Nov 01 00:00:00 UTC 2013
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Jun 13 00:00:00 UTC 2013
In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.
PloS one
Cabrera M,Pewe LL,Harty JT,Frevert U
12-0081 was used in Flow cytometry/Cell sorting to better understand the mechanism of parasite elimination in vivo by monitoring CD8+ T cells in the livers a specific mouse populaion via intravital microscopy.
Tue Mar 18 00:00:00 UTC 2014
A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.
PloS one
Schuster C,Brosi H,Stifter K,Boehm BO,Schirmbeck R
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Apr 08 00:00:00 UTC 2014
Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis caused by LCMV WE.
PloS one
Khattar R,Luft O,Yavorska N,Shalev I,Phillips MJ,Adeyi O,Gao D,Bartczak A,Urbanellis P,Shyu W,Zhang J,Manuel J,Levy GA,Selzner N
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that targeting FGL2 may enhance the efficacy of current anti-viral therapies for hepatotropic viruses.
Thu Jul 24 00:00:00 UTC 2014
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.
Circulation
Dinh TN,Kyaw TS,Kanellakis P,To K,Tipping P,Toh BH,Bobik A,Agrotis A
12-0081 was used in Flow cytometry/Cell sorting to examine the capacity of a modified IL-2/anti-IL-2 monoclonal antibody treatment to expand Tregs and attenuate atherosclerosis in mice.
Tue Sep 04 00:00:00 UTC 2012
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
12-0081 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 UTC 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 UTC 2012
Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.
Cellular & molecular immunology
Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y
12-0081 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.
Sun Jan 01 00:00:00 UTC 2012
TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice.
The Journal of clinical investigation
Reinert LS,Harder L,Holm CK,Iversen MB,Horan KA,Dagnæs-Hansen F,Ulhøi BP,Holm TH,Mogensen TH,Owens T,Nyengaard JR,Thomsen AR,Paludan SR
12-0081 was used in Flow cytometry/Cell sorting to investigate the cell type that mediates the role of TLR3 in the immunological control of HSV.
Sun Apr 01 00:00:00 UTC 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
12-0081 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 UTC 2012
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
12-0081 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 UTC 2012
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Cancer research
Waitz R,Solomon SB,Petre EN,Trumble AE,Fassò M,Norton L,Allison JP
12-0081 was used in Flow cytometry/Cell sorting to demonstrate a novel combination therapy for the augmentation of antitumour immunity and metastatic rejection.
Sun Jan 15 00:00:00 UTC 2012
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Cancer research
Waitz R,Solomon SB,Petre EN,Trumble AE,Fassò M,Norton L,Allison JP
12-0081 was used in Flow cytometry/Cell sorting to demonstrate a novel combination therapy for the augmentation of antitumour immunity and metastatic rejection.
Sun Jan 15 00:00:00 UTC 2012
Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.
Oncogene
Darlington Y,Nguyen TA,Moon SH,Herron A,Rao P,Zhu C,Lu X,Donehower LA
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of WIP1 on Atm deficiency, showing that absence of WIP1 partially rescues Atm deficiency and may be a strategy for cancer treatment.
Thu Mar 01 00:00:00 UTC 2012
The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.
International journal of cancer
Hatiboglu MA,Kong LY,Wei J,Wang Y,McEnery KA,Fuller GN,Qiao W,Davies MA,Priebe W,Heimberger AB
12-0081 was used in Immunofluorescence to examine the efficacy of a treatment method using cyclophosphamide combined with WP1066 against melanoma.
Sun Jul 01 00:00:00 UTC 2012
Cytip regulates dendritic-cell function in contact hypersensitivity.
European journal of immunology
Heib V,Sparber F,Tripp CH,Ortner D,Stoitzner P,Heufler C
12-0081 was used in Flow cytometry/Cell sorting to evaluate the functional consequences of cytohesin-interacting protein (Cytip) deficiency in dendritic cells using Cytip knockout mice.
Thu Mar 01 00:00:00 UTC 2012
Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.
European journal of immunology
Dahlem T,Cho S,Spangrude GJ,Weis JJ,Weis JH
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional repressor Snai3 protein in the derivation of cells of the haematopoietic system.
