Product References
Role of affinity in plasma cell development in the germinal center light zone.
The Journal of experimental medicine
ElTanbouly MA,Ramos V,MacLean AJ,Chen ST,Loewe M,Steinbach S,Ben Tanfous T,Johnson B,Cipolla M,Gazumyan A,Oliveira TY,Nussenzweig MC
47-0081-82 was used in Flow Cytometry to show that initial PC selection overlaps with GC B cell selection, but that the PC compartment accumulates a less diverse and higher affinity collection of antibodies over time.
Mon Jan 01 00:00:00 UTC 2024
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
Nature
Schaefer-Babajew D,Wang Z,Muecksch F,Cho A,Loewe M,Cipolla M,Raspe R,Johnson B,Canis M,DaSilva J,Ramos V,Turroja M,Millard KG,Schmidt F,Witte L,Dizon J,Shimeliovich I,Yao KH,Oliveira TY,Gazumyan A,Gaebler C,Bieniasz PD,Hatziioannou T,Caskey M,Nussenzweig MC
47-0081-82 was used in Flow cytometry/Cell sorting to indicate that pre-existing high-affinity antibodies bias germinal centre and memory B cell selection through two distinct mechanisms: (1) by lowering the activation threshold for B cells, thereby permitting abundant lower-affinity clones to participate in the immune response; and (2) through direct masking of their cognate epitopes.
Sun Jan 01 00:00:00 UTC 2023
Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Cancer immunology, immunotherapy : CII
Symonds ALJ,Miao T,Busharat Z,Li S,Wang P
47-0081-82 was used in Flow cytometry/Cell sorting to conclude that Egr2 and 3 are important for maintaining anti-tumour responses of exhausted CD8 + TILs.
Mon May 01 00:00:00 UTC 2023
Continuous germinal center invasion contributes to the diversity of the immune response.
Cell
Hägglöf T,Cipolla M,Loewe M,Chen ST,Mesin L,Hartweger H,ElTanbouly MA,Cho A,Gazumyan A,Ramos V,Stamatatos L,Oliveira TY,Nussenzweig MC,Viant C
47-0081-82 was used in Flow cytometry/Cell sorting to show that naive B cells continuously enter GCs where they compete for T cell help and undergo clonal expansion.
Thu Jan 05 00:00:00 UTC 2023
Divergent metabolic programmes control two populations of MAIT cells that protect the lung.
Nature cell biology
Riffelmacher T,Paynich Murray M,Wientjens C,Chandra S,Cedillo-Castelán V,Chou TF,McArdle S,Dillingham C,Devereaux J,Nilsen A,Brunel S,Lewinsohn DM,Hasty J,Seumois G,Benedict CA,Vijayanand P,Kronenberg M
47-0081-82 was used in Flow cytometry/Cell sorting to investigate the metabolic dependencies that enable tuning of memory-like MAIT cell responses following pulmonary immunization with a Salmonella vaccine strain, revealing distinct CD127+ and Klrg1+ MAIT cell populations with divergent metabolic profiles and functions.
Thu Jun 01 00:00:00 UTC 2023
Antigen-presenting T cells provide critical B7 co-stimulation for thymic iNKT cell development via CD28-dependent trogocytosis.
Cell reports
Watanabe M,Celli S,Alkhaleel FA,Hodes RJ
47-0081-82 was used in Flow Cytometry to demonstrate a mechanism of B7 co-stimulation in thymic T cell development by antigen-presenting T cells.
Tue Nov 29 00:00:00 UTC 2022
Nanomaterials-Mediated Co-Stimulation of Toll-Like Receptors and CD40 for Antitumor Immunity.
Advanced materials (Deerfield Beach, Fla.)
Yan J,Zhang Y,Du S,Hou X,Li W,Zeng C,Zhang C,Cheng J,Deng B,McComb DW,Zhao W,Xue Y,Kang DD,Cheng X,Dong Y
47-0081-82 was used in Flow cytometry/Cell sorting to develop an immunotherapy regimen that enables co-stimulation of TLR7/8- and CD40-mediated pathways.
Tue Nov 01 00:00:00 UTC 2022
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis.
Cell death and differentiation
Hajjar S,Nathan N,Joseph J,Mottawea W,Ariana A,Pyatibrat S,Harper ME,Alain T,Blais A,Russell RC,Sad S
47-0081-82 was used in Flow cytometry/Cell sorting to show that Foxo3a restricts the abundance of colitogenic microbiota in IL-10-deficient mice.
