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NeoBiotechnologies
CD91/LDL Receptor Related Protein 1 (LRP1) Monoclonal Antibody (LRP1/7152)
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Product Details
4035-MSM2-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2, kappa
Class
Monoclonal
Type
Antibody
Clone
LRP1/7152
Immunogen
Recombinant fragment of human LRP1 protein (exact sequence is proprietary)
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: brain or lung. Human liver
Cellular Location: Cytoplasm. Nucleus. Cell surface.
Target Information
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; low density lipoprotein receptor-related protein 1; LRP-1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor
Gene Aliases: A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954
Entrez Gene ID: (Human) 4035
retinoid metabolic process
receptor-mediated endocytosis
protein kinase C-activating G-protein coupled receptor signaling pathway
aging
cell proliferation
positive regulation of cholesterol efflux
negative regulation of neuron projection development
negative regulation of smooth muscle cell migration
cerebral cortex development
negative regulation of Wnt signaling pathway
positive regulation of lipid transport
regulation of cholesterol transport
regulation of phospholipase A2 activity
regulation of actin cytoskeleton organization
aorta morphogenesis
lipoprotein metabolic process
lipoprotein transport
apoptotic cell clearance
negative regulation of neuron apoptotic process
positive regulation of protein transport
beta-amyloid clearance
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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