Sun Apr 01 00:00:00 UTC 2012
Activated T cell exosomes promote tumor invasion via Fas signaling pathway.
Journal of immunology (Baltimore, Md. : 1950)
Cai Z,Yang F,Yu L,Yu Z,Jiang L,Wang Q,Yang Y,Wang L,Cao X,Wang J
12-0081 was used in Flow cytometry/Cell sorting to investigate the effect of FasL-containing exosomes on cell apoptosis in tumours, showing that they promote tumour invasion.
Fri Jun 15 00:00:00 UTC 2012
Cutting edge: intravascular staining redefines lung CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Anderson KG,Sung H,Skon CN,Lefrancois L,Deisinger A,Vezys V,Masopust D
12-0081 was used in Immunofluorescence to elucidate T cell trafficking and differentiation within the lung after systemic infection.
Sat Sep 15 00:00:00 UTC 2012
Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells.
Journal of immunology (Baltimore, Md. : 1950)
Richmond JM,Lee J,Green DS,Kornfeld H,Cruikshank WW
12-0081 was used in Flow cytometry/Cell sorting to examine the ability of ManLAM to desensitize T cells to other chemoattractants during mycobacterial infection.
Sat Dec 15 00:00:00 UTC 2012
Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Kaneko T,Saito Y,Kotani T,Okazawa H,Iwamura H,Sato-Hashimoto M,Kanazawa Y,Takahashi S,Hiromura K,Kusakari S,Kaneko Y,Murata Y,Ohnishi H,Nojima Y,Takagishi K,Matozaki T
12-0081 was used in Flow cytometry/Cell sorting to investigate the molecules that regulate dendritic cells to protect against autoimmunity, showing that loss of Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Fri Jun 01 00:00:00 UTC 2012
CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.
Journal of immunology (Baltimore, Md. : 1950)
Sestero CM,McGuire DJ,De Sarno P,Brantley EC,Soldevila G,Axtell RC,Raman C
12-0081 was used in Flow cytometry/Cell sorting to determine the physiological significance of CD5-dependent casein kinase 2 activation in T cells.
Sat Sep 15 00:00:00 UTC 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Tue Feb 14 00:00:00 UTC 2012
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.
Genesis (New York, N.Y. : 2000)
Berquam-Vrieze KE,Swing DA,Tessarollo L,Dupuy AJ
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Wed Feb 01 00:00:00 UTC 2012
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
12-0081 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 UTC 2012
Endostatin gene therapy stimulates upregulation of ICAM-1 and VCAM-1 in a metastatic renal cell carcinoma model.
Cancer gene therapy
Chaves KC,Peron JP,Chammas R,Turaça LT,Pesquero JB,Braga MS,Foguer K,Schor N,Bellini MH
12-0081-82 was used in Flow cytometry/Cell sorting to demonstrate an antitumor inflammatory effect of Endostatin (ES) in an mRCC model, and this effect is mediated by an increase in ICAM-1 and VCAM-1 expression in tumor-associated endothelial cells.
Wed Aug 01 00:00:00 UTC 2012
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
12-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 UTC 2011
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
The Journal of experimental medicine
Kendal AR,Chen Y,Regateiro FS,Ma J,Adams E,Cobbold SP,Hori S,Waldmann H
12-0081 was used in Flow cytometry/Cell sorting to assess the role of CD4(+)Foxp3(+) cells in infection tolerance induced by nonablative anti-T cell antibodies.
Mon Sep 26 00:00:00 UTC 2011
Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.
The Journal of experimental medicine
Pyzik M,Charbonneau B,Gendron-Pontbriand EM,Babić M,Krmpotić A,Jonjić S,Vidal SM
12-0081 was used in Flow cytometry/Cell sorting to study how multiple activating Ly49 receptors may participate in H-2-dependent recognition of MCMV infection, providing a common mechanism of NK cell-mediated resistance against viral infection.
Mon May 09 00:00:00 UTC 2011
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine
Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C
12-0081 was used in Flow cytometry/Cell sorting to validate sensitised phenotypic screening of segmental aneuploidy lines as a strategy for systematically identifying disease susceptibility genes in mice.