Tue Mar 01 00:00:00 UTC 2022
Neoantigen cancer vaccine augments anti-CTLA-4 efficacy.
NPJ vaccines
Salvatori E,Lione L,Compagnone M,Pinto E,Conforti A,Ciliberto G,Aurisicchio L,Palombo F
47-0081-82 was used in Flow Cytometry to support the use of NCV delivered by DNA-EP with αCTLA-4 and suggest a new combined therapy for clinical testing.
Wed Feb 02 00:00:00 UTC 2022
Circadian Dependence of the Acute Immune Response to Myocardial Infarction.
Frontiers in pharmacology
Kilgallen AB,van den Akker F,Feyen DAM,Crnko S,Snijders Blok CJB,Gremmels H,du Pré BC,Reijers R,Doevendans PA,de Jager SCA,Sluijter JPG,Sampaio-Pinto V,van Laake LW
47-0081-82 was used in Flow cytometry/Cell sorting to characterize the immune response and myocardial damage 3 hours after a MI occurs over a full twenty-four-hour period to investigate the role of the circadian rhythms in this response.
Sat Sep 16 00:00:00 UTC 2023
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.
eLife
Abdel-Haq R,Schlachetzki JCM,Boktor JC,Cantu-Jungles TM,Thron T,Zhang M,Bostick JW,Khazaei T,Chilakala S,Morais LH,Humphrey G,Keshavarzian A,Katz JE,Thomson M,Knight R,Gradinaru V,Hamaker BR,Glass CK,Mazmanian SK
47-0081-82 was used in Flow Cytometry to investigate whether a fiber-rich diet influences microglial function in α-synuclein overexpressing (ASO) mice, a preclinical model with PD-like symptoms and pathology.
Tue Nov 08 00:00:00 UTC 2022
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells.
Cell
Omer-Javed A,Pedrazzani G,Albano L,Ghaus S,Latroche C,Manzi M,Ferrari S,Fiumara M,Jacob A,Vavassori V,Nonis A,Canarutto D,Naldini L
47-0081-82 was used in flow cytometry to provide a potentially valuable strategy paving the way to broader and safer use of HSPC-GT.
Thu Jun 23 00:00:00 UTC 2022
YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.
Cell reports
Grenov A,Hezroni H,Lasman L,Hanna JH,Shulman Z
47-0081-82 was used in Flow Cytometry to reveal how post-transcriptional suppression of gene expression directs appropriate B cell fate commitment during initiation of the adaptive immune response.
Tue May 03 00:00:00 UTC 2022
Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.
iScience
Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS
47-0081-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.
Fri Jun 17 00:00:00 UTC 2022
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells.
The Journal of clinical investigation
Liikanen I,Lauhan C,Quon S,Omilusik K,Phan AT,Bartrolí LB,Ferry A,Goulding J,Chen J,Scott-Browne JP,Yustein JT,Scharping NE,Witherden DA,Goldrath AW
47-0081-82 was used in Flow Cytometry to show that HIF activity in CD8+ TILs promotes accumulation and antitumor activity, providing a new strategy to enhance the efficacy of ACTs.
Thu Apr 01 00:00:00 UTC 2021
Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.
The EMBO journal
Wang X,Ray R,Kratochvil S,Melzi E,Lin YC,Giguere S,Xu L,Warner J,Cheon D,Liguori A,Groschel B,Phelps N,Adachi Y,Tingle R,Wu L,Crotty S,Kirsch KH,Nair U,Schief WR,Batista FD
47-0081 was used in Flow cytometry/Cell sorting to report a one-step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.
Fri Jan 15 00:00:00 UTC 2021
Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice.
Dose-response : a publication of International Hormesis Society
Rey N,Ebrahimian T,Gloaguen C,Kereselidze D,Magneron V,Bontemps CA,Demarquay C,Olsson G,Haghdoost S,Lehoux S,Ebrahimian TG
47-0081-82 was used in Flow Cytometry to investigate the immunomodulatory response of different doses and dose-rates of irradiation in ApoE-/- mice.
Fri Jun 25 00:00:00 UTC 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
47-0081-82 was used in Flow cytometry/Cell sorting to find that decreased microbiota diversity induced by prolonged antibiotic (ATB) treatment is associated with higher intratumor specific immune responses and consequently to a better antitumor effect induced by neoantigen cancer vaccines (NCVs) delivered by DNA-EP.
