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CDA1 Polyclonal Antibody

CDA1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

CDA1 Antibody (12087-2-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using TSPYL2 antibody 12087-2-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IGG (green). Blue pseudocolor = DAPI (fluorescent DNA dye).

CDA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CDA1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12087-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDA1 Fusion Protein Ag2722 (344-693 aa encoded by BC024270)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: WHRGQEPQA RRHGNQDASH SFFSWFSNHS LPEADRIAEI IKNDLWVNPL RYYLRERGSR IKRKKQEMKK RKTRGRCEVV IMEDAPDYYA VEDIFSEISD IDETIHDIKI SDFMETTDYF ETTDNEITDI NENICDSENP DHNEVPNNET TDNNESADDH ETTDNNESAD DNNENPEDNN KNTDDNEENP NNNENTYGNN FFKGGFWGSH GNNQDSSDSD NEADEASDDE DNDGNEGDNE GSDDDGNEGD NEGSDDDDRD IEYYEKVIED FDKDQADYED VIEIISDESV EEEGIEEGIQ QDEDIYEEGN YEEEGSEDVW EEGEDSDDSD LEDVLQVPNG WANPGKRGKT G (344-693 aa encoded by BC024270)

Target Information

This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER). This protein is an acidic phospho-protein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease (PCLD). Alternatively spliced transcript variants encoding distinct isoforms have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.

Cell death & disease

Zhang S,Tong X,Liu S,Huang J,Zhang L,Zhang T,Wang D,Fan H

Fri Jun 30 00:00:00 UTC 2023

AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.

Cell death & disease

Zhang S,Tong X,Liu S,Huang J,Zhang L,Zhang T,Wang D,Fan H

Fri Jun 30 00:00:00 UTC 2023

Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.

Journal of ginseng research

Pan H,Yang L,Bai H,Luo J,Deng Y

Thu Sep 01 00:00:00 UTC 2022

Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.

Journal of ginseng research

Pan H,Yang L,Bai H,Luo J,Deng Y

Thu Sep 01 00:00:00 UTC 2022

The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner.

Oncotarget

Kido T,Li Y,Tanaka Y,Dahiya R,Chris Lau YF

Tue Feb 19 00:00:00 UTC 2019

Expression of Genes Related to Germ Cell Lineage and Pluripotency in Single Cells and Colonies of Human Adult Germ Stem Cells.

Stem cells international

Conrad S,Azizi H,Hatami M,Kubista M,Bonin M,Hennenlotter J,Sievert KD,Skutella T

Wed Dec 09 00:00:00 UTC 2015

Expression of Genes Related to Germ Cell Lineage and Pluripotency in Single Cells and Colonies of Human Adult Germ Stem Cells.

Stem cells international

Conrad S,Azizi H,Hatami M,Kubista M,Bonin M,Hennenlotter J,Sievert KD,Skutella T

Wed Dec 09 00:00:00 UTC 2015

TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation.

Cell death and differentiation

Epping MT,Lunardi A,Nachmani D,Castillo-Martin M,Thin TH,Cordon-Cardo C,Pandolfi PP

Sat Aug 01 00:00:00 UTC 2015

TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation.

Cell death and differentiation

Epping MT,Lunardi A,Nachmani D,Castillo-Martin M,Thin TH,Cordon-Cardo C,Pandolfi PP

Sat Aug 01 00:00:00 UTC 2015

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.

Cell

Eyler CE,Wu Q,Yan K,MacSwords JM,Chandler-Militello D,Misuraca KL,Lathia JD,Forrester MT,Lee J,Stamler JS,Goldman SA,Bredel M,McLendon RE,Sloan AE,Hjelmeland AB,Rich JN

Fri Jul 08 00:00:00 UTC 2011

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.

Cell

Eyler CE,Wu Q,Yan K,MacSwords JM,Chandler-Militello D,Misuraca KL,Lathia JD,Forrester MT,Lee J,Stamler JS,Goldman SA,Bredel M,McLendon RE,Sloan AE,Hjelmeland AB,Rich JN

Fri Jul 08 00:00:00 UTC 2011

The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway.

PloS one

Kido T,Ou JH,Lau YF

Tue Dec 06 00:00:00 UTC 2011

The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway.

PloS one

Kido T,Ou JH,Lau YF

Tue Dec 06 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: CASK-interacting nucleosome assembly protein; Cell division autoantigen 1; CTCL tumor antigen se20-4; CTCL-associated antigen se20-4; Cutaneous T-cell lymphoma-associated antigen se20-4; cutaneous T-cell lymphoma-associated tumor antigen se20-4; differentially expressed nucleolar TGF-beta1 target; Differentially-expressed nucleolar TGF-beta1 target protein; NP79; Nuclear protein of 79 kDa; RP1-290F12.2; testis-specific protein Y encoded-like 2; Testis-specific Y-encoded-like protein 2; TSPY-like 2; TSPY-like protein 2

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Gene Aliases: CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79; SE204; TSPX; TSPYL2

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UniProt ID: (Human) Q9H2G4

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Entrez Gene ID: (Human) 64061

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Function(s)

rDNA binding

Process(es)

nucleosome assembly transcription, DNA-templated regulation of transcription, DNA-templated cell cycle negative regulation of DNA replication regulation of signal transduction covalent chromatin modification negative regulation of cell growth IRE1-mediated unfolded protein response negative regulation of cell cycle regulation of protein kinase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDA1 Polyclonal Antibody

CDA1 Antibody (12087-2-AP) in ICC/IF

Product Details

12087-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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