Sat Jan 01 00:00:00 UTC 2011
Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Lal G,Yin N,Xu J,Lin M,Schroppel S,Ding Y,Marie I,Levy DE,Bromberg JS
12-0081 was used in Flow cytometry/Cell sorting to investigate how different inflammatory signals affect Foxp3 expression and Tregs plasticity, showing that distinct signals have physiologically divergent effects on Foxp3 epigenetic regulation.
Tue Feb 01 00:00:00 UTC 2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Diabetes
Thayer TC,Delano M,Liu C,Chen J,Padgett LE,Tse HM,Annamali M,Piganelli JD,Moldawer LL,Mathews CE
12-0081 was used in Flow cytometry/Cell sorting to determine the cellular sources of ROS that are necessary for type 1 diabetes initiation, showing that superoxide production by macrophages and T cells is critical.
Mon Aug 01 00:00:00 UTC 2011
UV exposure boosts transcutaneous immunization and improves tumor immunity: cytotoxic T-cell priming through the skin.
The Journal of investigative dermatology
Stein P,Rechtsteiner G,Warger T,Bopp T,Fuhr T,Prüfer S,Probst HC,Stassen M,Langguth P,Schild H,Radsak MP
12-0081 was used in Flow Cytometry to explore the effects of ultraviolet irradiation on imiquimod-based transcutaneous immunisation.
Sat Jan 01 00:00:00 UTC 2011
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice.
Development (Cambridge, England)
Okubo T,Kawamura A,Takahashi J,Yagi H,Morishima M,Matsuoka R,Takada S
12-0081 was used in Flow cytometry/Cell sorting to show that Ripply3 can modulate Tbx1 activity and plays a role in the development of the pharyngeal apparatus.
Sat Jan 01 00:00:00 UTC 2011
IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice.
The American journal of pathology
Fujimoto H,Hirase T,Miyazaki Y,Hara H,Ide-Iwata N,Nishimoto-Hazuku A,Saris CJ,Yoshida H,Node K
12-0081 was used in Immunofluorescence to evaluate inflammatory cell infiltration to pancreatic islets in wild-type, EBI3(-/-), and WSX-1(-/-) mice treated with streptozotocin.
Tue Nov 01 00:00:00 UTC 2011
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Published figure using CD8a monoclonal antibody (Product # 12-0081-82) in Flow Cytometry
Thu Dec 01 00:00:00 UTC 2011
Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.
Journal of immunology (Baltimore, Md. : 1950)
Kondilis-Mangum HD,Shih HY,Mahowald G,Sleckman BP,Krangel MS
12-0081 was used in Flow cytometry/Cell sorting to analyse the contributions of chromatin accessibility and locus conformation to feedback inhibition.
Thu Dec 15 00:00:00 UTC 2011
Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Butler NS,Harty JT
12-0081 was used in Flow cytometry/Cell sorting to investigate how the threshold of memory CD8 T cells required for protective immunity is influenced by Plasmodium-host interactions.
Sun May 15 00:00:00 UTC 2011
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Harty JT
12-0081 was used in Flow cytometry/Cell sorting to investigate whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells, showing that attrition of Plasmodium-specific cells is rescued by booster immunisation.
Fri Apr 01 00:00:00 UTC 2011
CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Endharti AT,Okuno Y,Shi Z,Misawa N,Toyokuni S,Ito M,Isobe K,Suzuki H
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of CD8(+)CD122(+) regulatory T cells (Tregs) in maintenance of immune homeostasis, showing that CD8(+)CD122(+) Tregs and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.
Sat Jan 01 00:00:00 UTC 2011
RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency.
Gene therapy
Wang ST,Chang CC,Yen MC,Tu CF,Chu CL,Peng YT,Chen DY,Lan JL,Lin CC
12-0081 was used in Flow cytometry/Cell sorting to study whether silencing Foxo3 enhances the antitumour immunity of cancer vaccines.
Fri Apr 01 00:00:00 UTC 2011
Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.