Tue Mar 23 00:00:00 UTC 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
47-0081-82 was used in Flow Cytometry to analyze the BCRs of different mouse B cell populations for somatic hypermutations, clonal and phylogenic relationships, and their affinity for cognate antigen.
Fri Jun 18 00:00:00 UTC 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
47-0081-82 was used in Flow Cytometry to demonstrate homotypic and heterotypic conjugation of 8 different hemagglutinin trimers.
Fri Oct 15 00:00:00 UTC 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
47-0081-82 was used in Flow Cytometry to understand the molecular mechanism underlying the generation of follicular helper T cells.
Mon Dec 20 00:00:00 UTC 2021
IFNγ-Producing γ/δ T Cells Accumulate in the Fetal Brain Following Intrauterine Inflammation.
Frontiers in immunology
Lewis EL,Tulina N,Anton L,Brown AG,Porrett PM,Elovitz MA
47-0081-82 was used in Flow Cytometry to investigates how inflammation transverses across multiple anatomic compartments from the maternal reproductive tract to the fetal brain and what specific cell types in the fetal brain may cause long-term neuronal injury.
Wed Jan 05 00:00:00 UTC 2022
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
mAbs
Schofield DJ,Percival-Alwyn J,Rytelewski M,Hood J,Rothstein R,Wetzel L,McGlinchey K,Adjei G,Watkins A,Machiesky L,Chen W,Andrews J,Groves M,Morrow M,Stewart RA,Leinster A,Wilkinson RW,Hammond SA,Luheshi N,Dobson C,Oberst M
47-0081-82 was used in Flow cytometry/Cell sorting to show that anti-PD-L1 and anti-CTLA-4 murine surrogates with pharmacologic properties similar to those of durvalumab and tremelimumab demonstrated anti-tumor activity in a subset of commonly used mouse syngeneic tumor models.
Thu Oct 14 00:00:00 UTC 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
47-0081 was used in Flow cytometry/Cell sorting to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 UTC 2020
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
47-0081 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 UTC 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
47-0081-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 UTC 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
47-0081-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 UTC 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
47-0081 was used in Flow cytometry/Cell sorting to show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype.
Mon May 11 00:00:00 UTC 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
47-0081-82 was used in Flow Cytometry to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 UTC 2020
Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Eixarch H,Calvo-Barreiro L,Costa C,Reverter-Vives G,Castillo M,Gil V,Del Río JA,Montalban X,Espejo C
47-0081-82 was used in Flow Cytometry to suggest a role for BMPs in early immune events that take place in myelin oligodendrocyte glycoprotein (MOG)-induced EAE.
Thu Oct 01 00:00:00 UTC 2020
CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Nature communications
Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ
47-0081 was used in Flow cytometry/Cell sorting to demonstrate the stimulatory effect of CD40L-overexpressing CAR T cells on innate and adaptive immune cells, and provide a rationale for using CD40L-overexpressing CAR T cells to improve immunotherapy responses.
Wed Dec 02 00:00:00 UTC 2020
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.
Oncoimmunology
Ye X,Waite JC,Dhanik A,Gupta N,Zhong M,Adler C,Malahias E,Ni M,Wei Y,Gurer C,Zhang W,Macdonald LE,Murphy AJ,Sleeman MA,Skokos D
47-0081 was used in Flow cytometry/Cell sorting to reveal that endogenous retroviral antigens expressed by tumour cells may represent an important and underappreciated category of tumour antigens that could be readily targeted in the clinic.
Wed May 13 00:00:00 UTC 2020
Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function.
Communications biology
Abdullah CS,Aishwarya R,Alam S,Morshed M,Remex NS,Nitu S,Kolluru GK,Traylor J,Miriyala S,Panchatcharam M,Hartman B,King J,Bhuiyan MAN,Chandran S,Woolard MD,Yu X,Goeders NE,Dominic P,Arnold CL,Stokes K,Kevil CG,Orr AW,Bhuiyan MS
47-0081-82 was used in Flow Cytometry to show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy.
Tue Nov 17 00:00:00 UTC 2020
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
47-0081 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of two commercial multispecies probiotics-Lactibiane iki and Vivomixx-on the clinical outcome of established experimental autoimmune encephalomyelitis (EAE).
Tue Apr 07 00:00:00 UTC 2020
B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
Cell reports
Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z
47-0081-82 was used in Flow cytometry/Cell sorting to demonstrate that T cell-derived help to B cells in PPs includes SAP-dependent and SAP-independent functions.
Tue Feb 11 00:00:00 UTC 2020
MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.
Journal for immunotherapy of cancer
Jiang X,Dudzinski S,Beckermann KE,Young K,McKinley E,J McIntyre O,Rathmell JC,Xu J,Gore JC
47-0081-82 was used in Flow Cytometry to propose an innovative concept that a sufficiently large influx of tumor infiltrating T cells, which have a smaller diameter than cancer cells, will change the diameter distribution and decrease the average size of cells within a volume to a degree that can be quantified by non-invasive MRI.
Mon Jun 01 00:00:00 UTC 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
47-0081 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 UTC 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
47-0081-82 was used in Flow Cytometry to develop an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1 to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires.
Sat Jun 01 00:00:00 UTC 2019
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
47-0081 was used in Flow cytometry/Cell sorting to reveal an unexpected autophagy regulatory mechanism mediated by eIF5A at the translational level, which can be harnessed to reverse immune senescence in humans.
Thu Oct 03 00:00:00 UTC 2019
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges.
The Journal of experimental medicine
Silva HM,Báfica A,Rodrigues-Luiz GF,Chi J,Santos PDA,Reis BS,Hoytema van Konijnenburg DP,Crane A,Arifa RDN,Martin P,Mendes DAGB,Mansur DS,Torres VJ,Cadwell K,Cohen P,Mucida D,Lafaille JJ
47-0081 was used in Flow cytometry/Cell sorting to investigate if tissue-resident macrophages from healthy epididymal white adipose tissue (eWAT), not only surround adipocytes but also associate tightly with blood vessels, being among the most endocytic cells in the body for blood-borne macromolecules.
Mon Apr 01 00:00:00 UTC 2019
Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers.
Cancer research
Bhatia S,Oweida A,Lennon S,Darragh LB,Milner D,Phan AV,Mueller AC,Van Court B,Raben D,Serkova NJ,Wang XJ,Jimeno A,Clambey ET,Pasquale EB,Karam SD
47-0081 was used in Flow cytometry/Cell sorting to show EphB4-ephrin-B2 inhibition displayed tumor growth suppression, indicating a possible alternative for those that cannot receive anti-PDL1 therapy.
Wed May 15 00:00:00 UTC 2019
Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
Haematologica
Di Genua C,Norfo R,Rodriguez-Meira A,Wen WX,Drissen R,Booth CAG,Povinelli B,Repapi E,Gray N,Carrelha J,Kettyle LM,Jamieson L,Neo WH,Thongjuea S,Nerlov C,Mead AJ
47-0081 was used in Flow cytometry/Cell sorting to study the mechanism behind absence of KRAS signalling mutations in pre-malignant hematopoietic stem cell compartments.
Fri Nov 01 00:00:00 UTC 2019
CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression.
Oncogene
Westrich JA,Vermeer DW,Silva A,Bonney S,Berger JN,Cicchini L,Greer RO,Song JI,Raben D,Slansky JE,Lee JH,Spanos WC,Pyeon D
47-0081-82 was used in Flow Cytometry to show that the CXCL14-mediated antitumor CD8+ T-cell responses require antigen specificity.
Fri Nov 01 00:00:00 UTC 2019
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Journal of immunology (Baltimore, Md. : 1950)
Kotov DI,Mitchell JS,Pengo T,Ruedl C,Way SS,Langlois RA,Fife BT,Jenkins MK
47-0081-82 was used in Flow Cytometry to study TCR affinity and influence on regulation of genes in naive T cells that control the differentiation process in cells.
Wed May 01 00:00:00 UTC 2019
A new role for Notch in the control of polarity and asymmetric cell division of developing T cells.
Journal of cell science
Charnley M,Ludford-Menting M,Pham K,Russell SM
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that Notch signalling controls the distribution of Notch1 itself and cell fate determinants, α-adaptin and Numb, and cooperated with CXCR4 signalling to drive polarity during T cell development.
Thu Oct 24 00:00:00 UTC 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
47-0081-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 UTC 2020
Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.
Cell reports
Leylek R,Alcántara-Hernández M,Lanzar Z,Lüdtke A,Perez OA,Reizis B,Idoyaga J
47-0081 was used in Flow cytometry/Cell sorting to provide a framework for deciphering the function of pDCs and tDCs during diseases, which has the potential to open new avenues for therapeutic design.