PloS one
Pazirandeh A,Sultana T,Mirza M,Rozell B,Hultenby K,Wallis K,Vennström B,Davis B,Arner A,Heuchel R,Löhr M,Philipson L,Sollerbrant K
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that CAR exerts important functions in the physiology of several organs in vivo in mice.
Fri Sep 30 00:00:00 UTC 2011
T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.
PloS one
Moro H,Otero DC,Tanabe Y,David M
12-0081 was used in Flow cytometry/Cell sorting to demonstrate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells.
Fri Feb 03 00:00:00 UTC 2012
Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.
Journal of virology
Nakamura R,Maeda N,Shibata K,Yamada H,Kase T,Yoshikai Y
12-0081 was used in Flow cytometry/Cell sorting to determine why interleukin-15 knockout mice exhibit reduced mortality after infection with influenza virus A.
Tue Jun 01 00:00:00 UTC 2010
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
12-0081 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 UTC 2010
Dendritic cells continue to capture and present antigens after maturation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Drutman SB,Trombetta ES
12-0081 was used in Flow cytometry/Cell sorting to study the dynamics of Ag capture and presentation in situ, showing that dendritic cells continue to capture and present antigens after maturation.
Sun Aug 15 00:00:00 UTC 2010
Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.
Journal of immunology (Baltimore, Md. : 1950)
Ito H,Hoshi M,Ohtaki H,Taguchi A,Ando K,Ishikawa T,Osawa Y,Hara A,Moriwaki H,Saito K,Seishima M
12-0081 was used in Flow cytometry/Cell sorting to study the immunological effects of IDO in α-galactosylceramide (α-GalCer)-induced hepatitis.
Fri Oct 15 00:00:00 UTC 2010
CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors.
Journal of immunology (Baltimore, Md. : 1950)
Haynes NM,Hawkins ED,Li M,McLaughlin NM,Hämmerling GJ,Schwendener R,Winoto A,Wensky A,Yagita H,Takeda K,Kershaw MH,Darcy PK,Smyth MJ
12-0081 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms contributing to the antitumour activity of selective antagonism of death receptors 4 and 5, showing that CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy.
Thu Jul 01 00:00:00 UTC 2010
CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.
Infection and immunity
Eppert BL,Motz GT,Wortham BW,Flury JL,Borchers MT
12-0081 was used in Flow cytometry/Cell sorting to investigate the roles of CCR7 in the host defense against pulmonary infection, showing that CCR7 deficiency leads to leukocyte activation and increased infection clearance.
Sat May 01 00:00:00 UTC 2010
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN
Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD
12-0081 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.
Sat Aug 01 00:00:00 UTC 2009
Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.
European journal of immunology
Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H
12-0081-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.
Sat Aug 01 00:00:00 UTC 2009
CD4+ T cells are required for the priming of CD8+ T cells following infection with herpes simplex virus type 1.
Journal of virology
Rajasagi NK,Kassim SH,Kollias CM,Zhao X,Chervenak R,Jennings SR
12-0081 was used in Flow cytometry/Cell sorting to suggest that CD4(+)-T-cell help is essential for the generation of fully functional CD8(+) T cells during the primary response to Herpres Simplex Virus type-1 infection.
Fri May 01 00:00:00 UTC 2009
Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads.
Journal of virology
Lin YW,Chang KC,Kao CM,Chang SP,Tung YY,Chen SH
12-0081 was used in Flow cytometry/Cell sorting to investigate the functions of lymphocyte and antibody responses in EV71 infection.
Wed Jul 01 00:00:00 UTC 2009
Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.
Journal of immunology (Baltimore, Md. : 1950)
Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.
Wed Jul 15 00:00:00 UTC 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-0081 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 UTC 2009
The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.
Journal of immunology (Baltimore, Md. : 1950)
Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL
12-0081 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.
Sun Feb 01 00:00:00 UTC 2009
CD1d-based combination therapy eradicates established tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Teng MW,Sharkey J,McLaughlin NM,Exley MA,Smyth MJ
12-0081 was used in Flow cytometry/Cell sorting to test an approach to directly activate/mature antigen presenting cells using anti-CD1d mAbs for the treatment of cancer.