Tue Dec 10 00:00:00 UTC 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
47-0081 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 UTC 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
47-0081-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 UTC 2019
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.
Immunity
Li J,Lee Y,Li Y,Jiang Y,Lu H,Zang W,Zhao X,Liu L,Chen Y,Tan H,Yang Z,Zhang MQ,Mak TW,Ni L,Dong C
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that increased B7S1 expression in myeloid cells from human hepatocellular carcinoma is correlated with CD8+ T cell dysfunction.
Tue Apr 17 00:00:00 UTC 2018
Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression.
Frontiers in immunology
Vashist N,Trittel S,Ebensen T,Chambers BJ,Guzmán CA,Riese P
47-0081 was used in Flow cytometry/Cell sorting to discover the regulation behind ILC1s during infection and their capacity to interact with cells of the adaptive immune system.
Fri May 10 00:00:00 UTC 2019
Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice.
Scientific reports
Lee JTC,Shanina I,Chu YN,Horwitz MS,Johnson JD
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that carbamazepine reduces the development of type 1 diabetes in non-obese diabetic mice by maintaining functional beta-cell mass.
Thu Mar 15 00:00:00 UTC 2018
IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.
PloS one
Kulkarni U,Herrmenau C,Win SJ,Bauer M,Kamradt T
47-0081 was used in Flow cytometry/Cell sorting to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment.
Mon Apr 09 00:00:00 UTC 2018
Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Nature communications
Lorentsen KJ,Cho JJ,Luo X,Zuniga AN,Urban JF,Zhou L,Gharaibeh R,Jobin C,Kladde MP,Avram D
47-0081 was used in Flow cytometry/Cell sorting to establish novel roles for Bcl11b in the regulatory loop that licenses Th2 program in vivo.
Thu Apr 26 00:00:00 UTC 2018
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.
Scientific reports
Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA
47-0081 was used in Flow cytometry/Cell sorting to study the role of type 2 innate lymphoid cells in enhancing anti-cancer immunity and controlling metastasis.
Tue Feb 13 00:00:00 UTC 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
47-0081 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.
Mon Jul 16 00:00:00 UTC 2018
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Scientific reports
Osum KC,Burrack AL,Martinov T,Sahli NL,Mitchell JS,Tucker CG,Pauken KE,Papas K,Appakalai B,Spanier JA,Fife BT
47-0081 was used in Flow cytometry/Cell sorting to suggest that insulin-producing Β cells respond to pancreatic inflammation and IFN-γ production by upregulating PD-L1 expression to limit self-reactive T cells.
Tue May 29 00:00:00 UTC 2018
A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin.
PloS one
Carlow DA,Tra MC,Ziltener HJ
47-0081 was used in Flow cytometry to examine P-selectin ligand expression on activated CD8+ T cells in murine adoptive transfer models.
Tue Mar 26 00:00:00 UTC 2019
Evaluation of the capacities of mouse TCR profiling from short read RNA-seq data.
PloS one
Bai Y,Wang D,Li W,Huang Y,Ye X,Waite J,Barry T,Edelmann KH,Levenkova N,Guo C,Skokos D,Wei Y,Macdonald LE,Fury W
47-0081 was used in Flow cytometry to systematically assess short read transcriptome sequencing in T cell receptor profiling.
Tue Apr 16 00:00:00 UTC 2019
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
47-0081 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 UTC 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
47-0081 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 UTC 2017
CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.
Journal of the American Society of Nephrology : JASN
Chang J,Eggenhuizen P,O'Sullivan KM,Alikhan MA,Holdsworth SR,Ooi JD,Kitching AR
47-0081 was used in Flow cytometry/Cell sorting to study the pathological role of CD8+ T cells in ANCA-associated vasculitis.
Sun Jan 01 00:00:00 UTC 2017
Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.
Journal of immunology (Baltimore, Md. : 1950)
Zaid A,Hor JL,Christo SN,Groom JR,Heath WR,Mackay LK,Mueller SN
47-0081 was used in Flow cytometry/Cell sorting to examine the signals required for the migration of tissue-resident memory T cells within the constrained epidermal environment.
Sun Oct 01 00:00:00 UTC 2017
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
47-0081 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 UTC 2017
Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.
Scientific reports
Van Den Ham KM,Smith LK,Richer MJ,Olivier M
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of protein tyrosine phosphatase activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology.
Fri Jul 14 00:00:00 UTC 2017
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.
Oncoimmunology
Oweida A,Lennon S,Calame D,Korpela S,Bhatia S,Sharma J,Graham C,Binder D,Serkova N,Raben D,Heasley L,Clambey E,Nemenoff R,Karam SD
47-0081 was used in Flow cytometry/Cell sorting to investigate whether local radiation can transform the tumour immune landscape and render poorly immunogenic head and neck squamous cell carcinoma tumours sensitive to PD-L1 inhibition.
Fri Apr 08 00:00:00 UTC 2022
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
47-0081 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 UTC 2016
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
47-0081 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 UTC 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
47-0081 was used in Flow cytometry/Cell sorting to suggest persistent viral lytic gene expression during latency causes chronic inflammatory response inducing exhaustion of resident T cells in the ependyma.
Mon Aug 15 00:00:00 UTC 2016
B cells establish, but do not maintain, long-lived murine anti-peanut IgE(a).
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Moutsoglou DM,Dreskin SC
47-0081 was used in Flow cytometry/Cell sorting to study the role of CD20+ cells in maintaining lifelong anti-peanut IgE levels.
Fri Apr 01 00:00:00 UTC 2016
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols
von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC
47-0081-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.
Sat Oct 01 00:00:00 UTC 2016
Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.
PloS one
Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B
47-0081 was used in Flow cytometry/Cell sorting to investigate the potential of a previously uncharacterized property of natural human adenovirus infection to dictate, modulate and/or alter the course of HCV infection upon exposure.
Tue Jul 19 00:00:00 UTC 2016
Enrichment of IFN-γ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite.
Scientific reports
Teixeira L,Marques RM,Ferreirinha P,Bezerra F,Melo J,Moreira J,Pinto A,Correia A,Ferreira PG,Vilanova M
47-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of NK and T cells to the production of IFN-γ in the adipose tissue of Neospora caninum infected mice.
Tue Mar 22 00:00:00 UTC 2016
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Nature communications
Spanier JA,Frederick DR,Taylor JJ,Heffernan JR,Kotov DI,Martinov T,Osum KC,Ruggiero JL,Rust BJ,Landry SJ,Jenkins MK,McLachlan JB,Fife BT
47-0081 was used in Flow cytometry/Cell sorting to develop a novel approach for the generation and screening of peptide:MHCII reactive mAbs that exploits the use of recombinant peptide:MHC monomers as immunogens.
Mon Jun 13 00:00:00 UTC 2016
Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease.
Journal of hematology & oncology
Fransolet G,Ehx G,Somja J,Delens L,Hannon M,Muller J,Dubois S,Drion P,Caers J,Humblet-Baron S,Delvenne P,Beguin Y,Conteduca G,Baron F
47-0081 was used in Flow cytometry/Cell sorting to assessed the impact of azacytidine on cGVHD in a murine model of sclerodermic cGVHD.
Mon Jul 04 00:00:00 UTC 2016
Quantitative and Qualitative Analysis of Bone Marrow CD8(+) T Cells from Different Bones Uncovers a Major Contribution of the Bone Marrow in the Vertebrae.
Frontiers in immunology
Geerman S,Hickson S,Brasser G,Pascutti MF,Nolte MA
47-0081 was used in Flow cytometry/Cell sorting to suggest that in respect to CD8(+) T cells, BM harvested from a single bone is a fair reflection of the rest of the BM present in the murine body.
Thu Jan 21 00:00:00 UTC 2016
Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
PLoS pathogens
Wiesner DL,Specht CA,Lee CK,Smith KD,Mukaremera L,Lee ST,Lee CG,Elias JA,Nielsen JN,Boulware DR,Bohjanen PR,Jenkins MK,Levitz SM,Nielsen K
47-0081 was used in Flow cytometry/Cell sorting to investigate Th2 cell responses to pulmonary fungal infection, showing that chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
Sun Mar 01 00:00:00 UTC 2015
The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Soukup K,Halfmann A,Le Bras M,Sahin E,Vittori S,Poyer F,Schuh C,Luger R,Niederreiter B,Haider T,Stoiber D,Blüml S,Schabbauer G,Kotlyarov A,Gaestel M,Felzmann T,Dohnal AM
47-0081 was used in Flow cytometry/Cell sorting to investigate the role of MK2 in dendritic cells, showing that it attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis.