Sat Aug 01 00:00:00 UTC 2009
Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer.
Human gene therapy
Chuang CM,Monie A,Wu A,Mao CP,Hung CF
12-0081 was used in Flow cytometry/Cell sorting to demonstrate the potential of combined CpG-ODN-LL-37 peptide treatment for the control of ovarian tumours.
Wed Apr 01 00:00:00 UTC 2009
Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells.
International journal of clinical and experimental medicine
Fan H,Wang J,Zhou X,Liu Z,Zheng SG
12-0081 was used in Magnetic cell separation to investigate the use of TGF-beta-induced Treg cells to protect MHC-mismatched organ grafts from rejection in a clinical setting.
Tue Aug 25 00:00:00 UTC 2009
MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
PloS one
Kumamoto Y,Denda-Nagai K,Aida S,Higashi N,Irimura T
12-0081 was used in Flow cytometry/Cell sorting to investigate the functional and phenotypic differences between Langerhans and dermal dendritic cells, showing that macrophage galactose-type C-type lectin (MGL) 2 is only expression in dermal dendritic cells, which are sufficient to initiate contact hypersensitivity in vivo.
Thu Aug 06 00:00:00 UTC 2009
Containment of tumor-colonizing bacteria by host neutrophils.
Cancer research
Westphal K,Leschner S,Jablonska J,Loessner H,Weiss S
12-0081 was used in Flow cytometry/Cell sorting to study the ability of host neutrophils to contain tumour-colonising bacteria, and how bacteria-mediated tumour therapy may be amplified by depletion of host neutrophils.
Tue Apr 15 00:00:00 UTC 2008
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A
12-0081 was used in Flow cytometry/Cell sorting to determine that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression.
Sat Nov 01 00:00:00 UTC 2008
Programmed death-1 expression is associated with the disease status in hepatitis B virus infection.
World journal of gastroenterology
Ye P,Weng ZH,Zhang SL,Zhang JA,Zhao L,Dong JH,Jie SH,Pang R,Wei RH
12-0081 was used in Flow cytometry/Cell sorting to confirm a negative correlation between the level of PD-1 and the intensity of virus specific CD8+ T cell response.
Mon Jul 28 00:00:00 UTC 2008
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 UTC 2008
Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.
International archives of allergy and immunology
Muralimohan G,Rossi RJ,Vella AT
12-0081 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.
Tue Sep 09 00:00:00 UTC 2008
Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis.
Infection and immunity
Stevenson HL,Crossley EC,Thirumalapura N,Walker DH,Ismail N
12-0081 was used in Flow cytometry/Cell sorting to investigate the physiopathological roles of natural killer T cells in lethal ehrlichial infection using CD1d-deficient mice.
Tue Apr 01 00:00:00 UTC 2008
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.
Blood
Van Meter ME,Díaz-Flores E,Archard JA,Passegué E,Irish JM,Kotecha N,Nolan GP,Shannon K,Braun BS
12-0081 was used in Flow cytometry/Cell sorting to investigate the effects of an oncogenic KrasG12D allele on phosphorylated signaling molecules in primary c-kitlin/low hematopoietic progenitor cells.
Tue May 01 00:00:00 UTC 2007
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF
12-0081 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.
Tue Apr 24 00:00:00 UTC 2007
A new approach for analyzing cellular infiltration during allergic airway inflammation.
Journal of immunological methods
Hoffmann PR,Gurary A,Hoffmann FW,Jourdan-Le Saux C,Teeters K,Hashimoto AC,Tam EK,Berry MJ
12-0081 was used in Flow cytometry/Cell sorting to investigate a new approach for analyzing cellular infiltration during allergic airway inflammation.
Sat Dec 01 00:00:00 UTC 2007
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 UTC 2006
In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses.
Journal of virology
Kassim SH,Rajasagi NK,Zhao X,Chervenak R,Jennings SR
12-0081 was used in Flow cytometry/Cell sorting to investigate the role of different dendritic cell subsets in response to herpes simplex virus type 1 infection in mice.
Sat Apr 01 00:00:00 UTC 2006