Wed Jul 15 00:00:00 UTC 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
47-0081 was used in Flow cytometry/Cell sorting to show limited miR-17-92 overexpression can drive hematologic malignancies.
Sun Mar 01 00:00:00 UTC 2015
Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo.
PloS one
Costa M,Cruz E,Oliveira S,Benes V,Ivacevic T,Silva MJ,Vieira I,Dias F,Fonseca S,Gonçalves M,Lima M,Leitão C,Muckenthaler MU,Pinto J,Porto G
47-0081 was used in Flow cytometry/Cell sorting to elucidate the role of the hereditary haemochromatosis-associated protein HFE in influencing CD8+ T-lymphocyte homeostasis.
Fri Apr 15 00:00:00 UTC 2016
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Oncotarget
Edgington-Mitchell LE,Rautela J,Duivenvoorden HM,Jayatilleke KM,van der Linden WA,Verdoes M,Bogyo M,Parker BS
47-0081 was used in Flow cytometry/Cell sorting to suggest that cysteine protease inhibition is associated with enhanced osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Tue Sep 29 00:00:00 UTC 2015
Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.
PloS one
Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M
47-0081 was used in Flow cytometry/Cell sorting to study the effect of iron in attenuating CXCR3-mediated T cell chemotaxis and migration to the brain and therefore inhibiting Experimental Cerebral Malaria pathology.
Thu Jan 21 00:00:00 UTC 2016
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nature communications
Kanno A,Tanimura N,Ishizaki M,Ohko K,Motoi Y,Onji M,Fukui R,Shimozato T,Yamamoto K,Shibata T,Sano S,Sugahara-Tobinai A,Takai T,Ohto U,Shimizu T,Saitoh S,Miyake K
47-0081 was used in Flow cytometry/Cell sorting to show that Toll-like receptor 7 (TLR7) is present on the cell surface of immune cells and that TLR7 responses can be inhibited by an anti-TLR7 antibody.
Wed Feb 04 00:00:00 UTC 2015
Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
Nature immunology
Au-Yeung BB,Melichar HJ,Ross JO,Cheng DA,Zikherman J,Shokat KM,Robey EA,Weiss A
47-0081 was used in Flow cytometry/Cell sorting to show that CD4(+)CD8(+) thymocytes integrate multiple, transient, Zap70-dependent signals over more than 36 h to reach a cumulative threshold for positive selection.
Tue Jul 01 00:00:00 UTC 2014
CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
The Journal of experimental medicine
Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P
47-0081 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.
Mon Dec 15 00:00:00 UTC 2014
Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury.
Cardiovascular research
De Hoog VC,Timmers L,Van Duijvenvoorde A,De Jager SC,Van Middelaar BJ,Smeets MB,Woodruff TM,Doevendans PA,Pasterkamp G,Hack CE,De Kleijn DP
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that selective blocking of C5aR might be a promising strategy to prevent myocardial ischaemia-reperfusion injury.
Mon Sep 01 00:00:00 UTC 2014
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.
eLife
Baptista AP,Roozendaal R,Reijmers RM,Koning JJ,Unger WW,Greuter M,Keuning ED,Molenaar R,Goverse G,Sneeboer MM,den Haan JM,Boes M,Mebius RE
47-0081 was used in Flow cytometry/Cell sorting to investigate the role of MHC-II in lymph node stromal cells, showing that stromal cells constrain immunity through MHC-II expression.
Wed Nov 19 00:00:00 UTC 2014
Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection.
PLoS pathogens
Maroof A,Yorgensen YM,Li Y,Evans JT
47-0081 was used in Flow cytometry/Cell sorting to highlight the importance of both route of vaccination and adjuvant selection in vaccine development.
Wed Jan 01 00:00:00 UTC 2014
CD40 ligand preferentially modulates immune response and enhances protection against influenza virus.
Journal of immunology (Baltimore, Md. : 1950)
Hashem AM,Gravel C,Chen Z,Yi Y,Tocchi M,Jaentschke B,Fan X,Li C,Rosu-Myles M,Pereboev A,He R,Wang J,Li X
47-0081 was used in Flow cytometry/Cell sorting to characterise an increased in vivo load of CD40-targeted Ag upon the secretion of the NP-CD40L fusion protein from adenovirus-infected cells.
Tue Jul 15 00:00:00 UTC 2014
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.
PloS one
Markwart R,Condotta SA,Requardt RP,Borken F,Schubert K,Weigel C,Bauer M,Griffith TS,Förster M,Brunkhorst FM,Badovinac VP,Rubio I
47-0081 was used in Flow cytometry/Cell sorting to investigate the nature of defects of T-cell immunity in post-acute phases of systemic inflammatory response, showing an induced loss of naive T-cells but no enduring cell-autonomous defects in T-cell function.
Thu Aug 27 00:00:00 UTC 2015
Chemotherapy enhances cross-presentation of nuclear tumor antigens.
PloS one
Anyaegbu CC,Lake RA,Heel K,Robinson BW,Fisher SA
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that chemotherapy improves nuclear tumor antigen cross-presentation.
Mon Dec 07 00:00:00 UTC 2015
Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.
Journal of translational medicine
Fisher SA,Cleaver A,Lakhiani DD,Khong A,Connor T,Wylie B,Lesterhuis WJ,Robinson BW,Lake RA
47-0081 was used in Flow cytometry/Cell sorting to characterise changes in the proportion and activation status of immune cells associated with anti-tumour immunity.
Thu Sep 04 00:00:00 UTC 2014
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
47-0081 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 UTC 2013
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
47-0081 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 UTC 2013
Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.
The American journal of pathology
Guijarro MV,Dahiya S,Danielson LS,Segura MF,Vales-Lara FM,Menendez S,Popiolek D,Mittal K,Wei JJ,Zavadil J,Cordon-Cardo C,Pandolfi PP,Hernando E
47-0081 was used in Flow cytometry/Cell sorting to elucidate the mechanisms driving cytogenetically complex sarcoma development.
Sat Jun 01 00:00:00 UTC 2013
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence.
PloS one
Macleod MK,David A,Jin N,Noges L,Wang J,Kappler JW,Marrack P
47-0081 was used in Flow cytometry/Cell sorting to investigate the potential for a nucleoprotein vaccine solution for influenza A, expressing an altered nucleoprotein version.
Thu Nov 14 00:00:00 UTC 2013
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
47-0081 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 UTC 2012
Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.
Journal of immunology (Baltimore, Md. : 1950)
Yang RK,Kalogriopoulos NA,Rakhmilevich AL,Ranheim EA,Seo S,Kim K,Alderson KL,Gan J,Reisfeld RA,Gillies SD,Hank JA,Sondel PM
47-0081 was used in Flow cytometry/Cell sorting to study how IT-IC resulted in increased numbers of activated T and NK cells within tumours, better IC retention in the tumour, enhanced inhibition of tumour growth, and improved survival compared with i.v.-IC.
Sat Sep 01 00:00:00 UTC 2012
The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.
Blood
Popovic J,Li LP,Kloetzel PM,Leisegang M,Uckert W,Blankenstein T
47-0081 was used in Flow cytometry/Cell sorting to investigate whether targeting tumour-specific mutations reduces risk of autoimmunity.
Thu Jul 28 00:00:00 UTC 2011
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Hwang J,Kita R,Kwon HS,Choi EH,Lee SH,Udey MC,Morasso MI
47-0081 was used in Flow cytometry/Cell sorting to investigate the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, showing that ablation is linked to IL-17-associated skin inflammation.
Tue Jul 12 00:00:00 UTC 2011
Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950)
Mosenden R,Singh P,Cornez I,Heglind M,Ruppelt A,Moutschen M,Enerbäck S,Rahmouni S,Taskén K
47-0081 was used in Flow cytometry/Cell sorting to study how the cAMP-type I PKA pathway in T cells may be a target for therapeutic intervention in immunodeficiency diseases.
Sun May 01 00:00:00 UTC 2011
Genetic variation determines mast cell functions in experimental asthma.
Journal of immunology (Baltimore, Md. : 1950)
Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M
47-0081 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.
Wed Jun 15 00:00:00 UTC 2011
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
47-0081 was used in Flow cytometry/Cell sorting to investigate the role of FLT3 in early granulocyte-monocyte progenitors (GMPs), showing that most GMPs are derived from FLT3-expressing progenitors.
Thu Jun 17 00:00:00 UTC 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
47-0081 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 UTC 2010
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
47-0081 was used in Flow cytometry/Cell sorting to study the role of Tc17 cells in influenza infection, showing that they protect against lethality.
Sun Mar 15 00:00:00 UTC 2009
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 UTC 2008
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 UTC 2006
